[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100607945":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":35,"centralContacts":40,"locations":46,"responsibleParty":233,"collaborators":236,"id":240,"slug":241,"hasResults":242,"nctId":243,"briefTitle":244,"officialTitle":244,"acronym":245,"eligibilityCriteria":246,"healthyVolunteers":242,"sex":247,"minAge":248,"maxAge":11,"enrollmentInfo":249,"targetDuration":11,"studyType":252,"phases":253,"briefSummary":255,"conditions":256,"keywords":259,"overallStatus":129,"whyStopped":11,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":271,"completionDateStruct":273,"leadSponsor":275,"locationsCount":276},{"fullName":5,"class":6},"Dolnośląskie Centrum Chorób Serca im.prof. Zbigniewa Religi MEDINET Sp. z o.o.","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Prasugrel 10 mg + Low Dose Aspirin 75 mg","EXPERIMENTAL",null,[13],"Drug: DAPT (Low-Dose Aspirin 75 mg + Prasugrel 10 mg)",{"label":15,"type":16,"description":11,"interventionNames":17},"Low-Dose Aspirin 75 mg","ACTIVE_COMPARATOR",[18],"Drug: Low-Dose Aspirin 75 mg",{"label":20,"type":16,"description":11,"interventionNames":21},"High-Dose Aspirin 300 mg",[22],"Drug: High-Dose Aspirin 300 mg",[24,28,32],{"type":25,"name":20,"description":26,"armGroupLabels":27,"otherNames":11},"DRUG","High-dose Aspirin 300 mg once daily taken orally for three months",[20],{"type":25,"name":29,"description":30,"armGroupLabels":31,"otherNames":11},"DAPT (Low-Dose Aspirin 75 mg + Prasugrel 10 mg)","Drug: Prasugrel 10 mg\n\nPrasugrel 10 mg once daily taken orally for 3 months\n\nDrug: Low-Dose Aspirin\n\n75 mg once daily taken orally",[9],{"type":25,"name":15,"description":33,"armGroupLabels":34,"otherNames":11},"Low-Dose Aspirin 75 mg once daily taken orally",[15],[36],{"name":37,"affiliation":38,"role":39},"Sleiman Sebastian Aboul-Hassan, MD, PhD","Zbigniew Religa Heart Center \"Medinet\"","PRINCIPAL_INVESTIGATOR",[41],{"name":42,"role":43,"phone":44,"phoneExt":11,"email":45},"Aleksandra Pawlik","CONTACT","+48 71 320 94 50","badaniakliniczne@medinet.pl",[47,62,73,84,95,106,117,128,138,149,160,171,179,190,199,207,218,225],{"facility":48,"status":49,"city":50,"state":11,"zip":11,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"University Clinical Hospital in Bialystok","NOT_YET_RECRUITING","Bialystok","Poland","PL",{"type":54,"coordinates":55},"Point",[56,57],23.16433,53.13333,{"lat":57,"lon":56},[60],{"name":61,"role":43,"phone":11,"phoneExt":11,"email":11},"Szymon Kocanda, MD, PhD",{"facility":63,"status":49,"city":64,"state":11,"zip":11,"country":51,"countryCode":52,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"Nicolaus Copernicus University Ludwik Rydygier Collegium Medicum in Bydgoszcz","Bydgoszcz",{"type":54,"coordinates":66},[67,68],18.00762,53.1235,{"lat":68,"lon":67},[71],{"name":72,"role":43,"phone":11,"phoneExt":11,"email":11},"Wojciech Pawliszak, MD, PhD",{"facility":74,"status":49,"city":75,"state":11,"zip":11,"country":51,"countryCode":52,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"Medical University of Gdansk","Gdansk",{"type":54,"coordinates":77},[78,79],18.64912,54.35227,{"lat":79,"lon":78},[82],{"name":83,"role":43,"phone":11,"phoneExt":11,"email":11},"Andrzej Los, MD, PhD",{"facility":85,"status":49,"city":86,"state":11,"zip":11,"country":51,"countryCode":52,"cosmosGeoPoint":87,"geoPoint":91,"contacts":92},"Regional Specialist Hospital in Grudziadz","Grudziądz",{"type":54,"coordinates":88},[89,90],18.75366,53.48411,{"lat":90,"lon":89},[93],{"name":94,"role":43,"phone":11,"phoneExt":11,"email":11},"Marian Burysz, MD, PhD",{"facility":96,"status":49,"city":97,"state":11,"zip":11,"country":51,"countryCode":52,"cosmosGeoPoint":98,"geoPoint":102,"contacts":103},"Upper-Silesian Heart Center","Katowice",{"type":54,"coordinates":99},[100,101],19.02173,50.2597,{"lat":101,"lon":100},[104],{"name":105,"role":43,"phone":11,"phoneExt":11,"email":11},"Radoslaw Gocol, MD, PhD",{"facility":107,"status":49,"city":108,"state":11,"zip":11,"country":51,"countryCode":52,"cosmosGeoPoint":109,"geoPoint":113,"contacts":114},"John Paul II Hospital","Krakow",{"type":54,"coordinates":110},[111,112],19.93658,50.06143,{"lat":112,"lon":111},[115],{"name":116,"role":43,"phone":11,"phoneExt":11,"email":11},"Janusz Konstanty-Kalandyk, MD, PhD",{"facility":118,"status":49,"city":119,"state":11,"zip":11,"country":51,"countryCode":52,"cosmosGeoPoint":120,"geoPoint":124,"contacts":125},"Medical University of Lodz","Lodz",{"type":54,"coordinates":121},[122,123],19.47395,51.77058,{"lat":123,"lon":122},[126],{"name":127,"role":43,"phone":11,"phoneExt":11,"email":11},"Michal Krejca, MD, PhD",{"facility":38,"status":129,"city":130,"state":11,"zip":11,"country":51,"countryCode":52,"cosmosGeoPoint":131,"geoPoint":135,"contacts":136},"RECRUITING","Nowa Sól",{"type":54,"coordinates":132},[133,134],15.71702,51.80333,{"lat":134,"lon":133},[137],{"name":37,"role":43,"phone":11,"phoneExt":11,"email":11},{"facility":139,"status":49,"city":140,"state":11,"zip":11,"country":51,"countryCode":52,"cosmosGeoPoint":141,"geoPoint":145,"contacts":146},"Provincial Specialist Hospital in Olsztyn","Olsztyn",{"type":54,"coordinates":142},[143,144],20.49272,53.78376,{"lat":144,"lon":143},[147],{"name":148,"role":43,"phone":11,"phoneExt":11,"email":11},"Anna Witt-Majchrzak, MD, PhD",{"facility":150,"status":49,"city":151,"state":11,"zip":11,"country":51,"countryCode":52,"cosmosGeoPoint":152,"geoPoint":156,"contacts":157},"Institute of Medical Sciences in Opole","Opole",{"type":54,"coordinates":153},[154,155],17.92604,50.67119,{"lat":155,"lon":154},[158],{"name":159,"role":43,"phone":11,"phoneExt":11,"email":11},"Marek Cisowski, MD, PhD",{"facility":161,"status":49,"city":162,"state":11,"zip":11,"country":51,"countryCode":52,"cosmosGeoPoint":163,"geoPoint":167,"contacts":168},"J. Struś Hospital","Poznan",{"type":54,"coordinates":164},[165,166],16.92993,52.40692,{"lat":166,"lon":165},[169],{"name":170,"role":43,"phone":11,"phoneExt":11,"email":11},"Pawel Bugajski, MD, PhD",{"facility":172,"status":49,"city":162,"state":11,"zip":11,"country":51,"countryCode":52,"cosmosGeoPoint":173,"geoPoint":175,"contacts":176},"Poznan University of Medical Sciences",{"type":54,"coordinates":174},[165,166],{"lat":166,"lon":165},[177],{"name":178,"role":43,"phone":11,"phoneExt":11,"email":11},"Bartlomiej Perek, MD, PhD",{"facility":180,"status":49,"city":181,"state":11,"zip":11,"country":51,"countryCode":52,"cosmosGeoPoint":182,"geoPoint":186,"contacts":187},"Pomeranian Medical University","Szczecin",{"type":54,"coordinates":183},[184,185],14.55302,53.42894,{"lat":185,"lon":184},[188],{"name":189,"role":43,"phone":11,"phoneExt":11,"email":11},"Jerzy Pacholewicz, MD, PhD",{"facility":191,"status":192,"city":193,"state":11,"zip":11,"country":51,"countryCode":52,"cosmosGeoPoint":194,"geoPoint":198,"contacts":11},"Central Clinical Hospital of the Ministry of Interior and Administration","ACTIVE_NOT_RECRUITING","Warsaw",{"type":54,"coordinates":195},[196,197],21.01178,52.22977,{"lat":197,"lon":196},{"facility":200,"status":129,"city":193,"state":11,"zip":11,"country":51,"countryCode":52,"cosmosGeoPoint":201,"geoPoint":203,"contacts":204},"Medicover Hospital",{"type":54,"coordinates":202},[196,197],{"lat":197,"lon":196},[205],{"name":206,"role":43,"phone":11,"phoneExt":11,"email":11},"Krzysztof Wrobel, MD, PhD",{"facility":208,"status":49,"city":209,"state":11,"zip":11,"country":51,"countryCode":52,"cosmosGeoPoint":210,"geoPoint":214,"contacts":215},"Wroclaw Medical University","Wroclaw",{"type":54,"coordinates":211},[212,213],17.03006,51.10286,{"lat":213,"lon":212},[216],{"name":217,"role":43,"phone":11,"phoneExt":11,"email":11},"Maciej Bochenek, MD",{"facility":38,"status":129,"city":209,"state":11,"zip":11,"country":51,"countryCode":52,"cosmosGeoPoint":219,"geoPoint":221,"contacts":222},{"type":54,"coordinates":220},[212,213],{"lat":213,"lon":212},[223],{"name":224,"role":43,"phone":11,"phoneExt":11,"email":11},"Mikolaj Berezowski, MD",{"facility":226,"status":192,"city":227,"state":11,"zip":11,"country":51,"countryCode":52,"cosmosGeoPoint":228,"geoPoint":232,"contacts":11},"Silesian Centre for Heart Diseases in Zabrze","Zabrze",{"type":54,"coordinates":229},[230,231],18.78576,50.32492,{"lat":231,"lon":230},{"type":39,"investigatorFullName":234,"investigatorTitle":235,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Sleiman Sebastian Aboul-Hassan","Principal Investigator: Sleiman Sebastian Aboul-Hassan MD, PhD",[237],{"name":238,"class":239},"Medical Research Agency, Poland","OTHER_GOV","100607945","phase-3-comparing-high-and-low-dose-aspirin-with-dual-antiplatelet-therapy-for-three-months-using-prasugrel-and-aspirin-following-coronary-artery-bypass-grafting-optimus-cabg-trial-100607945",false,"NCT07195149","Comparing High and lOw-dose asPirin With Dual anTIplatelet Therapy for Three Months Using prasUgrel and aSpirin Following Coronary Artery Bypass Grafting. (OPTIMUS-CABG Trial)","OPTIMUS-CABG","Inclusion Criteria:\n\nA. Baseline (preoperative) inclusion criteria\n\n1. Age \\>18 years\n2. Primary isolated CABG patients with stable coronary artery disease (chronic coronary syndrome) planned for at least 2 grafts. Coronary artery disease will be defined as a stenosis ≥ 70% based on coronary angiography, a FFR value ≤ 0.80 or iFr value ≤0.89; a left main diameter stenosis ≥ 50%, left main IVUS MLA value ≤ 6 mm2, or equivalent OCT measurements will also be considered.\n3. Ability to comply with all study procedures and follow-up procedures\n4. Signed Informed Consent to participate in the study.\n\nB. Operative inclusion criteria:\n\n1. Intraoperative graft evaluation using transit time flow measurement in all grafts, normal flow in any graft is defined as mean graft flow \\> 15 mL\u002Fmin with Pulsatility Index \\\u003C 5\n2. Left anterior descending artery grafted with internal thoracic artery\n3. No intraoperative decision for hybrid revascularization due to incomplete revascularization (Percutaneous coronary intervention (PCI) of the ungrafted vessel)\n4. No endarterectomy of the grafted vessel performed\n5. Patient did not have any additional unplanned procedure (Ex. LAAC, Ablation, valve intervention, aortic intervention)\n\nExclusion Criteria:\n\nA. Baseline (preoperative) exclusion criteria:\n\n1. Cardiogenic shock\n2. Patients with recent acute coronary syndrome (ACS) (\\\u003C12 months)\n3. Single vessel CABG\n4. Patients with preoperative atrial fibrillation\n5. Dialysis\n6. Thrombocytopenia (platelet count \\\u003C 100 000 platelets\u002FuL)\n7. Anemia (Hemoglobin level \\\u003C 10 g\u002FdL)\n8. Severe liver failure Child-Pugh classification \\>4\n9. Known, active infections with HIV, HBV, HCV, tuberculosis\n10. Active malignant disease or history of malignancy within the past 5 years\n11. Indication for DAPT (e.g. recent PCI or ACS or recent stents of peripheral arteries)\n12. Indication for oral anticoagulant treatment 13 Indications for the use of methotrexate at a dose of 15 mg\u002Fweek or more\n\n14\\. Any contraindication for prasugrel or ASA 15. Planned additional cardiac or non-cardiac surgery within 12 months 16. Non-cardiac co-morbidity with life expectancy less than 12 months 17. History of any bleeding complications due to the use of DAPT 18. History of intracranial bleeding 19. History of gastro-intestinal bleeding 20. Pregnancy or breastfeeding 21. Lack of compliance with the use of a highly effective method of birth control 22. Planned coronary endarterectomy 23. Severe impaired renal function (eGFR \\\u003C40mL\u002Fmin\u002F1.73 m2).\n\nB. Postoperative and prior randomization exclusion criteria:\n\n1. Perioperative cardiogenic shock\n2. Intraoperative death or death prior randomization\n3. Myocardial infarction within 12-24 hours following CABG or prior randomization\n4. Ischemic or hemorrhagic stroke within 12-24 hours following CABG or prior randomization\n5. Any postoperative complication that may increase patients' risk with DAPT\n6. Atrial Fibrillation prior randomization\n7. Gastro-intestinal bleeding prior randomization","ALL","18 Years",{"count":250,"type":251},1703,"ESTIMATED","INTERVENTIONAL",[254],"PHASE3","The purpose of this study is to compare the effect of prasugrel plus low-dose aspirin versus high dose aspirin alone (300mg) and versus low dose aspirin alone (75 mg) in patients with chronic coronary disease undergoing coronary artery bypass grafting.",[257,258],"Chronic Coronary Syndrome","Stable Coronary Artery Disease CAD",[260,261,262,263,264,265,266],"DAPT","CABG","Prasugrel","Aspirin","CCS","Chronic coronary syndrome","Stable coronary artery disease","2026-06-04",{"date":269,"type":270},"2026-06-05","ACTUAL",{"date":272,"type":270},"2025-11-25",{"date":274,"type":251},"2030-11-30",{"name":5,"class":6},18]