[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636751":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":27,"centralContacts":40,"locations":46,"responsibleParty":700,"collaborators":27,"id":702,"slug":703,"hasResults":704,"nctId":705,"briefTitle":706,"officialTitle":707,"acronym":27,"eligibilityCriteria":708,"healthyVolunteers":704,"sex":709,"minAge":710,"maxAge":711,"enrollmentInfo":712,"targetDuration":27,"studyType":715,"phases":716,"briefSummary":718,"conditions":719,"keywords":27,"overallStatus":721,"whyStopped":27,"lastUpdateSubmitDate":722,"lastUpdatePostDateStruct":723,"startDateStruct":726,"completionDateStruct":728,"leadSponsor":730,"locationsCount":731},{"fullName":5,"class":6},"Chia Tai Tianqing Pharmaceutical Group Co., Ltd.","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"TQB2934 injection","EXPERIMENTAL","TQB2934 injection, 28 days as a treatment cycle.",[13],"Drug: TQB2934 injection",{"label":15,"type":16,"description":17,"interventionNames":18},"Selinexor and Dexamethasone or Pomalidomide Dexamethasone","ACTIVE_COMPARATOR","Selinexor and Dexamethasone, 28 days as a treatment cycle or Pomalidomide Dexamethasone, 28 days as a treatment cycle",[19,20,21],"Drug: Pomalidomide Capsule","Drug: Selinexor tablets","Drug: Dexamethasone tablets",[23,28,32,36],{"type":24,"name":9,"description":25,"armGroupLabels":26,"otherNames":27},"DRUG","TQB2934 injection is a bispecific antibody targeting B-cell maturation antigen (BCMA) and Cluster of Differentiation 3 (CD3).",[9],null,{"type":24,"name":29,"description":30,"armGroupLabels":31,"otherNames":27},"Pomalidomide Capsule","Pomalidomide capsules are an immunomodulatory(IMiD).",[15],{"type":24,"name":33,"description":34,"armGroupLabels":35,"otherNames":27},"Selinexor tablets","Selinexor is a selective nuclear export protein inhibitor.",[15],{"type":24,"name":37,"description":38,"armGroupLabels":39,"otherNames":27},"Dexamethasone tablets","Dexamethasone tablets are a type of adrenocortical hormone drug.",[15],[41],{"name":42,"role":43,"phone":44,"phoneExt":27,"email":45},"Peng Liu, Doctor","CONTACT","18286006744","liu.peng@zs-hospital.sh.cn",[47,65,79,89,99,114,125,140,151,166,177,188,202,217,232,247,261,275,290,305,319,329,340,355,369,384,395,409,424,435,450,465,476,491,505,516,530,544,556,567,582,596,611,625,635,650,665,675,689],{"facility":48,"status":27,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"The First Affiliated Hospital of Bengbu Medical University","Bengbu","Anhui","233004","China","CN",{"type":55,"coordinates":56},"Point",[57,58],117.36083,32.94083,{"lat":58,"lon":57},[61],{"name":62,"role":43,"phone":63,"phoneExt":27,"email":64},"Jiajia Li, Doctor","13955207283","4119469@qq.com",{"facility":66,"status":27,"city":67,"state":50,"zip":68,"country":52,"countryCode":53,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"The First Affiliated Hospital of Anhui Medical University","Hefei","230022",{"type":55,"coordinates":70},[71,72],117.28083,31.86389,{"lat":72,"lon":71},[75],{"name":76,"role":43,"phone":77,"phoneExt":27,"email":78},"Jian Ge, Doctor","13064587120","gejian52@163.com",{"facility":80,"status":27,"city":81,"state":82,"zip":83,"country":52,"countryCode":53,"cosmosGeoPoint":84,"geoPoint":88,"contacts":27},"Beijing Chao-Yang Hospital,Capital Medical University","Beijing","Beijing Municipality","100020",{"type":55,"coordinates":85},[86,87],116.39723,39.9075,{"lat":87,"lon":86},{"facility":90,"status":27,"city":81,"state":82,"zip":83,"country":52,"countryCode":53,"cosmosGeoPoint":91,"geoPoint":93,"contacts":94},"Beijing Jishuitan Hospital,Capital Medical University",{"type":55,"coordinates":92},[86,87],{"lat":87,"lon":86},[95],{"name":96,"role":43,"phone":97,"phoneExt":27,"email":98},"Li Bao, Doctor","13010837430","baoli@jst-hosp.com.cn",{"facility":100,"status":27,"city":101,"state":102,"zip":103,"country":52,"countryCode":53,"cosmosGeoPoint":104,"geoPoint":108,"contacts":109},"The First Affiliated Hospital of Chongqing Medical University","Chongqing","Chongqing Municipality","400010",{"type":55,"coordinates":105},[106,107],106.55771,29.56026,{"lat":107,"lon":106},[110],{"name":111,"role":43,"phone":112,"phoneExt":27,"email":113},"Li Yang, Doctor","18623578818","2664486657@qq.com",{"facility":115,"status":27,"city":101,"state":102,"zip":116,"country":52,"countryCode":53,"cosmosGeoPoint":117,"geoPoint":119,"contacts":120},"The Southwest Hospital of Amu","400038",{"type":55,"coordinates":118},[106,107],{"lat":107,"lon":106},[121],{"name":122,"role":43,"phone":123,"phoneExt":27,"email":124},"Shuangnian Xu, Doctor","13650596553","xushuangnian@163.com",{"facility":126,"status":27,"city":127,"state":128,"zip":129,"country":52,"countryCode":53,"cosmosGeoPoint":130,"geoPoint":134,"contacts":135},"Gansu Provincial Maternal and Child Health Hospital (Gansu Provincial Central Hospital)","Lanzhou","Gansu","730000",{"type":55,"coordinates":131},[132,133],103.83987,36.05701,{"lat":133,"lon":132},[136],{"name":137,"role":43,"phone":138,"phoneExt":27,"email":139},"Li Lin, Doctor","13519665507","gs_linli@163.com",{"facility":141,"status":27,"city":127,"state":128,"zip":142,"country":52,"countryCode":53,"cosmosGeoPoint":143,"geoPoint":145,"contacts":146},"Lanzhou University Second Hospital","730030",{"type":55,"coordinates":144},[132,133],{"lat":133,"lon":132},[147],{"name":148,"role":43,"phone":149,"phoneExt":27,"email":150},"Lingling Yu, Doctor","13893110667","Yll8942344@163.com",{"facility":152,"status":27,"city":153,"state":154,"zip":155,"country":52,"countryCode":53,"cosmosGeoPoint":156,"geoPoint":160,"contacts":161},"Sun Yat-sen Memorial Hospital, Sun Yat-sen University","Guangzhou","Guangdong","510000",{"type":55,"coordinates":157},[158,159],113.25,23.11667,{"lat":159,"lon":158},[162],{"name":163,"role":43,"phone":164,"phoneExt":27,"email":165},"Jie Xiao, Doctor","13826426842","xiaojie01981@126.com",{"facility":167,"status":27,"city":153,"state":154,"zip":168,"country":52,"countryCode":53,"cosmosGeoPoint":169,"geoPoint":171,"contacts":172},"Sun Yat-Sen University Cancer Center","510062",{"type":55,"coordinates":170},[158,159],{"lat":159,"lon":158},[173],{"name":174,"role":43,"phone":175,"phoneExt":27,"email":176},"Zhongjun Xia, Doctor","13602713223","xiazj@sysucc.org.cn",{"facility":178,"status":27,"city":153,"state":154,"zip":179,"country":52,"countryCode":53,"cosmosGeoPoint":180,"geoPoint":182,"contacts":183},"Zhujiang Hospital of Southern Medical University","510280",{"type":55,"coordinates":181},[158,159],{"lat":159,"lon":158},[184],{"name":185,"role":43,"phone":186,"phoneExt":27,"email":187},"Yanjie He, Doctor","13631381275","hyjgzh2006@163.com",{"facility":189,"status":27,"city":190,"state":154,"zip":191,"country":52,"countryCode":53,"cosmosGeoPoint":192,"geoPoint":196,"contacts":197},"Affiliated Hospital of Guangdong Medical University","Zhanjiang","524023",{"type":55,"coordinates":193},[194,195],110.38749,21.23391,{"lat":195,"lon":194},[198],{"name":199,"role":43,"phone":200,"phoneExt":27,"email":201},"Honghua He, Master","13828229695","192880@qq.com",{"facility":203,"status":27,"city":204,"state":205,"zip":206,"country":52,"countryCode":53,"cosmosGeoPoint":207,"geoPoint":211,"contacts":212},"The First Affiliated Hospital of Guangxi Medical University","Nanning","Guangxi","530000",{"type":55,"coordinates":208},[209,210],108.31667,22.81667,{"lat":210,"lon":209},[213],{"name":214,"role":43,"phone":215,"phoneExt":27,"email":216},"Lin Luo, Doctor","13597007307","554359122@qq.com",{"facility":218,"status":27,"city":219,"state":220,"zip":221,"country":52,"countryCode":53,"cosmosGeoPoint":222,"geoPoint":226,"contacts":227},"The Affiliated Hospital of Guizhou Medical University","Guiyang","Guizhou","550001",{"type":55,"coordinates":223},[224,225],106.71667,26.58333,{"lat":225,"lon":224},[228],{"name":229,"role":43,"phone":230,"phoneExt":27,"email":231},"Jie Xiong, Doctor","18786687021","929438808@qq.com",{"facility":233,"status":27,"city":234,"state":235,"zip":236,"country":52,"countryCode":53,"cosmosGeoPoint":237,"geoPoint":241,"contacts":242},"Cangzhou People'S Hospital","Cangzhou","Hebei","061000",{"type":55,"coordinates":238},[239,240],116.85334,38.31124,{"lat":240,"lon":239},[243],{"name":244,"role":43,"phone":245,"phoneExt":27,"email":246},"Hongmei Ma, Bachelor","18031798229","mhm-sspc@163.com",{"facility":248,"status":27,"city":249,"state":235,"zip":250,"country":52,"countryCode":53,"cosmosGeoPoint":251,"geoPoint":255,"contacts":256},"Affiliated Hospital of Chengde Medical University","Chengde","067000",{"type":55,"coordinates":252},[253,254],117.95883,40.9519,{"lat":254,"lon":253},[257],{"name":258,"role":43,"phone":259,"phoneExt":27,"email":260},"Zhihua Zhang, Master","15633142905","zzhangzhihua@163.com",{"facility":262,"status":27,"city":263,"state":235,"zip":264,"country":52,"countryCode":53,"cosmosGeoPoint":265,"geoPoint":269,"contacts":270},"The Second Hospital of Hebeimedical University","Shijiazhuang","050000",{"type":55,"coordinates":266},[267,268],114.47861,38.04139,{"lat":268,"lon":267},[271],{"name":272,"role":43,"phone":273,"phoneExt":27,"email":274},"Lin Yang, Doctor","18631116656","ylhbsjz@163.com",{"facility":276,"status":27,"city":277,"state":278,"zip":279,"country":52,"countryCode":53,"cosmosGeoPoint":280,"geoPoint":284,"contacts":285},"The Second Affiliated Hospital of Harbin Medical University","Harbin","Heilongjiang","150086",{"type":55,"coordinates":281},[282,283],126.65,45.75,{"lat":283,"lon":282},[286],{"name":287,"role":43,"phone":288,"phoneExt":27,"email":289},"Wei Wang, Doctor","13604880743","ww0453@163.com",{"facility":291,"status":27,"city":292,"state":293,"zip":294,"country":52,"countryCode":53,"cosmosGeoPoint":295,"geoPoint":299,"contacts":300},"Luoyang Central Hospital","Luoyang","Henan","471000",{"type":55,"coordinates":296},[297,298],112.43684,34.67345,{"lat":298,"lon":297},[301],{"name":302,"role":43,"phone":303,"phoneExt":27,"email":304},"Shuli Guo, Master","13698827020","13698827020@163.com",{"facility":306,"status":27,"city":307,"state":293,"zip":308,"country":52,"countryCode":53,"cosmosGeoPoint":309,"geoPoint":313,"contacts":314},"Henan Cancer Hospital","Zhengzhou","450000",{"type":55,"coordinates":310},[311,312],113.64861,34.75778,{"lat":312,"lon":311},[315],{"name":316,"role":43,"phone":317,"phoneExt":27,"email":318},"Baijun Fang, Doctor","13826607830","fdation@126.com",{"facility":320,"status":27,"city":307,"state":293,"zip":308,"country":52,"countryCode":53,"cosmosGeoPoint":321,"geoPoint":323,"contacts":324},"Henan Provincial People'S Hospital",{"type":55,"coordinates":322},[311,312],{"lat":312,"lon":311},[325],{"name":326,"role":43,"phone":327,"phoneExt":27,"email":328},"Zunmin Zhu, Master","13603712008","zhuzm1964@163.com",{"facility":330,"status":27,"city":307,"state":293,"zip":331,"country":52,"countryCode":53,"cosmosGeoPoint":332,"geoPoint":334,"contacts":335},"The First Affiliated Hospital Of Zhengzhou University","451191",{"type":55,"coordinates":333},[311,312],{"lat":312,"lon":311},[336],{"name":337,"role":43,"phone":338,"phoneExt":27,"email":339},"Chong Wang, Doctor","13526681242","fccwangc@zzu.edu.cn",{"facility":341,"status":27,"city":342,"state":343,"zip":344,"country":52,"countryCode":53,"cosmosGeoPoint":345,"geoPoint":349,"contacts":350},"The Third Xiangya Hospital of Central South University","Changsha","Hunan","410013",{"type":55,"coordinates":346},[347,348],112.97087,28.19874,{"lat":348,"lon":347},[351],{"name":352,"role":43,"phone":353,"phoneExt":27,"email":354},"Xin Li, Doctor","13808418932","972978226@qq.com",{"facility":356,"status":27,"city":357,"state":343,"zip":358,"country":52,"countryCode":53,"cosmosGeoPoint":359,"geoPoint":363,"contacts":364},"Zhuzhou Central Hospital","Zhuzhou","412007",{"type":55,"coordinates":360},[361,362],113.15,27.83333,{"lat":362,"lon":361},[365],{"name":366,"role":43,"phone":367,"phoneExt":27,"email":368},"Chanjuan Shen, Master","13707333899","Shenchuanjuan@163.com",{"facility":370,"status":27,"city":371,"state":372,"zip":373,"country":52,"countryCode":53,"cosmosGeoPoint":374,"geoPoint":378,"contacts":379},"Zhongda Hospital Southeast University","Nanjing","Jiangsu","210009",{"type":55,"coordinates":375},[376,377],118.77778,32.06167,{"lat":377,"lon":376},[380],{"name":381,"role":43,"phone":382,"phoneExt":27,"email":383},"Zheng Ge, Doctor","13915993701","gezheng2008@163.com",{"facility":385,"status":27,"city":371,"state":372,"zip":386,"country":52,"countryCode":53,"cosmosGeoPoint":387,"geoPoint":389,"contacts":390},"Jiangsu Province Hospital","210029",{"type":55,"coordinates":388},[376,377],{"lat":377,"lon":376},[391],{"name":392,"role":43,"phone":393,"phoneExt":27,"email":394},"Xiaoyan Qu, Doctor","13770720898","quxiaoyan205@126.com",{"facility":396,"status":27,"city":397,"state":372,"zip":398,"country":52,"countryCode":53,"cosmosGeoPoint":399,"geoPoint":403,"contacts":404},"The Affiliated Hospital of Xuzhou Medical University","Xuzhou","221004",{"type":55,"coordinates":400},[401,402],117.28386,34.20442,{"lat":402,"lon":401},[405],{"name":406,"role":43,"phone":407,"phoneExt":27,"email":408},"Huanxin Zhang, Master","15162171726","Huanxinzhang0212@163.com",{"facility":410,"status":27,"city":411,"state":412,"zip":413,"country":52,"countryCode":53,"cosmosGeoPoint":414,"geoPoint":418,"contacts":419},"The Second Affiliated Hospital of Nanchang University","Nanchang","Jiangxi","330006",{"type":55,"coordinates":415},[416,417],115.85306,28.68396,{"lat":417,"lon":416},[420],{"name":421,"role":43,"phone":422,"phoneExt":27,"email":423},"Qingming Wang, Doctor","13407911812","Wqming163@163.com",{"facility":425,"status":27,"city":411,"state":412,"zip":426,"country":52,"countryCode":53,"cosmosGeoPoint":427,"geoPoint":429,"contacts":430},"Jiangxi Provincial People's Hospital","330038",{"type":55,"coordinates":428},[416,417],{"lat":417,"lon":416},[431],{"name":432,"role":43,"phone":433,"phoneExt":27,"email":434},"Hongbo Cheng, Doctor","13707085405","784260212@qq.com",{"facility":436,"status":27,"city":437,"state":438,"zip":439,"country":52,"countryCode":53,"cosmosGeoPoint":440,"geoPoint":444,"contacts":445},"Shengjing Hospital of China Medical University","Shenyang","Liaoning","110000",{"type":55,"coordinates":441},[442,443],123.43278,41.79222,{"lat":443,"lon":442},[446],{"name":447,"role":43,"phone":448,"phoneExt":27,"email":449},"Aijun Liao, Doctor","18940259833","liaoaijun@sina.com",{"facility":451,"status":27,"city":452,"state":453,"zip":454,"country":52,"countryCode":53,"cosmosGeoPoint":455,"geoPoint":459,"contacts":460},"The Second Affiliated Hospital Of Xi'an Jiaotong University","Xi'an","Shaanxi","710004",{"type":55,"coordinates":456},[457,458],108.92861,34.25833,{"lat":458,"lon":457},[461],{"name":462,"role":43,"phone":463,"phoneExt":27,"email":464},"Fangxia Wang, Doctor","13324551809","wfx197478@163.com",{"facility":466,"status":27,"city":452,"state":453,"zip":467,"country":52,"countryCode":53,"cosmosGeoPoint":468,"geoPoint":470,"contacts":471},"The First Affiliated Hospital of Xi'an Jiao Tong University","710048",{"type":55,"coordinates":469},[457,458],{"lat":458,"lon":457},[472],{"name":473,"role":43,"phone":474,"phoneExt":27,"email":475},"Pengcheng He, Doctor","18991232609","Hepc_gcp@163.com",{"facility":477,"status":27,"city":478,"state":479,"zip":480,"country":52,"countryCode":53,"cosmosGeoPoint":481,"geoPoint":485,"contacts":486},"Binzhou Medical University Hospital","Binzhou","Shandong","256600",{"type":55,"coordinates":482},[483,484],118.01667,37.36667,{"lat":484,"lon":483},[487],{"name":488,"role":43,"phone":489,"phoneExt":27,"email":490},"Na Gao, Doctor","15966356316","gn2882155@163.com",{"facility":492,"status":27,"city":493,"state":479,"zip":494,"country":52,"countryCode":53,"cosmosGeoPoint":495,"geoPoint":499,"contacts":500},"Shandong Provincial Hospital Affiliated to Shandong First Medical University（Shandong Provincial Hospital）","Jinan","250021",{"type":55,"coordinates":496},[497,498],116.99722,36.66833,{"lat":498,"lon":497},[501],{"name":502,"role":43,"phone":503,"phoneExt":27,"email":504},"Xiangxiang Zhou, Doctor","15866695595","Zhouxx90@126.com",{"facility":506,"status":27,"city":493,"state":479,"zip":507,"country":52,"countryCode":53,"cosmosGeoPoint":508,"geoPoint":510,"contacts":511},"Cancer Hospital of Shandong First Medical University (Shandong Cancer Institute,Shandong Cancer Hospital)","250117",{"type":55,"coordinates":509},[497,498],{"lat":498,"lon":497},[512],{"name":513,"role":43,"phone":514,"phoneExt":27,"email":515},"Zengjun Li, Doctor","13642138692","zengjunli@163.com",{"facility":517,"status":27,"city":518,"state":479,"zip":519,"country":52,"countryCode":53,"cosmosGeoPoint":520,"geoPoint":524,"contacts":525},"Jining No.1 People'S Hospital","Jining","272111",{"type":55,"coordinates":521},[522,523],116.58139,35.405,{"lat":523,"lon":522},[526],{"name":527,"role":43,"phone":528,"phoneExt":27,"email":529},"Haiguo Zhang, Master","13666374406","149184728@qq.com",{"facility":531,"status":27,"city":532,"state":479,"zip":533,"country":52,"countryCode":53,"cosmosGeoPoint":534,"geoPoint":538,"contacts":539},"Qingdao Municipal Hospital","Qingdao","266011",{"type":55,"coordinates":535},[536,537],120.38042,36.06488,{"lat":537,"lon":536},[540],{"name":541,"role":43,"phone":542,"phoneExt":27,"email":543},"Yuping Zhong, Doctor","17669757939","zhongyp3352@126.com",{"facility":545,"status":27,"city":546,"state":547,"zip":548,"country":52,"countryCode":53,"cosmosGeoPoint":549,"geoPoint":553,"contacts":554},"ZhongShan Hospital Fudan University","Shanghai","Shanghai Municipality","200032",{"type":55,"coordinates":550},[551,552],121.45806,31.22222,{"lat":552,"lon":551},[555],{"name":42,"role":43,"phone":44,"phoneExt":27,"email":45},{"facility":557,"status":27,"city":546,"state":547,"zip":558,"country":52,"countryCode":53,"cosmosGeoPoint":559,"geoPoint":561,"contacts":562},"Shanghai Sixth People's Hospital","200233",{"type":55,"coordinates":560},[551,552],{"lat":552,"lon":551},[563],{"name":564,"role":43,"phone":565,"phoneExt":27,"email":566},"Xiaoling Guo, Doctor","13764643870","changchunkang7010@aliyun.com",{"facility":568,"status":27,"city":569,"state":570,"zip":571,"country":52,"countryCode":53,"cosmosGeoPoint":572,"geoPoint":576,"contacts":577},"Heping Hospital Affiliated to Changzhi Medical College","Changzhi","Shanxi","46000",{"type":55,"coordinates":573},[574,575],113.10528,36.18389,{"lat":575,"lon":574},[578],{"name":579,"role":43,"phone":580,"phoneExt":27,"email":581},"Xuliang Shen, Doctor","13015365546","shenxlcyp@sohu.com",{"facility":583,"status":27,"city":584,"state":570,"zip":585,"country":52,"countryCode":53,"cosmosGeoPoint":586,"geoPoint":590,"contacts":591},"Shanxi Provincial Cancer Hospital","Taiyuan","30000",{"type":55,"coordinates":587},[588,589],112.56028,37.86944,{"lat":589,"lon":588},[592],{"name":593,"role":43,"phone":594,"phoneExt":27,"email":595},"Liping Su, Doctor","13835158122","slpsy2022@163.com",{"facility":597,"status":27,"city":598,"state":599,"zip":600,"country":52,"countryCode":53,"cosmosGeoPoint":601,"geoPoint":605,"contacts":606},"Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital","Chengdu","Sichuan","610072",{"type":55,"coordinates":602},[603,604],104.06667,30.66667,{"lat":604,"lon":603},[607],{"name":608,"role":43,"phone":609,"phoneExt":27,"email":610},"Xiaobing Huang, Doctor","18981838236","hxb_trial@163.com",{"facility":612,"status":27,"city":613,"state":599,"zip":614,"country":52,"countryCode":53,"cosmosGeoPoint":615,"geoPoint":619,"contacts":620},"The Affiliated Hospital of Southwest Medical University","Luzhou","646000",{"type":55,"coordinates":616},[617,618],105.42575,28.8903,{"lat":618,"lon":617},[621],{"name":622,"role":43,"phone":623,"phoneExt":27,"email":624},"Xiaoming Li, Master","13700986866","Lxm6358@21cn.com",{"facility":626,"status":27,"city":627,"state":628,"zip":629,"country":52,"countryCode":53,"cosmosGeoPoint":630,"geoPoint":634,"contacts":27},"Tianjin Union Medical Center","Tianjin","Tianjin Municipality","300121",{"type":55,"coordinates":631},[632,633],117.17667,39.14222,{"lat":633,"lon":632},{"facility":636,"status":27,"city":637,"state":638,"zip":639,"country":52,"countryCode":53,"cosmosGeoPoint":640,"geoPoint":644,"contacts":645},"People's Hospital of Xinjiang Uygur Autonomous Region","Ürümqi","Xinjiang","830000",{"type":55,"coordinates":641},[642,643],87.60046,43.80096,{"lat":643,"lon":642},[646],{"name":647,"role":43,"phone":648,"phoneExt":27,"email":649},"Yan Li, Master","13639935315","liyan232917@139.com",{"facility":651,"status":27,"city":652,"state":653,"zip":654,"country":52,"countryCode":53,"cosmosGeoPoint":655,"geoPoint":659,"contacts":660},"The First Affiliated Hospital of Kunming Medical University","Kunming","Yunnan","650000",{"type":55,"coordinates":656},[657,658],102.71833,25.03889,{"lat":658,"lon":657},[661],{"name":662,"role":43,"phone":663,"phoneExt":27,"email":664},"Mingxia Shi, Doctor","13888060581","shmxia2002@sina.com",{"facility":666,"status":27,"city":667,"state":668,"zip":669,"country":52,"countryCode":53,"cosmosGeoPoint":670,"geoPoint":674,"contacts":27},"The First Affiliated Hospital, College of Medicine, Zhejiang University","Hangzhou","Zhejiang","310000",{"type":55,"coordinates":671},[672,673],120.16142,30.29365,{"lat":673,"lon":672},{"facility":676,"status":27,"city":677,"state":668,"zip":678,"country":52,"countryCode":53,"cosmosGeoPoint":679,"geoPoint":683,"contacts":684},"The First Affiliated Hospital of Ningbo Universty","Ningbo","315000",{"type":55,"coordinates":680},[681,682],121.54945,29.87819,{"lat":682,"lon":681},[685],{"name":686,"role":43,"phone":687,"phoneExt":27,"email":688},"Kaihong Xu, Doctor","13605887040","xukaho@163.com",{"facility":690,"status":27,"city":677,"state":668,"zip":691,"country":52,"countryCode":53,"cosmosGeoPoint":692,"geoPoint":694,"contacts":695},"Ningbo No.2 Hospitai","315016",{"type":55,"coordinates":693},[681,682],{"lat":682,"lon":681},[696],{"name":697,"role":43,"phone":698,"phoneExt":27,"email":699},"Suying Qian, Master","18069075307","qiansuyinghao@163.com",{"type":701,"investigatorFullName":27,"investigatorTitle":27,"investigatorAffiliation":27,"oldNameTitle":27,"oldOrganization":27},"SPONSOR","100636751","phase-3-clinical-study-of-tqb2934-injection-in-relapsedrefractory-multiple-myeloma-100636751",false,"NCT07569757","Clinical Study of TQB2934 Injection in Relapsed\u002FRefractory Multiple Myeloma","A Randomized, Open-Label, Multicenter Phase III Clinical Trial to Evaluate the Efficacy and Safety of TQB2934 Injection Versus Investigator-Selected Regimens in Patients With Relapsed\u002FRefractory Multiple Myeloma","Inclusion Criteria:\n\n* Voluntarily join this study, sign the Informed Consent Form (ICF), and demonstrate good compliance.\n* Aged 18 to 75 years old (as of the date of signing the ICF); gender not limited; Eastern Cooperative Oncology Group Performance Status (ECOG) of 0-2.\n* Expected survival greater than 3 months.\n* Patients with relapsed or refractory multiple myeloma.\n* During or after the most recent treatment, there is evidence of disease progression or failure to achieve remission after the last line of treatment。\n* Measurable disease at screening.\n* Adequate organ function as indicated by laboratory tests meeting the criteria.\n* Women of childbearing potential must agree to use effective contraception during the study and for 12 months after the last dose of study treatment, and agree not to donate eggs for reproduction during this period. Must not be breastfeeding and must have a negative serum or urine pregnancy test within 7 days prior to enrollment. Men who have not had a vasectomy and their female partners of childbearing potential should also agree to use effective contraception during the study and for 12 months after the last dose of study treatment, and agree not to donate sperm during this period.\n\nExclusion Criteria:\n\n* History of other malignancies within 5 years prior to informed consent or concurrent presence of other malignancies. The following exceptions are allowed: other malignancies cured by surgery alone with a disease-free survival (DFS) ≥5 years; cured carcinoma in situ of the cervix, non-melanoma skin cancer, and superficial bladder tumors \\[Ta (non-invasive tumor), Tis (carcinoma in situ), and T1 (tumor invading the basement membrane)\\].\n* Diagnosis of plasma cell leukemia (defined as circulating plasma cells ≥5% in peripheral blood according to standard classification), Waldenström macroglobulinemia, primary light-chain (AL) amyloidosis, POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein \\[M protein\\], and skin changes), or solitary plasmacytoma.\n* History of prior anticancer treatment, including but not limited to:\n\n  1. Receipt of chimeric antigen receptor T-cell (CAR-T), Chimeric Antigen Receptor T-Cell Immunotherapy(CAR-T), Chimeric Antigen Receptor Natural Killer Cells (CAR-NK), or other cellular therapies within 3 months prior to randomization;\n  2. Receipt of autologous stem cell transplantation within 3 months prior to randomization;\n  3. Receipt of allogeneic stem cell transplantation within 6 months prior to randomization; subjects must have discontinued all immunosuppressive therapy for ≥6 weeks and have no signs or symptoms of graft-versus-host disease (GVHD);\n  4. Receipt of molecular targeted therapy, investigational drugs, or invasive investigational medical devices within 3 weeks or 5 drug half-lives (whichever is shorter) prior to randomization;\n  5. Receipt of monoclonal antibodies, bispecific antibodies, chemotherapy, etc., within 3 weeks prior to randomization;\n  6. Receipt of proteasome inhibitors (PI), immunomodulatory drugs (IMiDs), localized radiotherapy, palliative radiotherapy, or Chinese patent medicines with antitumor indications approved by the National Medical Products Administration (NMPA) within 2 weeks prior to randomization.\n* Previously refractory to control group drugs, or with contraindications, life-threatening allergic reactions, or intolerance to previous treatments.\n* Receipt of systemic corticosteroids at a cumulative dose ≥140 mg prednisone (or equivalent) within 2 weeks prior to randomization. Topical, ophthalmic, intra-articular, intranasal, and inhaled corticosteroids are excluded from the cumulative dose calculation (see Appendix for dose conversion).\n* Toxicities from prior antitumor therapy have not recovered to baseline or ≤ Grade 1, except for Grade 2 alopecia, non-clinically significant and asymptomatic laboratory abnormalities, and hypothyroidism stabilized by hormone replacement therapy, as judged by the investigator to pose no safety risk.\n* History of Grade ≥3 cytokine release syndrome (CRS) associated with any T-cell redirecting therapy (e.g., CD3-redirecting therapies or CAR-T cell therapy).\n* Presence of conditions affecting intravenous infusion or blood collection, dysphagia, chronic diarrhea, intestinal obstruction, or other active gastrointestinal dysfunction that may interfere with drug administration or absorption.\n* Known central nervous system (CNS) involvement of multiple myeloma (MM), or clinical signs\u002Fsymptoms suggestive of leptomeningeal involvement. If either is suspected, both brain MRI and lumbar puncture cytology must be negative.\n* Major surgery, significant traumatic injury, or planned major surgery during the study treatment period within 4 weeks prior to randomization, or presence of non-healed wounds or fractures (major surgery defined as Grade ≥3 according to the 2022 national surgical classification catalogue).\n* Any severe (≥ CTCAE Grade 3) bleeding or hemorrhagic event within 6 months prior to randomization.\n* Arterial or venous thrombotic events within 6 months prior to randomization, including cerebrovascular events (including transient ischemic attack), deep vein thrombosis, pulmonary embolism, or any other serious thromboembolism (implantable venous port- or catheter-related thrombosis and superficial thrombosis are not considered \"serious\").\n* Active hepatitis or decompensated cirrhosis (Child-Pugh Class B or C)\n* Significant cardiovascular disease.\n* Neurological or psychiatric disorders.\n* Pulmonary diseases, including any of the following:\n\n  1. Current or prior non-infectious pneumonitis requiring corticosteroid treatment (including but not limited to acute respiratory distress syndrome, acute hypersensitivity pneumonitis, drug-related pneumonitis, bronchospasm, acute interstitial pneumonitis, idiopathic pulmonary fibrosis, etc.);\n  2. Known or suspected chronic obstructive pulmonary disease (COPD) with forced expiratory volume in 1 second (FEV1) \\\u003C60% of predicted.\n* Active or uncontrolled infections (≥ CTCAE Grade 2), including bacterial, fungal, or viral infections, such as active pneumonia\u002Fpulmonary infection, syphilis, tuberculosis, or Corona Virus Disease 2019 (COVID-19). Subjects with positive Cytomegalovirus (CMV) DNA or Epstein-Barr virus (EBV) plasma DNA during screening are not eligible.\n* Current or prior autoimmune diseases requiring systemic treatment. Subjects with hypothyroidism on stable replacement therapy, well-controlled type 1 diabetes, or skin diseases not requiring systemic therapy (e.g., vitiligo, psoriasis) are eligible.\n* History of immunodeficiency, including HIV positivity or other acquired or congenital immunodeficiency disorders.\n* Known or suspected history of hemophagocytic lymphohistiocytosis (HLH).\n* Known history of hypersensitivity to humanized monoclonal antibodies, or known allergy, hypersensitivity, or intolerance to any component of the investigational product.\n* Any other severe, acute, or chronic medical or psychiatric condition or laboratory abnormality that, in the investigator's opinion, may increase the risk associated with study participation or interfere with interpretation of study results.\n* Investigator considers that the subject is likely to have poor compliance with study participation.","ALL","18 Years","75 Years",{"count":713,"type":714},260,"ESTIMATED","INTERVENTIONAL",[717],"PHASE3","This study is a randomized, open-label, multicenter Phase III clinical trial involving patients with relapsed\u002Frefractory multiple myeloma. The estimated total sample size is 260 cases, who will be randomly assigned in a 1:1 ratio to the test group and the control group. The primary objective of the study is to demonstrate the efficacy of TQB2934 for injection compared to the investigator-selected regimen in subjects with relapsed or refractory multiple myeloma (RRMM) by evaluating progression-free survival (PFS).",[720],"Multiple Myeloma","NOT_YET_RECRUITING","2026-05-07",{"date":724,"type":725},"2026-05-08","ACTUAL",{"date":727,"type":714},"2026-06",{"date":729,"type":714},"2030-12",{"name":5,"class":6},49]