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Current or recent (within two months) non-topical treatment for sarcoidosis\n2. Current Oral\u002FIV treatment of duration greater than 5 days\n3. Currently taking Methotrexate or Prednisone for another health condition\n4. Intolerance or contra-indication to Methotrexate or Prednisone\n5. Patient does not meet all of the above listed inclusion criteria\n6. Patient is unable or unwilling to provide informed consent\n7. Patient is included in another randomized clinical trial\n8. Patient has a contraindication to PET imaging or is unlikely to tolerate due to severe claustrophobia\n9. Pregnancy (all women of child bearing age and potential will have a negative BHCG test before enrollment)\n10. Breastfeeding\n11. Women of childbearing age who refuse to use a highly effective and medically acceptable form of contraception throughout the study\n12. 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