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9RT",{"type":63,"coordinates":2356},[2349,2350],{"lat":2350,"lon":2349},{"facility":2359,"status":70,"city":2360,"state":27,"zip":2361,"country":2318,"countryCode":2319,"cosmosGeoPoint":2362,"geoPoint":2366,"contacts":27},"Kent Oncology Centre - Maidstone Hospital","Maidstone","ME16 9QQ",{"type":63,"coordinates":2363},[2364,2365],0.51667,51.26667,{"lat":2365,"lon":2364},{"facility":2368,"status":70,"city":2369,"state":27,"zip":2370,"country":2318,"countryCode":2319,"cosmosGeoPoint":2371,"geoPoint":2375,"contacts":27},"The Christie Nhs Foundation Trust Uk","Manchester","M20 4BX",{"type":63,"coordinates":2372},[2373,2374],-2.23743,53.48095,{"lat":2374,"lon":2373},{"facility":2377,"status":70,"city":2378,"state":27,"zip":2379,"country":2318,"countryCode":2319,"cosmosGeoPoint":2380,"geoPoint":2384,"contacts":27},"The Royal Marsden Nhs Foundation Trust - Sutton","Sutton","SM2 5PT",{"type":63,"coordinates":2381},[2382,2383],-0.2,51.35,{"lat":2383,"lon":2382},{"type":2386,"investigatorFullName":27,"investigatorTitle":27,"investigatorAffiliation":27,"oldNameTitle":27,"oldOrganization":27},"SPONSOR","100614842","phase-3-a-study-to-evaluate-the-efficacy-and-safety-of-standard-of-care-chemotherapy-and-bevacizumab-with-or-without-inca33890-in-the-first-line-treatment-of-metastatic-microsatellite-stable-colorectal-cancer-100614842",false,"NCT07284849","A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer","A Randomized, Double-Blind, Phase 3 Study of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer","Inclusion Criteria:\n\n* Stage IV colorectal adenocarcinoma not amenable to curative resection.\n* No prior systemic treatment for unresectable or metastatic disease. Participants who received adjuvant or neoadjuvant therapy may enroll if there was no recurrence within 12 months of the end of treatment.\n* Measurable disease per RECIST v1.1.\n* ECOG performance status of 0 or 1.\n* Adequate organ function determined by laboratory results.\n\nExclusion Criteria:\n\n* MSI-H\u002FdMMR per historical data in the medical record.\n* BRAF V600E mutation per historical data in the medical record.\n* Untreated and\u002For progressing CNS metastases.\n* History of other malignancy within 2 years.\n* Treatment with an anti-PD-(L)1 or other immune checkpoint inhibitor for any indication within the last 3 years.\n* Active autoimmune disease that has required systemic treatment in the past 2 years.\n* Significant concurrent and\u002For uncontrolled medical condition.\n* History of organ transplant, including allogeneic stem cell transplantation.\n\nOther protocol-defined inclusion\u002Fexclusion criteria apply.","ALL","18 Years",{"count":2397,"type":2398},700,"ESTIMATED","INTERVENTIONAL",[2401],"PHASE3","The purpose of this study is to evaluate the efficacy and safety of standard-of-care chemotherapy and bevacizumab with or without INCA33890 in the first-line treatment of metastatic microsatellite stable colorectal cancer.",[2404],"CRC (Colorectal Cancer)",[2406,2407,9],"Metastatic Colorectal Cancer","Colon Cancer","2026-06-29",{"date":2410,"type":2411},"2026-06-30","ACTUAL",{"date":2413,"type":2411},"2026-03-05",{"date":2415,"type":2398},"2029-09-28",{"name":5,"class":6},275]