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Written informed consent.\n\nExclusion Criteria:\n\n1. Women who are pregnant, breastfeeding, or of childbearing potential who are not using an effective method of contraception. Or women who intend to donate oocytes.\n2. Men who plan to father children during the study period or who are unwilling to use effective forms of contraception. Or men who intend to donate sperm.\n3. Any contraindication or known intolerance to colchicine.\n4. Chronic use of -or need for- colchicine.\n5. Auto-immune disease or other condition requiring current or planned chronic systemic steroids, immunosuppressant or biologic drug targeting the immune system (for example, TNF blockers, anakinra, rituximab, abatacept, tocilizumab etc.).\n6. Creatinine clearance \\\u003C30 mL\u002Fmin\u002F1.73 m2.\n7. Cirrhosis Child-Pugh stadium B and C, or acute severe liver disease\n8. Neuromuscular disease or non-transient CK levels \\> 5 x ULN (unless due to MI).\n9. History of cancer or lymphoproliferative disease within the last 3 years, other than successfully treated non-metastatic cutaneous squamous cell or basal cell carcinoma, or localized cervix carcinoma in situ.\n10. Current or planned use of any strong inhibitor of CYP3A4 or p-glycoprotein: macrolide antibiotics (clarithromycin, telithromycin), azole antifungal agents (ketoconazole, voriconazole, fluconazole, itraconazole), cyclosporine, HIV medication (ritonavir, lopinavir, tipranavir, atazanavir, darunavir, indinavir, saquinavir).\n11. Chronic diarrhea, or inflammatory owel disease (Crohn's disease or ulcerative colitis).\n12. Drug or alcohol abuse.\n13. Planned cardiovascular intervention known on the day of screening.\n14. Currently enrolled in another investigational trial.\n15. 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