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EAP regimen is the etoposide, cytarabine, and PEG-rhG-CSF combination therapy.",[13,14,15,16],"Drug: Etoposide","Drug: Cytarabine","Drug: PEG-rhG-CSF","Drug: G-CSF",{"label":18,"type":19,"description":20,"interventionNames":21},"Disease-specific chemotherapy mobilization regimens group","ACTIVE_COMPARATOR","33 subjects will be enrolled into the disease-specific chemotherapy mobilization regimens group. The disease-specific chemotherapy mobilization regimens include but not limited to: CHOP, Hyper-CVAD, ID-MTX+Ara-C.",[22,23,24,25,26,27,28,29,16],"Combination Product: CHOP","Combination Product: Hyper-CVAD","Combination Product: ID-MTX + Ara-C","Combination Product: DA-EPOCH","Combination Product: GDP","Combination Product: GDPE","Combination Product: ICE","Combination Product: DICE",[31,38,44,49,53,58,62,66,70,74,78,82,86],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"DRUG","Etoposide","Day 1\\~Day 2: 75mg\u002Fm\\^2",[9],[37],"VP-16",{"type":32,"name":39,"description":40,"armGroupLabels":41,"otherNames":42},"Cytarabine","Day 1\\~Day 2: 200g\u002Fm\\^2, q12h",[9],[43],"Ara-C",{"type":32,"name":45,"description":46,"armGroupLabels":47,"otherNames":48},"PEG-rhG-CSF","Day 6: 6mg",[9],null,{"type":32,"name":50,"description":51,"armGroupLabels":52,"otherNames":48},"G-CSF","Starting from the 9th day, if the white blood cell count is less than 20,000\u002FμL, 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Zhou","13738368586","Zhousj320@163.com",{"type":309,"investigatorFullName":48,"investigatorTitle":48,"investigatorAffiliation":48,"oldNameTitle":48,"oldOrganization":48},"SPONSOR",[311,314,316,318,319,321,322,323,325,327,328,330,332,334,335],{"name":312,"class":313},"First Affiliated Hospital of Zhejiang University","OTHER",{"name":315,"class":313},"First Affiliated Hospital of Wenzhou Medical University",{"name":317,"class":313},"Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University",{"name":195,"class":313},{"name":320,"class":313},"The Central Hospital of Lishui City",{"name":240,"class":313},{"name":253,"class":313},{"name":324,"class":313},"Zhejiang Provincial Tongde Hospital",{"name":326,"class":313},"Taizhou Hospital",{"name":104,"class":313},{"name":329,"class":313},"Affiliated Hospital of Jiaxing University",{"name":331,"class":313},"Huzhou Central Hospital",{"name":333,"class":313},"Second Affiliated Hospital of Wenzhou Medical University",{"name":218,"class":6},{"name":182,"class":313},"100556059","phase-3-comparison-study-of-eap-and-disease-specific-chemotherapy-regimens-in-hematopoietic-stem-cell-mobilization-for-lymphoma-100556059",false,"NCT06520163","Comparison Study of EAP and Disease-Specific Chemotherapy Regimens in Hematopoietic Stem Cell Mobilization for Lymphoma","A Prospective, Multicenter, Randomized Controlled Trial Comparing the Efficacy and Safety of Etoposide, Cytarabine, and PEG-rhG-CSF Combination Therapy vs. Disease-Specific Chemotherapy for Hematopoietic Stem Cell Mobilization in Lymphoma","Inclusion Criteria:\n\n* Diagnosed with non-Hodgkin's lymphoma before enrollment.\n* Indication for autologous stem cell transplantation (ASCT).\n* Eastern Cooperative Oncology Group (ECOG) performance status of 0\\~1.\n* Achieved complete remission after multiple courses of chemotherapy.\n* Life expectancy ≥ 3 months.\n* Subjects must be able to understand the protocol and sign the informed consent.\n\nExclusion Criteria:\n\n* Cardiac function class II or higher or cardiac ejection fraction \\\u003C 40%.\n* Serum direct bilirubin (DBIL) more than twice of the upper limit of normal (ULN).\n* Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) more than three times the upper limit of normal (ULN).\n* Serum creatinine clearance rate ≤ 50%.\n* Patients with active infection.\n* History of prior hematopoietic stem cell mobilization.","ALL","18 Years","75 Years",{"count":347,"type":348},99,"ESTIMATED","INTERVENTIONAL",[351],"PHASE3","This study utilizes a prospective, multicenter, randomized two-arm design to evaluate the efficacy and safety of the etoposide, cytarabine, and pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) combination therapy (EAP regimen) in mobilizing hematopoietic stem cells in patients with non-Hodgkin's lymphoma (NHL). A total of 99 NHL patients will be enrolled as research subjects and will be randomly allocated in a 2:1 ratio to compare the EAP regimen versus disease-specific chemotherapy mobilization regimen. The primary endpoint is the proportion of patients achieving the ideal collection value after a single collection (CD34+ cells ≥5×10\\^6\u002Fkg).",[354,355],"Non-Hodgkin's Lymphoma","Hematopoietic Stem Cell Mobilization",[354,357,358,359],"Disease-Specific Chemotherapy","Hematopoietic stem cell mobilization","Etoposide, Cytarabine Combined with PEG-rhG-CSF","2025-11-27",{"date":362,"type":363},"2025-12-04","ACTUAL",{"date":365,"type":363},"2024-08-01",{"date":367,"type":348},"2026-08",{"name":5,"class":6},17]