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Zamenhofa","Bialystok","15-274","Poland","PL",{"type":48,"coordinates":1138},[1139,1140],23.16433,53.13333,{"lat":1140,"lon":1139},{"facility":1143,"status":245,"city":1144,"state":25,"zip":1145,"country":1135,"countryCode":1136,"cosmosGeoPoint":1146,"geoPoint":1150,"contacts":25},"Uniwersyteckie Centrum Kliniczne","Gdansk","80-952",{"type":48,"coordinates":1147},[1148,1149],18.64912,54.35227,{"lat":1149,"lon":1148},{"facility":1152,"status":55,"city":1153,"state":25,"zip":1154,"country":1135,"countryCode":1136,"cosmosGeoPoint":1155,"geoPoint":1159,"contacts":25},"Uniwersytecki Szpital Dzieciecy w Krakowie","Krakow","30-663",{"type":48,"coordinates":1156},[1157,1158],19.93658,50.06143,{"lat":1158,"lon":1157},{"facility":1161,"status":245,"city":1162,"state":25,"zip":1163,"country":1135,"countryCode":1136,"cosmosGeoPoint":1164,"geoPoint":1168,"contacts":25},"Instytut Centrum Zdrowia Matki Polki","Lodz","93-338",{"type":48,"coordinates":1165},[1166,1167],19.47395,51.77058,{"lat":1167,"lon":1166},{"facility":1170,"status":85,"city":1171,"state":25,"zip":1172,"country":1135,"countryCode":1136,"cosmosGeoPoint":1173,"geoPoint":1177,"contacts":25},"Dzieciecy Szpital Kliniczny im. Jozefa Brudzinskiego","Warsaw","02-091",{"type":48,"coordinates":1174},[1175,1176],21.01178,52.22977,{"lat":1176,"lon":1175},{"facility":1179,"status":245,"city":1171,"state":25,"zip":1180,"country":1135,"countryCode":1136,"cosmosGeoPoint":1181,"geoPoint":1183,"contacts":25},"Instytut \"Pomnik - Centrum Zdrowia Dziecka\"","04-730",{"type":48,"coordinates":1182},[1175,1176],{"lat":1176,"lon":1175},{"facility":1185,"status":55,"city":1186,"state":25,"zip":1187,"country":1135,"countryCode":1136,"cosmosGeoPoint":1188,"geoPoint":1192,"contacts":25},"Uniwersytecki Szpital Kliniczny UM we Wroclawiu","Wroclaw","50-556",{"type":48,"coordinates":1189},[1190,1191],17.03006,51.10286,{"lat":1191,"lon":1190},{"facility":1194,"status":85,"city":1195,"state":25,"zip":1196,"country":1197,"countryCode":1198,"cosmosGeoPoint":1199,"geoPoint":1203,"contacts":25},"Unidade Local de Saúde de Braga E.P.E. - Centro Clínico Académico de Braga - Serviço de Pediatria","Braga","4710-243","Portugal","PT",{"type":48,"coordinates":1200},[1201,1202],-8.42311,41.5514,{"lat":1202,"lon":1201},{"facility":1205,"status":234,"city":1206,"state":25,"zip":377,"country":1197,"countryCode":1198,"cosmosGeoPoint":1207,"geoPoint":1211,"contacts":25},"Unidade Local de Saúde de Coimbra, E.P.E. - Hospital Pediátrico - Serviço de Pediatria Ambulatória - Nefrologia","Coimbra",{"type":48,"coordinates":1208},[1209,1210],-8.41996,40.20686,{"lat":1210,"lon":1209},{"facility":1213,"status":85,"city":1214,"state":25,"zip":1215,"country":1197,"countryCode":1198,"cosmosGeoPoint":1216,"geoPoint":1220,"contacts":25},"Hospital Santa Maria | Centro de Investigacao Clinica","Lisbon","1649-035",{"type":48,"coordinates":1217},[1218,1219],-9.1498,38.72509,{"lat":1219,"lon":1218},{"facility":1222,"status":245,"city":1223,"state":25,"zip":1224,"country":1197,"countryCode":1198,"cosmosGeoPoint":1225,"geoPoint":1229,"contacts":25},"Unidade Local de Saúde de Santo António, E.P.E","Porto","4050-651",{"type":48,"coordinates":1226},[1227,1228],-8.61097,41.1485,{"lat":1228,"lon":1227},{"facility":1231,"status":66,"city":1232,"state":1233,"zip":1234,"country":1235,"countryCode":1236,"cosmosGeoPoint":1237,"geoPoint":1241,"contacts":25},"Wits Vaccines & Infectious Diseases Analytics (VIDA) Research Unit","Soweto","Gauteng","1862","South Africa","ZA",{"type":48,"coordinates":1238},[1239,1240],27.85849,-26.26781,{"lat":1240,"lon":1239},{"facility":1243,"status":245,"city":1244,"state":1245,"zip":1246,"country":1247,"countryCode":25,"cosmosGeoPoint":1248,"geoPoint":1252,"contacts":25},"Seoul National University Bundang Hospital","Seongnam-si","Gyeonggi-do","13620","South Korea",{"type":48,"coordinates":1249},[1250,1251],127.13778,37.43861,{"lat":1251,"lon":1250},{"facility":1254,"status":66,"city":1255,"state":1256,"zip":1257,"country":1247,"countryCode":25,"cosmosGeoPoint":1258,"geoPoint":1262,"contacts":25},"Pusan National University Yangsan Hospital","Yangsan","Gyeongsangnam-do","50612",{"type":48,"coordinates":1259},[1260,1261],129.03358,35.34199,{"lat":1261,"lon":1260},{"facility":1264,"status":66,"city":1265,"state":1266,"zip":1267,"country":1247,"countryCode":25,"cosmosGeoPoint":1268,"geoPoint":1272,"contacts":25},"Seoul National University Hospital","Seoul","Seoul Teugbyeolsi","03080",{"type":48,"coordinates":1269},[1270,1271],126.9784,37.566,{"lat":1271,"lon":1270},{"facility":1274,"status":245,"city":1265,"state":1266,"zip":1275,"country":1247,"countryCode":25,"cosmosGeoPoint":1276,"geoPoint":1278,"contacts":25},"Korea University Guro Hospital","08308",{"type":48,"coordinates":1277},[1270,1271],{"lat":1271,"lon":1270},{"facility":1280,"status":245,"city":1281,"state":25,"zip":1282,"country":1247,"countryCode":25,"cosmosGeoPoint":1283,"geoPoint":1287,"contacts":25},"Kyungpook National University Hospital","Daegu","41944",{"type":48,"coordinates":1284},[1285,1286],128.59111,35.87028,{"lat":1286,"lon":1285},{"facility":1289,"status":245,"city":1290,"state":25,"zip":1291,"country":1292,"countryCode":1293,"cosmosGeoPoint":1294,"geoPoint":1298,"contacts":25},"Hospital Universitari Vall D Hebron | Nefrologia pediatrica","Barcelona","08035","Spain","ES",{"type":48,"coordinates":1295},[1296,1297],2.15899,41.38879,{"lat":1297,"lon":1296},{"facility":1300,"status":245,"city":1290,"state":25,"zip":1301,"country":1292,"countryCode":1293,"cosmosGeoPoint":1302,"geoPoint":1304,"contacts":25},"Hospital Sant Joan De Deu Barcelona | Nefrologia pediatrica","08950",{"type":48,"coordinates":1303},[1296,1297],{"lat":1297,"lon":1296},{"facility":1306,"status":245,"city":1307,"state":25,"zip":1308,"country":1292,"countryCode":1293,"cosmosGeoPoint":1309,"geoPoint":1313,"contacts":25},"Hospital Universitario 12 De Octubre | Nefrologia pediatrica","Madrid","28041",{"type":48,"coordinates":1310},[1311,1312],-3.70256,40.4165,{"lat":1312,"lon":1311},{"facility":1315,"status":245,"city":1307,"state":25,"zip":1316,"country":1292,"countryCode":1293,"cosmosGeoPoint":1317,"geoPoint":1319,"contacts":25},"Hospital Universitario La Paz | Nefrologia pediatrica","28046",{"type":48,"coordinates":1318},[1311,1312],{"lat":1312,"lon":1311},{"facility":1321,"status":234,"city":1322,"state":25,"zip":1323,"country":1292,"countryCode":1293,"cosmosGeoPoint":1324,"geoPoint":1328,"contacts":25},"Hospital Universitario Regional De Malaga | Nefrologia pediatrica","Málaga","29010",{"type":48,"coordinates":1325},[1326,1327],-4.42034,36.72016,{"lat":1327,"lon":1326},{"facility":1330,"status":245,"city":1331,"state":25,"zip":1332,"country":1292,"countryCode":1293,"cosmosGeoPoint":1333,"geoPoint":1337,"contacts":25},"Hospital Universitario Virgen Del Rocio S.L. | Nefrologia pediatrica","Seville","41013",{"type":48,"coordinates":1334},[1335,1336],-5.97317,37.38283,{"lat":1336,"lon":1335},{"facility":1339,"status":245,"city":1340,"state":1341,"zip":1342,"country":1343,"countryCode":1344,"cosmosGeoPoint":1345,"geoPoint":1349,"contacts":25},"Skånes Universitetssjukhus - Lund - Barnnefroenheten","Lund","Skåne County","221 85","Sweden","SE",{"type":48,"coordinates":1346},[1347,1348],13.19321,55.70584,{"lat":1348,"lon":1347},{"facility":1351,"status":234,"city":1352,"state":1353,"zip":1354,"country":1343,"countryCode":1344,"cosmosGeoPoint":1355,"geoPoint":1359,"contacts":25},"Karolinska University Hospital","Stockholm","Stockholm County","141 86",{"type":48,"coordinates":1356},[1357,1358],18.06871,59.32938,{"lat":1358,"lon":1357},{"facility":1361,"status":41,"city":1362,"state":1363,"zip":1364,"country":1343,"countryCode":1344,"cosmosGeoPoint":1365,"geoPoint":1369,"contacts":25},"OBSOLETE_Uppsala University Hospital","Uppsala","Uppsala County","751 85",{"type":48,"coordinates":1366},[1367,1368],17.63889,59.85882,{"lat":1368,"lon":1367},{"facility":1371,"status":245,"city":1372,"state":1373,"zip":1374,"country":1375,"countryCode":1376,"cosmosGeoPoint":1377,"geoPoint":1381,"contacts":25},"Universitäts-Kinderspital UKBB","Basel","Canton of Basel-City","4031","Switzerland","CH",{"type":48,"coordinates":1378},[1379,1380],7.57327,47.55839,{"lat":1380,"lon":1379},{"facility":1383,"status":245,"city":1384,"state":1385,"zip":1386,"country":1375,"countryCode":1376,"cosmosGeoPoint":1387,"geoPoint":1391,"contacts":25},"Centre Hospitalier Universitaire Vaudois (CHUV)","Lausanne","Canton of Vaud","1012",{"type":48,"coordinates":1388},[1389,1390],6.63282,46.516,{"lat":1390,"lon":1389},{"facility":1393,"status":245,"city":1394,"state":25,"zip":1395,"country":1375,"countryCode":1376,"cosmosGeoPoint":1396,"geoPoint":1400,"contacts":25},"Hopital des Enfants HUG","Geneva","1211",{"type":48,"coordinates":1397},[1398,1399],6.14569,46.20222,{"lat":1399,"lon":1398},{"facility":1402,"status":66,"city":1403,"state":1404,"zip":1405,"country":1406,"countryCode":1407,"cosmosGeoPoint":1408,"geoPoint":1412,"contacts":25},"Chang Gung Memorial Hospital (CGMH) - Kaohsiung Branch","Guishan","Taoyuan","83301","Taiwan","TW",{"type":48,"coordinates":1409},[1410,1411],121.33672,24.99436,{"lat":1411,"lon":1410},{"facility":1414,"status":85,"city":1415,"state":25,"zip":1416,"country":1406,"countryCode":1407,"cosmosGeoPoint":1417,"geoPoint":1421,"contacts":25},"Kaohsiung Veterans General Hospital","Kaohsiung City","813414",{"type":48,"coordinates":1418},[1419,1420],120.31333,22.61626,{"lat":1420,"lon":1419},{"facility":1423,"status":66,"city":1424,"state":25,"zip":1425,"country":1406,"countryCode":1407,"cosmosGeoPoint":1426,"geoPoint":1430,"contacts":25},"National Cheng Kung University Hospital","Tainan","704",{"type":48,"coordinates":1427},[1428,1429],120.21333,22.99083,{"lat":1429,"lon":1428},{"facility":1432,"status":245,"city":1433,"state":25,"zip":1434,"country":1406,"countryCode":1407,"cosmosGeoPoint":1435,"geoPoint":1439,"contacts":25},"National Taiwan University Hospital","Taipei","100229",{"type":48,"coordinates":1436},[1437,1438],121.52639,25.05306,{"lat":1438,"lon":1437},{"facility":1441,"status":66,"city":1433,"state":25,"zip":1442,"country":1406,"countryCode":1407,"cosmosGeoPoint":1443,"geoPoint":1445,"contacts":25},"Chang Gung Memorial Hospital at Linkou","10507",{"type":48,"coordinates":1444},[1437,1438],{"lat":1438,"lon":1437},{"facility":1447,"status":234,"city":1433,"state":25,"zip":1448,"country":1406,"countryCode":1407,"cosmosGeoPoint":1449,"geoPoint":1451,"contacts":25},"Taipei Veterans General Hospital","11217",{"type":48,"coordinates":1450},[1437,1438],{"lat":1438,"lon":1437},{"facility":1453,"status":66,"city":1454,"state":25,"zip":1455,"country":1456,"countryCode":25,"cosmosGeoPoint":1457,"geoPoint":1461,"contacts":25},"Cukurova Univ. Tip. Fak. Balcali Hastanesi","Adana","01790","Turkey (Türkiye)",{"type":48,"coordinates":1458},[1459,1460],35.32531,36.98615,{"lat":1460,"lon":1459},{"facility":1463,"status":245,"city":1464,"state":25,"zip":1465,"country":1456,"countryCode":25,"cosmosGeoPoint":1466,"geoPoint":1470,"contacts":25},"Hacettepe Universitesi Tip Fakultesi","Ankara","06230",{"type":48,"coordinates":1467},[1468,1469],32.85427,39.91987,{"lat":1469,"lon":1468},{"facility":1472,"status":245,"city":1464,"state":25,"zip":1473,"country":1456,"countryCode":25,"cosmosGeoPoint":1474,"geoPoint":1476,"contacts":25},"Baskent Universitesi Tip Fakultesi Hastanesi","6490",{"type":48,"coordinates":1475},[1468,1469],{"lat":1469,"lon":1468},{"facility":1478,"status":234,"city":1464,"state":25,"zip":1479,"country":1456,"countryCode":25,"cosmosGeoPoint":1480,"geoPoint":1482,"contacts":25},"Gazi Universitesi Tip Fakultesi","6560",{"type":48,"coordinates":1481},[1468,1469],{"lat":1469,"lon":1468},{"facility":1484,"status":245,"city":1464,"state":25,"zip":355,"country":1456,"countryCode":25,"cosmosGeoPoint":1485,"geoPoint":1487,"contacts":25},"T.C. Saglik Bakanligi Ankara Bilkent Sehir Hastanesi Noroloji ve Ortopedi Hastanesi Noroloji Bolumu",{"type":48,"coordinates":1486},[1468,1469],{"lat":1469,"lon":1468},{"facility":1489,"status":245,"city":1490,"state":25,"zip":1491,"country":1456,"countryCode":25,"cosmosGeoPoint":1492,"geoPoint":1496,"contacts":25},"Istanbul Faculty of Medicine, Department of Internal Medicine, Department of Pediatrics","Istanbul","34093",{"type":48,"coordinates":1493},[1494,1495],28.94966,41.01384,{"lat":1495,"lon":1494},{"facility":1498,"status":66,"city":1490,"state":25,"zip":1499,"country":1456,"countryCode":25,"cosmosGeoPoint":1500,"geoPoint":1502,"contacts":25},"Istanbul Universitesi Cerrahpasa - Cocuk Nefrolojisi","34098",{"type":48,"coordinates":1501},[1494,1495],{"lat":1495,"lon":1494},{"facility":1504,"status":245,"city":1490,"state":25,"zip":1505,"country":1456,"countryCode":25,"cosmosGeoPoint":1506,"geoPoint":1508,"contacts":25},"Marmara University Medical Faculty | Pediatric Nephrology","34899",{"type":48,"coordinates":1507},[1494,1495],{"lat":1495,"lon":1494},{"facility":1510,"status":66,"city":1511,"state":1512,"zip":1513,"country":1514,"countryCode":1515,"cosmosGeoPoint":1516,"geoPoint":1520,"contacts":25},"Great Ormond Street Hospital for Children NHS Foundation Trust | Great Ormond Street Hospital - Clinical Research Facility","London","Greater London","WC1N 3JH","United Kingdom","UK",{"type":48,"coordinates":1517},[1518,1519],-0.12574,51.50853,{"lat":1519,"lon":1518},{"facility":1522,"status":66,"city":1523,"state":1524,"zip":1525,"country":1514,"countryCode":1515,"cosmosGeoPoint":1526,"geoPoint":1530,"contacts":25},"Manchester University NHS Foundation Trust | Royal Manchester Children's Hospital - Clinical Research Facility","Manchester","Greater Manchester","M13 9WL",{"type":48,"coordinates":1527},[1528,1529],-2.23743,53.48095,{"lat":1529,"lon":1528},{"facility":1532,"status":234,"city":1533,"state":1534,"zip":1535,"country":1514,"countryCode":1515,"cosmosGeoPoint":1536,"geoPoint":1540,"contacts":25},"Nottingham University Hospitals NHS Trust | Queens Medical Centre - Childrens Clinical Research Facility","Nottingham","Nottinghamshire","NG7 2UH",{"type":48,"coordinates":1537},[1538,1539],-1.15047,52.9536,{"lat":1539,"lon":1538},{"facility":1542,"status":66,"city":1543,"state":1544,"zip":1545,"country":1514,"countryCode":1515,"cosmosGeoPoint":1546,"geoPoint":1550,"contacts":25},"NHS Greater Glasgow and Clyde | Royal Hospital for Children - Glasgow Clinical Research Facility","Glasgow","Scotland","G51 4TF",{"type":48,"coordinates":1547},[1548,1549],-4.25763,55.86515,{"lat":1549,"lon":1548},{"facility":1552,"status":85,"city":1553,"state":1554,"zip":1555,"country":1514,"countryCode":1515,"cosmosGeoPoint":1556,"geoPoint":1560,"contacts":25},"Birmingham Children's Hospital","Birmingham","West Midlands","B4 6NH",{"type":48,"coordinates":1557},[1558,1559],-1.89983,52.48142,{"lat":1559,"lon":1558},{"type":1562,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100454322","phase-3-a-study-to-learn-more-about-how-well-the-study-treatment-finerenone-works-how-safe-it-is-how-it-moves-into-through-and-out-of-the-body-and-the-effects-it-has-on-the-body-when-taken-with-an-ace-inhibitor-or-angiotensin-receptor-blocker-in-children-with-chronic-kidney-disease-and-proteinuria-100454322",false,"NCT05196035","A Study to Learn More About How Well the Study Treatment Finerenone Works, How Safe it is, How it Moves Into, Through, and Out of the Body, and the Effects it Has on the Body When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker in Children With Chronic Kidney Disease and Proteinuria","A 6-month Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety and PK\u002FPD of an age-and Body Weight-adjusted Oral Finerenone Regimen, in Addition to an ACEI or ARB, for the Treatment of Children, 6 Months to \u003C18 Years of Age, With Chronic Kidney Disease and Proteinuria","FIONA","Inclusion Criteria:\n\n* Participants must be 6 months to \\\u003C18 years old at the time when the informed consent\u002Fassent is signed\n* Participants must have a clinical diagnosis of chronic kidney disease (CKD) at screening which is defined as\n\n  * CKD stages 1-3 (eGFR ≥30 mL\u002Fmin\u002F1.73m\\^2) for children ≥1 year to \\\u003C18 years of age or\n  * a serum creatinine ≤ 0.40 mg\u002FdL for infants 6 months to \\\u003C 1 year of age and\n  * severely increased proteinuria as defined by\n\n    * Urinary protein-to-creatinine ratio (UPCR) of ≥ 0.50 g\u002Fg in participants ≥ 2 years with CKD stage 2 and 3 or\n    * UPCR ≥ 1.0 g\u002Fg for patients \\\u003C 2 years of age or ≥ 2 years of age and with CKD stage 1\n* Participants must have stable kidney function between screening and D0 defined as:\n\n  * For participants with a creatinine of \\> 0.8 mg\u002FdL at screening: no increase or decrease in eGFR by ≥ 20% at D0\n  * For participants with a creatinine of ≤ 0.8 mg\u002FdL at screening: no increase or decrease in creatinine ≥ 0.15 mg\u002FdL at D0.\n* Treated with an angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) at optimized doses defined as maximally tolerable doses within the recommended dose range according to guidelines on blood pressure management, unchanged for at least 30 days prior to screening\n* K+ ≤5.0 mmol\u002FL for children ≥2 years of age at both screening and D0, and ≤5.3 mmol\u002FL for children \\\u003C2 years of age at both screening and D0\n\nExclusion Criteria:\n\n* Planned urological surgery expected to influence renal function\n* Children with hemolytic uremic syndrome (HUS) diagnosed ≤6 months prior to screening\n* Patients with nephrotic syndrome receiving albumin infusions within the last 6 months prior to screening\n* Patients who are candidates for renal transplantation, i.e., a kidney transplantation scheduled within the study time frame\n* Renal allograft in place\n* Bilateral renal artery stenosis\n* Acute kidney injury requiring dialysis within 6 months prior to screening\n* Systemic hypertension stage 2 in children ≥1 year of age defined according to guidelines on blood pressure management at screening or randomization\n* Systolic blood pressure (SBP) above 110 mmHg in infants 6 months to \\\u003C1 year of age at screening or randomization\n* Systemic hypotension defined as a systolic blood pressure below the 5th percentile for age, sex and height at either screening or randomization but no lower than 80 mmHg (although for some participants the 5th percentile of SBP is \\\u003C 80 mmHg they must be excluded if their SBP is \\\u003C80 mmHg)\n* Participants with immune-mediated CKD using rituximab, cyclophosphamide, abatacept, or high-dose glucocorticoids, within \\\u003C6 months prior to screening","ALL","6 Months","17 Years",{"count":1575,"type":1576},219,"ESTIMATED","INTERVENTIONAL",[1579],"PHASE3","Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria, a condition in which a person´s kidneys leak protein into the urine.\n\nThe kidneys filter waste and fluid from the blood to form urine. In children with CKD, the kidney´s filters do not work as well as they should. This can lead to accumulation of waste and fluid in the body and proteinuria. CKD can lead to other medical problems, such as high blood pressure, also known as hypertension. Vice versa, hypertension and proteinuria can also contribute to worsening of CKD. Therefore, the treatment of CKD aims to control blood pressure and proteinuria. There are treatments available for doctors to prescribe to children with CKD and hypertension and\u002For proteinuria. These include \"angiotensin-converting enzyme inhibitors\" (ACEI) and \"angiotensin receptor blockers\" (ARB). Both ACEI and ARB can improve kidney function by helping the renin-angiotensin-aldosterone system (RAAS) to work normally. The RAAS is a system that works with the kidneys to control blood pressure and the balance of fluid and electrolytes in the blood. In people with CKD, the RAAS is often too active, which can stop the kidneys from working properly and cause hypertension and proteinuria. However, ACEI or ARB treatment alone does not work for all patients with CKD as they only target the angiotensin part of the renin-angiotensin-aldosterone system.\n\nThe study treatment, finerenone, is expected to help control RAAS overactivation together with an ACEI or ARB.\n\nSo, the researchers in this study want to learn more about whether finerenone given in addition to either an ACEI or ARB can help their kidney function.\n\nThe main purpose of this study is to learn more about whether finerenone added to either ACEI or ARB can help reduce the amount of protein in the participants' urine more than a placebo. A placebo looks like a treatment but does not have any medicine in it. Participants will also continue to receive their other medications.\n\nTo see how the treatment work, the doctors will take samples of the participants' urine to measure their protein levels before and during taking treatment and after their last treatment. In addition, blood samples will be taken to monitor kidney function, electrolytes and the amount of finerenone in the blood as well as for other tests.\n\nThis study will include children with CKD and proteinuria aged from 6 months up to less than 18 years. The participants will take:\n\n* either finerenone or the placebo, in addition to\n* either ACEI or ARB, whichever they take as part of their normal treatment\n\nTwo visits are required up to 104 days, to check whether a child can take part in the treatment phase of the study. If participants qualify for the treatment phase, they will then undergo treatment for about 180 days. During this time, they will visit the study site at least 7 times. During these visits, the participants will:\n\n* have their blood pressure, heart rate, temperature, height and weight measured\n* have blood and urine samples taken\n* have physical examinations\n* have their heart examined by an electrocardiogram and echocardiography (a sonogram of the heart)\n* answer questions about their medication and whether they have any adverse events , or have their parents or guardians answer\n* answer questions about how they are feeling, or have their parents or guardians answer\n* answer question about how they like the study medication, or have their parents or guardians answer\n\nThe doctors will keep track of any adverse events. An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events that happen in studies, even if they do not think the adverse events might be related to the study treatments.\n\nThe doctors will check the participants' health about 30 days after the participants take their last treatment.",[1582,1583],"Chronic Kidney Disease","Proteinuria","2026-06-18",{"date":1586,"type":1587},"2026-06-22","ACTUAL",{"date":1589,"type":1587},"2022-03-28",{"date":1591,"type":1576},"2027-06-30",{"name":5,"class":6},164]