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40707","Bydgoszcz","Poland","PL",{"type":56,"coordinates":1329},[1330,1331],18.00762,53.1235,{"lat":1331,"lon":1330},{"facility":1334,"status":49,"city":1335,"state":33,"zip":33,"country":1326,"countryCode":1327,"cosmosGeoPoint":1336,"geoPoint":1340,"contacts":33},"Ep0162 40677","Gdansk",{"type":56,"coordinates":1337},[1338,1339],18.64912,54.35227,{"lat":1339,"lon":1338},{"facility":1342,"status":111,"city":1343,"state":33,"zip":33,"country":1326,"countryCode":1327,"cosmosGeoPoint":1344,"geoPoint":1348,"contacts":33},"Ep0162 40219","Krakow",{"type":56,"coordinates":1345},[1346,1347],19.93658,50.06143,{"lat":1347,"lon":1346},{"facility":1350,"status":72,"city":1343,"state":33,"zip":33,"country":1326,"countryCode":1327,"cosmosGeoPoint":1351,"geoPoint":1353,"contacts":33},"Ep0162 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40153","Poznan",{"type":56,"coordinates":1379},[1380,1381],16.92993,52.40692,{"lat":1381,"lon":1380},{"facility":1384,"status":72,"city":1385,"state":33,"zip":33,"country":1326,"countryCode":1327,"cosmosGeoPoint":1386,"geoPoint":1390,"contacts":33},"Ep0162 40678","Świdnik",{"type":56,"coordinates":1387},[1388,1389],22.69621,51.21898,{"lat":1389,"lon":1388},{"facility":1392,"status":49,"city":1393,"state":33,"zip":33,"country":1394,"countryCode":1395,"cosmosGeoPoint":1396,"geoPoint":1400,"contacts":33},"Ep0162 40160","Barcelona","Spain","ES",{"type":56,"coordinates":1397},[1398,1399],2.15899,41.38879,{"lat":1399,"lon":1398},{"facility":1402,"status":49,"city":1403,"state":33,"zip":33,"country":1394,"countryCode":1395,"cosmosGeoPoint":1404,"geoPoint":1408,"contacts":33},"Ep0162 40157","L'Hospitalet de Llobregat",{"type":56,"coordinates":1405},[1406,1407],2.10028,41.35967,{"lat":1407,"lon":1406},{"facility":1410,"status":49,"city":1411,"state":33,"zip":33,"country":1394,"countryCode":1395,"cosmosGeoPoint":1412,"geoPoint":1416,"contacts":33},"Ep0162 40540","Madrid",{"type":56,"coordinates":1413},[1414,1415],-3.70256,40.4165,{"lat":1415,"lon":1414},{"facility":1418,"status":49,"city":1419,"state":33,"zip":33,"country":1394,"countryCode":1395,"cosmosGeoPoint":1420,"geoPoint":1424,"contacts":33},"Ep0162 40352","Pamplona",{"type":56,"coordinates":1421},[1422,1423],-1.64323,42.81687,{"lat":1423,"lon":1422},{"facility":1426,"status":49,"city":1427,"state":33,"zip":33,"country":1394,"countryCode":1395,"cosmosGeoPoint":1428,"geoPoint":1432,"contacts":33},"Ep0162 40668","Seville",{"type":56,"coordinates":1429},[1430,1431],-5.97317,37.38283,{"lat":1431,"lon":1430},{"facility":1434,"status":49,"city":1435,"state":33,"zip":33,"country":1394,"countryCode":1395,"cosmosGeoPoint":1436,"geoPoint":1440,"contacts":33},"Ep0162 40453","Terrassa",{"type":56,"coordinates":1437},[1438,1439],2.01667,41.56667,{"lat":1439,"lon":1438},{"facility":1442,"status":49,"city":1443,"state":33,"zip":33,"country":1394,"countryCode":1395,"cosmosGeoPoint":1444,"geoPoint":1448,"contacts":33},"Ep0162 40230","Valencia",{"type":56,"coordinates":1445},[1446,1447],-0.37966,39.47391,{"lat":1447,"lon":1446},{"facility":1450,"status":72,"city":1451,"state":33,"zip":33,"country":1394,"countryCode":1395,"cosmosGeoPoint":1452,"geoPoint":1456,"contacts":33},"Ep0162 40667","Valladolid",{"type":56,"coordinates":1453},[1454,1455],-4.72353,41.65541,{"lat":1455,"lon":1454},{"facility":1458,"status":49,"city":1459,"state":33,"zip":33,"country":1460,"countryCode":1461,"cosmosGeoPoint":1462,"geoPoint":1466,"contacts":33},"Ep0162 40686","Birmingham","United Kingdom","UK",{"type":56,"coordinates":1463},[1464,1465],-1.89983,52.48142,{"lat":1465,"lon":1464},{"facility":1468,"status":111,"city":1469,"state":33,"zip":33,"country":1460,"countryCode":1461,"cosmosGeoPoint":1470,"geoPoint":1474,"contacts":33},"Ep0162 40300","Cardiff",{"type":56,"coordinates":1471},[1472,1473],-3.18,51.48,{"lat":1473,"lon":1472},{"facility":1476,"status":49,"city":1477,"state":33,"zip":33,"country":1460,"countryCode":1461,"cosmosGeoPoint":1478,"geoPoint":1482,"contacts":33},"Ep0162 40735","Glasgow",{"type":56,"coordinates":1479},[1480,1481],-4.25763,55.86515,{"lat":1481,"lon":1480},{"facility":1484,"status":49,"city":1485,"state":33,"zip":33,"country":1460,"countryCode":1461,"cosmosGeoPoint":1486,"geoPoint":1490,"contacts":33},"Ep0162 40833","London",{"type":56,"coordinates":1487},[1488,1489],-0.12574,51.50853,{"lat":1489,"lon":1488},{"facility":1492,"status":49,"city":1493,"state":33,"zip":33,"country":1460,"countryCode":1461,"cosmosGeoPoint":1494,"geoPoint":1498,"contacts":33},"Ep0162 40163","Oxford",{"type":56,"coordinates":1495},[1496,1497],-1.25596,51.75222,{"lat":1497,"lon":1496},{"facility":1500,"status":49,"city":1501,"state":33,"zip":33,"country":1460,"countryCode":1461,"cosmosGeoPoint":1502,"geoPoint":1506,"contacts":33},"Ep0162 40108","Salford",{"type":56,"coordinates":1503},[1504,1505],-2.29042,53.48771,{"lat":1505,"lon":1504},{"type":1508,"investigatorFullName":33,"investigatorTitle":33,"investigatorAffiliation":33,"oldNameTitle":33,"oldOrganization":33},"SPONSOR","100445243","phase-3-a-study-to-test-the-efficacy-and-safety-of-staccato-alprazolam-in-study-participants-12-years-of-age-and-older-with-stereotypical-prolonged-seizures-100445243",false,"NCT05077904","A Study to Test the Efficacy and Safety of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures","A Double-Blind, Randomized, Placebo-Controlled, Multicenter, Outpatient, Parallel-Group Study to Assess the Efficacy and Safety of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures","Inclusion Criteria:\n\n* Participant must be ≥12 years of age at the Baseline\u002FRandomization Visit\n* Participant must have a study caregiver ≥18 years of age at the Screening Visit; the study caregiver(s) must be a relative, partner, friend, or legally authorized representative (LAR) of the participant, or a person who provides daily care to the participant and has a significant personal relationship with the participant; the study caregiver(s) must be able to recognize and observe the participant's seizures\n* Participants with an established diagnosis of focal or generalized epilepsy or combined focal and generalized epilepsy with a documented history of stereotypical episodes of prolonged seizures that includes at least 1 of the following:\n\n  1. Generalized seizure episodes starting with a flurry of absence seizures or myoclonic seizures with a minimum total duration of 5 minutes\n  2. Episodes of a focal seizure with a minimum duration of 3 minutes\n  3. Episodes of a focal seizure or a flurry of myoclonic seizures for at least 90 seconds followed by a generalized\u002Fbilateral tonic-clonic seizure with a minimum total duration of 3 minutes\n* Prior to the Screening Visit, participant has experienced ≥4 stereotypical episodes of prolonged seizures in the past 6 months, and the last 2 stereotypical episodes of prolonged seizures must have occurred within the 3 months prior to the Screening Visit\n* Participant has had a documented brain computerized tomography or magnetic resonance imaging review, performed after diagnosis of epilepsy and within the 5 years prior to the Screening Visit, that confirms the absence of a progressive neurological disorder\n* Participant is receiving a regimen of antiseizure medications (ASMs) that has been stable (ie, no addition or removal of ASM\\[s\\]; dose adjustments are permitted to ASM\\[s\\]; dose adjustments are not permitted for benzodiazepines) for 30 days prior to the Screening Visit\n* Male and female participants:\n\n  1. A male participant must agree to use contraception during the Outpatient Treatment Period and for at least 7 days after IMP administration and refrain from donating sperm during this period\n  2. A female participant is eligible to participate if she is not pregnant, not breastfeeding, and at least 1 of the following conditions applies:\n\n  i) Not a woman of childbearing potential (WOCBP) OR ii) A WOCBP who agrees to follow the contraceptive guidance during the Outpatient Treatment Period and for at least 30 days after IMP administration\n* Participant is capable of giving signed informed consent (or giving assent, where required), which includes compliance with the requirements and restrictions listed in the informed consent form (ICF), the protocol, and the individualized participant management plan (iPMP). The ICF or a specific assent form, where required, will be signed and dated by minors\n* The participant's study caregiver(s) must be capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the ICF, the protocol, and the iPMP\n\nExclusion Criteria:\n\n* Participant has a current history of alcohol or drug use disorder, as defined in the Diagnostic and Statistical Manual of Mental Disorders 5, within the previous 1 year\n* Participant has a known hypersensitivity to any components of the IMP or comparable drugs (and\u002For an investigational device) as stated in this protocol or to albuterol (or similar bronchospasm rescue medication if needed to meet country-specific requirements)\n* Participant has a diagnosis of atrial fibrillation or mitral stenosis\n* Participant has a history of convulsive (generalized tonic-clonic) status epilepticus in the 8 weeks prior to the Screening Visit\n* Participant has a history or presence of known nonepileptic seizures which cannot be distinguished from qualifying epileptic seizures\n* Participant has a clinically significant known airway hypersensitivity (eg, bronchospasm to known allergens, such as pollen, animals, or food) and\u002For acute respiratory signs\u002Fsymptoms (eg, shortness of breath, wheezing on lung auscultation)\n* Participant has a clinically significant chronic pulmonary disorder other than mild asthma (eg, chronic obstructive pulmonary disease, restrictive lung diseases \\[including idiopathic pulmonary fibrosis\\]) and\u002For recent history or presence of hemoptysis or pneumothorax\n* Participant has had a positive antigen test for acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and experienced moderate to severe signs\u002Fsymptoms of respiratory distress necessitating hospitalization or outpatient treatment such as ambulatory oxygen, extensive treatment with inhaler medications, and\u002For oral medications for a duration of 4 weeks or more, unless full resolution occurred at least 6 months prior to Screening\n* Participant has experienced a upper respiratory tract infection within 4 weeks or bronchitis\u002Fpneumonia within 3 months before the Screening Visit\n* Participant has a history or presence of acute narrow-angle glaucoma\n* Participant has a condition for which oral alprazolam is contraindicated (eg, myasthenia gravis, severe respiratory insufficiency, and sleep apnea syndrome)\n* Participant has a history or presence of long QT syndrome, a family history of sudden death due to long QT syndrome, or unexplained syncope\n* Chronic use of benzodiazepines for more than 3 days within a period of 7 days will be allowed for approximately 30 % of study participants\n* Participant is taking any drug that is a strong CYP3A4 inhibitor, including azole antifungal agents (ketoconazole and itraconazole) and nefazodone\n* Participant is taking any opioids (eg, fentanyl, oxycodone, morphine) or sedative hypnotics on a chronic basis\n* Participant is taking nonselective beta blockers on a chronic basis\n* Participant is taking pharmacotherapy for an active major psychiatric disorder where major changes in regimen are needed or anticipated during the study\n* Participant has been treated with vagal nerve stimulation (VNS) for less than 6 months or VNS settings have changed within 30 days before the Screening Visit\n* Participant has a clinically significant laboratory abnormality that may increase the risk associated with study participation or may interfere with the interpretation of study results, according to the judgment of the Investigator\n* Participant has an oxygen saturation \\\u003C95 % (or less than normal in regions of altitude \\>2500 meters) for greater than 30 seconds during the Screening Visit. In case of an out-of-range result, 1 repeat will be allowed. If the readings are out of range again, the study participant will be excluded\n* Participant has \\>2.0x upper limit of normal (ULN) of any of the following: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), or \\>1.0xULN total bilirubin (≥1.5xULN total bilirubin if known Gilbert's syndrome or \\>2.0xULN total bilirubin for liver impairment)\n* Participant has current unstable liver or biliary disease per Investigator assessment defined by the presence of ascites, encephalopathy, coagulopathy, hypoalbuminemia, esophageal or gastric varices, persistent jaundice, or cirrhosis\n* Participant has a QT interval corrected for heart rate (QTc) \\>450 msec (males), QTc interval \\>470 msec (females), or QTc interval \\>480 msec (participants with bundle branch block), PR interval ≥220 msec, or any other clinically significant electrocardiogram (ECG) abnormality according to the Investigator i) The QTc is the QT interval corrected for heart rate according to Fridericia's formula (QTcF). It is either machine-read or manually over-read\n* Participant has a positive urine screen for drugs of abuse at the Screening Visit\n* Participant has a blood pressure (BP) or heart rate (HR) outside the following range after 5 minutes rest: systolic BP: 90 mmHg to 150 mmHg; diastolic BP: 4 0mmHg to 95 mmHg; HR: 50 bpm to 100 bpm. In case of an out-of-range result, 1 repeat will be allowed. If the readings are out of range again, the study participant will be excluded","ALL","12 Years",{"count":1519,"type":1520},350,"ESTIMATED","INTERVENTIONAL",[1523],"PHASE3","The purpose of the study is to assess the success of a single administration of Staccato alprazolam compared with placebo both in rapidly terminating a seizure episode within 90 seconds and with no recurrence of seizure(s) up to 2 hours after investigational medicinal product (IMP) administration.",[1526],"Stereotypical Prolonged Seizures",[1528,1529,23],"Stereotypical prolonged seizures","Phase 3","2026-06-30",{"date":1532,"type":1533},"2026-07-01","ACTUAL",{"date":1535,"type":1533},"2021-12-07",{"date":1537,"type":1520},"2026-07-31",{"name":1539,"class":6},"UCB Biopharma SRL",183]