[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100588893":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":33,"centralContacts":33,"locations":34,"responsibleParty":65,"collaborators":33,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":71,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":33,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":37,"whyStopped":33,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Ain Shams University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Unilateral Erector Spinae group","ACTIVE_COMPARATOR","-The patient will be turned to the lateral decubitus position and the surgical side superiorly. After proper sterilization; The linear probe will be put in a parasagittal plane over the transverse process of thoracic 4 or thoracic 5 vertebrae, approximately 2.5 cm lateral to the spinous processes. The transverse process has a square form contour as compared to the rib which is rounded form contour. Then the 3 muscle layers or sheets with facial plane are distinguished from superficial to deep as trapezius, rhomboid major, and erector spinae with flickering pleura in between the transverse processes. The block will be managed unilaterally by in-plane technique using 22-gauge, 50 mm, echogenic needle which will be inserted in a cranial-caudal orientation and the block needle will be proceeded through the trapezius, rhomboid major, and erector spinae to smoothly contact the transverse process. Needle location will be confirmed by hydro-dissection on injecting 2-3 ml normal saline.",[13],"Procedure: Unilateral Erector Spinae group",{"label":15,"type":10,"description":16,"interventionNames":17},"Unilateral Serratus Anterior group","-After skin sterilization, with the patient in the lateral decubitus position and the side of surgery superiorly, the ultrasound linear probe will be put longitudinally oblique just below the mid-clavicle. After distinguish the second rib, the probe will be mobilized caudally and laterally (obliquely), towards the mid-axillary line to distinguish the third, fourth and fifth ribs. The ideal and definite probe position has its cephalad end at the anterior axillary line and the caudal end at the posterior axillary line. The facial plane between the serratus anterior muscle and ribs four and five will be identified between the 4th and 5th rib in the mid-axillary region. Under sonar guided, 50 mm echogenic needle will be advanced in-plane to introduce this facial plane in cranio-caudal direction.",[18],"Procedure: Unilateral Serratus Anterior group",[20,27],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"PROCEDURE","On injecting 30 ml of bupivacaine 0.25% with 20 mcg Dexamedetomidine into the interfacial plane below erector spinae; a manifest linear pattern will be visualized uplifting the muscle.",[9],[25,26],"Peripheral Nerve Block using Precedex","Erector Spinae block with Precedex as an adjuvant drug",{"type":21,"name":15,"description":28,"armGroupLabels":29,"otherNames":30},"Once the needle will be in perfect position, confirmed by hydro-dissection on injecting 2-3 ml of normal saline, then 30 ml of bupivacaine 0.25% with 20 mcg Dexamedetomidine.",[15],[31,32],"Peripheral Nerve Block using dexmedetomidine","Serratus Anterior Block with dexmedetomidine as an adjuvant drug",null,[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Faculty of Medicine, Ain-Shams University","RECRUITING","Cairo","Waili","0000","Egypt","EG",{"type":44,"coordinates":45},"Point",[46,47],31.24967,30.06263,{"lat":47,"lon":46},[50,55,58,61,63],{"name":51,"role":52,"phone":53,"phoneExt":33,"email":54},"Kholoud Usama Soliman, Master degree","CONTACT","+20 01285303039","kholoud.usama@med.asu.edu.eg",{"name":56,"role":57,"phone":33,"phoneExt":33,"email":33},"Amir Ibrahim Mohamed Salah, Doctorate degree, Professor","PRINCIPAL_INVESTIGATOR",{"name":59,"role":60,"phone":33,"phoneExt":33,"email":33},"Randa Ali Shoukry Mohamed, Doctorate degree, Professor","SUB_INVESTIGATOR",{"name":62,"role":60,"phone":33,"phoneExt":33,"email":33},"Sanaa Mohamed Mohamed Elfawal, Doctorate degree, Professor",{"name":64,"role":60,"phone":33,"phoneExt":33,"email":33},"Mohamed Ibrahim Ibrahim Sobhy, Doctorate degree, Lecturer",{"type":66,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"SPONSOR_INVESTIGATOR","Kholoud Usama","Assistant Lecturer","100588893","phase-3-comparison-between-erector-spinae-plane-block-versus-serratus-anterior-plane-block-regarding-analgesia-post-modified-radical-mastectomy-100588893",false,"NCT06947330","Comparison Between Erector Spinae Plane Block Versus Serratus Anterior Plane Block Regarding Analgesia Post Modified Radical Mastectomy","Comparison Between Ultrasound Guided Erector Spinae Plane Block Versus Ultrasound Guided Serratus Anterior Plane Block Regarding Analgesia Post Modified Radical Mastectomy","FMASUMD66\u002F2025","Inclusion Criteria:\n\n* ASA Physical Status II, or III.\n* Age 21 - 65 years.\n* Female gender\n\nExclusion Criteria:\n\n* ASA IV, V, VI.\n* Infection at site of block.\n* Coagulopathy, or patients on antiplatelets, or anticoagulants.\n* Previous anesthetic allergy to bupivacaine.\n* Distant organ metastasis.\n* Male gender.","FEMALE","21 Years","65 Years",{"count":81,"type":82},100,"ESTIMATED","INTERVENTIONAL",[85],"PHASE3","The goal of this clinical trial is to compare Ultrasound Guided Erector Spinae and Ultrasound Guided Serratus Anterior Plane Block post Modified Radical Mastectomy in adult females. the main questions it aims to answer are:\n\n* Which of the two blocks has a better analgesic effect?\n* Which of the two blocks is safer as regards inducing a pneumothorax and affecting the hemodynamics?\n\nParticipants:\n\n* Will be divided into two groups after signing the informed consent.\n* After being anesthetized and before surgical incision; the blocks will be given to the patient.\n* Lung Ultrasound will be done for each patient to rule out pnemothorax once before the surgery and another after the end of surgery while the patient is being anesthetized.\n* Patients that will experience pneuomothorax will be excluded from the study, and will be treated according to its size.\n* Follow up of the patient for 24 hours postoperative to record the VAS score continuously, with giving increments of pethidine intravenously to relief pain.",[88,89],"Modified Radical Mastectomy","Breast Cancer",[89,88,91,92,93,94,95,96],"Peripheral Nerve Block","Dexmedetomidine","Erector Spinae Plane Block","Serratus Anterior Plane Block","Ultrasound Guided","Adult Female","2025-04-20",{"date":99,"type":100},"2025-04-27","ACTUAL",{"date":102,"type":100},"2025-03-03",{"date":104,"type":82},"2026-03-04",{"name":67,"class":6},1]