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The tablet should be kept in mouth until completely dissolved.\n\nOn day 1 of treatment, 8 tablets should be taken using the following regimen: 1 tablet every 30 minutes for the first 2 hours (5 tablets in total for 2 hours), then 1 more tablet 3 times at equal intervals during the same day. On day 2 and onwards, 1 tablet should be taken 3 times a day. The duration of treatment is 5 days.",[13],"Drug: Raphamin",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Placebo using the Raphamin dosage regimen.",[19],"Drug: Placebo",[21,27],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Tablet for oral use.",[9],[26],"MMH-407",{"type":22,"name":15,"description":23,"armGroupLabels":28,"otherNames":29},[15],null,[31],{"name":32,"role":33,"phone":34,"phoneExt":35,"email":36},"Mikhail Putilovskiy, MD,PhD","CONTACT","+74952761571","302","PutilovskiyMA@materiamedica.ru",[38,56,69,79,93,103,116,126,136,143,157,170,183,196,206,219,232,242,251,260,273,286,296,306,316,326,339,349,362,375,388,401,414,424,437],{"facility":39,"status":40,"city":41,"state":29,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Gatchina Clinical Interdistrict Hospital","RECRUITING","Gatchina","188300","Russia","RU",{"type":46,"coordinates":47},"Point",[48,49],30.12833,59.57639,{"lat":49,"lon":48},[52,54],{"name":53,"role":33,"phone":29,"phoneExt":29,"email":29},"Asmik Asatryan, MD",{"name":53,"role":55,"phone":29,"phoneExt":29,"email":29},"PRINCIPAL_INVESTIGATOR",{"facility":57,"status":40,"city":58,"state":29,"zip":59,"country":43,"countryCode":44,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"Kazan State Medical University\u002FDepartment of Hospital Pediatrics","Kazan'","420012",{"type":46,"coordinates":61},[62,63],49.12214,55.78874,{"lat":63,"lon":62},[66,68],{"name":67,"role":33,"phone":29,"phoneExt":29,"email":29},"Hakim Vakhitov, MD, PhD",{"name":67,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":70,"status":40,"city":58,"state":29,"zip":71,"country":43,"countryCode":44,"cosmosGeoPoint":72,"geoPoint":74,"contacts":75},"LLC \"MedLight\"","420097",{"type":46,"coordinates":73},[62,63],{"lat":63,"lon":62},[76,78],{"name":77,"role":33,"phone":29,"phoneExt":29,"email":29},"Alsu Nurmeeva, MD, PhD",{"name":77,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":80,"status":40,"city":81,"state":29,"zip":82,"country":43,"countryCode":44,"cosmosGeoPoint":83,"geoPoint":87,"contacts":88},"Regional Clinical Hospital # 2","Krasnodar","350012",{"type":46,"coordinates":84},[85,86],38.98178,45.04534,{"lat":86,"lon":85},[89,91],{"name":90,"role":33,"phone":29,"phoneExt":29,"email":29},"Konstantin Lobanov, MD",{"name":92,"role":55,"phone":29,"phoneExt":29,"email":29},"Konstantin Lobanov, Konstantin",{"facility":94,"status":40,"city":81,"state":29,"zip":95,"country":43,"countryCode":44,"cosmosGeoPoint":96,"geoPoint":98,"contacts":99},"Specialized Clinical Infectious Diseases Hospital","350015",{"type":46,"coordinates":97},[85,86],{"lat":86,"lon":85},[100,102],{"name":101,"role":33,"phone":29,"phoneExt":29,"email":29},"Larisa Dubova, MD, PhD",{"name":101,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":104,"status":40,"city":105,"state":29,"zip":106,"country":43,"countryCode":44,"cosmosGeoPoint":107,"geoPoint":111,"contacts":112},"Central Research Institute of Epidemiology\u002FClinical Department of Infectious Pathology","Moscow","111123",{"type":46,"coordinates":108},[109,110],37.61781,55.75204,{"lat":110,"lon":109},[113,115],{"name":114,"role":33,"phone":29,"phoneExt":29,"email":29},"Antonina Ploskireva, MD, PhD",{"name":114,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":117,"status":40,"city":105,"state":29,"zip":118,"country":43,"countryCode":44,"cosmosGeoPoint":119,"geoPoint":121,"contacts":122},"Morozovskaya Children's City Clinical Hospital of the Moscow City Health Department","119049",{"type":46,"coordinates":120},[109,110],{"lat":110,"lon":109},[123,125],{"name":124,"role":33,"phone":29,"phoneExt":29,"email":29},"Alexey Rtishchev, MD, PhD",{"name":124,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":127,"status":40,"city":105,"state":29,"zip":128,"country":43,"countryCode":44,"cosmosGeoPoint":129,"geoPoint":131,"contacts":132},"First Moscow State Medical University named after I.M. Sechenov\u002FDepartment of Childhood Diseases","119991",{"type":46,"coordinates":130},[109,110],{"lat":110,"lon":109},[133,135],{"name":134,"role":33,"phone":29,"phoneExt":29,"email":29},"Natalia Geppe, Prof.",{"name":134,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":137,"status":138,"city":105,"state":29,"zip":139,"country":43,"countryCode":44,"cosmosGeoPoint":140,"geoPoint":142,"contacts":29},"Llc \"Diagnostics and Vaccines\"","TERMINATED","129515",{"type":46,"coordinates":141},[109,110],{"lat":110,"lon":109},{"facility":144,"status":145,"city":146,"state":29,"zip":147,"country":43,"countryCode":44,"cosmosGeoPoint":148,"geoPoint":152,"contacts":153},"LLC \"Health Laboratory\"","NOT_YET_RECRUITING","Mytishchi","141002",{"type":46,"coordinates":149},[150,151],37.72964,55.91099,{"lat":151,"lon":150},[154,156],{"name":155,"role":33,"phone":29,"phoneExt":29,"email":29},"Evgeniya Uleva, MD",{"name":155,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":158,"status":40,"city":159,"state":29,"zip":160,"country":43,"countryCode":44,"cosmosGeoPoint":161,"geoPoint":165,"contacts":166},"Novosibirsk State Medical University\u002FClinic \"Medical Advisory Center\"","Novosibirsk","630091",{"type":46,"coordinates":162},[163,164],82.93175,55.02259,{"lat":164,"lon":163},[167,169],{"name":168,"role":33,"phone":29,"phoneExt":29,"email":29},"Elena Kondyurina, Prof.",{"name":168,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":171,"status":40,"city":172,"state":29,"zip":173,"country":43,"countryCode":44,"cosmosGeoPoint":174,"geoPoint":178,"contacts":179},"Omsk State Medical University\u002FDepartment of Hospital Pediatrics with a Course of Continuing Professional Education","Omsk","644099",{"type":46,"coordinates":175},[176,177],73.36859,54.99244,{"lat":177,"lon":176},[180,182],{"name":181,"role":33,"phone":29,"phoneExt":29,"email":29},"Elena Pavlinova, Prof.",{"name":181,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":184,"status":40,"city":185,"state":29,"zip":186,"country":43,"countryCode":44,"cosmosGeoPoint":187,"geoPoint":191,"contacts":192},"City Children's Clinical Polyclinic # 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2",{"type":46,"coordinates":245},[225,226],{"lat":226,"lon":225},[248,250],{"name":249,"role":33,"phone":29,"phoneExt":29,"email":29},"Stanislav Maltsev, MD, PhD",{"name":249,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":252,"status":145,"city":221,"state":29,"zip":234,"country":43,"countryCode":44,"cosmosGeoPoint":253,"geoPoint":255,"contacts":256},"Rostov State Medical University\u002FDepartment of Childhood Diseases # 3",{"type":46,"coordinates":254},[225,226],{"lat":226,"lon":225},[257,259],{"name":258,"role":33,"phone":29,"phoneExt":29,"email":29},"Marina Lukashevich, MD, PhD",{"name":258,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":261,"status":40,"city":262,"state":29,"zip":263,"country":43,"countryCode":44,"cosmosGeoPoint":264,"geoPoint":268,"contacts":269},"Ryazan State Medical University named after Academician I.P. Pavlov\u002FDepartment of Children's Diseases with a course in hospital pediatrics","Ryazan","390026",{"type":46,"coordinates":265},[266,267],39.70415,54.62696,{"lat":267,"lon":266},[270,272],{"name":271,"role":33,"phone":29,"phoneExt":29,"email":29},"Andrey Dmitriev, MD, PhD",{"name":271,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":274,"status":40,"city":275,"state":29,"zip":276,"country":43,"countryCode":44,"cosmosGeoPoint":277,"geoPoint":281,"contacts":282},"Children's City Polyclinic # 44","Saint Petersburg","191144",{"type":46,"coordinates":278},[279,280],30.31413,59.93863,{"lat":280,"lon":279},[283,285],{"name":284,"role":33,"phone":29,"phoneExt":29,"email":29},"Andrey Kamaev, Md, PhD",{"name":284,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":287,"status":40,"city":275,"state":29,"zip":288,"country":43,"countryCode":44,"cosmosGeoPoint":289,"geoPoint":291,"contacts":292},"Saint Petersburg State Pediatric Medical University\u002FDepartment of Infectious Diseases of Adults and Epidemiology","194100",{"type":46,"coordinates":290},[279,280],{"lat":280,"lon":279},[293,295],{"name":294,"role":33,"phone":29,"phoneExt":29,"email":29},"Elena Esaulenko, Prof.",{"name":294,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":297,"status":40,"city":275,"state":29,"zip":298,"country":43,"countryCode":44,"cosmosGeoPoint":299,"geoPoint":301,"contacts":302},"Children's City Polyclinic # 35","196191",{"type":46,"coordinates":300},[279,280],{"lat":280,"lon":279},[303,305],{"name":304,"role":33,"phone":29,"phoneExt":29,"email":29},"Tatiana Antonova, MD, PhD",{"name":304,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":307,"status":145,"city":275,"state":29,"zip":308,"country":43,"countryCode":44,"cosmosGeoPoint":309,"geoPoint":311,"contacts":312},"City Polyclinic # 3","199155",{"type":46,"coordinates":310},[279,280],{"lat":280,"lon":279},[313,315],{"name":314,"role":33,"phone":29,"phoneExt":29,"email":29},"Gleb Kondratiev, MD",{"name":314,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":317,"status":145,"city":275,"state":29,"zip":318,"country":43,"countryCode":44,"cosmosGeoPoint":319,"geoPoint":321,"contacts":322},"City Polyclinic # 4","199178",{"type":46,"coordinates":320},[279,280],{"lat":280,"lon":279},[323,325],{"name":324,"role":33,"phone":29,"phoneExt":29,"email":29},"Natalia Soroka, MD, PhD",{"name":324,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":327,"status":40,"city":328,"state":29,"zip":329,"country":43,"countryCode":44,"cosmosGeoPoint":330,"geoPoint":334,"contacts":335},"Samara Regional Children's Clinical Hospital named after N.N. Ivanovoy\u002FDepartment of Medical Rehabilitation","Samara","443079",{"type":46,"coordinates":331},[332,333],50.13553,53.20767,{"lat":333,"lon":332},[336,338],{"name":337,"role":33,"phone":29,"phoneExt":29,"email":29},"Tatiana Romanova, MD, PhD",{"name":337,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":340,"status":40,"city":328,"state":29,"zip":341,"country":43,"countryCode":44,"cosmosGeoPoint":342,"geoPoint":344,"contacts":345},"Samara State Medical University\u002FDepartment of Hospital Pediatrics","443099",{"type":46,"coordinates":343},[332,333],{"lat":333,"lon":332},[346,348],{"name":347,"role":33,"phone":29,"phoneExt":29,"email":29},"Liliya Mazur, Prof.",{"name":347,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":350,"status":40,"city":351,"state":29,"zip":352,"country":43,"countryCode":44,"cosmosGeoPoint":353,"geoPoint":357,"contacts":358},"National Research Mordovian State University named after N.P. Ogarev\u002FDepartment of Pediatrics\u002F","Saransk","430005",{"type":46,"coordinates":354},[355,356],45.17166,54.18485,{"lat":356,"lon":355},[359,361],{"name":360,"role":33,"phone":29,"phoneExt":29,"email":29},"Larisa Balykova, Prof.",{"name":360,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":363,"status":40,"city":364,"state":29,"zip":365,"country":43,"countryCode":44,"cosmosGeoPoint":366,"geoPoint":370,"contacts":371},"Saratov City Children's Clinical Hospital","Saratov","410064",{"type":46,"coordinates":367},[368,369],45.9901,51.54048,{"lat":369,"lon":368},[372,374],{"name":373,"role":33,"phone":29,"phoneExt":29,"email":29},"Elena Mikhailova, Prof.",{"name":373,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":376,"status":40,"city":377,"state":29,"zip":378,"country":43,"countryCode":44,"cosmosGeoPoint":379,"geoPoint":383,"contacts":384},"Smolensk State Medical University\u002FDepartment of Children's Diseases of the Medical and Dental Faculties","Smolensk","214019",{"type":46,"coordinates":380},[381,382],32.05088,54.77826,{"lat":382,"lon":381},[385,387],{"name":386,"role":33,"phone":29,"phoneExt":29,"email":29},"Vladimir Bekezin, Prof.",{"name":386,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":389,"status":40,"city":390,"state":29,"zip":391,"country":43,"countryCode":44,"cosmosGeoPoint":392,"geoPoint":396,"contacts":397},"Bashkir State Medical University\u002FDepartment of Outpatient and Emergency Pediatrics","Ufa","450008",{"type":46,"coordinates":393},[394,395],55.96779,54.74306,{"lat":395,"lon":394},[398,400],{"name":399,"role":33,"phone":29,"phoneExt":29,"email":29},"Lyudmila Yakovleva, Prof.",{"name":399,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":402,"status":40,"city":403,"state":29,"zip":404,"country":43,"countryCode":44,"cosmosGeoPoint":405,"geoPoint":409,"contacts":410},"Yaroslavl State Medical University\u002FDepartment of Pediatrics, Institute of Continuous Professional Education","Yaroslavl","150000",{"type":46,"coordinates":406},[407,408],39.87368,57.62987,{"lat":408,"lon":407},[411,413],{"name":412,"role":33,"phone":29,"phoneExt":29,"email":29},"Elena Shubina, MD, PhD",{"name":412,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":415,"status":40,"city":403,"state":29,"zip":416,"country":43,"countryCode":44,"cosmosGeoPoint":417,"geoPoint":419,"contacts":420},"Clinical Hospital # 2","150030",{"type":46,"coordinates":418},[407,408],{"lat":408,"lon":407},[421,423],{"name":422,"role":33,"phone":29,"phoneExt":29,"email":29},"Irina Melnikova, Prof.",{"name":422,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":425,"status":40,"city":426,"state":29,"zip":427,"country":43,"countryCode":44,"cosmosGeoPoint":428,"geoPoint":432,"contacts":433},"Children's City Clinical Hospital # 11 Ekaterinburg","Yekaterinburg","620028",{"type":46,"coordinates":429},[430,431],60.61529,56.85733,{"lat":431,"lon":430},[434,436],{"name":435,"role":33,"phone":29,"phoneExt":29,"email":29},"Sofia Tsarkova, Prof.",{"name":435,"role":55,"phone":29,"phoneExt":29,"email":29},{"facility":438,"status":40,"city":426,"state":29,"zip":427,"country":43,"countryCode":44,"cosmosGeoPoint":439,"geoPoint":441,"contacts":442},"Ural State Medical University\u002FDepartment of Infectious Diseases, Phthisiology and Pulmonology",{"type":46,"coordinates":440},[430,431],{"lat":431,"lon":430},[443,445],{"name":444,"role":33,"phone":29,"phoneExt":29,"email":29},"Alebay Sabitov, Prof.",{"name":444,"role":55,"phone":29,"phoneExt":29,"email":29},{"type":447,"investigatorFullName":29,"investigatorTitle":29,"investigatorAffiliation":29,"oldNameTitle":29,"oldOrganization":29},"SPONSOR","100571103","phase-3-clinical-trial-of-the-efficacy-and-safety-of-raphamin-in-the-treatment-of-arvi-in-children-aged-3-12-years-100571103",false,"NCT06715891","Clinical Trial of the Efficacy and Safety of Raphamin in the Treatment of ARVI in Children Aged 3-12 Years","A Multicenter, Double-blind, Placebo-controlled, Randomized, Parallel-group Clinical Trial of the Efficacy and Safety of Raphamin in the Treatment of Acute Respiratory Viral Infection in Children Aged 3-12 Years","Inclusion Criteria:\n\n1. Children of either gender aged 3 to12 years .\n2. Diagnosis of ARVI based on the medical examination: axillary temperature ≥37.8°C at the time of examination + total severity of general symptom score ≥4 points, nasal\u002Fthroat\u002Fchest symptoms ≥2 points (ARVI Symptom Severity Score).\n3. 24 hours from the ARVI onset .\n4. Availability of a patient information sheet and an informed consent form for the patient's parents\u002Fadopters for patient participation in the clinical trial signed by one parent\u002Fadopter of the patient.\n\nExclusion Criteria:\n\n1. Clinical symptoms of severe influenza\u002FARVI requiring hospitalization.\n2. Suspected pneumonia, bacterial infection (including otitis media, sinusitis, urinary tract infection, meningitis, sepsis, etc.) requiring the administration of antibiotics from the first day of disease.\n3. Suspected early manifestations of diseases that have onset symptoms similar to those of ARVI (other infectious diseases, influenza-like syndrome at the onset of systemic connective tissue diseases and other pathologies).\n4. Patients who require administration of antiviral medications that are prohibited for use in this trial.\n5. History or prior diagnosis of primary and secondary immunodeficiency.\n6. History\u002Fsuspicion of oncology of any localization (except for benign neoplasms).\n7. Exacerbation or decompensation of chronic diseases (diabetes mellitus, cerebral palsy, cystic fibrosis, primary ciliary dyskinesia, bronchopulmonary dysplasia, malformations of the respiratory and ENT organs, etc.) affecting the patient's ability to participate in the clinical trial.\n8. Malabsorption syndrome, including congenital or acquired lactase or other disaccharidase deficiency, galactosemia.\n9. Allergy\u002Fhypersensitivity to any component of the medicines used in the treatment.\n10. Use of medications listed under \"Prohibited Concomitant Treatment\" within 2 weeks prior to inclusion in the trial.\n11. Patients whose parents\u002Fadopters, from the investigator's point of view, will not comply with the observation requirements during the trial or follow the procedure for taking the test drugs.\n12. History of mental illness of the patient (except for attention deficit hyperactivity disorder), parents\u002Fadopters of the patient.\n13. Participation in other clinical trials within 3 months prior to inclusion in this trial.\n14. A patient's parent\u002Fadopter is related to any of the on-site research personnel directly involved in the trial, or is the immediate family member of the investigator. 'Immediate family members' mean spouses, parents, children, or siblings, whether related or adopted.\n15. The patient's parent\u002Fadopter is employed by OOO \"NPF \"MATERIA MEDICA HOLDING\", i.e., is an employee of the company, a temporary contract employee, or a designated official responsible for conducting the trial or their immediate family member.","ALL","3 Years","12 Years",{"count":459,"type":460},374,"ESTIMATED","INTERVENTIONAL",[463],"PHASE3","Multicenter double-blind placebo-controlled randomized in parallel groups clinical trial.",[466],"Acute Respiratory Viral Infection",[468,469,470],"respiratory viral infection","children","aged 3-12 years","2026-03-11",{"date":473,"type":474},"2026-03-13","ACTUAL",{"date":476,"type":474},"2024-11-11",{"date":478,"type":460},"2027-12-31",{"name":5,"class":6},35]