[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100436045":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":38,"locations":45,"responsibleParty":62,"collaborators":64,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":43,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":77,"maxAge":43,"enrollmentInfo":78,"targetDuration":43,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":47,"whyStopped":43,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"University of Southern California","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Cefixime","EXPERIMENTAL","Oral cefixime 400mg, taken twice a day for 10 days",[13],"Drug: Cefixime 400mg",{"label":15,"type":16,"description":17,"interventionNames":18},"Benzathine Penicillin G","ACTIVE_COMPARATOR","Single intramuscular injection of 2.4 million units of benzathine penicillin G",[19],"Drug: benzathine penicillin",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Cefixime 400mg","Oral cefixime 400 mg, one capsule, twice a day for 10 days",[9],[27],"supprax",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"benzathine penicillin","Standard of care benzathine penicillin G, one intramuscular injection, 2.4MU",[15],[33],"bicillin",[35],{"name":36,"affiliation":5,"role":37},"Jeffrey D Klausner, MD MPH","PRINCIPAL_INVESTIGATOR",[39],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},"Jeffrey D Klausner","CONTACT","(415) 876-8901",null,"jdklausner@med.usc.edu",[46],{"facility":5,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"RECRUITING","Los Angeles","California","90032","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-118.24368,34.05223,{"lat":57,"lon":56},[60],{"name":61,"role":41,"phone":42,"phoneExt":43,"email":44},"Jeffrey D Klausner, MD",{"type":37,"investigatorFullName":40,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":43,"oldOrganization":43},"Clinical Professor",[65,67],{"name":66,"class":6},"AIDS Healthcare Foundation",{"name":68,"class":6},"Universidad Peruana Cayetano Heredia","100436045","phase-3-cefixime-clinical-trial-100436045",false,"NCT04958122","Cefixime Clinical Trial","Clinical Trial Comparing the Effectiveness of Cefixime Versus Penicillin G for Treatment of Early Syphilis","Inclusion Criteria:\n\n* Diagnosed cases of primary, secondary, or early latent syphilis with RPR titer ≥1:8 within 3 weeks prior to enrollment\n* 18 years of age or older\n* Able to provide informed consent\n* Individuals with HIV infection must be on treatment for HIV infection and virologically suppressed (viral load \\\u003C200 copies\u002FmL) or have a CD4 count ≥ 350 cells\u002Fmm3 according to most recent labs before study enrollment\n\nExclusion Criteria:\n\n* Pregnancy or a positive pregnancy test on the day of enrollment\n* Patients showing signs and symptoms of neurosyphilis\n* Serofast RPR titer, defined as persistently positive RPR titer without more than 4-fold (2-titer level) change for 12 months or greater\n* Recent (within the past 7 days) or concomitant antimicrobial therapy with activity against syphilis, namely azithromycin, doxycycline, ceftriaxone, or other beta-lactam antibiotics (e.g. amoxicillin)\n* Individuals with HIV infection who report HIV treatment interruption for more than 4 weeks since their most recent viral load or CD4 test\n* Self-reported allergy to cephalosporins or penicillin\n* Unwilling or unable to attend follow-up visits","ALL","18 Years",{"count":79,"type":80},400,"ESTIMATED","INTERVENTIONAL",[83],"PHASE3","This study aims to evaluate the efficacy of cefixime compared to benzathine penicillin G in the treatment of syphilis.",[86,87],"Syphilis","Human Immunodeficiency Virus",[9,89,90,91],"Treponema pallidum","Penicillin","Early Syphilis","2026-04-27",{"date":94,"type":95},"2026-05-04","ACTUAL",{"date":97,"type":95},"2021-06-20",{"date":99,"type":80},"2027-06-30",{"name":5,"class":6},1]