[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100402562":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":32,"locations":37,"responsibleParty":63,"collaborators":25,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":67,"sex":73,"minAge":74,"maxAge":25,"enrollmentInfo":75,"targetDuration":25,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":40,"whyStopped":25,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"London School of Hygiene and Tropical Medicine","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active","ACTIVE_COMPARATOR","A single dose of Tranexamic acid 500mg given by intramuscular injection",[13],"Drug: Tranexamic Acid 500 MG",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","One Injection of the placebo which is 10 mL Sodium Chloride (0.9%)",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Tranexamic Acid 500 MG","given once as an intramuscular injection",[9,15],null,[27,30],{"name":28,"affiliation":5,"role":29},"Haleema Shakur-Still","STUDY_CHAIR",{"name":31,"affiliation":5,"role":29},"Ian Roberts",[33],{"name":28,"role":34,"phone":35,"phoneExt":25,"email":36},"CONTACT","+4407714139500","Haleema.Shakur@lshtm.ac.uk",[38,54],{"facility":39,"status":40,"city":41,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"The Royal London Hospital","RECRUITING","London","E1 1FR","United Kingdom","UK",{"type":46,"coordinates":47},"Point",[48,49],-0.12574,51.50853,{"lat":49,"lon":48},[52],{"name":53,"role":34,"phone":25,"phoneExt":25,"email":25},"Ben Bloom",{"facility":55,"status":40,"city":41,"state":41,"zip":56,"country":43,"countryCode":44,"cosmosGeoPoint":57,"geoPoint":59,"contacts":60},"St George's Hospital","SW17 0QT",{"type":46,"coordinates":58},[48,49],{"lat":49,"lon":48},[61],{"name":62,"role":34,"phone":25,"phoneExt":25,"email":25},"Heather Jarman",{"type":64,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100402562","phase-3-clinical-randomisation-of-an-anti-fibrinolytic-in-symptomatic-mild-head-injury-in-older-adults-100402562",false,"NCT04521881","Clinical Randomisation of an Anti-fibrinolytic in Symptomatic Mild Head Injury in Older Adults","Intramuscular Tranexamic Acid for the Treatment of Symptomatic Mild Traumatic Brain Injury in Older Adults: a Randomised, Double-blind, Placebo-controlled Trial","CRASH-4","Inclusion Criteria:\n\n* 50 years or older (actual or estimated)\n* History or evidence of head injury (e.g. laceration, bruise, swelling or pain in head or face)\n* GCS ≥ 13\n* Has one or more of the following:\n\n  1. has or had any impaired consciousness (loss of consciousness, amnesia, or confusion)\n  2. nausea or vomiting\n* Within 3 hours of injury (do not include if interval cannot be estimated e.g. patient unable to confirm time of fall or patient found on floor after an unwitnessed fall and home alone)\n* Not living in a nursing home, mental health institution or prison\n* Patient will be conveyed to or is admitted to a participating hospital\n\nExclusion Criteria:\n\n\\- TXA not clearly indicated (e.g. major bleeding) or contraindicated (e.g. suspected stroke)","ALL","50 Years",{"count":76,"type":77},5000,"ESTIMATED","INTERVENTIONAL",[80],"PHASE3","Tranexamic acid (TXA) reduces head injury deaths. The CRASH-4 trial aims to assess the effects of early intramuscular TXA on intracranial haemorrhage, disability, death, and dementia in older adults with symptomatic mild head injury",[83],"Traumatic Brain Injury",[85],"Traumatic brain injury, tranexamic acid, older adults","2026-03-09",{"date":88,"type":89},"2026-03-12","ACTUAL",{"date":91,"type":89},"2021-04-18",{"date":93,"type":77},"2028-01-31",{"name":5,"class":6},2]