[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613423":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":38,"centralContacts":39,"locations":44,"responsibleParty":913,"collaborators":38,"id":915,"slug":916,"hasResults":917,"nctId":918,"briefTitle":919,"officialTitle":920,"acronym":38,"eligibilityCriteria":921,"healthyVolunteers":917,"sex":922,"minAge":923,"maxAge":38,"enrollmentInfo":924,"targetDuration":38,"studyType":927,"phases":928,"briefSummary":930,"conditions":931,"keywords":936,"overallStatus":47,"whyStopped":38,"lastUpdateSubmitDate":945,"lastUpdatePostDateStruct":946,"startDateStruct":949,"completionDateStruct":951,"leadSponsor":953,"locationsCount":954},{"fullName":5,"class":6},"Celldex Therapeutics","INDUSTRY",[8,14,20,24],{"label":9,"type":10,"description":11,"interventionNames":12},"barzolvolimab in patients with Cold Induced Urticaria","EXPERIMENTAL","barzolvolimab 450mg injection subcutaneously at randomization , then 150mg injection subcutaneously every 4 weeks for 24 weeks followed by 300mg barzolvolimab every 8 weeks for 28 weeks.",[13],"Drug: Barzolvolimab",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo in patients with Cold Induced Urticaria","PLACEBO_COMPARATOR","Placebo injection subcutaneously every 4 weeks for 24 weeks followed by 300mg barzolvolimab every 8 weeks for 28 weeks.",[19],"Drug: Matching Placebo",{"label":21,"type":10,"description":22,"interventionNames":23},"barzolvolimab in patients with Symptomatic Dermographism","barzolvolimab 450mg injection subcutaneously at randomization, then 150mg injection subcutaneously every 4 weeks for 24 weeks followed by 300mg barzolvolimab every 8 weeks for 28 weeks.",[13],{"label":25,"type":16,"description":17,"interventionNames":26},"Placebo in patients with Symptomatic Dermographism",[19],[28,35],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"DRUG","Barzolvolimab","Subcutaneous Administration",[9,21],[34],"CDX-0159",{"type":29,"name":36,"description":31,"armGroupLabels":37,"otherNames":38},"Matching Placebo",[15,25],null,[40],{"name":5,"role":41,"phone":42,"phoneExt":38,"email":43},"CONTACT","844-723-9363","clinicaltrials@celldex.com",[45,63,77,91,104,117,130,143,157,170,183,196,209,223,237,251,265,278,292,306,318,328,339,353,367,381,395,405,417,429,441,453,465,473,485,493,505,517,529,541,553,567,576,588,597,612,622,634,643,651,660,672,680,692,700,712,724,736,748,760,774,786,798,807,816,828,837,849,861,875,887,897,905],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Cahaba Dermatology & Skin Health Center, LLC","RECRUITING","Birmingham","Alabama","35244","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-86.80249,33.52066,{"lat":57,"lon":56},[60],{"name":61,"role":41,"phone":38,"phoneExt":38,"email":62},"Jennifer Perry","jperry@cahabaderm.com",{"facility":64,"status":47,"city":65,"state":66,"zip":67,"country":51,"countryCode":52,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"One of a Kind Clinical Research Center, LLC","Scottsdale","Arizona","85258",{"type":54,"coordinates":69},[70,71],-111.89903,33.50921,{"lat":71,"lon":70},[74],{"name":75,"role":41,"phone":38,"phoneExt":38,"email":76},"Jordan Byers","jordan@1-oak.net",{"facility":78,"status":47,"city":79,"state":80,"zip":81,"country":51,"countryCode":52,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"Kern Research, Inc.","Bakersfield","California","93301",{"type":54,"coordinates":83},[84,85],-119.01871,35.37329,{"lat":85,"lon":84},[88],{"name":89,"role":41,"phone":38,"phoneExt":38,"email":90},"Wandy Noriega","wandy.noriega@kernresearch.com",{"facility":92,"status":47,"city":93,"state":80,"zip":94,"country":51,"countryCode":52,"cosmosGeoPoint":95,"geoPoint":99,"contacts":100},"One of a Kind Clinical Research Center","Napa","94558",{"type":54,"coordinates":96},[97,98],-122.28553,38.29714,{"lat":98,"lon":97},[101],{"name":102,"role":41,"phone":38,"phoneExt":38,"email":103},"Michelle Humbard","michelle@1-oak.net",{"facility":105,"status":47,"city":106,"state":80,"zip":107,"country":51,"countryCode":52,"cosmosGeoPoint":108,"geoPoint":112,"contacts":113},"Allergy & Asthma Consultants","Redwood City","94063",{"type":54,"coordinates":109},[110,111],-122.23635,37.48522,{"lat":111,"lon":110},[114],{"name":115,"role":41,"phone":38,"phoneExt":38,"email":116},"Sherry Lipson","sherry.lipsonallergy@gmail.com",{"facility":118,"status":47,"city":119,"state":80,"zip":120,"country":51,"countryCode":52,"cosmosGeoPoint":121,"geoPoint":125,"contacts":126},"Amicis Research Center","Sherman Oaks","91403",{"type":54,"coordinates":122},[123,124],-118.44925,34.15112,{"lat":124,"lon":123},[127],{"name":128,"role":41,"phone":38,"phoneExt":38,"email":129},"William Calder","w.calder@amicisresearch.com",{"facility":131,"status":47,"city":132,"state":80,"zip":133,"country":51,"countryCode":52,"cosmosGeoPoint":134,"geoPoint":138,"contacts":139},"FOMAT - Allergy, Asthma & Immunology Medical Group","Ventura","93003",{"type":54,"coordinates":135},[136,137],-119.29317,34.27834,{"lat":137,"lon":136},[140],{"name":141,"role":41,"phone":38,"phoneExt":38,"email":142},"Thai Orantes","torantes@fomatmedical.com",{"facility":144,"status":47,"city":145,"state":146,"zip":147,"country":51,"countryCode":52,"cosmosGeoPoint":148,"geoPoint":152,"contacts":153},"Direct Helpers Research Center","Hialeah","Florida","33012",{"type":54,"coordinates":149},[150,151],-80.27811,25.8576,{"lat":151,"lon":150},[154],{"name":155,"role":41,"phone":38,"phoneExt":38,"email":156},"Monica Merino-Lopez","monica@dhrtrials.com",{"facility":158,"status":47,"city":159,"state":146,"zip":160,"country":51,"countryCode":52,"cosmosGeoPoint":161,"geoPoint":165,"contacts":166},"Well Pharma Medical Research, Corp.","Miami","33143",{"type":54,"coordinates":162},[163,164],-80.19366,25.77427,{"lat":164,"lon":163},[167],{"name":168,"role":41,"phone":38,"phoneExt":38,"email":169},"Yudesiy Izquierdo","yizquierdo@wpharma.com",{"facility":171,"status":47,"city":172,"state":146,"zip":173,"country":51,"countryCode":52,"cosmosGeoPoint":174,"geoPoint":178,"contacts":179},"Deluxe Health Center, LLC","Miami Lakes","33014",{"type":54,"coordinates":175},[176,177],-80.30866,25.90871,{"lat":177,"lon":176},[180],{"name":181,"role":41,"phone":38,"phoneExt":38,"email":182},"Leidy Caballero","lcaballero@deluxehealthcenter.com",{"facility":184,"status":47,"city":185,"state":146,"zip":186,"country":51,"countryCode":52,"cosmosGeoPoint":187,"geoPoint":191,"contacts":192},"GCP, Global Clinical Professionals","St. Petersburg","33705",{"type":54,"coordinates":188},[189,190],-82.67927,27.77086,{"lat":190,"lon":189},[193],{"name":194,"role":41,"phone":38,"phoneExt":38,"email":195},"Nailis Echevarria","nechevarria@researchgcp.com",{"facility":197,"status":47,"city":198,"state":146,"zip":199,"country":51,"countryCode":52,"cosmosGeoPoint":200,"geoPoint":204,"contacts":205},"Advanced Clinical Research Institute","Tampa","33607",{"type":54,"coordinates":201},[202,203],-82.45843,27.94752,{"lat":203,"lon":202},[206],{"name":207,"role":41,"phone":38,"phoneExt":38,"email":208},"Lisbet Rodriguez","lisbet@acrinstitute.com",{"facility":210,"status":47,"city":211,"state":212,"zip":213,"country":51,"countryCode":52,"cosmosGeoPoint":214,"geoPoint":218,"contacts":219},"Centricity Research Columbus Dermatology","Columbus","Georgia","31904",{"type":54,"coordinates":215},[216,217],-84.98771,32.46098,{"lat":217,"lon":216},[220],{"name":221,"role":41,"phone":38,"phoneExt":38,"email":222},"Cheyenne Dempsey","cheyenne.dempsey@centricityresearch.com",{"facility":224,"status":47,"city":225,"state":226,"zip":227,"country":51,"countryCode":52,"cosmosGeoPoint":228,"geoPoint":232,"contacts":233},"Treasure Valley Medical Research","Boise","Idaho","83706",{"type":54,"coordinates":229},[230,231],-116.20345,43.6135,{"lat":231,"lon":230},[234],{"name":235,"role":41,"phone":38,"phoneExt":38,"email":236},"Jackie Allen","jallen@tvmedresearch.com",{"facility":238,"status":47,"city":239,"state":240,"zip":241,"country":51,"countryCode":52,"cosmosGeoPoint":242,"geoPoint":246,"contacts":247},"Endeavor Health Clinical Trials Center","Skokie","Illinois","60077",{"type":54,"coordinates":243},[244,245],-87.73339,42.03336,{"lat":245,"lon":244},[248],{"name":249,"role":41,"phone":38,"phoneExt":38,"email":250},"Alba Berty","alba.berty@endeavorhealth.org",{"facility":252,"status":47,"city":253,"state":254,"zip":255,"country":51,"countryCode":52,"cosmosGeoPoint":256,"geoPoint":260,"contacts":261},"Equity Medical, LLC","Bowling Green","Kentucky","42104",{"type":54,"coordinates":257},[258,259],-86.4436,36.99032,{"lat":259,"lon":258},[262],{"name":263,"role":41,"phone":38,"phoneExt":38,"email":264},"Kristen Newman","knewman@equity-med.com",{"facility":266,"status":47,"city":267,"state":254,"zip":268,"country":51,"countryCode":52,"cosmosGeoPoint":269,"geoPoint":273,"contacts":274},"Advanced ENT and Allergy, PLLC","Louisville","40207",{"type":54,"coordinates":270},[271,272],-85.75941,38.25424,{"lat":272,"lon":271},[275],{"name":276,"role":41,"phone":38,"phoneExt":38,"email":277},"Rhonda Dase","rdase@advancedentandallergy.com",{"facility":279,"status":47,"city":280,"state":281,"zip":282,"country":51,"countryCode":52,"cosmosGeoPoint":283,"geoPoint":287,"contacts":288},"Johns Hopkins University","Baltimore","Maryland","21224",{"type":54,"coordinates":284},[285,286],-76.61219,39.29038,{"lat":286,"lon":285},[289],{"name":290,"role":41,"phone":38,"phoneExt":38,"email":291},"Kellie Devine","kdevine1@jhmi.edu",{"facility":293,"status":47,"city":294,"state":295,"zip":296,"country":51,"countryCode":52,"cosmosGeoPoint":297,"geoPoint":301,"contacts":302},"Revival Research Institute, LLC","Troy","Michigan","48084",{"type":54,"coordinates":298},[299,300],-83.14993,42.60559,{"lat":300,"lon":299},[303],{"name":304,"role":41,"phone":38,"phoneExt":38,"email":305},"Ria Abraham","rabraham@rev-research.com",{"facility":252,"status":47,"city":307,"state":307,"zip":308,"country":51,"countryCode":52,"cosmosGeoPoint":309,"geoPoint":313,"contacts":314},"New York","10023",{"type":54,"coordinates":310},[311,312],-74.00597,40.71427,{"lat":312,"lon":311},[315],{"name":316,"role":41,"phone":38,"phoneExt":38,"email":317},"Adugna Deboch","adugna.getahun@primeglobalresearch.com",{"facility":319,"status":47,"city":307,"state":307,"zip":320,"country":51,"countryCode":52,"cosmosGeoPoint":321,"geoPoint":323,"contacts":324},"Markowitz Medical PLLC dba OptiSkin Medical","10128",{"type":54,"coordinates":322},[311,312],{"lat":312,"lon":311},[325],{"name":326,"role":41,"phone":38,"phoneExt":38,"email":327},"Nathan Schwab","nathan@optiskinmedical.com",{"facility":329,"status":330,"city":331,"state":332,"zip":333,"country":51,"countryCode":52,"cosmosGeoPoint":334,"geoPoint":338,"contacts":38},"University of Cincinnati","NOT_YET_RECRUITING","Cincinnati","Ohio","45267",{"type":54,"coordinates":335},[336,337],-84.51439,39.12711,{"lat":337,"lon":336},{"facility":340,"status":47,"city":341,"state":342,"zip":343,"country":51,"countryCode":52,"cosmosGeoPoint":344,"geoPoint":348,"contacts":349},"Allergy, Asthma & Clinical Research Center","Oklahoma City","Oklahoma","73120",{"type":54,"coordinates":345},[346,347],-97.51643,35.46756,{"lat":347,"lon":346},[350],{"name":351,"role":41,"phone":38,"phoneExt":38,"email":352},"Meryem Assaoui","meryem@mtarpay.com",{"facility":354,"status":47,"city":355,"state":356,"zip":357,"country":51,"countryCode":52,"cosmosGeoPoint":358,"geoPoint":362,"contacts":363},"Advanced Dermatology and Cosmetic Surgery - Spartanburg","Spartanburg","South Carolina","29307",{"type":54,"coordinates":359},[360,361],-81.93205,34.94957,{"lat":361,"lon":360},[364],{"name":365,"role":41,"phone":38,"phoneExt":38,"email":366},"Rion Allen","rion.allen@adcsclinics.com",{"facility":368,"status":47,"city":369,"state":370,"zip":371,"country":51,"countryCode":52,"cosmosGeoPoint":372,"geoPoint":376,"contacts":377},"RFSA Dermatology","San Antonio","Texas","78212",{"type":54,"coordinates":373},[374,375],-98.49363,29.42412,{"lat":375,"lon":374},[378],{"name":379,"role":41,"phone":38,"phoneExt":38,"email":380},"Jonathan Joseph","jonathanj.rfsadermatology@gmail.com",{"facility":382,"status":47,"city":383,"state":384,"zip":385,"country":51,"countryCode":52,"cosmosGeoPoint":386,"geoPoint":390,"contacts":391},"Allergy Associates of Utah","Sandy City","Utah","84093",{"type":54,"coordinates":387},[388,389],-111.8841,40.59161,{"lat":389,"lon":388},[392],{"name":393,"role":41,"phone":38,"phoneExt":38,"email":394},"Holly Anderson","holly.anderson@utahallergies.com",{"facility":396,"status":330,"city":397,"state":38,"zip":38,"country":398,"countryCode":399,"cosmosGeoPoint":400,"geoPoint":404,"contacts":38},"Universitätsklinikum Augsburg, Klinik für Dermatologie und Allergologie","Augsburg","Germany","DE",{"type":54,"coordinates":401},[402,403],10.89851,48.37154,{"lat":403,"lon":402},{"facility":406,"status":47,"city":407,"state":38,"zip":38,"country":398,"countryCode":399,"cosmosGeoPoint":408,"geoPoint":412,"contacts":413},"Fraunhofer-Institut für Translationale Medizin und Pharmakologie ITMP Immunologie und Allergologie IA c\u002Fo Charité - Universitätsmedizin Berlin","Berlin",{"type":54,"coordinates":409},[410,411],13.41053,52.52437,{"lat":411,"lon":410},[414],{"name":415,"role":41,"phone":38,"phoneExt":38,"email":416},"Natascha Koculak","natascha.koculak@itmp.fraunhofer.de",{"facility":418,"status":47,"city":419,"state":38,"zip":38,"country":398,"countryCode":399,"cosmosGeoPoint":420,"geoPoint":424,"contacts":425},"Elbe Kliniken Buxtehude Dermatologie","Buxtehude",{"type":54,"coordinates":421},[422,423],9.68968,53.46994,{"lat":423,"lon":422},[426],{"name":427,"role":41,"phone":38,"phoneExt":38,"email":428},"Dana Etz","dana.etz@elbekliniken.de",{"facility":430,"status":47,"city":431,"state":38,"zip":38,"country":398,"countryCode":399,"cosmosGeoPoint":432,"geoPoint":436,"contacts":437},"Rosenpark Research GmbH","Darmstadt",{"type":54,"coordinates":433},[434,435],8.65027,49.87167,{"lat":435,"lon":434},[438],{"name":439,"role":41,"phone":38,"phoneExt":38,"email":440},"Christine Muetschard","christine.muetschard@rosenparkresearch.de",{"facility":442,"status":47,"city":443,"state":38,"zip":38,"country":398,"countryCode":399,"cosmosGeoPoint":444,"geoPoint":448,"contacts":449},"Universitätsklinikum Carl Gustav Carus Dresden, Klinik und Poliklinik für Dermatologie","Dresden",{"type":54,"coordinates":445},[446,447],13.73832,51.05089,{"lat":447,"lon":446},[450],{"name":451,"role":41,"phone":38,"phoneExt":38,"email":452},"Katharina Blümlein","katharina.bluemlein@ukdd.de",{"facility":454,"status":47,"city":455,"state":38,"zip":38,"country":398,"countryCode":399,"cosmosGeoPoint":456,"geoPoint":460,"contacts":461},"Department of Dermatology, University Hospital Dusseldorf","Düsseldorf",{"type":54,"coordinates":457},[458,459],6.77927,51.22319,{"lat":459,"lon":458},[462],{"name":463,"role":41,"phone":38,"phoneExt":38,"email":464},"Mayumi Waldmann","mayumi.waldmann@med.uni-duesseldorf.de",{"facility":466,"status":330,"city":467,"state":38,"zip":38,"country":398,"countryCode":399,"cosmosGeoPoint":468,"geoPoint":472,"contacts":38},"Hautklinik, Uniklinkum Erlangen","Erlangen",{"type":54,"coordinates":469},[470,471],11.00783,49.59099,{"lat":471,"lon":470},{"facility":474,"status":47,"city":475,"state":38,"zip":38,"country":398,"countryCode":399,"cosmosGeoPoint":476,"geoPoint":480,"contacts":481},"Universitätsklinikum Göttingen -- George-August-Universitat Göttinggen, Klinik für Dermatoogie, Venerologie und Allergologie","Göttingen",{"type":54,"coordinates":477},[478,479],9.93228,51.53443,{"lat":479,"lon":478},[482],{"name":483,"role":41,"phone":38,"phoneExt":38,"email":484},"Kerstin Specht","kerstin.specht@med.uni-goettingen.de",{"facility":486,"status":330,"city":487,"state":38,"zip":38,"country":398,"countryCode":399,"cosmosGeoPoint":488,"geoPoint":492,"contacts":38},"Universitätsklinikum Heidelberg, Klinik für Dermatologie","Heidelberg",{"type":54,"coordinates":489},[490,491],8.69079,49.40768,{"lat":491,"lon":490},{"facility":494,"status":47,"city":495,"state":38,"zip":38,"country":398,"countryCode":399,"cosmosGeoPoint":496,"geoPoint":500,"contacts":501},"MVZ DermaKiel GmbH","Kiel",{"type":54,"coordinates":497},[498,499],10.13489,54.32133,{"lat":499,"lon":498},[502],{"name":503,"role":41,"phone":38,"phoneExt":38,"email":504},"Birgit Johannsson","stud.birgit.johannsson@gmx.de",{"facility":506,"status":47,"city":507,"state":38,"zip":38,"country":398,"countryCode":399,"cosmosGeoPoint":508,"geoPoint":512,"contacts":513},"Universitätsklinikum Schleswig-Holstein Universität zu Lübeck - Campus Lübeck","Lübeck",{"type":54,"coordinates":509},[510,511],10.68729,53.86893,{"lat":511,"lon":510},[514],{"name":515,"role":41,"phone":38,"phoneExt":38,"email":516},"Lena Pommerien","malena.pommerien@uksh.de",{"facility":518,"status":47,"city":519,"state":38,"zip":38,"country":398,"countryCode":399,"cosmosGeoPoint":520,"geoPoint":524,"contacts":525},"Klinik und Poliklinik für Dermatologie und Allergologie, LMU Klinikum; DASZ-Dermato-Allergologisches Studienzentrum","München",{"type":54,"coordinates":521},[522,523],13.31243,51.60698,{"lat":523,"lon":522},[526],{"name":527,"role":41,"phone":38,"phoneExt":38,"email":528},"Julia Morgenstern","julia.morgenstern@med.uni-muenchen.de",{"facility":530,"status":47,"city":531,"state":38,"zip":38,"country":398,"countryCode":399,"cosmosGeoPoint":532,"geoPoint":536,"contacts":537},"Universitätsklinikum Münster, Klinik u. Poliklinik f. Dermatologie","Münster",{"type":54,"coordinates":533},[534,535],7.62571,51.96236,{"lat":535,"lon":534},[538],{"name":539,"role":41,"phone":38,"phoneExt":38,"email":540},"Katrin Kieslich","katrin.kieslich@ukmuenster.de",{"facility":542,"status":47,"city":543,"state":38,"zip":38,"country":398,"countryCode":399,"cosmosGeoPoint":544,"geoPoint":548,"contacts":549},"Universitäts-Hautklinik Tübingen Studienzentrum Immundermatologie","Tübingen",{"type":54,"coordinates":545},[546,547],9.05222,48.52266,{"lat":547,"lon":546},[550],{"name":551,"role":41,"phone":38,"phoneExt":38,"email":552},"Gabriele Blank","gabriele.blank@med.uni-tuebingen.de",{"facility":554,"status":47,"city":555,"state":38,"zip":38,"country":556,"countryCode":557,"cosmosGeoPoint":558,"geoPoint":562,"contacts":563},"CD8 Klinika","Kaunas","Lithuania","LT",{"type":54,"coordinates":559},[560,561],23.90909,54.90156,{"lat":561,"lon":560},[564],{"name":565,"role":41,"phone":38,"phoneExt":38,"email":566},"Ina Miteleva","registracija@cd8klinika.lt",{"facility":568,"status":47,"city":555,"state":38,"zip":38,"country":556,"countryCode":557,"cosmosGeoPoint":569,"geoPoint":571,"contacts":572},"UAB Ausros Medicinos Centras",{"type":54,"coordinates":570},[560,561],{"lat":561,"lon":560},[573],{"name":574,"role":41,"phone":38,"phoneExt":38,"email":575},"Margarita Paulauskiene","paulauskiene.margarita@gmail.com",{"facility":577,"status":47,"city":578,"state":38,"zip":38,"country":556,"countryCode":557,"cosmosGeoPoint":579,"geoPoint":583,"contacts":584},"Santaros KTC (klinikiniu tyrimu centras)","Vilnius",{"type":54,"coordinates":580},[581,582],25.2798,54.68916,{"lat":582,"lon":581},[585],{"name":586,"role":41,"phone":38,"phoneExt":38,"email":587},"Linas Liekis","linas.liekis@inlita.lt",{"facility":589,"status":47,"city":578,"state":38,"zip":38,"country":556,"countryCode":557,"cosmosGeoPoint":590,"geoPoint":592,"contacts":593},"UAB Alerginių susirgimų diagnostikos ir gydymo centras",{"type":54,"coordinates":591},[581,582],{"lat":582,"lon":581},[594],{"name":595,"role":41,"phone":38,"phoneExt":38,"email":596},"Auksė Zinkevičienė","aukse.zinkeviciene@gmail.com",{"facility":598,"status":47,"city":599,"state":38,"zip":600,"country":601,"countryCode":602,"cosmosGeoPoint":603,"geoPoint":607,"contacts":608},"Synexus Polska Sp. z o.o. Oddział w Gdańsku","Gdansk","80-382","Poland","PL",{"type":54,"coordinates":604},[605,606],18.64912,54.35227,{"lat":606,"lon":605},[609],{"name":610,"role":41,"phone":38,"phoneExt":38,"email":611},"Magdalena Rodzik","magdalena.rodzik@trialmed.com",{"facility":613,"status":47,"city":599,"state":38,"zip":614,"country":601,"countryCode":602,"cosmosGeoPoint":615,"geoPoint":617,"contacts":618},"Centrum Badań Klinicznych PI-House Sp. z o.o.","80-546",{"type":54,"coordinates":616},[605,606],{"lat":606,"lon":605},[619],{"name":620,"role":41,"phone":38,"phoneExt":38,"email":621},"Alicja Kubiak","a.kubiak@pihouse.pl",{"facility":623,"status":47,"city":624,"state":38,"zip":38,"country":601,"countryCode":602,"cosmosGeoPoint":625,"geoPoint":629,"contacts":630},"Centrum Medyczne ALL-MED Badania Kliniczne","Krakow",{"type":54,"coordinates":626},[627,628],19.93658,50.06143,{"lat":628,"lon":627},[631],{"name":632,"role":41,"phone":38,"phoneExt":38,"email":633},"Dominika Olejniczak","dominika.olejniczak@gazeta.pl",{"facility":635,"status":47,"city":624,"state":38,"zip":38,"country":601,"countryCode":602,"cosmosGeoPoint":636,"geoPoint":638,"contacts":639},"Centrum Nowoczesnych Terapii Dobry Lekarz Sp. z o.o.",{"type":54,"coordinates":637},[627,628],{"lat":628,"lon":627},[640],{"name":641,"role":41,"phone":38,"phoneExt":38,"email":642},"Piotr Zurek","m.poczatko@dobrylekarz.com.pl",{"facility":644,"status":330,"city":645,"state":38,"zip":38,"country":601,"countryCode":602,"cosmosGeoPoint":646,"geoPoint":650,"contacts":38},"Oddzial Kliniczny Chorob Wewnetrznych, Astmy i Alergii z Odcinkiem dla Dzieci, Uniwersytecki Szpital Kliniczny nr 1 w Lodzi","Lodz",{"type":54,"coordinates":647},[648,649],19.47395,51.77058,{"lat":649,"lon":648},{"facility":652,"status":47,"city":645,"state":38,"zip":38,"country":601,"countryCode":602,"cosmosGeoPoint":653,"geoPoint":655,"contacts":656},"Santa Familia PTG Lodz",{"type":54,"coordinates":654},[648,649],{"lat":649,"lon":648},[657],{"name":658,"role":41,"phone":38,"phoneExt":38,"email":659},"Kamila Musial","kamila.musial@ptg-network.com",{"facility":661,"status":47,"city":662,"state":38,"zip":38,"country":601,"countryCode":602,"cosmosGeoPoint":663,"geoPoint":667,"contacts":668},"Luxderm Specjalistyczny Gabinet Dermatologiczny Prof. dr hab. N. med. Dorota Krasowska","Lublin",{"type":54,"coordinates":664},[665,666],22.57009,51.25058,{"lat":666,"lon":665},[669],{"name":670,"role":41,"phone":38,"phoneExt":38,"email":671},"Aleksandra Pacion","aleksandra.pacion86@gmail.com",{"facility":673,"status":330,"city":674,"state":38,"zip":38,"country":601,"countryCode":602,"cosmosGeoPoint":675,"geoPoint":679,"contacts":38},"Uniwersytecki Szpital Kliniczny w Opolu","Opole",{"type":54,"coordinates":676},[677,678],17.92604,50.67119,{"lat":678,"lon":677},{"facility":681,"status":47,"city":682,"state":38,"zip":38,"country":601,"countryCode":602,"cosmosGeoPoint":683,"geoPoint":687,"contacts":688},"Medicome Sp. z o.o.","Oświęcim",{"type":54,"coordinates":684},[685,686],19.21037,50.03437,{"lat":686,"lon":685},[689],{"name":690,"role":41,"phone":38,"phoneExt":38,"email":691},"Anna Olejniczak","aolejniczak@medicome.pl",{"facility":693,"status":330,"city":694,"state":38,"zip":38,"country":601,"countryCode":602,"cosmosGeoPoint":695,"geoPoint":699,"contacts":38},"EMC Instytut Medyczny S.A.PL CERTUS Szpital i Ambulatorium","Poznan",{"type":54,"coordinates":696},[697,698],16.92993,52.40692,{"lat":698,"lon":697},{"facility":701,"status":47,"city":702,"state":38,"zip":38,"country":601,"countryCode":602,"cosmosGeoPoint":703,"geoPoint":707,"contacts":708},"Uniwersytecki Szpital Kliniczny im. Fryderyka Chopina w Rzeszowie; Klinika Dermatologii i Dermatologii Onkologicznej","Rzeszów",{"type":54,"coordinates":704},[705,706],21.99901,50.04132,{"lat":706,"lon":705},[709],{"name":710,"role":41,"phone":38,"phoneExt":38,"email":711},"Magdalena Sapa","sapamagdalena97@gmail.com",{"facility":713,"status":47,"city":714,"state":38,"zip":38,"country":601,"countryCode":602,"cosmosGeoPoint":715,"geoPoint":719,"contacts":720},"Alergo-med Ośrodek Badań Klinicznych Sp. z o. o.","Tarnów",{"type":54,"coordinates":716},[717,718],20.98698,50.01381,{"lat":718,"lon":717},[721],{"name":722,"role":41,"phone":38,"phoneExt":38,"email":723},"Anna Maj","anna.maj@alergo-med.eu",{"facility":725,"status":47,"city":726,"state":38,"zip":38,"country":601,"countryCode":602,"cosmosGeoPoint":727,"geoPoint":731,"contacts":732},"MICS Centrum Medyczne Toruń","Torun",{"type":54,"coordinates":728},[729,730],18.59814,53.01375,{"lat":730,"lon":729},[733],{"name":734,"role":41,"phone":38,"phoneExt":38,"email":735},"Anna Mazur","anna.mazur@mics.medicover.com",{"facility":737,"status":47,"city":738,"state":38,"zip":38,"country":601,"countryCode":602,"cosmosGeoPoint":739,"geoPoint":743,"contacts":744},"Klinika Ambroziak Dermatologia","Warsaw",{"type":54,"coordinates":740},[741,742],21.01178,52.22977,{"lat":742,"lon":741},[745],{"name":746,"role":41,"phone":38,"phoneExt":38,"email":747},"Michał Korolczuk","michal@klinikaambroziak.pl",{"facility":749,"status":47,"city":750,"state":38,"zip":38,"country":601,"countryCode":602,"cosmosGeoPoint":751,"geoPoint":755,"contacts":756},"Cityclinic Przychodnia Lekarsko-Psychologiczna Matusiak Spolka Partnerska","Wroclaw",{"type":54,"coordinates":752},[753,754],17.03006,51.10286,{"lat":754,"lon":753},[757],{"name":758,"role":41,"phone":38,"phoneExt":38,"email":759},"Marta Zaleska","marta.zaleska.work@gmail.com",{"facility":761,"status":47,"city":762,"state":38,"zip":38,"country":763,"countryCode":764,"cosmosGeoPoint":765,"geoPoint":769,"contacts":770},"Worthwhile Clinical Trials","Benoni","South Africa","ZA",{"type":54,"coordinates":766},[767,768],28.32078,-26.18848,{"lat":768,"lon":767},[771],{"name":772,"role":41,"phone":38,"phoneExt":38,"email":773},"Mageshni Iyer","mageshni@wwct.co.za",{"facility":775,"status":47,"city":776,"state":38,"zip":38,"country":763,"countryCode":764,"cosmosGeoPoint":777,"geoPoint":781,"contacts":782},"Allergy & Immunology Unit, University of Cape Town Lung Institute","Cape Town",{"type":54,"coordinates":778},[779,780],18.42322,-33.92584,{"lat":780,"lon":779},[783],{"name":784,"role":41,"phone":38,"phoneExt":38,"email":785},"Juliet Esterhuizen","juliet.esterhuizen@uct.ac.za",{"facility":787,"status":47,"city":788,"state":38,"zip":38,"country":763,"countryCode":764,"cosmosGeoPoint":789,"geoPoint":793,"contacts":794},"Dr. PJ Sebastian","Durban",{"type":54,"coordinates":790},[791,792],31.0292,-29.8579,{"lat":792,"lon":791},[795],{"name":796,"role":41,"phone":38,"phoneExt":38,"email":797},"Deborah Amy Sebastian","dasebastian@iafrica.com",{"facility":799,"status":47,"city":788,"state":38,"zip":38,"country":763,"countryCode":764,"cosmosGeoPoint":800,"geoPoint":802,"contacts":803},"Infinity Dermatology Inc",{"type":54,"coordinates":801},[791,792],{"lat":792,"lon":791},[804],{"name":805,"role":41,"phone":38,"phoneExt":38,"email":806},"Kufanelesibonge Mafoko","bmfanelo@yahoo.com",{"facility":808,"status":47,"city":788,"state":38,"zip":38,"country":763,"countryCode":764,"cosmosGeoPoint":809,"geoPoint":811,"contacts":812},"Synapta Clinical Research Centre",{"type":54,"coordinates":810},[791,792],{"lat":792,"lon":791},[813],{"name":814,"role":41,"phone":38,"phoneExt":38,"email":815},"Sibongile Gloria Lembethe","sibongile@synapta.co.za",{"facility":817,"status":47,"city":818,"state":38,"zip":38,"country":763,"countryCode":764,"cosmosGeoPoint":819,"geoPoint":823,"contacts":824},"Newtown Clinical Research Centre","Johannesburg",{"type":54,"coordinates":820},[821,822],28.04363,-26.20227,{"lat":822,"lon":821},[825],{"name":826,"role":41,"phone":38,"phoneExt":38,"email":827},"Busisiwe Zwane","busisiwezwane@ymail.com",{"facility":829,"status":47,"city":818,"state":38,"zip":38,"country":763,"countryCode":764,"cosmosGeoPoint":830,"geoPoint":832,"contacts":833},"Sandton Medical Research Centre",{"type":54,"coordinates":831},[821,822],{"lat":822,"lon":821},[834],{"name":835,"role":41,"phone":38,"phoneExt":38,"email":836},"Nomsa Tshetlo","n.tshetlo@smrc.co.za",{"facility":838,"status":47,"city":839,"state":38,"zip":38,"country":763,"countryCode":764,"cosmosGeoPoint":840,"geoPoint":844,"contacts":845},"Global Clinical Trials (Pty) Ltd","Pretoria",{"type":54,"coordinates":841},[842,843],28.18783,-25.74486,{"lat":843,"lon":842},[846],{"name":847,"role":41,"phone":38,"phoneExt":38,"email":848},"Priscilla Diakanyo Kwati","priscilla@gctrials.co.za",{"facility":850,"status":47,"city":851,"state":38,"zip":38,"country":763,"countryCode":764,"cosmosGeoPoint":852,"geoPoint":856,"contacts":857},"Allergy and Asthma Centre","Westville",{"type":54,"coordinates":853},[854,855],30.937,-29.82554,{"lat":855,"lon":854},[858],{"name":859,"role":41,"phone":38,"phoneExt":38,"email":860},"Nothile Dlamini","nothiled@outlook.com",{"facility":862,"status":47,"city":863,"state":38,"zip":38,"country":864,"countryCode":865,"cosmosGeoPoint":866,"geoPoint":870,"contacts":871},"Hospital del Mar","Barcelona","Spain","ES",{"type":54,"coordinates":867},[868,869],2.15899,41.38879,{"lat":869,"lon":868},[872],{"name":873,"role":41,"phone":38,"phoneExt":38,"email":874},"Montserrat Barber Gonzalez","mbarber@researchmar.cat",{"facility":876,"status":47,"city":877,"state":38,"zip":38,"country":864,"countryCode":865,"cosmosGeoPoint":878,"geoPoint":882,"contacts":883},"Clinica Universidad de Navarra","Pamplona",{"type":54,"coordinates":879},[880,881],-1.64323,42.81687,{"lat":881,"lon":880},[884],{"name":885,"role":41,"phone":38,"phoneExt":38,"email":886},"Iker Azparren Diaz","iazparren@unav.es",{"facility":888,"status":330,"city":889,"state":38,"zip":38,"country":890,"countryCode":891,"cosmosGeoPoint":892,"geoPoint":896,"contacts":38},"Addenbrooke's Hospital","Cambridge","United Kingdom","UK",{"type":54,"coordinates":893},[894,895],0.11667,52.2,{"lat":895,"lon":894},{"facility":898,"status":330,"city":899,"state":38,"zip":38,"country":890,"countryCode":891,"cosmosGeoPoint":900,"geoPoint":904,"contacts":38},"Queen Elizabeth University Hospital","Glasgow",{"type":54,"coordinates":901},[902,903],-4.25763,55.86515,{"lat":903,"lon":902},{"facility":906,"status":330,"city":907,"state":38,"zip":38,"country":890,"countryCode":891,"cosmosGeoPoint":908,"geoPoint":912,"contacts":38},"Salford Care Organisation NCA NHS Trust","Manchester",{"type":54,"coordinates":909},[910,911],-2.23743,53.48095,{"lat":911,"lon":910},{"type":914,"investigatorFullName":38,"investigatorTitle":38,"investigatorAffiliation":38,"oldNameTitle":38,"oldOrganization":38},"SPONSOR","100613423","phase-3-a-study-to-investigate-efficacy-safety-and-tolerability-of-barzolvolimab-versus-placebo-in-adults-with-cold-induced-urticaria-and-symptomatic-dermographism-inadequately-controlled-by-h1-antihistamines-embarq---coldu-and-sd-100613423",false,"NCT07266402","A Study to Investigate Efficacy, Safety and Tolerability of Barzolvolimab Versus Placebo in Adults With Cold Induced Urticaria and Symptomatic Dermographism Inadequately Controlled by H1-antihistamines (EMBARQ - ColdU and SD)","A Phase 3 Randomized, Double-Blind, Placebo-Controlled, Multi-Center, Parallel-Group Study of Barzolvolimab in Participants With Cold Induced Urticaria and Symptomatic Dermographism (EMBARQ-COLDU and SD)","Key Inclusion Criteria:\n\n1. Males and females, \\>\u002F= 18 years of age.\n2. Diagnosis of cold induced urticaria or symptomatic dermographism \\>\u002F= 3 months.\n3. Diagnosis of cold induced urticaria or symptomatic dermographism despite the use of a stable regimen of second generation non-sedating H1-antihistamine as defined by:\n\n   1. The presence of hives for \\>\u002F= 6 weeks at any time prior to Visit 1 despite the use of H1-antihistamines.\n   2. Must be on a stable regimen of second generation non-sedating H1-antihistamine for \\>\u002F= 4 weeks prior to study treatment.\n   3. Cold induced urticaria: A Critical Threshold Temperature (CTT) of ≥ 15 °C and \\\u003C 37 °C using the TempTest® and a numerical rating scale score of ≥ 5 for itch after the provocation test.\n   4. Symptomatic dermographism: A Critical Friction Threshold (CFT) of ≥ 3 using the FricTest® and a numerical rating scale score of ≥ 5 for itch after the provocation test.\n4. Cold induced urticaria: Positive ice-cube test resulting in hives at the provocation site during Screening\n5. Normal blood counts and liver function tests.\n6. Both males and females of child-bearing potential must agree to use highly effective contraceptives during the study and for ≥ 150 days after treatment.\n7. Willing and able to complete a daily symptom electronic diary and comply with study visits.\n8. Participants with and without prior biologic experience are eligible.\n\nKey Exclusion Criteria:\n\n1. Women who are pregnant or nursing.\n2. Clearly defined cause for chronic urticaria.\n3. Active, pruritic skin condition in addition to cold induced urticaria or symptomatic dermographism.\n4. Medical condition that would cause additional risk or interfere with study procedures.\n5. Known HIV, hepatitis B or hepatitis C infection.\n6. Vaccination with a live vaccine within 30 days prior to screening (subjects must agree to avoid vaccination with a live vaccine during the study). Inactivated vaccines are allowed such as seasonal influenza injection or COVID-19 vaccine.\n7. History of anaphylaxis, unless due to cold exposure over a large part of the body (such as swimming in cold water).\n8. Prior treatment with barzolvolimab\n\nThere are additional criteria that your study doctor will review with you to confirm you are eligible for the study.","ALL","18 Years",{"count":925,"type":926},240,"ESTIMATED","INTERVENTIONAL",[929],"PHASE3","The purpose of this Phase 3, randomized, double-blind, placebo-controlled study is to assess the activity and safety of barzolvolimab compared to placebo in participants with cold induced urticaria or symptomatic dermographism who remain symptomatic despite the use of H1-antihistamines.",[932,933,934,935],"Chronic Inducible Urticaria","Cold Urticaria","Cold-Induced Urticaria","Symptomatic Dermographism",[937,938,939,940,941,942,943,944,34],"Chronic Inducible urticaria","cold urticaria","cold-induced urticaria","ColdU","symptomatic dermographism,","SD","barzolvolimab","CDX0159","2026-06-30",{"date":947,"type":948},"2026-07-01","ACTUAL",{"date":950,"type":948},"2026-01-15",{"date":952,"type":926},"2028-10",{"name":5,"class":6},73]