[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100484128":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":40,"responsibleParty":58,"collaborators":60,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":71,"sex":77,"minAge":78,"maxAge":26,"enrollmentInfo":79,"targetDuration":26,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":43,"whyStopped":26,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"University of Southampton","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention","PLACEBO_COMPARATOR","Flucloxacillin 500mg four times a day (QDS) for 5 days (unblinded NHS prescription) followed by blinded placebo QDS for 2 days (5 days of antibiotic)",[13,14],"Drug: Flucloxacillin Only Product in Oral Dose Form","Drug: Placebo Only Product in Oral Dose Form",{"label":16,"type":17,"description":18,"interventionNames":19},"Control","ACTIVE_COMPARATOR","Flucloxacillin 500mg QDS for 5 days (unblinded NHS prescription) followed by flucloxacillin 500mg QDS (blinded) for 2 days (7 days of antibiotic)",[13],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Flucloxacillin Only Product in Oral Dose Form","Patients will be prescribed flucloxacillin 500mg QDS for 5 days followed by blinded flucloxacillin 500mg for 2 days, reaching a total of 7 days of antibiotic treatment",[16,9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo Only Product in Oral Dose Form","Patients will be prescribed flucloxacillin 500mg QDS for 5 days followed by a blinded placebo for 2 days, reaching a total of 5 days of antibiotic treatment",[9],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Sophie Varkonyi-Clifford","CONTACT","0 23 8059 1532","coat@soton.ac.uk",{"name":38,"role":34,"phone":39,"phoneExt":26,"email":36},"Ella Bourke","02381550206",[41],{"facility":42,"status":43,"city":44,"state":26,"zip":26,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Royal South Hants Hospital","RECRUITING","Southampton","United Kingdom","UK",{"type":48,"coordinates":49},"Point",[50,51],-1.40428,50.90395,{"lat":51,"lon":50},[54,56],{"name":55,"role":34,"phone":26,"phoneExt":26,"email":26},"Ian Ward",{"name":55,"role":57,"phone":26,"phoneExt":26,"email":26},"PRINCIPAL_INVESTIGATOR",{"type":59,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[61,63,65,67],{"name":62,"class":6},"University of East Anglia",{"name":64,"class":6},"University of Nottingham",{"name":66,"class":6},"Norfolk and Norwich University Hospitals NHS Foundation Trust",{"name":68,"class":6},"University Hospital Southampton NHS Foundation Trust","100484128","phase-3-cellulitis-optimal-antibiotic-treatment-100484128",false,"NCT05584007","Cellulitis Optimal Antibiotic Treatment","A Blinded, Non-inferiority Phase III Trial of 5 Versus 7 Days of Oral Flucloxacillin in Primary Care Patients With Lower Limb Cellulitis","COAT","Inclusion Criteria:\n\n* Must be aged 18 years or older\n* Currently showing symptoms of cellulitis (such as pain, tenderness, redness, other change in skin color, warmth to touch) in one leg for 10 days or less\n* Pain rated as 3\u002F10 or higher on a numerical rating scale (0-10) at baseline assessment\n* Be willing to be randomized to either trial arm (5-day or 7-day treatment)\n* Able to complete trial procedures in the English language.\n\nExclusion Criteria:\n\n* Have penicillin allergy\n* Have bilateral cellulitis\n* Have had antibiotics for cellulitis within the past month\n* Have post-operative cellulitis (within 30 days of operative procedures on the same leg)\n* Have cellulitis resulting from human\u002Fanimal bite injury\n* Have Cellulitis associated with chronic (\\>6 weeks) leg ulceration\n* Require immediate hospital admission or out-patient intravenous antibiotic therapy","ALL","18 Years",{"count":80,"type":81},334,"ESTIMATED","INTERVENTIONAL",[84],"PHASE3","To determine whether a short course of oral flucloxacillin (5 days) is non-inferior to a standard course (7 days) in terms of pain over days 6-14 (indicative of persistence or recurrence associated with the symptoms of most importance to patients) in adults with cellulitis of the leg presenting in primary care.",[87],"Cellulitis of Leg",[89,90,91,92,93],"Primary care","Antibiotic treatment","Antibiotic resistance","Pain","Cost consequences","2026-05-14",{"date":96,"type":97},"2026-05-15","ACTUAL",{"date":99,"type":97},"2023-08-29",{"date":101,"type":81},"2027-07",{"name":5,"class":6},1]