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Sağlık Bakanlığı Alaaddin Keykubat Üniversitesi Alanya Eğitim ve Araştırma Hastanesi-Göğüs Hastalıkları","Alanya\u002F Antalya","07400","Turkey (Türkiye)",{"facility":820,"status":43,"city":821,"state":25,"zip":822,"country":818,"countryCode":25,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"İstanbul İl Sağlik Müdürlüğü Süreyyapaşa Göğüs Hastaliklari Ve Göğüs Cerrahisi Eğitim Ve Araştirma Hastanesi","Maltepe\u002Fİstanbull","34843",{"facility":824,"status":43,"city":825,"state":25,"zip":826,"country":818,"countryCode":25,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"İnönü Üniversitesi Turgut Özal Tıp Merkezi Hastanesi- Göğüs Hastalıkları","Merkez\u002FBattalgazi\u002FMalatya","44280",{"facility":828,"status":43,"city":829,"state":25,"zip":830,"country":818,"countryCode":25,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"Hitit Üniversitesi Çorum Erol Olçok Eğitim ve Araştırma Hastanesi-Göğüs Hastalıkları","Merkez\u002FÇorum","19040",{"facility":832,"status":43,"city":833,"state":25,"zip":834,"country":818,"countryCode":25,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"Ankara Etlik Şehir Hastanesi-Göğüs Hastalıkları","Yenimahalle \u002F Ankara","06170",{"facility":836,"status":43,"city":837,"state":25,"zip":838,"country":818,"countryCode":25,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"Adana Şehir Eğitim ve Araştırma Hastanesi-Dahiliye","Yuregir\u002FAdana","01060",{"facility":840,"status":43,"city":841,"state":25,"zip":842,"country":818,"countryCode":25,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi-Göğüs Hastalıkları","Yıldırım\u002FBursa","16310",{"facility":844,"status":43,"city":845,"state":25,"zip":846,"country":818,"countryCode":25,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"Yedikule Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi","Zeytinburnu\u002Fİstanbul","34020",{"type":848,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100054210","phase-3-amaze-4-a-research-study-investigating-how-well-the-medicine-nnc0487-0111-helps-people-with-excess-body-weight-and-obstructive-sleep-apnoea-treated-with-positive-airway-pressure-lose-weight-and-improve-sleep-apnoea-100054210",false,"NCT07571109","AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea","Efficacy and Safety of NNC0487-0111 s.c. Once-weekly in Participants With Overweight or Obesity, and Obstructive Sleep Apnoea Treated With Positive Airway Pressure (AMAZE 4)","AMAZE 4","Key Inclusion Criteria:\n\n* Male or female (sex at birth)\n* Age 18 years or above at the time of signing informed consent\n* Previously diagnosed moderate-to-severe OSA with an AHI ≥ 15, as diagnosed with polysomnography (PSG), home sleep apnoea test (HSAT), or other method that meets local guidelines prior to screening\n\nKey Exclusion Criteria:\n\n* Glycated haemoglobin (HbA1c) ≥ 6.5% (48 mmol\u002Fmol) as measured by the central laboratory at screening\n* History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records\n* Any planned or previous surgery within 90 days prior to screening for sleep apnoea, including septoplasty, turbinoplasty, or other ear, nose, and throat surgeries, including tonsillectomy and adenoidectomy\n* Significant craniofacial abnormalities that may affect breathing at baseline, for example Treacher Collins syndrome and Pierre Robin Sequence\n* Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonist (RA), dual GLP-1\u002Fgastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening","ALL","18 Years",{"count":860,"type":861},300,"ESTIMATED","INTERVENTIONAL",[864],"PHASE3","This study is being done to look at the efficacy and safety of NNC0487-0111 in participants with overweight or obesity, and obstructive sleep apnoea treated with positive airway pressure. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the treatment being tested) or Placebo (a treatment that has no active medicine in it) and which treatment participants get is decided by chance.",[867,868,869],"Obesity","Overweight","Obstructive Sleep Apnoea","2026-07-09",{"date":872,"type":873},"2026-07-13","ACTUAL",{"date":875,"type":873},"2026-05-05",{"date":877,"type":861},"2028-08-21",{"name":5,"class":6},92]