[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633946":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":30,"responsibleParty":44,"collaborators":20,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":20,"eligibilityCriteria":52,"healthyVolunteers":48,"sex":53,"minAge":54,"maxAge":20,"enrollmentInfo":55,"targetDuration":20,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":67,"whyStopped":20,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Bacteriophage Therapy","EXPERIMENTAL","To evaluate the infection control effect of bacteriophage therapy in treatment of refractory orthopedic implant-associated infections",[13],"Biological: bacteriophage preparation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BIOLOGICAL","bacteriophage preparation","After undergoing standard surgical debridement for orthopedic implant-associated infection. Bacteriophage preparation was administered primarily via postoperative indwelling catheter infusion. An appropriate volume of bacteriophage solution (adjusted according to joint cavity size and clinical assessment) was instilled directly through the catheter into the infected site, twice daily (bid) for 3 consecutive days per treatment cycle. During administration, strict aseptic procedures were maintained, and the distribution of the bacteriophage preparation within the joint cavity was ensured. Throughout the treatment period, patients were closely monitored for local and systemic adverse events related to bacteriophage therapy.",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Zhao Ming Ye","CONTACT","86-1360651549","yezhaominghz@163.com",{"name":28,"role":24,"phone":20,"phoneExt":20,"email":29},"Min Jun Yao","yao_minjun@163.com",[31],{"facility":32,"status":20,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":20},"the Second Affiliated Hospital of Zhejiang University School of Medicine","Hangzhou","Zhejiang","China 310000","China","CN",{"type":39,"coordinates":40},"Point",[41,42],120.16142,30.29365,{"lat":42,"lon":41},{"type":45,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100633946","phase-3-bacteriophage-therapy-for-orthopedic-implant-associated-infections-100633946",false,"NCT07533292","Bacteriophage Therapy for Orthopedic Implant-Associated Infections","Prospective, Single-Center, Single-Arm, Pre-Post Self-Controlled Study Evaluating the Efficacy and Safety of Bacteriophage Therapy in Orthopedic Implant-Associated Infections","Inclusion Criteria:\n\n* Known allergy or hypersensitivity to bacteriophages or any components of the bacteriophage preparation;\n* Pregnant or breastfeeding women;\n* Participation in another interventional clinical trial within the study period;\n* Lack of feasible routes of administration other than intravenous injection;\n* Patients deemed unsuitable for participation in this study by the investigator;\n* Inability or unwillingness of the subject to comply with study procedures.\n\nExclusion Criteria:\n\n* Withdrawal of informed consent by the participant at any time during the study;\n* Occurrence of serious adverse events related to bacteriophage therapy that, in the investigator's judgment, necessitate discontinuation of treatment.","ALL","18 Years",{"count":56,"type":57},100,"ESTIMATED","INTERVENTIONAL",[60],"PHASE3","A Prospective, Single-Center, Single-Arm Clinical Study with a Pre-Post Self-Controlled Design Evaluating the Efficacy and Safety of Bacteriophage Therapy for Refractory Orthopedic Implant-Associated Infections",[63,64],"Orthopedic","Implant Infection",[9,66],"Orthopedic Implant-Associated Infections","NOT_YET_RECRUITING","2026-04-09",{"date":70,"type":71},"2026-04-16","ACTUAL",{"date":73,"type":57},"2026-04-05",{"date":75,"type":57},"2030-12-31",{"name":5,"class":6},1]