[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100441314":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":33,"locations":38,"responsibleParty":260,"collaborators":262,"id":266,"slug":267,"hasResults":268,"nctId":269,"briefTitle":270,"officialTitle":270,"acronym":11,"eligibilityCriteria":271,"healthyVolunteers":268,"sex":272,"minAge":273,"maxAge":274,"enrollmentInfo":275,"targetDuration":11,"studyType":278,"phases":279,"briefSummary":281,"conditions":282,"keywords":284,"overallStatus":40,"whyStopped":11,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":291,"startDateStruct":294,"completionDateStruct":296,"leadSponsor":298,"locationsCount":299},{"fullName":5,"class":6},"University of Alabama at Birmingham","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control Group","PLACEBO_COMPARATOR",null,[13],"Other: Control Group",{"label":15,"type":16,"description":11,"interventionNames":17},"AZM 20mg\u002Fkg Treatment Group","ACTIVE_COMPARATOR",[18],"Drug: AZM Group",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DRUG","AZM Group","AZM at 20 mg\u002Fkg will be given intravenous daily for 3 days once patients are consented and enrolled into the study.",[15],{"type":6,"name":9,"description":26,"armGroupLabels":27,"otherNames":11},"Saline will be given intravenous daily for 3 days once patients are consented and enrolled into the study.",[9],[29],{"name":30,"affiliation":31,"role":32},"Michele Kong, MD","The University of Alabama at Birmingham","PRINCIPAL_INVESTIGATOR",[34],{"name":30,"role":35,"phone":36,"phoneExt":11,"email":37},"CONTACT","205-638-9387","mkong@uabmc.edu",[39,55,72,86,102,116,130,145,159,174,188,201,215,230,245],{"facility":31,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RECRUITING","Birmingham","Alabama","35233","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-86.80249,33.52066,{"lat":50,"lon":49},[53,54],{"name":30,"role":35,"phone":36,"phoneExt":11,"email":37},{"name":30,"role":32,"phone":11,"phoneExt":11,"email":11},{"facility":56,"status":40,"city":57,"state":58,"zip":59,"country":44,"countryCode":45,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"University of California San Francisco","San Francisco","California","94143",{"type":47,"coordinates":61},[62,63],-122.41942,37.77493,{"lat":63,"lon":62},[66,69],{"name":67,"role":35,"phone":11,"phoneExt":11,"email":68},"Matt Zinter, MD","Matt.Zinter@ucsf.edu",{"name":70,"role":35,"phone":11,"phoneExt":11,"email":71},"James Howard, MD","James.Howard@ucsf.edu",{"facility":73,"status":40,"city":74,"state":75,"zip":76,"country":44,"countryCode":45,"cosmosGeoPoint":77,"geoPoint":81,"contacts":82},"Yale School of Medicine","New Haven","Connecticut","06520-8064",{"type":47,"coordinates":78},[79,80],-72.92816,41.30815,{"lat":80,"lon":79},[83],{"name":84,"role":35,"phone":11,"phoneExt":11,"email":85},"Vince Faustino, MD","vince.faustino@yale.edu",{"facility":87,"status":40,"city":88,"state":89,"zip":90,"country":44,"countryCode":45,"cosmosGeoPoint":91,"geoPoint":95,"contacts":96},"Children's National Hospital","Washington D.C.","District of Columbia","20010",{"type":47,"coordinates":92},[93,94],-77.03637,38.89511,{"lat":94,"lon":93},[97,100],{"name":98,"role":35,"phone":11,"phoneExt":11,"email":99},"Michael Shoykhet, MD","mshoykhet@childrensnational.org",{"name":98,"role":101,"phone":11,"phoneExt":11,"email":11},"SUB_INVESTIGATOR",{"facility":103,"status":40,"city":104,"state":105,"zip":106,"country":44,"countryCode":45,"cosmosGeoPoint":107,"geoPoint":111,"contacts":112},"Ann & Robert H. Lurie Children's Hospital of Chicago","Chicago","Illinois","60611",{"type":47,"coordinates":108},[109,110],-87.65005,41.85003,{"lat":110,"lon":109},[113],{"name":114,"role":35,"phone":11,"phoneExt":11,"email":115},"Bria Coates, MD","b-coates@northwestern.edu",{"facility":117,"status":40,"city":118,"state":119,"zip":120,"country":44,"countryCode":45,"cosmosGeoPoint":121,"geoPoint":125,"contacts":126},"Riley Children's Health","Indianapolis","Indiana","46202",{"type":47,"coordinates":122},[123,124],-86.15804,39.76838,{"lat":124,"lon":123},[127],{"name":128,"role":35,"phone":11,"phoneExt":11,"email":129},"Michael J Hobson, MD","mjhobson@iu.edu",{"facility":131,"status":40,"city":132,"state":133,"zip":134,"country":44,"countryCode":45,"cosmosGeoPoint":135,"geoPoint":139,"contacts":140},"St. Louis Children's Hospital","St Louis","Missouri","63110",{"type":47,"coordinates":136},[137,138],-90.19789,38.62727,{"lat":138,"lon":137},[141],{"name":142,"role":35,"phone":143,"phoneExt":11,"email":144},"Ashley Turner, MD","(314) 454-6000","ashley.turner@wustl.edu",{"facility":146,"status":40,"city":147,"state":148,"zip":149,"country":44,"countryCode":45,"cosmosGeoPoint":150,"geoPoint":154,"contacts":155},"University of Nebraska Medical Center","Omaha","Nebraska","68198",{"type":47,"coordinates":151},[152,153],-95.94043,41.25626,{"lat":153,"lon":152},[156],{"name":157,"role":35,"phone":11,"phoneExt":11,"email":158},"Eleanor Gradidge, MD","egradidge@childrensnebraska.org",{"facility":160,"status":40,"city":161,"state":162,"zip":163,"country":44,"countryCode":45,"cosmosGeoPoint":164,"geoPoint":168,"contacts":169},"University of North Carolina at Chapel Hill","Chapel Hill","North Carolina","27599",{"type":47,"coordinates":165},[166,167],-79.05584,35.9132,{"lat":167,"lon":166},[170],{"name":171,"role":35,"phone":172,"phoneExt":11,"email":173},"Tracie Walker, MD","9198431577","tracie_walker@med.unc.edu",{"facility":175,"status":40,"city":176,"state":177,"zip":178,"country":44,"countryCode":45,"cosmosGeoPoint":179,"geoPoint":183,"contacts":184},"Rainbow Babies and Children's Hospital","Cleveland","Ohio","44106",{"type":47,"coordinates":180},[181,182],-81.69541,41.4995,{"lat":182,"lon":181},[185],{"name":186,"role":35,"phone":11,"phoneExt":11,"email":187},"Steven Shein, MD","Steven.Shein@UHhospitals.org",{"facility":189,"status":40,"city":190,"state":177,"zip":191,"country":44,"countryCode":45,"cosmosGeoPoint":192,"geoPoint":196,"contacts":197},"Nationwide Children's Hospital","Columbus","43205",{"type":47,"coordinates":193},[194,195],-82.99879,39.96118,{"lat":195,"lon":194},[198],{"name":199,"role":35,"phone":11,"phoneExt":11,"email":200},"Katherine Bline, MD","katherine.bline@nationwidechildrens.org",{"facility":202,"status":40,"city":203,"state":204,"zip":205,"country":44,"countryCode":45,"cosmosGeoPoint":206,"geoPoint":210,"contacts":211},"Oklahoma Health Sciences","Oklahoma City","Oklahoma","73104",{"type":47,"coordinates":207},[208,209],-97.51643,35.46756,{"lat":209,"lon":208},[212],{"name":213,"role":35,"phone":11,"phoneExt":11,"email":214},"Christine Allen, MD","Christine-allen@ouhsc.edu",{"facility":216,"status":40,"city":217,"state":218,"zip":219,"country":44,"countryCode":45,"cosmosGeoPoint":220,"geoPoint":224,"contacts":225},"Children's Hospital of Philadelphia","Philadelphia","Pennsylvania","19104",{"type":47,"coordinates":221},[222,223],-75.16362,39.95238,{"lat":223,"lon":222},[226],{"name":227,"role":35,"phone":228,"phoneExt":11,"email":229},"Garrett Keim, MD","215-590-3800","keimG@chop.edu",{"facility":231,"status":40,"city":232,"state":233,"zip":234,"country":44,"countryCode":45,"cosmosGeoPoint":235,"geoPoint":239,"contacts":240},"The University of Texas Southwestern Medical Center","Dallas","Texas","75247",{"type":47,"coordinates":236},[237,238],-96.80667,32.78306,{"lat":238,"lon":237},[241],{"name":242,"role":35,"phone":243,"phoneExt":11,"email":244},"Ananya Manchikalapati, MD","2144561600","ananya.manchikalapati@UTsouthwestern.edu",{"facility":246,"status":40,"city":247,"state":248,"zip":249,"country":44,"countryCode":45,"cosmosGeoPoint":250,"geoPoint":254,"contacts":255},"University of Utah","Salt Lake City","Utah","84112",{"type":47,"coordinates":251},[252,253],-111.89105,40.76078,{"lat":253,"lon":252},[256],{"name":257,"role":35,"phone":258,"phoneExt":11,"email":259},"Kevin Watt, MD","801-587-7404","kevin.watt@hsc.utah.edu",{"type":32,"investigatorFullName":30,"investigatorTitle":261,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PI",[263],{"name":264,"class":265},"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","NIH","100441314","phase-3-azithromycin-treatment-for-respiratory-syncytial-virus-induced-respiratory-failure-in-children-100441314",false,"NCT05026749","Azithromycin Treatment for Respiratory Syncytial Virus-induced Respiratory Failure in Children","Inclusion criteria:\n\n* Admission to the pediatric ICU with a confirmed diagnosis of RSV infection. RSV infection is based on a positive nasal swab for RSV fluorescent antibody or via multiplex assay or culture;\n* Requiring intensive respiratory support defined as either mechanical ventilation or NIV (BiPAP or CPAP) or HFNC (at \\>1 L\u002Fkg\u002Fmin of flow\n* Enrollment into the study within 48 hours of ICU admission and placement on intensive respiratory support;\n* Onset of RSV-related symptoms must be less than 5 days\n* Age: Neonates-2 years. For those less than 1 week of age, they must have been discharged home from the hospital after their birth.\n\nExclusion criteria:\n\n* AZM use within 7 days of ICU admission;\n* Contraindication to AZM use including known hypersensitivity to AZM, erythromycin, any macrolide, or ketolide drug, patients with significant hepatic impairment (direct bilirubin \\>1.5 mg\u002FdL or ALT ≥ 10 times the upper limits of normal);\n* Patients with known cardiac disease, cardiac arrhythmia or with electrocardiogram QT interval corrected for heart rate (QTc) ≥ 450 milisecond (ms);\n* Intensive respiratory support greater than 48 hours prior to ICU admission;\n* Chronic ventilation or supplemental oxygen need at home;\n* Immunosuppressive conditions such as those post heart or hematopoietic stem cell transplant or receiving chemotherapy and chronic steroids;\n* History of pyloric stenosis;\n* AZM is deemed necessary for clinical treatment (for instance, if patient has pertussis).","ALL","3 Days","2 Years",{"count":276,"type":277},370,"ESTIMATED","INTERVENTIONAL",[280],"PHASE3","The overarching hypothesis of the ARRC trial is that administration of Azithromycin (AZM) during acute, Respiratory Syncytial Virus (RSV)-induced respiratory failure will be beneficial, mediated through the matrix metalloproteinase (MMP)-9 pathway.",[283],"Respiratory Syncytial Virus Infections",[285,286,287,288,289],"RSV","AZM","ICU","Respiratory Support","Children","2026-02-04",{"date":292,"type":293},"2026-02-09","ACTUAL",{"date":295,"type":293},"2022-02-27",{"date":297,"type":277},"2028-07-31",{"name":5,"class":6},15]