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5PT",{"type":108,"coordinates":5945},[5946,5947],-0.2,51.35,{"lat":5947,"lon":5946},{"facility":100,"status":101,"city":5950,"state":25,"zip":5951,"country":5778,"countryCode":5779,"cosmosGeoPoint":5952,"geoPoint":5956,"contacts":25},"Sutton in Ashfield","NG17 4JL",{"type":108,"coordinates":5953},[5954,5955],-1.26135,53.12542,{"lat":5955,"lon":5954},{"facility":100,"status":101,"city":5958,"state":25,"zip":5959,"country":5778,"countryCode":5779,"cosmosGeoPoint":5960,"geoPoint":5964,"contacts":25},"Taunton","TA1 5DA",{"type":108,"coordinates":5961},[5962,5963],-3.10293,51.01494,{"lat":5963,"lon":5962},{"facility":100,"status":157,"city":5966,"state":25,"zip":5967,"country":5778,"countryCode":5779,"cosmosGeoPoint":5968,"geoPoint":5972,"contacts":25},"Warwick","CV34 5BW",{"type":108,"coordinates":5969},[5970,5971],-1.58333,52.28333,{"lat":5971,"lon":5970},{"facility":100,"status":101,"city":5974,"state":25,"zip":5975,"country":5778,"countryCode":5779,"cosmosGeoPoint":5976,"geoPoint":5980,"contacts":25},"Whitchurch","CF14 2TL",{"type":108,"coordinates":5977},[5978,5979],-3.22083,51.51167,{"lat":5979,"lon":5978},{"type":5982,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[5984],{"name":5985,"class":5986},"Austrian Breast & Colorectal Cancer Study Group","NETWORK","100512446","phase-3-an-adjuvant-endocrine-based-therapy-study-of-camizestrant-azd9833-in-erher2--early-breast-cancer-cambria-2-100512446",false,"NCT05952557","An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+\u002FHER2- Early Breast Cancer (CAMBRIA-2)","CAMBRIA-2: A Phase III, Open-Label, Randomised Study to Assess the Efficacy and Safety of Camizestrant (AZD9833, a Next Generation, Oral Selective Estrogen Receptor Degrader) vs Standard Endocrine Therapy (Aromatase Inhibitor or Tamoxifen) as Adjuvant Treatment for Patients With ER+\u002FHER2- Early Breast Cancer and an Intermediate-High or High Risk of Recurrence Who Have Completed Definitive Locoregional Treatment and Have No Evidence of Disease","CAMBRIA-2","Inclusion Criteria:\n\n* Women and Men; ≥18 years at the time of screening (or per national guidelines)\n* Histologically confirmed ER+\u002FHER2- early-stage resected invasive breast cancer with absence of any evidence of metastatic disease as defined in the protocol.\n* Completed adequate (definitive) locoregional therapy (surgery with or without radiotherapy) for the primary breast tumour(s), with or without (neo)adjuvant chemotherapy.\n* Patients must be randomised within 12 months of definitive breast surgery.\n* Patients may have received up to 12 weeks of endocrine therapy prior to randomisation.\n* Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 1\n* Adequate organ and bone marrow function\n\nExclusion Criteria:\n\n* Inoperable locally advanced or metastatic breast cancer\n* Pathological complete response following treatment with neoadjuvant therapy\n* History of any other cancer (except non-melanoma skin cancer or carcinoma in situ of the cervix or considered a very low risk of recurrence per investigator judgement) unless in complete remission with no therapy for a minimum of 5 years from the date of randomisation\n* Any evidence of severe or uncontrolled systemic diseases which, in the investigator's opinion precludes participation in the study or compliance \"\n* Known LVEF \\\u003C50% with heart failure NYHA Grade ≥2.\n* Mean resting QTcF interval \\> 480 ms at screening\n* Concurrent exogenous reproductive hormone therapy or non topical hormonal therapy for non-cancer-related conditions\n* Any concurrent anti-cancer treatment not specified in the protocol with the exception of bisphosphonates (e.g. zoledronic acid) or RANKL inhibitors ( eg, denosumab)\n* Previous treatment with camizestrant, investigational SERDs\u002Finvestigational ER targeting agents, or fulvestrant\n* Currently pregnant (confirmed with positive serum pregnancy test) or breastfeeding.\n* Patients with known hypersensitivity to active or inactive excipients of camizestrant or drugs with a similar chemical structure or class to camizestrant. In pre-\u002Fperi-menopausal female and male patients, known hypersensitivity or intolerance to LHRH agonists that would preclude the patient from receiving any LHRH agonist.","ALL","18 Years","130 Years",{"count":5999,"type":6000},5500,"ESTIMATED","INTERVENTIONAL",[6003],"PHASE3","This is a Phase III open-label study to assess if camizestrant improves outcomes compared to standard adjuvant endocrine therapy for patients with ER+\u002FHER2- early breast cancer with intermediate-high or high risk for disease recurrence who completed definitive locoregional therapy (with or without chemotherapy). The planned duration of treatment in either arm within the study will be 7 years.",[6006],"Breast Cancer, Early Breast Cancer",[6008,6009,6010],"ER+","HER2-","breast cancer","2026-06-24",{"date":6013,"type":6014},"2026-06-25","ACTUAL",{"date":6016,"type":6014},"2023-10-05",{"date":6018,"type":6000},"2037-05-06",{"name":5,"class":6},798]