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40108","Salford",{"type":53,"coordinates":655},[656,657],-2.29042,53.48771,{"lat":657,"lon":656},{"type":660,"investigatorFullName":41,"investigatorTitle":41,"investigatorAffiliation":41,"oldNameTitle":41,"oldOrganization":41},"SPONSOR","100609810","phase-3-a-study-to-evaluate-the-efficacy-and-safety-of-bimekizumab-in-study-participants-with-palmoplantar-pustulosis-100609810",false,"NCT07219420","A Study to Evaluate the Efficacy and Safety of Bimekizumab in Study Participants With Palmoplantar Pustulosis","A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study With Open-Label Extension to Evaluate the Efficacy and Safety of Bimekizumab in Study Participants With Palmoplantar Pustulosis","BeSeen","Inclusion Criteria:\n\n* At least 18 years of age inclusive, at the time of signing the informed consent form (ICF)\n* Have a palmoplantar pustulosis (PPP) diagnosis for at least 24 weeks prior to the Screening Visit\n* Have PPPASI ≥12 at the Screening Visit and Baseline Visit\n* Have PPP-IGA ≥3 at the Screening Visit and Baseline Visit\n* Have pustules on the palms of the hands and\u002For soles of the feet at the Screening Visit and Baseline Visit, defined as pustule severity ≥2 and having more than 5 active pustules\n* Participant must be a candidate for systemic therapy or phototherapy\n\nExclusion Criteria:\n\n* Has PPP symptoms which improve significantly between the Screening Visit and Baseline Visit, defined as a reduction in the PPPASI score\n* Has the following: palmoplantar PSO (plaque PSO on palms\u002Fsoles), guttate PSO, erythrodermic PSO (EP), generalized pustular PSO (GPP), Acrodermatitis continua of Hallopeau (ACH), atopic dermatitis, dyshidrotic eczema or chronic hand eczema.\n* Has drug-induced PSO (eg, first onset or current exacerbation due to beta blockers, calcium channel inhibitors, lithium, or tumor necrosis factor \\[TNF\\] inhibitor) or drug-induced pustular PSO (eg, acute generalized exanthematous pustulosis, acute localized exanthematous pustulosis)\n* Has cutaneous lesions that may interfere with the evaluation of the affected area and\u002For evaluation of the severity of PPP\n* Is taking or has taken prohibited or restricted medications without meeting the mandatory discontinuation or stability period relative to the Baseline Visit\n* Is taking or has ever taken an interleukin (IL)-17A\u002FIL-17F inhibitor, including bimekizumab, or has participated in a bimekizumab investigational study","ALL","18 Years",{"count":672,"type":673},320,"ESTIMATED","INTERVENTIONAL",[676],"PHASE3","The purpose of this study is to evaluate the efficacy and safety of bimekizumab compared with placebo in participants with palmoplantar pustulosis (PPP).",[679],"Palmoplantar Pustulosis",[681],"Bimekizumab, PPP","2026-06-18",{"date":684,"type":685},"2026-06-22","ACTUAL",{"date":687,"type":685},"2025-11-14",{"date":689,"type":673},"2029-11-22",{"name":691,"class":6},"UCB Biopharma SRL",77]