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Sağlık Bakanlığı Alaaddin Keykubat Üniversitesi Alanya Eğitim ve Araştırma Hastanesi-Göğüs Hastalıkları","Alanya\u002F Antalya","07400","Turkey (Türkiye)",{"facility":713,"status":43,"city":714,"state":25,"zip":715,"country":711,"countryCode":25,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"İstanbul İl Sağlik Müdürlüğü Süreyyapaşa Göğüs Hastaliklari Ve Göğüs Cerrahisi Eğitim Ve Araştirma Hastanesi","Maltepe\u002Fİstanbull","34843",{"facility":717,"status":43,"city":718,"state":25,"zip":719,"country":711,"countryCode":25,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"İnönü Üniversitesi Turgut Özal Tıp Merkezi Hastanesi- Göğüs Hastalıkları","Merkez\u002FBattalgazi\u002FMalatya","44280",{"facility":721,"status":43,"city":722,"state":25,"zip":723,"country":711,"countryCode":25,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"Hitit Üniversitesi Çorum Erol Olçok Eğitim ve Araştırma Hastanesi-Göğüs Hastalıkları","Merkez\u002FÇorum","19040",{"facility":725,"status":43,"city":726,"state":25,"zip":727,"country":711,"countryCode":25,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"Ankara Etlik Şehir Hastanesi-Göğüs Hastalıkları","Yenimahalle \u002F Ankara","06170",{"facility":729,"status":43,"city":730,"state":25,"zip":731,"country":711,"countryCode":25,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"Adana Şehir Eğitim ve Araştırma Hastanesi-Dahiliye","Yuregir\u002FAdana","01060",{"facility":733,"status":43,"city":734,"state":25,"zip":735,"country":711,"countryCode":25,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi-Göğüs Hastalıkları","Yıldırım\u002FBursa","16310",{"facility":737,"status":43,"city":738,"state":25,"zip":739,"country":711,"countryCode":25,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"Yedikule Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi","Zeytinburnu\u002Fİstanbul","34020",{"type":741,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100636847",false,"NCT07571005","AMAZE 3: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea","Efficacy and Safety of NNC0487-0111 s.c. Once-weekly in Participants With Overweight or Obesity, and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure (AMAZE 3)","AMAZE 3","Key Inclusion Criteria:\n\n* Male or female (sex at birth)\n* Age 18 years or above at the time of signing informed consent\n* Previously diagnosed moderate-to-severe OSA with an AHI ≥ 15, as diagnosed with polysomnography (PSG), home sleep apnoea test (HSAT), or other method that meets local guidelines prior to screening\n\nKey Exclusion Criteria:\n\n* Glycated haemoglobin (HbA1c) ≥ 6.5% (48 mmol\u002Fmol) as measured by the central laboratory at screening\n* History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records\n* Any planned or previous surgery within 90 days prior to screening for sleep apnoea, including septoplasty, turbinoplasty, or other ear, nose, and throat surgeries, including tonsillectomy and adenoidectomy\n* Significant craniofacial abnormalities that may affect breathing at baseline, for example Treacher Collins syndrome and Pierre Robin Sequence\n* Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonist (RA), dual GLP-1\u002Fgastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening","ALL","18 Years",{"count":752,"type":753},300,"ESTIMATED","INTERVENTIONAL",[756],"PHASE3","This study is being done to look at the efficacy and safety of NNC0487-0111 in participants with excess body weight and obstructive sleep apnoea not treated with positive airway pressure lose weight and improve sleep apnoea. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the treatment being tested) or Placebo (a treatment that has no active medicine in it) and which treatment participants get is decided by chance.",[759,760,761],"Obesity","Overweight","Obstructive Sleep Apnoea","2026-06-25",{"date":764,"type":765},"2026-06-26","ACTUAL",{"date":767,"type":765},"2026-05-05",{"date":769,"type":753},"2028-10-04",{"name":5,"class":6},80]