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Fryderyka Chopina W Rzeszowie","Rzeszów","35-055",{"type":59,"coordinates":657},[658,659],21.99901,50.04132,{"lat":659,"lon":658},{"facility":662,"status":116,"city":663,"state":35,"zip":664,"country":591,"countryCode":592,"cosmosGeoPoint":665,"geoPoint":669,"contacts":35},"Twoja Przychodnia Scm","Szczecin","71-500",{"type":59,"coordinates":666},[667,668],14.55302,53.42894,{"lat":668,"lon":667},{"facility":671,"status":116,"city":672,"state":35,"zip":673,"country":591,"countryCode":592,"cosmosGeoPoint":674,"geoPoint":678,"contacts":35},"Evimed Sp. Z O. 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Barts Health Nhs Trust","London","E1 1FR",{"type":59,"coordinates":780},[781,782],-0.12574,51.50853,{"lat":782,"lon":781},{"facility":785,"status":53,"city":777,"state":35,"zip":786,"country":768,"countryCode":769,"cosmosGeoPoint":787,"geoPoint":789,"contacts":35},"Guys Hospital","SE1 9RT",{"type":59,"coordinates":788},[781,782],{"lat":782,"lon":781},{"facility":791,"status":53,"city":777,"state":35,"zip":792,"country":768,"countryCode":769,"cosmosGeoPoint":793,"geoPoint":795,"contacts":35},"Great Ormond Street Hospital For Children Nhs Foundation Trust","WC1N 3JH",{"type":59,"coordinates":794},[781,782],{"lat":782,"lon":781},{"facility":797,"status":53,"city":798,"state":35,"zip":799,"country":768,"countryCode":769,"cosmosGeoPoint":800,"geoPoint":804,"contacts":35},"Queen'S Medical Centre - Nottingham University Hospitals Nhs Trust","Nottingham","NG7 2UH",{"type":59,"coordinates":801},[802,803],-1.15047,52.9536,{"lat":803,"lon":802},{"facility":806,"status":53,"city":807,"state":35,"zip":808,"country":768,"countryCode":769,"cosmosGeoPoint":809,"geoPoint":813,"contacts":35},"Sheffield Childrens Hospital","Sheffield","S10 2TH",{"type":59,"coordinates":810},[811,812],-1.4659,53.38297,{"lat":812,"lon":811},{"facility":815,"status":53,"city":816,"state":35,"zip":817,"country":768,"countryCode":769,"cosmosGeoPoint":818,"geoPoint":822,"contacts":35},"Manor Hospital (Walsall) - Walsall Healthcare Nhs Trust","Walsall","WS2 9PS",{"type":59,"coordinates":819},[820,821],-1.98396,52.58528,{"lat":821,"lon":820},{"type":824,"investigatorFullName":35,"investigatorTitle":35,"investigatorAffiliation":35,"oldNameTitle":35,"oldOrganization":35},"SPONSOR","100577939","phase-3-a-study-to-evaluate-the-efficacy-and-safety-of-ruxolitinib-cream-in-children-6-to--12-years-old-with-nonsegmental-vitiligo-100577939",false,"NCT06804811","A Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Children (6 to \u003C 12 Years Old) With Nonsegmental Vitiligo","A Phase 3, Randomized, Double-Blind, Efficacy, and Safety Study of Ruxolitinib Cream in Children (6 to \u003C 12 Years Old) With Nonsegmental Vitiligo","Inclusion Criteria:\n\n* Aged 6 to \\\u003C 12 years at the time of signing the ICF.\n* Clinical diagnosis of nonsegmental vitiligo with depigmented area including ≥ 0.5% BSA on the face, ≥ 0.5 F-VASI, ≥ 3% BSA on nonfacial areas, ≥ 3 T-VASI.\n* Total body vitiligo area does not exceed 10% BSA.\n* Pigmented hair within some of the areas of vitiligo on the face.\n* Must agree to discontinue all agents used to treat vitiligo from screening through the final safety follow-up visit.\n* For sexually active participants (except participants who are prepubescent) willingness to avoid pregnancy or fathering a child as defined in the protocol.\n\nExclusion Criteria:\n\n* Diagnosis of other forms of vitiligo (eg, segmental).\n* Other differential diagnosis of vitiligo or other skin depigmentation disorders (eg, piebaldism, pityriasis alba, leprosy, postinflammatory hypopigmentation, progressive macule hypomelanosis, nevus anemicus, chemical leukoderma, and tinea versicolor).\n* Any other skin disease that, in the opinion of the investigator, would interfere with the study drug application or study assessments.\n* Prior or current use of depigmentation treatments (eg, monobenzone).\n* Concurrent conditions and history of protocol-defined diseases\n* Any serious illness or medical, physical, or psychiatric condition(s) that, in the investigator's opinion, would interfere with full participation in the study, including application of study cream and attending required study visits; pose a significant risk to the participant; or interfere with interpretation of study data.\n* Use of protocol-defined treatments within the indicated washout period before baseline.\n* History of treatment failure with any systemic or topical JAK inhibitor for vitiligo or any other inflammatory condition.\n* Protocol-defined clinically significant abnormal laboratory values at screening.\n* BMI-for-age \\\u003C 5th percentile or ≥ 85th percentile according to the CDC BMI Percentile Calculator for Child and Teen.\n* Pregnant or lactating participants or those considering pregnancy during the period of their study participation.\n* In the opinion of the investigator, unable or unlikely to comply with the application schedule and study evaluations.\n* Living with anyone participating in any current Incyte-sponsored ruxolitinib cream study.\n* Employees of the sponsor or investigator or are otherwise dependents of them.\n* Known allergy or reaction to any component of the study cream formulation.\n* The following participants are excluded in France: vulnerable populations according to article L.1121-6 of the French Public Health Code and adults under legal protection, or who are unable to express their consent per article L.1121-8 of the French Public Health Code, not affiliated to a social security per article L.1121-8-1 of the French Public Health code.\n* In the EU, participants considered incapacitated according to EU CTR No. 536\u002F2014 Articles 2 and 31.\n\nOther protocol-defined Inclusion\u002FExclusion Criteria may apply.","ALL","6 Years","11 Years",{"count":836,"type":837},250,"ESTIMATED","INTERVENTIONAL",[840],"PHASE3","The purpose of this study is to evaluate the efficacy and safety of ruxolitinib cream in children (6 to \\\u003C 12 years old) with nonsegmental vitiligo.",[843],"NonSegmental Vitiligo",[843,845],"pediatric","2025-12-11",{"date":848,"type":849},"2025-12-17","ACTUAL",{"date":851,"type":849},"2025-11-13",{"date":853,"type":837},"2027-12-01",{"name":5,"class":6},86]