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Trier","Trier",{"type":56,"coordinates":1207},[1208,1209],6.63935,49.75565,{"lat":1209,"lon":1208},[1212,1215],{"name":1213,"role":43,"phone":24,"phoneExt":24,"email":1214},"Daniela Donovan","D.Donovan@bbtgruppe.de",{"name":1216,"role":32,"phone":24,"phoneExt":24,"email":24},"Terence J Donovan",{"facility":1218,"status":49,"city":1219,"state":1220,"zip":24,"country":1221,"countryCode":1222,"cosmosGeoPoint":1223,"geoPoint":1227,"contacts":1228},"Liverpool Heart and Chest Hospital NHS Foundation Trust","Liverpool","England","United Kingdom","UK",{"type":56,"coordinates":1224},[1225,1226],-2.97794,53.41058,{"lat":1226,"lon":1225},[1229,1231],{"name":1230,"role":32,"phone":24,"phoneExt":24,"email":24},"Andrew Muir",{"name":1232,"role":32,"phone":24,"phoneExt":24,"email":24},"Bilal Kirmani",{"facility":1234,"status":49,"city":780,"state":1220,"zip":24,"country":1221,"countryCode":1222,"cosmosGeoPoint":1235,"geoPoint":1239,"contacts":1240},"Barts Health NHS 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Billing",{"facility":1266,"status":112,"city":1267,"state":1268,"zip":24,"country":1221,"countryCode":1222,"cosmosGeoPoint":1269,"geoPoint":1273,"contacts":24},"Belfast Health and Social Care Trust","Belfast","Northern Ireland",{"type":56,"coordinates":1270},[1271,1272],-5.92541,54.59682,{"lat":1272,"lon":1271},{"facility":1275,"status":49,"city":1276,"state":24,"zip":24,"country":1221,"countryCode":1222,"cosmosGeoPoint":1277,"geoPoint":1281,"contacts":1282},"Blackpool Teaching Hospitals NHS Foundation Trust","Blackpool",{"type":56,"coordinates":1278},[1279,1280],-3.05,53.81667,{"lat":1280,"lon":1279},[1283,1286],{"name":1284,"role":43,"phone":24,"phoneExt":24,"email":1285},"Ronald Manuel","ronald.manuel@nhs.net",{"name":1287,"role":32,"phone":24,"phoneExt":24,"email":24},"Mohamad Bittar, MD",{"facility":1289,"status":49,"city":1290,"state":24,"zip":1291,"country":1221,"countryCode":1222,"cosmosGeoPoint":1292,"geoPoint":1296,"contacts":1297},"University Hospitals Bristol NHS Foundation 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5JQ",{"type":56,"coordinates":1316},[1317,1318],-0.7554,52.50243,{"lat":1318,"lon":1317},{"facility":1321,"status":112,"city":1322,"state":24,"zip":24,"country":1221,"countryCode":1222,"cosmosGeoPoint":1323,"geoPoint":1327,"contacts":24},"University Hospitals of Leicester NHS Trust","Leicester",{"type":56,"coordinates":1324},[1325,1326],-1.13169,52.6386,{"lat":1326,"lon":1325},{"facility":1329,"status":49,"city":1330,"state":24,"zip":24,"country":1221,"countryCode":1222,"cosmosGeoPoint":1331,"geoPoint":1335,"contacts":1336},"South Tees Hospitals NHS Foundation Trust","Middlesbrough",{"type":56,"coordinates":1332},[1333,1334],-1.23483,54.57623,{"lat":1334,"lon":1333},[1337,1340],{"name":1338,"role":43,"phone":24,"phoneExt":24,"email":1339},"Lynn Whitehouse","lynn.whitehouse@nhs.net",{"name":1341,"role":32,"phone":24,"phoneExt":24,"email":24},"Ralph 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Trust","Plymouth",{"type":56,"coordinates":1369},[1370,1371],-4.14305,50.37153,{"lat":1371,"lon":1370},{"facility":1374,"status":112,"city":1375,"state":24,"zip":24,"country":1221,"countryCode":1222,"cosmosGeoPoint":1376,"geoPoint":1380,"contacts":24},"Sheffield Teaching Hospitals NHS Foundation Trust","Sheffield",{"type":56,"coordinates":1377},[1378,1379],-1.4659,53.38297,{"lat":1379,"lon":1378},{"facility":1382,"status":49,"city":1383,"state":24,"zip":24,"country":1221,"countryCode":1222,"cosmosGeoPoint":1384,"geoPoint":1388,"contacts":1389},"University Hospital Southampton NHS Foundation Trust","Southampton",{"type":56,"coordinates":1385},[1386,1387],-1.40428,50.90395,{"lat":1387,"lon":1386},[1390],{"name":1391,"role":32,"phone":24,"phoneExt":24,"email":24},"Dimitrios Pousios",{"facility":1393,"status":49,"city":1394,"state":24,"zip":1395,"country":1221,"countryCode":1222,"cosmosGeoPoint":1396,"geoPoint":1400,"contacts":1401},"University Hospitals Sussex NHS Foundation Trust","Worthing","BN11 2DH",{"type":56,"coordinates":1397},[1398,1399],-0.37538,50.81795,{"lat":1399,"lon":1398},[1402,1405],{"name":1403,"role":43,"phone":24,"phoneExt":24,"email":1404},"Dawn Martinez","dawn.diokno@nhs.net",{"name":1406,"role":32,"phone":24,"phoneExt":24,"email":24},"Istiaq M Ahmed",{"type":32,"investigatorFullName":1408,"investigatorTitle":1409,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Annetine Gelijns","Chair, Department of Population Health Science & Policy Edmond A. Guggenheim Professor of Health Policy Co-Director, InCHOIR",[1411,1414],{"name":1412,"class":1413},"National Heart, Lung, and Blood Institute (NHLBI)","NIH",{"name":1415,"class":6},"Vanderbilt University Medical Center","100366007","phase-3-anticoagulation-for-new-onset-post-operative-atrial-fibrillation-after-cabg-100366007",false,"NCT04045665","Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG","PACES","Inclusion Criteria:\n\n* Patients of age ≥18 years who undergo isolated CABG for coronary artery disease\n* POAF that persists for \\>60 minutes or is recurrent (more than one episode) within 7 days after the index CABG surgery\n\nExclusion Criteria:\n\n* Clinical history of either permanent, persistent or paroxysmal atrial fibrillation\n* Any pre-existing clinical indication for long-term OAC\n* Any absolute contraindication to OAC\n* Planned use of post-operative dual antiplatelet therapy (DAPT)\n\n  a. This includes, but is not limited to, patients with recent PCI with drug-eluting or bare-metal stent.\n* Cardiogenic shock\n* Major perioperative complication\\* occurring between CABG and randomization\n\n  a. including, but not limited to, stroke, TIA, MI, major bleeding (BARC type 4 bleeding), severe sepsis, renal failure requiring dialysis, or need for reoperation due to bleeding (e.g. pericardial tamponade).\n* Concomitant left atrial appendage closure during CABG\n* Concomitant valve surgery during CABG or prior valve surgery (including aortic, mitral, tricuspid or pulmonary)\n* Concomitant mitral valve annuloplasty during CABG\n* Concomitant carotid artery endarterectomy during CABG\n* Concomitant aortic root replacement during CABG\n* Concomitant surgery for AF during CABG\n* Liver cirrhosis or Child-Pugh Class C chronic liver disease\n* Pharmacologic therapy with an investigational drug or device within 30-days prior to randomization or plan to enroll patient in an investigational drug or device trial during participation in this trial\n* Pregnancy at the time of randomization\n* Unable or unwilling to provide inform consent\n* Unable or unwilling to comply with the study treatment and follow-up\n* Existence of underlying disease that limits life expectancy to less than one year","ALL","18 Years",{"count":1426,"type":1427},3200,"ESTIMATED","INTERVENTIONAL",[1430],"PHASE3","The primary objective of this study is to evaluate the effectiveness (prevention of thromboembolic events) and safety (major bleeding) of adding oral anticoagulation (OAC) to background antiplatelet therapy in patients who develop new-onset post-operative atrial fibrillation (POAF) after isolated coronary artery bypass graft (CABG) surgery.\n\nAll patients with a qualifying POAF event, who decline randomization, will be offered the option of enrollment in a parallel registry that captures their baseline risk profile and their treatment strategy in terms of anticoagulants or antiplatelets received. These patients will also be asked to fill out a brief decliner survey.",[1433,1434,1435],"Atrial Fibrillation","Stroke","Bleeding",[1437,9,1438],"Anticoagulation","Post Operative Atrial Fibrillation","2026-06-25",{"date":1441,"type":1442},"2026-06-26","ACTUAL",{"date":1444,"type":1442},"2019-12-13",{"date":1446,"type":1427},"2026-08-31",{"name":5,"class":6},106]