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Klinika","Szeged",{"type":44,"coordinates":705},[706,707],20.14824,46.253,{"lat":707,"lon":706},[710],{"name":51,"role":31,"phone":52,"phoneExt":17,"email":53},{"type":712,"investigatorFullName":17,"investigatorTitle":17,"investigatorAffiliation":17,"oldNameTitle":17,"oldOrganization":17},"SPONSOR","100627537","phase-3-capri-a-phase-3-randomized-double-masked-study-comparing-the-efficacy-of-eyp-1901-against-aflibercept-in-dme-100627537",false,"NCT07449923","CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME","A Phase 3, Multicenter, Prospective, Randomized, Double-Masked, Parallel-Group Study of EYP-1901, a Tyrosine Kinase Inhibitor (TKI), Compared to Aflibercept (2 mg) in Participants With Diabetic Macular Edema (DME)","DME","Inclusion Criteria:\n\n* Previously treated or treatment naïve patients with a documented diagnosis of macular edema associated with diabetic retinopathy (DR) in the study eye, with onset of disease that began at any time prior to the Screening Visit.\n* Best-corrected visual acuity (BCVA) Early Treatment Diabetic Retinopathy Study (ETDRS) letter score of 35 letters (20\u002F200 Snellen equivalent) to 78 letters (20\u002F32 Snellen equivalent) in the study eye at the Screening Visit and at Baseline (Day 1).\n* For previously treated participants: at least 1 injection of anti-VEGF in the past 12 months, the most recent anti-VEGF treatment for DME must not have been administered less than 12 weeks prior to the Screening Visit.\n\nExclusion Criteria:\n\n* BCVA using ETDRS charts \\\u003C30 letters (20\u002F250 Snellen equivalent) in the fellow eye.","ALL","18 Years",{"count":724,"type":725},240,"ESTIMATED","INTERVENTIONAL",[728],"PHASE3","This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.",[731,719,732],"Diabetic Macular Edema","Diabetic Macular Edema (DME)",[734,735,731,11],"EyePoint","Tyrosine Kinase 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