[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614148":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":34,"centralContacts":43,"locations":49,"responsibleParty":65,"collaborators":34,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":34,"eligibilityCriteria":74,"healthyVolunteers":71,"sex":75,"minAge":76,"maxAge":34,"enrollmentInfo":77,"targetDuration":34,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":34,"overallStatus":86,"whyStopped":34,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Tanta University","OTHER",[8,14,19,24],{"label":9,"type":10,"description":11,"interventionNames":12},"proton pump inhibitor (PPI) with amoxicillin , without addition of zinc sulphate","ACTIVE_COMPARATOR","22 patients will receive proton pump inhibitor (PPI)-based triple therapy (Omeprazole \u002Fpantoprazole 40mg) with amoxicillin (1000mg) and clarithromycin (500mg) twice daily for 2 weeks.",[13],"Drug: proton pump inhibitor + amoxicillin",{"label":15,"type":10,"description":16,"interventionNames":17},"proton pump inhibitor (PPI) with amoxicillin , with addition of zinc sulphate","22 patients will receive proton pump inhibitor (PPI)-based triple therapy (Omeprazole \u002Fpantoprazole 40mg with amoxicillin 1000mg and clarithromycin 500mg twice daily) Plus 220mg Zinc Sulphate which is equivalent to 50mg elemental zinc for 2 weeks .",[18,13],"Drug: zinc sulfate",{"label":20,"type":10,"description":21,"interventionNames":22},"vonoprazan with amoxicillin and clarithromycin without using zinc sulphate","22 patients will receive potassium-competitive acid blocker (vonoprazan 20 mg with amoxicillin 1000mg and clarithromycin 500mg twice daily) for 2 weeks.",[23],"Drug: Vonoprazan + amoxicillin + clarithromycin",{"label":25,"type":10,"description":26,"interventionNames":27},"vonoprazan with amoxicillin and clarithromycin with addition of zinc sulphate","22 patients will receive potassium-competitive acid blocker (vonoprazan 20 mg with amoxicillin 1000mg and clarithromycin 500mg twice daily) Plus 220mg Zinc Sulphate which is equivalent to 50mg elemental zinc for 2 weeks .",[18,23],[29,35,39],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"DRUG","zinc sulfate","Effect of using Zinc in Helicobacter pylori Treatment",[15,25],null,{"type":30,"name":36,"description":37,"armGroupLabels":38,"otherNames":34},"Vonoprazan + amoxicillin + clarithromycin","Effect of using Vonoprazan + amoxicillin + clarithromycin in Helicobacter pylori Treatment",[25,20],{"type":30,"name":40,"description":41,"armGroupLabels":42,"otherNames":34},"proton pump inhibitor + amoxicillin","Effect of using proton pump inhibitor + amoxicillin in Helicobacter pylori Treatment",[15,9],[44],{"name":45,"role":46,"phone":47,"phoneExt":34,"email":48},"Eman A Mahmoud, Prof.","CONTACT","+201002415022","eabdelsameea@liver-eg.eg",[50],{"facility":51,"status":34,"city":52,"state":34,"zip":34,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"National Liver Institute","Shibīn al Kawm","Egypt","EG",{"type":56,"coordinates":57},"Point",[58,59],31.00904,30.55258,{"lat":59,"lon":58},[62],{"name":63,"role":46,"phone":47,"phoneExt":34,"email":64},"Eman A Mahmoud","eabdelsameea@liver-eg.org",{"type":66,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"PRINCIPAL_INVESTIGATOR","Dina Samir Ahmed Attalla","Pharmacist","100614148","phase-3-comparative-study-evaluating-safety-and-effectiveness-of--proton-pump-inhibitor-versus-vonoprazan--based-triple-therapy-with-or-without-zinc-to-eradicate-h-pylori-infection-100614148",false,"NCT07275827","Comparative Study Evaluating Safety and Effectiveness of ( Proton Pump Inhibitor Versus Vonoprazan ) Based Triple Therapy With or Without Zinc to Eradicate H. Pylori Infection","Inclusion Criteria:\n\n* Age \\> 18.\n* Both males and females.\n* Patients who are positive for H.pylori infection by non-invasive Stool Antigen Test (SAT).\n\nExclusion Criteria:\n\n* Prior H. pylori treatment: Previous treatment for H. pylori infection.\n* Allergies: Known allergies to study medications or components.\n* Patients cannot finish treatment course.\n* Pregnant and Lactating Women.\n* Patients with Kidney disease and eGFR \\\u003C 30ml\u002Fmin.\n* Patients with Liver disease with Child-Pugh B or C.","ALL","19 Years",{"count":78,"type":79},88,"ESTIMATED","INTERVENTIONAL",[82],"PHASE3","this Study Evaluating Safety and Effectiveness of (Proton Pump Inhibitor versus Vonoprazan) Based Triple Therapy with or without Zinc to Eradicate H. pylori Infection",[85],"HELICOBACTER PYLORI INFECTIONS","NOT_YET_RECRUITING","2025-12-18",{"date":89,"type":90},"2025-12-24","ACTUAL",{"date":92,"type":79},"2026-02-01",{"date":94,"type":79},"2026-10",{"name":5,"class":6},1]