[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100574396":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":41,"responsibleParty":55,"collaborators":26,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":63,"acronym":26,"eligibilityCriteria":64,"healthyVolunteers":61,"sex":65,"minAge":66,"maxAge":26,"enrollmentInfo":67,"targetDuration":26,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":82,"whyStopped":26,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Services Institute of Medical Sciences, Pakistan","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A","ACTIVE_COMPARATOR","The Group A will undergo curcumin treatment for oral submucous Fibrosis. In Group A curcumin capsule (500 mg) will be given two per day. Patient will receive 1000 mg curcumin per day and will be assessed month on month basis for three months.",[13],"Drug: Curcumin (Turmeric)",{"label":15,"type":16,"description":17,"interventionNames":18},"Group B","EXPERIMENTAL","The Group B will undergo Intralesional Steroids treatment in oral submucous fibrosis. In Group B Intralesional Steroid Injection will be administered weekly and assessed on monthly basis for three months.",[19],"Drug: Intralesional Steroid Injection",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Curcumin (Turmeric)","Curcumin Capsule will be given two per day for three months. Patient Recovery progress will be monitored month on month basis for consecutive three month.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Intralesional Steroid Injection","Intralesional Steroid Injection (1cc), one per week, will be administered in the fibrous bands wherever formed in the oral cavity. Patient recovery progress will be monitored on monthly basis for three months.",[15],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Hafiza Sara Adrees, BDS","CONTACT","+92 307 3002818","saramidrees113@gmail.com",{"name":38,"role":34,"phone":39,"phoneExt":26,"email":40},"Hafiz Aamer Iqbal, BDS FCPS OMFS","+92 333 4955789","haafiz.amer.iqbal@gmail.com",[42],{"facility":43,"status":26,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":26},"Services Institute of Medical Sciences","Lahore","Punjab Province","5400","Pakistan","PK",{"type":50,"coordinates":51},"Point",[52,53],74.35071,31.558,{"lat":53,"lon":52},{"type":56,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Hafiza Sara Adrees","Post Graduate Resident OMFS","100574396","phase-3-comparison-of-curcumin-and-intralesional-steroids-in-oral-submucous-fibrosis-100574396",false,"NCT06758739","Comparison of Curcumin and Intralesional Steroids in Oral Submucous Fibrosis","Inclusion Criteria:\n\n* Patients diagnosed with Oral submucous fibrosis in accordance with operational definition.\n* Male \\& Female\n\nExclusion Criteria:\n\n* Patient unable to quit the habit of gutkha, tobacco \\& betel nut chewing\n* Patient With uncontrolled diabetes\n* Patient with chronic kidney disease\n* Pregnant female\n* Patient with untreated malignancy\u002Ftaking immunosuppressant drugs\n* Patient with H\u002FO ORAL SUBMUCOUS FIBROSIS in last months","ALL","18 Years",{"count":68,"type":69},70,"ESTIMATED","INTERVENTIONAL",[72],"PHASE3","The goal of this clinical trial is to learn if Curcumin is better than Intralesional Steroid Injection for the treatment of oral submucous fibrosis. The main question it aims to answers are:\n\n1. If Curcumin is more effective to improve burning sensation as compared to Intralesional steroid.\n2. Does Curcumin treatment results in better mouth opening versus Intralesional steroid.\n3. Can Curcumin helps to improve tongue protrusion as compared to Intralesional steroids.\n\nParticipants will be:\n\n* Assessed for one month, two month and three month.\n* Burning Sensation will be assessed with visual analogue scale (VAS).\n* Mouth Opening will be measured in mm with ruler.\n* Tongue Protrusion will be assessed with the visual analogue scale (VAS).",[75],"Oral Submucous Fibrosis",[77,75,78,79,80,81],"Potentially Malignant Disorder","Intralesional Steroids","Curcumin","Anti-Inflammatory","Anti-Fibrotic","NOT_YET_RECRUITING","2025-03-05",{"date":85,"type":86},"2025-03-06","ACTUAL",{"date":88,"type":69},"2025-04",{"date":90,"type":69},"2025-10",{"name":5,"class":6},1]