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Children 7 to \\\u003C 16 years must also have an upright stability score (USS) score of 10 to ≤ 34 at baseline\n\nPart 1: Key exclusion criteria:\n\n* Glycosylated hemoglobin A1C (HbA1c) \\> 11%\n* B-type natriuretic peptide (BNP) \\> 200 picograms per milliliter (pg\u002FmL) at screening\n* Ejection fraction (EF) \\\u003C 40% \\[based on echocardiogram (ECHO) performed at screening visit\\]\n* Clinically significant cardiac disease except mild to moderate cardiomyopathy\n\nPart 2A: Eligibility criteria:\n\n* They have completed Part 1 of the study and no discontinuation criteria have been met.\n* Safety and tolerability data from Part 1 are supportive of continuation in the judgement of the investigator.\n\nPart 2B: Eligibility criteria:\n\n* Participants have completed Part 1 of the study and no discontinuation criteria have been met.\n* Safety and tolerability data from Part 1 are supportive of continuation in the judgement of the Investigator.\n\nNote: Other protocol-defined Inclusion\u002FExclusion criteria may apply.","ALL","2 Years","15 Years",{"count":601,"type":602},255,"ESTIMATED","INTERVENTIONAL",[605],"PHASE3","In this study, researchers will learn more about omaveloxolone, also known as BIIB141 or SKYCLARYS®. 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The mFARS tests movement ability, balance, coordination, speech, and arm and leg functions.\n\nThey will also use a number of questionnaires to learn more about participants' quality of life, muscle strength, and ability to perform daily tasks. Researchers will also note any changes as participants go through puberty.\n\nFinally, researchers will learn more about how the body processes omaveloxolone in children and teenagers.\n\nThis study will be done in 2 parts as follows:\n\n* Participants will be screened for up to 4 weeks to check if they can join the study.\n* In Part 1, participants will be randomly assigned to take either omaveloxolone or a placebo by mouth once a day for about 1 year. A placebo looks like the study drug but contains no real medicine.\n* Part 1 will be double blind. 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