[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642072":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":30,"locations":25,"responsibleParty":40,"collaborators":25,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":25,"eligibilityCriteria":50,"healthyVolunteers":46,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":25,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":25,"overallStatus":63,"whyStopped":25,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":25},{"fullName":5,"class":6},"University of Child Health Sciences and Children's Hospital, Lahore","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"melatonin along with Mgso4 infusion","EXPERIMENTAL","five doses of melatonin (10mg\u002Fkg daily enteral for 5days) along with Three doses of MgSO4 infusion at the rate of 250mg\u002Fkg per day intravenous over 1 hour on days 0, 1, and 2",[13],"Drug: Melatonin , Mgso4",{"label":15,"type":16,"description":17,"interventionNames":18},"Mgso4 alone","ACTIVE_COMPARATOR","Three doses of MgSO4 infusion at the rate of 250mg\u002Fkg per day intravenous over 1 hour on days 0, 1, and 2",[19],"Drug: MgSO4 (seizure prevention)",[21,26],{"type":22,"name":23,"description":17,"armGroupLabels":24,"otherNames":25},"DRUG","MgSO4 (seizure prevention)",[15],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Melatonin , Mgso4","Five doses of melatonin along with three doses of MgSO4 infusion at the rate of 250mg\u002Fkg per day intravenous over 1 hour on days 0, 1, and 2",[9],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"dr akasha rehman rehman, MD Pedatrics","CONTACT","923041867246","akasharehman55@gmail.com",{"name":37,"role":33,"phone":38,"phoneExt":25,"email":39},"alia ahmed, FCPS,MRCPCH,FRCPCH","923344081996","alia_ahmad99@yahoo.com",{"type":41,"investigatorFullName":42,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Akasha Rehman","DOCTOR","100642072","phase-3-comparison-of-outcome-of-hypoxic-ischemic-encephlopathy-managed-with-combination-of-magnesium-sulphate-and-melatonin-versus-magnesium-sulphate-alone-100642072",false,"NCT07652801","COMPARISON OF OUTCOME OF HYPOXIC ISCHEMIC ENCEPHLOPATHY MANAGED WITH COMBINATION OF MAGNESIUM SULPHATE AND MELATONIN VERSUS MAGNESIUM SULPHATE ALONE","COMPARISON OF OUTCOME OF HYPOXIC ENCEPHLOPATHY MANAGED WITH MgSO4 AND MELATONIN VERSUS MgSO4 ALONE","Inclusion Criteria:\n\n* Both genders\n* Born at term i.e \\>37weeks gestation\n* With APGAR score\\\u003C5 at 1min\n* Umblical artery acidemia(PH\\\u003C7 or base deficit\\>12mmol\u002FL\n* Evidence of atleast moderate grade ofHIE on sarnat scoring.\n\nExclusion Criteria:\n\n* With congenital anamolies\n* Intrauterine growth retadation\n* suspicion of neonatal sepsis\n* Congenital heart disese and those with IEM.","ALL","1 Hour","28 Days",{"count":55,"type":56},80,"ESTIMATED","INTERVENTIONAL",[59],"PHASE3","COMPARISON OF OUTCOME OF HYPOXIC ISCHEMIC ENCEPHALOPATHY MANAGED WITH COMBINATION OF MAGNESIUM SULPHATE AND MELATONIN VERSUS MAGNESIUM SULPHATE ALONE Participants of group A will have 3 doses of MgSO4 infusion at rate of 250mg\u002Fkg per day intravenous over 1hour on day 0,1,2 Participants of group B will have 5 doses of Melatonin 10mg\u002Fkg for 5days along with MgSO4. They will undergo reassessment of arterial PH and serum LDH after completion of therapy. They will be followed for length of hospital stay and time until feed is initiated.",[62],"HIE - Hypoxic - Ischemic Encephalopathy","NOT_YET_RECRUITING","2026-06-11",{"date":66,"type":67},"2026-06-17","ACTUAL",{"date":69,"type":56},"2026-07-01",{"date":71,"type":56},"2026-12-31",{"name":5,"class":6}]