[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100550175":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":42,"centralContacts":47,"locations":56,"responsibleParty":72,"collaborators":74,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":30,"eligibilityCriteria":85,"healthyVolunteers":81,"sex":86,"minAge":87,"maxAge":30,"enrollmentInfo":88,"targetDuration":30,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":58,"whyStopped":30,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta","OTHER",[8,13,19],{"label":9,"type":6,"description":10,"interventionNames":11},"ELTGOL group","Control group. Patients will do twice-daily ELTGOL technique",[12],"Other: ELTGOL",{"label":14,"type":15,"description":16,"interventionNames":17},"ELTGOL + isotonic saline solution (0,9%)","PLACEBO_COMPARATOR","Placebo group. Patients will do twice-daily ELTGOL technique and will receive 5ml of 0.9% saline before performing the ELTGOL technique in the morning",[18,12],"Drug: Isotonic saline",{"label":20,"type":21,"description":22,"interventionNames":23},"ELTGOL + hypertonic saline solution (7%)","EXPERIMENTAL","Experimental group. Patients will do twice-daily ELTGOL technique and will receive 5ml of 7% saline before performing the ELTGOL technique in the morning",[24,12],"Other: Hypertonic saline",[26,31,38],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"Hypertonic saline","Patients from intervention group will inhale hypertonic saline solution 5 minutes before performing the morning ELTGOL technique",[20],null,{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"DRUG","Isotonic saline","Patients from placebo group will inhale isotonic saline solution 5 minutes before performing the morning ELTGOL technique",[14],[37],"Physiologic saline",{"type":6,"name":39,"description":40,"armGroupLabels":41,"otherNames":30},"ELTGOL","Patients from control group will perform the ELTGOL technique twice-daily",[20,14,9],[43],{"name":44,"affiliation":45,"role":46},"Montserrat Vendrell, PhD MD","University Hospital of Girona Dr. Josep Trueta","PRINCIPAL_INVESTIGATOR",[48,53],{"name":49,"role":50,"phone":51,"phoneExt":30,"email":52},"Gerard Muñoz, PhD PT","CONTACT","0034-972940294","munoz.gerard@gmail.com",{"name":54,"role":50,"phone":51,"phoneExt":30,"email":55},"Neus Puigdevall, PT","neuspuigde@gmail.com",[57],{"facility":45,"status":58,"city":59,"state":30,"zip":30,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"RECRUITING","Girona","Spain","ES",{"type":63,"coordinates":64},"Point",[65,66],2.82493,41.98311,{"lat":66,"lon":65},[69,71],{"name":70,"role":50,"phone":30,"phoneExt":30,"email":30},"Montse Vendrell, PhD MD",{"name":49,"role":50,"phone":30,"phoneExt":30,"email":30},{"type":73,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR",[75,77],{"name":45,"class":76},"NETWORK",{"name":78,"class":6},"Germans Trias i Pujol Hospital","100550175","phase-3-benefits-of-inhalation-of-hypertonic-saline-solution-prior-to-physiotherapy-eltgol-technique-in-bronchiectasis-100550175",false,"NCT06443658","Benefits of Inhalation of Hypertonic Saline Solution Prior to Physiotherapy ELTGOL Technique in Bronchiectasis","Benefits of Inhalation of Hypertonic Saline Solution Prior to ELTGOL Physiotherapy in Bronchiectasis","Inclusion Criteria:\n\n* Adult patients with bronchiectasis confirmed by high resolution computed tomography\n* No exacerbations in the previous month\n* Chronic mucopurulent and purulent sputum\n* ≥10ml daily expectoration\n* At least one exacerbation in the previous year\n* (Forced expiratory volume the 1st second) FEV1 ≥30% after bronchodilation\n* Sign the informed consent\n\nExclusion Criteria:\n\n* Current smokers or a smoking history of ≥20 p-y\n* Asthma, allergic bronchopulmonary aspergillosis or Cystic Fibrosis\n* Pregnant or lactating women\n* Following mucoactive treatment in the previous month\n* Inability to perform ELTGOL, spirometry or to attend visits\n* Practicing pulmonary rehabilitation in the previous 6 months\n* Change of treatment the previous month\n* Uncontrolled hypertension","ALL","18 Years",{"count":89,"type":90},57,"ESTIMATED","INTERVENTIONAL",[93],"PHASE3","Bronchiectasis is a chronic bronchial disease in which the usual capacity to remove secretions does not function correctly, causing mucus retention that leads to chronic infection. As with all infections, the use of antibiotics and puss removal are essential treatment elements. Physiotherapeutic techniques are used to assist in the removal of secretions, although these are time-consuming practices that need to be much better studied and which patients often do not continue practicing diligently. A physiotherapeutic technique called (Slow prolonged expiration in lateral decubitus) ELTGOL has been shown to be somewhat effective but as the mucus is viscous in this disorder, it can be difficult to get it to move. It is thought that saline solution inhalations may reduce mucus viscosity and could help to ease expectoration, facilitating the removal of the mucus by the physiotherapeutic technique. This project aims to test this hypothesis, which if true could represent an advance in the treatment of this severely debilitating disease.",[96],"Bronchiectasis Adult",[98,99,100],"airway clearance","hypertonic saline","respiratory physiotherapy","2024-07-02",{"date":103,"type":104},"2024-07-03","ACTUAL",{"date":106,"type":104},"2024-06-01",{"date":108,"type":90},"2027-12",{"name":5,"class":6},1]