[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100507690":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":40,"responsibleParty":161,"collaborators":163,"id":171,"slug":172,"hasResults":173,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":177,"eligibilityCriteria":178,"healthyVolunteers":173,"sex":179,"minAge":180,"maxAge":26,"enrollmentInfo":181,"targetDuration":26,"studyType":184,"phases":185,"briefSummary":187,"conditions":188,"keywords":191,"overallStatus":43,"whyStopped":26,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":202},{"fullName":5,"class":6},"University Hospital, Basel, Switzerland","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental Group","EXPERIMENTAL","Study participants in the active study arm will receive a daily oral dose of 0.5 mg Colchicine for 3 months without a loading dose. The dose is recommended to be taken in the morning. There is no deviation from the usual treatment intake.",[13],"Drug: Colchicine",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group","PLACEBO_COMPARATOR","Study participants in the placebo group will receive a matched placebo.",[19],"Drug: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Colchicine","Colchicine 0.5 mg (oral) once daily for 90 days. The chemical name for colchicine is (S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9 oxobenzol\\[a\\]heptalen-7-yl) acetamide.\n\nColchicine consists of pale yellow scales or powder. It is soluble in water, freely soluble in alcohol, and slightly soluble in ether.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo","Matched placebo. Both the active drug and placebo will look similarly. The route and mode of administration is also similar to the active group.",[15],[32],{"name":33,"affiliation":5,"role":34},"Philipp Krisai, PD Dr. med.","PRINCIPAL_INVESTIGATOR",[36],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},"CONTACT","+41 61 265 25 25","Philipp.krisai@usb.ch",[41,55,74,88,103,118,133,148],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":26,"geoPoint":26,"contacts":49},"Cantonal Hospital Baselland (KSBL)","RECRUITING","Bruderholz","Basel-Landschaft","4101","Switzerland","CH",[50,54],{"name":51,"role":37,"phone":52,"phoneExt":26,"email":53},"Christian Maurer, Dr. med.","+41 61 436 21 90","christian.maurer@ksbl.ch,",{"name":51,"role":34,"phone":26,"phoneExt":26,"email":26},{"facility":56,"status":43,"city":57,"state":26,"zip":58,"country":47,"countryCode":48,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"University Hospital Basel","Basel","4031",{"type":60,"coordinates":61},"Point",[62,63],7.57327,47.55839,{"lat":63,"lon":62},[66,70,71,72],{"name":67,"role":37,"phone":68,"phoneExt":26,"email":69},"Christian Sticherling, Prof.","+41 61 265 55 26","christian.sticherling@usb.ch",{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},{"name":67,"role":34,"phone":26,"phoneExt":26,"email":26},{"name":33,"role":73,"phone":26,"phoneExt":26,"email":26},"SUB_INVESTIGATOR",{"facility":75,"status":43,"city":76,"state":26,"zip":77,"country":47,"countryCode":48,"cosmosGeoPoint":78,"geoPoint":82,"contacts":83},"University Hospital Bern","Bern","3010",{"type":60,"coordinates":79},[80,81],7.44744,46.94809,{"lat":81,"lon":80},[84,87],{"name":85,"role":37,"phone":26,"phoneExt":26,"email":86},"Tobias Reichlin, Prof.","tobias.reichlin@insel.ch",{"name":85,"role":34,"phone":26,"phoneExt":26,"email":26},{"facility":89,"status":43,"city":90,"state":26,"zip":91,"country":47,"countryCode":48,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"Lausanne University Hospital","Lausanne","1011",{"type":60,"coordinates":93},[94,95],6.63282,46.516,{"lat":95,"lon":94},[98,102],{"name":99,"role":37,"phone":100,"phoneExt":26,"email":101},"Etienne Pruvot, Prof. Dr.","+41 21 314 11 11","etienne.pruvot@chuv.ch",{"name":99,"role":34,"phone":26,"phoneExt":26,"email":26},{"facility":104,"status":43,"city":105,"state":26,"zip":106,"country":47,"countryCode":48,"cosmosGeoPoint":107,"geoPoint":111,"contacts":112},"Lucerne Cantonal Hospital","Lucerne","6000",{"type":60,"coordinates":108},[109,110],8.30635,47.05048,{"lat":110,"lon":109},[113,117],{"name":114,"role":37,"phone":115,"phoneExt":26,"email":116},"Ann-Kathrin Gamer, MD","+41 41 205 18 77","annkathrin.gamer@luks.ch",{"name":114,"role":34,"phone":26,"phoneExt":26,"email":26},{"facility":119,"status":43,"city":120,"state":26,"zip":121,"country":47,"countryCode":48,"cosmosGeoPoint":122,"geoPoint":126,"contacts":127},"Cantonal Hospital Olten","Olten","4600",{"type":60,"coordinates":123},[124,125],7.90329,47.34999,{"lat":125,"lon":124},[128,132],{"name":129,"role":37,"phone":130,"phoneExt":26,"email":131},"Frank-Peter Stephan, MD","+41 32 627 35 52","frank-peter.stephan@spital.so.ch",{"name":129,"role":34,"phone":26,"phoneExt":26,"email":26},{"facility":134,"status":43,"city":135,"state":26,"zip":136,"country":47,"countryCode":48,"cosmosGeoPoint":137,"geoPoint":141,"contacts":142},"Herzpraxis am Rhein","Rheinfelden","4310",{"type":60,"coordinates":138},[139,140],7.79403,47.55437,{"lat":140,"lon":139},[143,147],{"name":144,"role":37,"phone":145,"phoneExt":26,"email":146},"Flavio Scarcia, MD","+41 61 836 99 88","herzpraxisamrhein@hin.ch",{"name":144,"role":34,"phone":26,"phoneExt":26,"email":26},{"facility":149,"status":43,"city":150,"state":26,"zip":151,"country":47,"countryCode":48,"cosmosGeoPoint":152,"geoPoint":156,"contacts":157},"Solothurner Spitäler AG","Solothurn","4500",{"type":60,"coordinates":153},[154,155],7.53714,47.20791,{"lat":155,"lon":154},[158,159],{"name":129,"role":37,"phone":130,"phoneExt":26,"email":131},{"name":160,"role":34,"phone":26,"phoneExt":26,"email":26},"Frank-Peter Stephan",{"type":162,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[164,166,169],{"name":165,"class":6},"Swiss Heart Foundation",{"name":167,"class":168},"Fondation Machaon, Switzerland, Genf","UNKNOWN",{"name":170,"class":168},"Foundation for Cardiovascular Research Basel","100507690","phase-3-colchicine-after-electrocardioversion-for-atrial-fibrillation-100507690",false,"NCT05890664","Colchicine After Electrocardioversion for Atrial Fibrillation","Colchicine After Electrocardioversion for Atrial Fibrillation - The COLECTRO-AF Trial","COLECTRO-AF","Inclusion Criteria:\n\n* Age \\>18 years\n* ECG-documented AF prior to ECV\n* Successful ECV with conversion of AF to sinus rhythm with persistent sinus rhythm ≥30 minutes after ECV\n* Ability to give written informed consent\n\nExclusion Criteria:\n\n* AF persistence after cardioversion or early AF recurrence within 30 minutes after ECV\n* Any other rhythm than AF before cardioversion\n* Pulmonary vein isolation within 3 months prior to ECV or pulmonary vein isolation planned within 3 months after ECV\n* Known intolerance or hypersensitivity to Colchicine\n* Any other absolute indication for Colchicine intake\n* Intake of a strong inhibitor of CYP3A4 or P-Glycoprotein (clarithromycin, erythromycin, telithromycin, cyclosporine, ketoconazole or itraconazole)\n* Serious gastrointestinal disease (severe gastritis or diarrhea)\n* Clinically overt hepatic disease\n* Severe renal disease (eGFR\\< 30ml\u002Fmin\u002F1.73m2)\n* Clinically significant blood dyscrasia (e.g., myelodysplasia)\n* Significant immunosuppression (e.g. due to transplantation or rheumatic disease)\n* Pregnant or breastfeeding women, or women of child-bearing potential who do not use a highly effective form of birth control\n* Life expectancy \\<1 year","ALL","18 Years",{"count":182,"type":183},416,"ESTIMATED","INTERVENTIONAL",[186],"PHASE3","The purpose of this study is to investigate whether a 3 month treatment course of low-dose Colchicine decreases the recurrence of Atrial fibrillation (AF) after electrocardioversion (ECV) in patients with AF.",[189,190],"Atrial Fibrillation","Cardiac Arrhythmia",[192,23],"Electrocardioversion","2025-05-21",{"date":195,"type":196},"2025-05-28","ACTUAL",{"date":198,"type":196},"2024-04-14",{"date":200,"type":183},"2027-03",{"name":5,"class":6},8]