[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644994":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":47,"centralContacts":51,"locations":46,"responsibleParty":57,"collaborators":46,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":46,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":46,"enrollmentInfo":68,"targetDuration":46,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":83,"whyStopped":46,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":46},{"fullName":5,"class":6},"Regeneron Pharmaceuticals","INDUSTRY",[8,14,18,23],{"label":9,"type":10,"description":11,"interventionNames":12},"REGN-2Cat","EXPERIMENTAL","Part A and B",[13],"Drug: REGN-2Cat",{"label":15,"type":10,"description":11,"interventionNames":16},"Freneslerbart",[17],"Drug: Freneslerbart",{"label":19,"type":10,"description":20,"interventionNames":21},"Mevonlerbart","Part A",[22],"Drug: Mevonlerbart",{"label":24,"type":25,"description":11,"interventionNames":26},"Matching placebo","PLACEBO_COMPARATOR",[27],"Drug: Placebo",[29,35,39,43],{"type":30,"name":9,"description":31,"armGroupLabels":32,"otherNames":33},"DRUG","Administered per the protocol",[9],[34],"REGN1908-REGN1909",{"type":30,"name":15,"description":31,"armGroupLabels":36,"otherNames":37},[15],[38],"REGN1908",{"type":30,"name":19,"description":31,"armGroupLabels":40,"otherNames":41},[19],[42],"REGN1909",{"type":30,"name":44,"description":31,"armGroupLabels":45,"otherNames":46},"Placebo",[24],null,[48],{"name":49,"affiliation":5,"role":50},"Clinical Trial Management","STUDY_DIRECTOR",[52],{"name":53,"role":54,"phone":55,"phoneExt":46,"email":56},"Clinical Trials Administrator","CONTACT","844-734-6643","clinicaltrials@regeneron.com",{"type":58,"investigatorFullName":46,"investigatorTitle":46,"investigatorAffiliation":46,"oldNameTitle":46,"oldOrganization":46},"SPONSOR","100644994","phase-3-a-study-to-evaluate-the-efficacy-and-safety-of-fel-d-1-monoclonal-antibodies-in-adult-and-pediatric-participants-with-allergic-conjunctivitis-due-to-cat-allergy-100644994",false,"NCT07675811","A Study to Evaluate the Efficacy and Safety of Fel d 1 Monoclonal Antibodies in Adult and Pediatric Participants With Allergic Conjunctivitis Due to Cat Allergy","A Randomized, Double-Masked, Placebo-Controlled, Phase 3 Study to Assess the Efficacy and Safety of Fel d 1 Monoclonal Antibodies in Participants With Allergic Conjunctivitis Due to Cat Allergy","Key Inclusion Criteria:\n\n1. Part A: adult participants aged 18 years and older. For part B: pediatric participants ≥8 years and \\\u003C18 years, and adult participants aged 18 years and older.\n2. Positive SPT to cat allergen extract\n3. Positive specific Immunoglobulin E (sIgE) tests for cat and Fel d 1\n4. Positive CAC criteria\n\nKey Exclusion Criteria:\n\n1. Significant and\u002For severe environmental allergies causing symptoms (eg, ocular itching, ocular redness, etc) outside of the challenge setting that are expected to coincide or may interfere with study assessments\n2. Presence of any ophthalmic disease\u002F abnormality\u002F condition that may interfere with study assessments, affect the study outcomes or participant safety\n3. A clinical history of asthma with treatment of asthma requiring systemic (oral or parenteral) corticosteroid treatment as defined in the protocol\n\nNote: Other Protocol Defined Inclusion\u002F Exclusion Criteria Apply","ALL","8 Years",{"count":69,"type":70},570,"ESTIMATED","INTERVENTIONAL",[73],"PHASE3","This study is researching two experimental medicines, freneslerbart and mevonlerbart. Freneslerbart and mevonlerbart can be given alone or together. When given together, the medicine is called \"REGN-2Cat\". These medicines are also known as the \"study drugs\".\n\nThe aim of the study is to see what side effects freneslerbart, mevonlerbart, and REGN-2Cat may have and if they help reduce eye allergy symptoms caused by cat hair\u002Fdander compared with a placebo.\n\nThe study is looking at several other research questions, including:\n\n* How much study drug is in the blood at different times\n* Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)\n* How long the study drug effect lasts",[76],"Allergic Conjunctivitis",[78,79,80,81,82],"Cat allergy","Eye allergy","Cat-induced eye allergy","Ocular allergy signs\u002Fsymptoms","Allergic conjunctivitis signs\u002Fsymptoms","NOT_YET_RECRUITING","2026-06-23",{"date":86,"type":87},"2026-06-30","ACTUAL",{"date":89,"type":70},"2026-07-27",{"date":91,"type":70},"2028-06-30",{"name":5,"class":6}]