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Valme","Seville","41014",{"type":68,"coordinates":1293},[1294,1295],-5.97317,37.38283,{"lat":1295,"lon":1294},{"facility":1298,"status":75,"city":1225,"state":56,"zip":1299,"country":1090,"countryCode":1091,"cosmosGeoPoint":1300,"geoPoint":1304,"contacts":56},"Hospital Universitari i Politecnic La Fe","46026",{"type":68,"coordinates":1301},[1302,1303],-0.37966,39.47391,{"lat":1303,"lon":1302},{"facility":1306,"status":61,"city":1307,"state":56,"zip":1308,"country":1090,"countryCode":1091,"cosmosGeoPoint":1309,"geoPoint":1313,"contacts":56},"Hospital Clinico Lozano Blesa","Zaragoza","50009",{"type":68,"coordinates":1310},[1311,1312],-0.87734,41.65606,{"lat":1312,"lon":1311},{"facility":1315,"status":61,"city":1316,"state":1317,"zip":1318,"country":1319,"countryCode":1320,"cosmosGeoPoint":1321,"geoPoint":1325,"contacts":56},"Chang Gung Memorial Hospital - Linkou Branch","Taoyuan","Hunan Province","33305","Taiwan","TW",{"type":68,"coordinates":1322},[1323,1324],121.29696,24.99368,{"lat":1324,"lon":1323},{"facility":1327,"status":61,"city":1328,"state":56,"zip":1329,"country":1319,"countryCode":1320,"cosmosGeoPoint":1330,"geoPoint":1334,"contacts":56},"Changhua Christian Hospital","Changhua","50006",{"type":68,"coordinates":1331},[1332,1333],120.5512,24.0692,{"lat":1333,"lon":1332},{"facility":1336,"status":61,"city":1337,"state":56,"zip":1338,"country":1319,"countryCode":1320,"cosmosGeoPoint":1339,"geoPoint":1343,"contacts":56},"Hualien Tzu Chi Hospital","Hualien City","97002",{"type":68,"coordinates":1340},[1341,1342],121.60444,23.97694,{"lat":1342,"lon":1341},{"facility":1345,"status":61,"city":1346,"state":56,"zip":1347,"country":1319,"countryCode":1320,"cosmosGeoPoint":1348,"geoPoint":1352,"contacts":56},"Kaohsiung Medical University Hospital","Kaohsiung City","80756",{"type":68,"coordinates":1349},[1350,1351],120.31333,22.61626,{"lat":1351,"lon":1350},{"facility":1354,"status":61,"city":1346,"state":56,"zip":1355,"country":1319,"countryCode":1320,"cosmosGeoPoint":1356,"geoPoint":1358,"contacts":56},"Kaohsiung Chang Gung Memorial Hospital","83301",{"type":68,"coordinates":1357},[1350,1351],{"lat":1351,"lon":1350},{"facility":1360,"status":75,"city":1361,"state":56,"zip":1362,"country":1319,"countryCode":1320,"cosmosGeoPoint":1363,"geoPoint":1367,"contacts":56},"Taichung Veterans General Hospital","Taichung","40705",{"type":68,"coordinates":1364},[1365,1366],120.6839,24.1469,{"lat":1366,"lon":1365},{"facility":1369,"status":61,"city":1370,"state":56,"zip":1371,"country":1319,"countryCode":1320,"cosmosGeoPoint":1372,"geoPoint":1376,"contacts":56},"National Cheng Kung University Hospital","Tainan","701",{"type":68,"coordinates":1373},[1374,1375],120.21333,22.99083,{"lat":1375,"lon":1374},{"facility":1378,"status":61,"city":1379,"state":56,"zip":1380,"country":1319,"countryCode":1320,"cosmosGeoPoint":1381,"geoPoint":1385,"contacts":56},"Wanfang Hospital","Taipei","00116",{"type":68,"coordinates":1382},[1383,1384],121.52639,25.05306,{"lat":1384,"lon":1383},{"facility":1387,"status":61,"city":1379,"state":56,"zip":1388,"country":1319,"countryCode":1320,"cosmosGeoPoint":1389,"geoPoint":1391,"contacts":56},"National Taiwan University Hospital","10002",{"type":68,"coordinates":1390},[1383,1384],{"lat":1384,"lon":1383},{"facility":1393,"status":61,"city":1379,"state":56,"zip":1394,"country":1319,"countryCode":1320,"cosmosGeoPoint":1395,"geoPoint":1397,"contacts":56},"Tri-Service General Hospital","11490",{"type":68,"coordinates":1396},[1383,1384],{"lat":1384,"lon":1383},{"facility":1399,"status":61,"city":1400,"state":1401,"zip":1402,"country":1403,"countryCode":1404,"cosmosGeoPoint":1405,"geoPoint":1409,"contacts":56},"Addenbrooke's Hospital","Cambridge","Cambrigeshire","CB2 0QQ","United Kingdom","UK",{"type":68,"coordinates":1406},[1407,1408],0.11667,52.2,{"lat":1408,"lon":1407},{"facility":1411,"status":61,"city":1412,"state":1413,"zip":1414,"country":1403,"countryCode":1404,"cosmosGeoPoint":1415,"geoPoint":1419,"contacts":56},"Western General Hospital","Edinburgh","Scotland","EH4 2XU",{"type":68,"coordinates":1416},[1417,1418],-3.19648,55.95206,{"lat":1418,"lon":1417},{"facility":1421,"status":61,"city":1422,"state":1423,"zip":1424,"country":1403,"countryCode":1404,"cosmosGeoPoint":1425,"geoPoint":1429,"contacts":56},"Queen Elizabeth Hospital Birmingham","Birmingham","West Midlands","B15 2TH",{"type":68,"coordinates":1426},[1427,1428],-1.89983,52.48142,{"lat":1428,"lon":1427},{"facility":1431,"status":61,"city":1432,"state":56,"zip":1433,"country":1403,"countryCode":1404,"cosmosGeoPoint":1434,"geoPoint":1438,"contacts":56},"Barts Health NHS Trust","London","EC1A 7BE",{"type":68,"coordinates":1435},[1436,1437],-0.12574,51.50853,{"lat":1437,"lon":1436},{"facility":1440,"status":61,"city":1432,"state":56,"zip":1441,"country":1403,"countryCode":1404,"cosmosGeoPoint":1442,"geoPoint":1444,"contacts":56},"Guy's & St Thomas' NHS Foundation Trust","SE1 9RT",{"type":68,"coordinates":1443},[1436,1437],{"lat":1437,"lon":1436},{"facility":1446,"status":61,"city":1432,"state":56,"zip":1447,"country":1403,"countryCode":1404,"cosmosGeoPoint":1448,"geoPoint":1450,"contacts":56},"Royal Marsden Hospital","SW7 3RP",{"type":68,"coordinates":1449},[1436,1437],{"lat":1437,"lon":1436},{"facility":1452,"status":61,"city":1432,"state":56,"zip":1453,"country":1403,"countryCode":1404,"cosmosGeoPoint":1454,"geoPoint":1456,"contacts":56},"Hammersmith Hospital","W12 0HS",{"type":68,"coordinates":1455},[1436,1437],{"lat":1437,"lon":1436},{"facility":1458,"status":75,"city":1459,"state":56,"zip":1460,"country":1403,"countryCode":1404,"cosmosGeoPoint":1461,"geoPoint":1465,"contacts":56},"The Christie NHS Foundation Trust","Manchester","M20 4BX",{"type":68,"coordinates":1462},[1463,1464],-2.23743,53.48095,{"lat":1464,"lon":1463},{"type":1467,"investigatorFullName":56,"investigatorTitle":56,"investigatorAffiliation":56,"oldNameTitle":56,"oldOrganization":56},"SPONSOR","100495350","phase-3-a-trial-to-learn-how-well-linvoseltamab-works-compared-to-the-combination-of-elotuzumab-pomalidomide-and-dexamethasone-for-adult-participants-with-relapsedrefractory-multiple-myeloma-100495350",false,"NCT05730036","A Trial to Learn How Well Linvoseltamab Works Compared to the Combination of Elotuzumab, Pomalidomide and Dexamethasone for Adult Participants With Relapsed\u002FRefractory Multiple Myeloma","An Open-label, Randomized, Phase 3 Study of Linvoseltamab (REGN5458; Anti- BCMA x Anti-CD3 Bispecific Antibody) Versus the Combination of Elotuzumab, Pomalidomide, and Dexamethasone (EPd), in Patients With Relapsed\u002FRefractory Multiple Myeloma (LINKER-MM3)","LINKER-MM3","Key Inclusion Criteria:\n\n1. Age 18 years or older (or legal adult age in the country) at the time of the screening visit.\n2. Eastern Cooperative Oncology Group (ECOG) performance status ≤1. Patients with ECOG 2 solely due to local symptoms of myeloma (eg. pain) may be allowed after discussion with the Medical Monitor.\n3. Received at least 1 and no more than 4 prior lines of anti-neoplastic MM therapies, including lenalidomide and a proteasome inhibitor and demonstrated disease progression on or after the last therapy as defined by the 2016 IMWG criteria. Participants who have received only 1 line of prior line of antimyeloma therapy must be lenalidomide refractory, as described in the protocol.\n\n   Note: Participants in Israel also must have previously received a CD38 antibody. Participants in the EU and the UK must have previously received 2 to 4 prior lines of therapy, including a CD38 antibody.\n4. Patients must have measurable disease for response assessment as per the 2016 IMWG response assessment criteria, as described in the protocol\n5. Adequate hematologic function and hepatic function within 7 days of randomization, as well as adequate renal and cardiac function and corrected calcium\n6. Life expectancy of at least 6 months\n\nKey Exclusion Criteria:\n\n1. Diagnosis of plasma cell leukemia, amyloidosis, Waldenström macroglobulinemia, or POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes).\n2. Prior treatment with elotuzumab and\u002For pomalidomide\n3. Participants with known MM brain lesions or meningeal involvement\n4. Treatment with any systemic anti-cancer therapy within 5 half-lives or within 28 days before first administration of study drug, whichever is shorter\n5. History of allogeneic stem cell transplantation within 6 months, or autologous stem cell transplantation within 12 weeks of the start of study treatment. Participants who have received an allogeneic transplant must be off all immunosuppressive medications for 6 weeks without signs of graft-versus-host disease. Steroids at doses equivalent to suppletion doses may be acceptable.\n6. Prior treatment with B-cell maturation antigen (BCMA) directed immunotherapies Note: BCMA antibody-drug conjugates are allowed.\n7. History of progressive multifocal leukoencephalopathy (PML), known or suspected PML, or history of a neurocognitive condition or central nervous system (CNS) movement disorder (Parkinson's disease or Parkinsonism).\n8. Any infection requiring hospitalization or treatment with IV anti-infectives within 2 weeks of first administration of study drug\n9. Uncontrolled infection with human immunodeficiency virus (HIV), hepatitis B virus (HBV) or hepatitis C virus (HCV); or another uncontrolled infection, as defined in the protocol 10 Cardiac ejection fraction \\\u003C40%.\n\nNOTE: Other protocol defined inclusion\u002Fexclusion criteria apply","ALL","18 Years",{"count":1479,"type":1480},410,"ESTIMATED","INTERVENTIONAL",[1483],"PHASE3","This study is researching an experimental drug called linvoseltamab, also called REGN5458.\n\nLinvoseltamab has previously been studied by itself (without other cancer drugs) in participants who had advanced multiple myeloma that returned and needed to be treated again after many other therapies had failed. These participants were no longer benefiting from standard medications and had no good treatment options. In that study, some participants who were treated with linvoseltamab had improvement of their myeloma (shrinkage of their tumors), including some participants who had complete responses (that is, the treatment got rid of all evidence of myeloma in their bodies).\n\nThis study is focused on participants who have multiple myeloma that has returned or needs to be treated again after one to four prior treatments and have standard cancer treatment options available to them. The aim of this study is to see how safe and effective linvoseltamab is compared to a combination of three cancer drugs: elotuzumab, pomalidomide and dexamethasone, (called EPd) in participants who have returned after having received prior treatment that included lenalidomide, a proteosome inhibitor, and (for participants in some countries) a cluster of differentiation 38 (CD38) antibody. Half of the participants in this study will get linvoseltamab, and the other half will get EPd.\n\nThis study is looking at several other research questions, including:\n\n* How long participants benefit from receiving linvoseltamab compared with EPd\n* How many participants treated with linvoseltamab or EPd have improvement of their multiple myeloma and by how much\n* What side effects happen from taking linvoseltamab compared to EPd\n* How long participants live while receiving treatment or after treatment with linvoseltamab compared to EPd\n* If there is any improvement in pain after treatment with linvoseltamab compared to EPd",[1486],"Relapsed Refractory Multiple Myeloma (RRMM)",[1488,1489,1490,1491],"BCMA X CD3 Bispecific Monoclonal Antibody","CD38 antibody","Proteasome inhibitor","Lenalidomide","2026-03-05",{"date":1494,"type":1495},"2026-03-06","ACTUAL",{"date":1497,"type":1495},"2023-09-18",{"date":1499,"type":1480},"2033-04-19",{"name":5,"class":6},159]