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Jana Mikulicza-Radeckiego We Wroclawiu","Wroclaw","50-556",{"type":37,"coordinates":1160},[1161,1162],17.03006,51.10286,{"lat":1162,"lon":1161},{"facility":1165,"status":30,"city":1166,"state":20,"zip":1167,"country":1168,"countryCode":1169,"cosmosGeoPoint":1170,"geoPoint":1174,"contacts":20},"Unidade Local de Saúde de Braga E.P.E. - Centro Clínico Académico de Braga - Serviço de Pediatria","Braga","4710-243","Portugal","PT",{"type":37,"coordinates":1171},[1172,1173],-8.42311,41.5514,{"lat":1173,"lon":1172},{"facility":1176,"status":54,"city":1177,"state":20,"zip":373,"country":1168,"countryCode":1169,"cosmosGeoPoint":1178,"geoPoint":1182,"contacts":20},"Unidade Local de Saúde de Coimbra, E.P.E. - Hospital Pediátrico - Serviço de Pediatria Ambulatória - Nefrologia","Coimbra",{"type":37,"coordinates":1179},[1180,1181],-8.41996,40.20686,{"lat":1181,"lon":1180},{"facility":1184,"status":64,"city":1185,"state":20,"zip":1186,"country":1168,"countryCode":1169,"cosmosGeoPoint":1187,"geoPoint":1191,"contacts":20},"Hospital Santa Maria | Centro de Investigacao Clinica","Lisbon","1649-035",{"type":37,"coordinates":1188},[1189,1190],-9.1498,38.72509,{"lat":1190,"lon":1189},{"facility":1193,"status":54,"city":1194,"state":20,"zip":1195,"country":1168,"countryCode":1169,"cosmosGeoPoint":1196,"geoPoint":1200,"contacts":20},"Unidade Local de Saúde de Santo António, E.P.E","Porto","4050-651",{"type":37,"coordinates":1197},[1198,1199],-8.61097,41.1485,{"lat":1199,"lon":1198},{"facility":1202,"status":64,"city":1203,"state":1204,"zip":1205,"country":1206,"countryCode":1207,"cosmosGeoPoint":1208,"geoPoint":1212,"contacts":20},"Wits Vaccines & Infectious Diseases Analytics (VIDA) Research Unit","Soweto","Gauteng","1862","South Africa","ZA",{"type":37,"coordinates":1209},[1210,1211],27.85849,-26.26781,{"lat":1211,"lon":1210},{"facility":1214,"status":331,"city":1215,"state":1216,"zip":1217,"country":1218,"countryCode":20,"cosmosGeoPoint":1219,"geoPoint":1223,"contacts":20},"Seoul National University Bundang Hospital","Seongnam-si","Gyeonggi-do","13620","South Korea",{"type":37,"coordinates":1220},[1221,1222],127.13778,37.43861,{"lat":1222,"lon":1221},{"facility":1225,"status":54,"city":1226,"state":1227,"zip":1228,"country":1218,"countryCode":20,"cosmosGeoPoint":1229,"geoPoint":1233,"contacts":20},"Pusan National University Yangsan Hospital","Yangsan","Gyeongsangnam-do","50612",{"type":37,"coordinates":1230},[1231,1232],129.03358,35.34199,{"lat":1232,"lon":1231},{"facility":1235,"status":331,"city":1236,"state":20,"zip":1237,"country":1218,"countryCode":20,"cosmosGeoPoint":1238,"geoPoint":1242,"contacts":20},"Kyungpook National University Hospital","Daegu","41944",{"type":37,"coordinates":1239},[1240,1241],128.59111,35.87028,{"lat":1241,"lon":1240},{"facility":260,"status":54,"city":261,"state":20,"zip":20,"country":1218,"countryCode":20,"cosmosGeoPoint":20,"geoPoint":20,"contacts":20},{"facility":1245,"status":54,"city":1246,"state":20,"zip":1247,"country":1218,"countryCode":20,"cosmosGeoPoint":1248,"geoPoint":1252,"contacts":20},"Seoul National University Hospital","Seoul","03080",{"type":37,"coordinates":1249},[1250,1251],126.9784,37.566,{"lat":1251,"lon":1250},{"facility":1254,"status":30,"city":1246,"state":20,"zip":1255,"country":1218,"countryCode":20,"cosmosGeoPoint":1256,"geoPoint":1258,"contacts":20},"Korea University Guro Hospital","08308",{"type":37,"coordinates":1257},[1250,1251],{"lat":1251,"lon":1250},{"facility":1260,"status":54,"city":1261,"state":20,"zip":1262,"country":1263,"countryCode":1264,"cosmosGeoPoint":1265,"geoPoint":1269,"contacts":20},"Hospital Universitari Vall D Hebron | Nefrologia pediatrica","Barcelona","08035","Spain","ES",{"type":37,"coordinates":1266},[1267,1268],2.15899,41.38879,{"lat":1268,"lon":1267},{"facility":1271,"status":331,"city":1261,"state":20,"zip":1272,"country":1263,"countryCode":1264,"cosmosGeoPoint":1273,"geoPoint":1275,"contacts":20},"Hospital Sant Joan De Deu Barcelona | Nefrologia pediatrica","08950",{"type":37,"coordinates":1274},[1267,1268],{"lat":1268,"lon":1267},{"facility":1277,"status":54,"city":1278,"state":20,"zip":1279,"country":1263,"countryCode":1264,"cosmosGeoPoint":1280,"geoPoint":1284,"contacts":20},"Hospital Universitario 12 De Octubre | Nefrologia pediatrica","Madrid","28041",{"type":37,"coordinates":1281},[1282,1283],-3.70256,40.4165,{"lat":1283,"lon":1282},{"facility":1286,"status":54,"city":1278,"state":20,"zip":1287,"country":1263,"countryCode":1264,"cosmosGeoPoint":1288,"geoPoint":1290,"contacts":20},"Hospital Universitario La Paz | Nefrologia pediatrica","28046",{"type":37,"coordinates":1289},[1282,1283],{"lat":1283,"lon":1282},{"facility":1292,"status":54,"city":1293,"state":20,"zip":1294,"country":1263,"countryCode":1264,"cosmosGeoPoint":1295,"geoPoint":1299,"contacts":20},"Hospital Universitario Regional De Malaga | Nefrologia pediatrica","Málaga","29010",{"type":37,"coordinates":1296},[1297,1298],-4.42034,36.72016,{"lat":1298,"lon":1297},{"facility":260,"status":54,"city":261,"state":20,"zip":20,"country":1263,"countryCode":1264,"cosmosGeoPoint":20,"geoPoint":20,"contacts":20},{"facility":1302,"status":331,"city":1303,"state":20,"zip":1304,"country":1263,"countryCode":1264,"cosmosGeoPoint":1305,"geoPoint":1309,"contacts":20},"Hospital Universitario Virgen Del Rocio S.L. | Nefrologia pediatrica","Seville","41013",{"type":37,"coordinates":1306},[1307,1308],-5.97317,37.38283,{"lat":1308,"lon":1307},{"facility":1311,"status":542,"city":1312,"state":1313,"zip":1314,"country":1315,"countryCode":1316,"cosmosGeoPoint":1317,"geoPoint":1321,"contacts":20},"Skånes Universitetssjukhus - Lund - Barnnefroenheten","Lund","Skåne County","221 85","Sweden","SE",{"type":37,"coordinates":1318},[1319,1320],13.19321,55.70584,{"lat":1320,"lon":1319},{"facility":1323,"status":30,"city":1324,"state":1325,"zip":1326,"country":1315,"countryCode":1316,"cosmosGeoPoint":1327,"geoPoint":1331,"contacts":20},"Karolinska University Hospital","Stockholm","Stockholm County","141 86",{"type":37,"coordinates":1328},[1329,1330],18.06871,59.32938,{"lat":1330,"lon":1329},{"facility":1333,"status":30,"city":1334,"state":1335,"zip":1336,"country":1315,"countryCode":1316,"cosmosGeoPoint":1337,"geoPoint":1341,"contacts":20},"OBSOLETE_Uppsala University Hospital","Uppsala","Uppsala County","751 85",{"type":37,"coordinates":1338},[1339,1340],17.63889,59.85882,{"lat":1340,"lon":1339},{"facility":260,"status":64,"city":261,"state":20,"zip":20,"country":1315,"countryCode":1316,"cosmosGeoPoint":20,"geoPoint":20,"contacts":20},{"facility":1344,"status":54,"city":1345,"state":1346,"zip":1347,"country":1348,"countryCode":1349,"cosmosGeoPoint":1350,"geoPoint":1354,"contacts":20},"Universitäts-Kinderspital UKBB","Basel","Canton of Basel-City","4031","Switzerland","CH",{"type":37,"coordinates":1351},[1352,1353],7.57327,47.55839,{"lat":1353,"lon":1352},{"facility":1356,"status":54,"city":1357,"state":1358,"zip":1359,"country":1348,"countryCode":1349,"cosmosGeoPoint":1360,"geoPoint":1364,"contacts":20},"Centre Hospitalier Universitaire Vaudois (CHUV)","Lausanne","Canton of Vaud","1012",{"type":37,"coordinates":1361},[1362,1363],6.63282,46.516,{"lat":1363,"lon":1362},{"facility":1366,"status":54,"city":1367,"state":20,"zip":1368,"country":1348,"countryCode":1349,"cosmosGeoPoint":1369,"geoPoint":1373,"contacts":20},"Hopital des Enfants HUG","Geneva","1211",{"type":37,"coordinates":1370},[1371,1372],6.14569,46.20222,{"lat":1372,"lon":1371},{"facility":260,"status":54,"city":261,"state":20,"zip":20,"country":1348,"countryCode":1349,"cosmosGeoPoint":20,"geoPoint":20,"contacts":20},{"facility":1376,"status":64,"city":1377,"state":1378,"zip":1379,"country":1380,"countryCode":1381,"cosmosGeoPoint":1382,"geoPoint":1386,"contacts":20},"Chang Gung Memorial Hospital (CGMH) - Kaohsiung Branch","Guishan","Taoyuan","83301","Taiwan","TW",{"type":37,"coordinates":1383},[1384,1385],121.33672,24.99436,{"lat":1385,"lon":1384},{"facility":1388,"status":30,"city":1389,"state":20,"zip":1390,"country":1380,"countryCode":1381,"cosmosGeoPoint":1391,"geoPoint":1395,"contacts":20},"Kaohsiung Veterans General Hospital","Kaohsiung City","813414",{"type":37,"coordinates":1392},[1393,1394],120.31333,22.61626,{"lat":1394,"lon":1393},{"facility":1397,"status":30,"city":1398,"state":20,"zip":1399,"country":1380,"countryCode":1381,"cosmosGeoPoint":1400,"geoPoint":1404,"contacts":20},"National Cheng Kung University Hospital","Tainan","704",{"type":37,"coordinates":1401},[1402,1403],120.21333,22.99083,{"lat":1403,"lon":1402},{"facility":1406,"status":64,"city":1407,"state":20,"zip":1408,"country":1380,"countryCode":1381,"cosmosGeoPoint":1409,"geoPoint":1413,"contacts":20},"National Taiwan University Hospital","Taipei","100229",{"type":37,"coordinates":1410},[1411,1412],121.52639,25.05306,{"lat":1412,"lon":1411},{"facility":1415,"status":54,"city":1407,"state":20,"zip":1416,"country":1380,"countryCode":1381,"cosmosGeoPoint":1417,"geoPoint":1419,"contacts":20},"Chang Gung Memorial Hospital at Linkou","10507",{"type":37,"coordinates":1418},[1411,1412],{"lat":1412,"lon":1411},{"facility":1421,"status":64,"city":1407,"state":20,"zip":1422,"country":1380,"countryCode":1381,"cosmosGeoPoint":1423,"geoPoint":1425,"contacts":20},"Taipei Veterans General Hospital","11217",{"type":37,"coordinates":1424},[1411,1412],{"lat":1412,"lon":1411},{"facility":1427,"status":64,"city":1428,"state":20,"zip":1429,"country":1430,"countryCode":20,"cosmosGeoPoint":1431,"geoPoint":1435,"contacts":20},"Cukurova Univ. Tip. Fak. Balcali Hastanesi","Adana","01790","Turkey (Türkiye)",{"type":37,"coordinates":1432},[1433,1434],35.32531,36.98615,{"lat":1434,"lon":1433},{"facility":1437,"status":64,"city":1438,"state":20,"zip":1439,"country":1430,"countryCode":20,"cosmosGeoPoint":1440,"geoPoint":1444,"contacts":20},"Hacettepe Universitesi Tip Fakultesi","Ankara","06230",{"type":37,"coordinates":1441},[1442,1443],32.85427,39.91987,{"lat":1443,"lon":1442},{"facility":1446,"status":54,"city":1438,"state":20,"zip":1447,"country":1430,"countryCode":20,"cosmosGeoPoint":1448,"geoPoint":1450,"contacts":20},"Baskent Universitesi Tip Fakultesi Hastanesi","6490",{"type":37,"coordinates":1449},[1442,1443],{"lat":1443,"lon":1442},{"facility":1452,"status":64,"city":1438,"state":20,"zip":1453,"country":1430,"countryCode":20,"cosmosGeoPoint":1454,"geoPoint":1456,"contacts":20},"Gazi Universitesi Tip Fakultesi","6560",{"type":37,"coordinates":1455},[1442,1443],{"lat":1443,"lon":1442},{"facility":1458,"status":54,"city":1438,"state":20,"zip":1459,"country":1430,"countryCode":20,"cosmosGeoPoint":1460,"geoPoint":1462,"contacts":20},"T.C. Saglik Bakanligi Ankara Bilkent Sehir Hastanesi Noroloji ve Ortopedi Hastanesi Noroloji Bolumu","6800",{"type":37,"coordinates":1461},[1442,1443],{"lat":1443,"lon":1442},{"facility":1464,"status":54,"city":1465,"state":20,"zip":1466,"country":1430,"countryCode":20,"cosmosGeoPoint":1467,"geoPoint":1471,"contacts":20},"Istanbul Faculty of Medicine, Department of Internal Medicine, Department of Pediatrics","Istanbul","34093",{"type":37,"coordinates":1468},[1469,1470],28.94966,41.01384,{"lat":1470,"lon":1469},{"facility":1473,"status":54,"city":1465,"state":20,"zip":1474,"country":1430,"countryCode":20,"cosmosGeoPoint":1475,"geoPoint":1477,"contacts":20},"Istanbul Universitesi Cerrahpasa - Cocuk Nefrolojisi","34098",{"type":37,"coordinates":1476},[1469,1470],{"lat":1470,"lon":1469},{"facility":1479,"status":54,"city":1465,"state":20,"zip":1480,"country":1430,"countryCode":20,"cosmosGeoPoint":1481,"geoPoint":1483,"contacts":20},"Marmara University Medical Faculty | Pediatric Nephrology","34899",{"type":37,"coordinates":1482},[1469,1470],{"lat":1470,"lon":1469},{"facility":260,"status":54,"city":261,"state":20,"zip":20,"country":1430,"countryCode":20,"cosmosGeoPoint":20,"geoPoint":20,"contacts":20},{"facility":1486,"status":542,"city":1487,"state":1488,"zip":1489,"country":1490,"countryCode":1491,"cosmosGeoPoint":1492,"geoPoint":1496,"contacts":20},"Great Ormond Street Hospital for Children NHS Foundation Trust | Great Ormond Street Hospital - Clinical Research Facility","London","Greater London","WC1N 3JH","United Kingdom","UK",{"type":37,"coordinates":1493},[1494,1495],-0.12574,51.50853,{"lat":1495,"lon":1494},{"facility":1498,"status":54,"city":1499,"state":1500,"zip":1501,"country":1490,"countryCode":1491,"cosmosGeoPoint":1502,"geoPoint":1506,"contacts":20},"Manchester University NHS Foundation Trust | Royal Manchester Children's Hospital - Clinical Research Facility","Manchester","Greater Manchester","M13 9WL",{"type":37,"coordinates":1503},[1504,1505],-2.23743,53.48095,{"lat":1505,"lon":1504},{"facility":1508,"status":30,"city":1509,"state":1510,"zip":1511,"country":1490,"countryCode":1491,"cosmosGeoPoint":1512,"geoPoint":1516,"contacts":20},"Nottingham University Hospitals NHS Trust | Queens Medical Centre - Childrens Clinical Research Facility","Nottingham","Nottinghamshire","NG7 2UH",{"type":37,"coordinates":1513},[1514,1515],-1.15047,52.9536,{"lat":1515,"lon":1514},{"facility":1518,"status":54,"city":1519,"state":1520,"zip":1521,"country":1490,"countryCode":1491,"cosmosGeoPoint":1522,"geoPoint":1526,"contacts":20},"NHS Greater Glasgow and Clyde | Royal Hospital for Children - Glasgow Clinical Research Facility","Glasgow","Scotland","G51 4TF",{"type":37,"coordinates":1523},[1524,1525],-4.25763,55.86515,{"lat":1525,"lon":1524},{"facility":1528,"status":64,"city":1529,"state":1530,"zip":1531,"country":1490,"countryCode":1491,"cosmosGeoPoint":1532,"geoPoint":1536,"contacts":20},"Birmingham Children's Hospital","Birmingham","West Midlands","B4 6NH",{"type":37,"coordinates":1533},[1534,1535],-1.89983,52.48142,{"lat":1535,"lon":1534},{"facility":260,"status":54,"city":261,"state":20,"zip":20,"country":1490,"countryCode":1491,"cosmosGeoPoint":20,"geoPoint":20,"contacts":20},{"type":1539,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100474390","phase-3-a-study-to-learn-more-about-how-safe-the-study-treatment-finerenone-is-in-long-term-use-when-taken-with-an-ace-inhibitor-or-angiotensin-receptor-blocker-over-18-months-of-use-in-children-and-young-adults-from-1-to-18-years-of-age-with-chronic-kidney-disease-and-proteinuria-100474390",false,"NCT05457283","A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria","An 18-month, Open-label, Single-arm Safety Extension Study of an age-and Bodyweight-adjusted Oral Finerenone Regimen, in Addition to an ACEI or ARB, for the Treatment of Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria","FIONA OLE","Inclusion Criteria:\n\n* Participants must be ≥1 year to 18 years of age, at the time of signing the informed consent\u002Fassent.\n* Prior participation in the finerenone Phase 3 study FIONA (19920) and not permanently discontinued from treatment by the end of treatment (EoT) visit in FIONA.\n* Participants must have a clinical diagnosis of chronic kidney disease (CKD) at Visit 1 which is defined as\n\n  * CKD stages 1-3 (estimated glomerular filtration rate \\[eGFR\\] ≥30 mL\u002Fmin\u002F1.73m\\^2) for children ≥1 year to \\\u003C19 years of age at FIONA EoT and at Visit 1\n* Treated with an angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) at optimized doses defined as maximally tolerable doses within the recommended dose range according to guidelines on blood pressure (BP) management, unchanged for at least 30 days prior to Visit 1.\n* K+ ≤5.0 mmol\u002FL for children ≥2 years of age at both FIONA EoT and Visit 1, and ≤5.3 mmol\u002FL for children \\\u003C2 years of age at both FIONA EoT and Visit 1\n* Participants who have reached legal age of consent: Capable of giving signed informed consent.\n* Participant is able to receive enteral feeding (solid food, bottle or cup fed, feeding through nasogastric or gastric feeding tubes) with or without breastfeeding.\n\nExclusion Criteria:\n\n* Planned urological surgery expected to influence renal function\n* Patients who are candidates for renal transplantation, i.e., a kidney transplantation scheduled within the study time frame\n* Systemic hypertension Stage 2 defined according to institutional guidelines on BP management at Visit 1.\n* Systemic hypotension defined as symptomatic hypotension or a mean systolic BP below the 5th percentile for age, sex and height but no lower than 80 mmHg for participants \\\u003C18 years and symptomatic hypotension or a mean systolic blood pressure (SBP) \\\u003C90 mmHg in participants ≥18 years at Visit 1.\n* Known hypersensitivity to the study treatment (active substance or excipients)\n* Severe hepatic insufficiency defined by e.g. Child-Pugh C or analogous scores.\n* Participants using rituximab, cyclophosphamide, abatacept, or intravenous glucocorticoids\n* Concomitant therapy with a mineralocorticoid receptor antagonist (MRA)(eplerenone, spironolactone, esaxerenone, canrenone), any renin inhibitor (aliskiren, enalkiren, remikiren), any sodium-glucose co-transporter-2 (SGLT2) inhibitor (SGLT2i), sacubitril\u002Fvalsartan combination (ARNI), or potassium-sparing diuretic (amiloride, triamterene)\n* Concomitant therapy with both ACEI and ARBs together\n* Concomitant therapy with strong cytochrome P450 isoenzyme 3A4 (CYP3A4) inhibitors, moderate or strong CYP3A4 inducers\n* Previous assignment to treatment during this study\n* Simultaneous participation in another interventional clinical study (e.g., Phase 1 to 4 clinical studies).\n* Any suspected (serious) adverse event related to study intervention which led to permanent discontinuation during the FIONA study.\n* Pregnant or breastfeeding or intention to become pregnant during the study","ALL","1 Year","18 Years",{"count":1552,"type":1553},100,"ESTIMATED","INTERVENTIONAL",[1556],"PHASE3","Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria, a condition in which a person´s kidneys leak protein into the urine.\n\nThe kidneys filter waste and fluid from the blood to form urine. In children with CKD, the kidney´s filters do not work as well as they should. This can lead to accumulation of waste and fluid in the body and proteinuria. CKD can lead to other medical problems, such as high blood pressure, also known as hypertension. Vice versa, hypertension and proteinuria can also contribute to worsening of CKD. Therefore, the treatment of CKD aims to control blood pressure and proteinuria. There are treatments available for doctors to prescribe to children with CKD and hypertension and\u002For proteinuria. These include \"angiotensin-converting enzyme inhibitors\" (ACEI) and \"angiotensin receptor blockers\" (ARB). Both ACEI and ARB can help improve kidney function by reducing the activity of the renin-angiotensin-aldosterone system (RAAS). The RAAS is a system that works with the kidneys to control blood pressure and the balance of fluid and electrolytes in the blood. In people with CKD, the RAAS is often too active, which can impair the ability of the kidneys to work properly and cause hypertension and proteinuria. However, ACEI or ARB treatment alone does not work for all patients with CKD as they only target the angiotensin part of the renin-angiotensin-aldosterone system.\n\nThe study treatment, finerenone, is expected to help control RAAS overactivation together with an ACEI or ARB.\n\nSo, the researchers in this study want to learn more about whether finerenone given in addition to either an ACEI or ARB can help their kidney function.\n\nThe main purpose of this study is to learn how safe the treatment is when used of finerenone in addition to an ACEI or ARB in long-term.\n\nTo see how safe the treatment is, the study team will collect information on medical problems which are also known as \"treatment emergent adverse events\" (TEAEs). And they will also collect levels of an electrolyte called potassium in the blood by taking blood samples, and measure blood pressure during the study.\n\nThe secondary purpose of this study is to learn how well long-term use of finerenone can reduce the amount of protein in the participants' urine and benefit kidney function when taken with standard of care.\n\nTo see how the treatment works, the study team will collect participants' urine samples to assess urinary albumin-to-creatinine ratio (UACR) and urinary protein-to-creatinine ratio (UPCR), which are important assessments for calculating the level of protein in the urine. Researchers will also collect blood samples to analyze serum creatinine and calculate estimated glomerular filtration rate (eGFR). A significant decline in eGFR indicates worsening kidney function.\n\nThe study will include participants who had previously participated in FIONA study (NCT05196035). The participants will be aged from 1 year up to 18 years.\n\nThe participants will be in the study for approximately 19 months. They will take study treatment for up to 18 months and will be follow up for 1 month. During this period, at least 12 visits are planned for patients who newly start finerenone, and at least 8 visits for patients who already received finerenone.\n\nIn the visit, the study team will:\n\n* have their blood pressure, heart rate, temperature, height and weight measured\n* have blood and urine samples taken\n* have physical examinations\n* have their heart examined by an electrocardiogram and echocardiography (a sonogram of the heart)\n* answer questions about their medication and whether they have any adverse events, or have their parents or guardian's answer\n* answer questions about how they are feeling, or have their parents or guardian's answer\n* answer question about how they like the study medication, or have their parents or guardian's answer The doctors will keep track of any adverse events. An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events that happen in studies, even if they do not think the adverse events might be related to the study treatments.\n\nThe doctors will check the participants' health about 30 days after the participants take their last treatment.",[1559,1560,1561],"Chronic Kidney Disease","Proteinuria","Children","2026-06-25",{"date":1564,"type":1565},"2026-06-26","ACTUAL",{"date":1567,"type":1565},"2022-11-08",{"date":1569,"type":1553},"2028-12-28",{"name":5,"class":6},179]