[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100573426":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":33,"locations":41,"responsibleParty":61,"collaborators":64,"id":87,"slug":88,"hasResults":89,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":89,"sex":95,"minAge":96,"maxAge":97,"enrollmentInfo":98,"targetDuration":24,"studyType":101,"phases":102,"briefSummary":104,"conditions":105,"keywords":107,"overallStatus":44,"whyStopped":24,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":121},{"fullName":5,"class":6},"Beth Israel Deaconess Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"cleavage-stage embryo transfer","ACTIVE_COMPARATOR","embryo(s) will be transferred on day 3 of embryo development (cleavage-stage embryo)",[13],"Procedure: embryo transfer",{"label":15,"type":10,"description":16,"interventionNames":17},"blastocyst embryo transfer","embryo(s) will be transferred on day 5-7 of embryo development (blastocyst-stage embryo)",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"PROCEDURE","embryo transfer","transfer of embryo(s) into the uterine cavity",[15,9],null,[26,30],{"name":27,"affiliation":28,"role":29},"Werner Neuhausser, MD PhD","Beth Israel Deaconess Medical Center\u002FHarvard Medical School","PRINCIPAL_INVESTIGATOR",{"name":31,"affiliation":32,"role":29},"Dustin Rabideau, PhD","Massachusetts General Hospital",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":24,"email":38},"Beatrice Duvert","CONTACT","617-975-7632","bduvert@bidmc.harvard.edu",{"name":27,"role":36,"phone":24,"phoneExt":24,"email":40},"wneuhaus@bidmc.harvard.edu",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Boston IVF","RECRUITING","Boston","Massachusetts","02451","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-71.05977,42.35843,{"lat":54,"lon":53},[57],{"name":58,"role":36,"phone":59,"phoneExt":24,"email":60},"Alan Penzias, MD","(888) 300-2483","apenzias@bostonivf.com",{"type":29,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Werner Neuhausser","Principal Investigator",[65,67,68,70,72,74,76,78,81,83,85],{"name":66,"class":6},"Brigham and Women's Hospital",{"name":43,"class":6},{"name":69,"class":6},"Columbia University",{"name":71,"class":6},"Weill Medical College of Cornell University",{"name":73,"class":6},"Mayo Clinic",{"name":75,"class":6},"University of Michigan",{"name":77,"class":6},"Patient-Centered Outcomes Research Institute",{"name":79,"class":80},"Massachusetts General Hospital (MGH)","UNKNOWN",{"name":82,"class":6},"Yale University",{"name":84,"class":80},"UCSF Center for Reproductive Health",{"name":86,"class":6},"University of Pennsylvania","100573426","phase-3-cleavage-stage-versus-blastocyst-stage-embryo-transfer-in-ivf-patients-with-few-embryos-100573426",false,"NCT06746129","Cleavage-stage Versus Blastocyst-stage Embryo Transfer in IVF Patients With Few Embryos","Day 3 Versus Day 5 Embryo Transfer in IVF Patients With Few Embryos","PRECiSE","Inclusion Criteria:\n\n* autologous IVF cycle\n* ≤5 zygotes on day 1 of development\n* Fresh embryo transfer\n\nExclusion Criteria:\n\n* Planned preimplantation genetic testing (PGT) of all embryos\n* More than 2 previous IVF cycles\n* History of recurrent pregnancy loss (≥3)\n* Body mass index \\>40\n* Presence of uterine factor infertility\n* Planned gestational carrier\n* Endometrial lining \\\u003C6mm measured on the day of trigger\n* Lupron-only trigger, elevated progesterone in the fresh cycle (≥1.5ng\u002Fml)\n* Delayed fertilization (\\>18 hours)\n* Rescue intracytoplasmic sperm injection (following failed regular fertilization)\n* Use of non-ejaculated sperm (testicular sperm extraction)\n* Embryo transfer number outside American Society of Reproductive Medicine (ASRM) guidelines\n* Cycle is converted to a cycle in which all embryos are frozen","FEMALE","18 Years","44 Years",{"count":99,"type":100},1126,"ESTIMATED","INTERVENTIONAL",[103],"PHASE3","Infertility affects more than 6 million women the United States and is a major life event that results in a wide range of socio-cultural, emotional, physical and financial problems. The most successful treatment for infertility, in-vitro fertilization (IVF), fertilizes a woman's eggs with her partner's sperm in a culture dish and transfers the resulting embryos into the uterus. Most of the time, prior to being transferred, embryos are grown in the dish for 5-7 days after which some of them reach an advanced stage (blastocyst stage). This has several advantages such as a lower chance of a multiple pregnancies (twins, triplets etc.) after transfer and fewer transfer procedures. However, it is possible that embryos would survive better if transferred into the uterus at the 8-cell stage after growing them for only 3 days. Thus, when patients only have a small number of embryos they and their physicians face the difficult choice when to transfer because there are currently no studies available to guide this decision.\n\nThis randomized controlled trial is comparing pregnancy outcomes and patient satisfaction of poor prognosis patients with 5 or fewer embryos undergoing either transfer of an advanced (blastocyst) or an 8-cell embryo.\n\nThis study will provide the data for the development of guidelines for IVF providers to make evidence-based decisions when to transfer embryos in poor prognosis IVF patients, reduce patients' anxiety regarding cycle cancellation and improve patient counseling, which will increase patients' ability to participate in the development of their treatment plan.",[106],"Infertility (IVF Patients)",[108,109,110,111,21],"infertility","in vitro fertilization","cleavage stage embryo","blastocyst","2026-03-28",{"date":114,"type":115},"2026-04-02","ACTUAL",{"date":117,"type":115},"2025-09-10",{"date":119,"type":100},"2031-06-30",{"name":5,"class":6},1]