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factor inhibitor, immunotherapy or any anti-cancer therapy in the metastatic setting. Platinum-based chemotherapy in non-metastatic setting within 12 months prior to randomization.\n* History of another primary malignancy except for malignancy treated with curative intent with no known active disease within 2 years before the first dose of study intervention.\n* Any evidence of severe or uncontrolled systemic diseases, including, but not limited to active bleeding diseases, active infection, active ILD\u002Fpneumonitis, cardiac disease.\n* Has significant third-space fluid retention (example \\[eg.\\], ascites or pleural effusion) as judged by the investigator and is not amenable for required repeated drainage.\n* History of non-infectious ILD\u002Fpneumonitis including radiation pneumonitis that required steroids or drug-induced ILD, has current ILD\u002Fpneumonitis, or has suspected ILD\u002Fpneumonitis that cannot be ruled out by imaging at screening.\n* Has severe pulmonary function compromise resulting from intercurrent pulmonary illnesses.\n* Unstable spinal cord compression and\u002For unstable brain metastases.\n* Participants with symptomatic brain metastases (including leptomeningeal involvement).\n* Clinically significant corneal disease.\n* Uncontrolled infection requiring systemic antibiotics, antivirals, or antifungals, suspected infections or inability to rule out infections. Use of systemic antibiotics within 14 days of randomization.\n* Has known human immunodeficiency virus (HIV) infection that is not well controlled.","ALL","18 Years","130 Years",{"count":2358,"type":2359},744,"ESTIMATED","INTERVENTIONAL",[2362],"PHASE3","This study will assess the effect of Dato-DXd in combination with osimertinib or Dato-DXd monotherapy versus platinum-based doublet chemotherapy in terms of progression-free survival (PFS).",[2365],"Metastatic Non-small Cell Lung Cancer",[2367,2368,2369,2370,2371,2372,2373,35,39,42,47,51],"Epidermal growth factor receptor gene mutation","Standard of Care","Locally, advanced carcinoma","Metastatic carcinoma","Non-small cell lung cancer","Dato-dxd","Datopotamab deruxtecan","2026-05-13",{"date":2376,"type":2377},"2026-05-14","ACTUAL",{"date":2379,"type":2377},"2024-10-04",{"date":2381,"type":2359},"2028-09-27",{"name":5,"class":6},303]