[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100585813":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":30,"locations":41,"responsibleParty":60,"collaborators":26,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":26,"enrollmentInfo":71,"targetDuration":26,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":82,"overallStatus":86,"whyStopped":26,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Ottawa Heart Institute Research Corporation","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Interventional","EXPERIMENTAL","Participants will receive 10mg dapagliflozin orally for 12 months",[13],"Drug: Dapagliflozin (DAPA)",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Participants will receive a placebo once daily for 12 months.",[19],"Drug: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Dapagliflozin (DAPA)","Dapagliflozin 10mg orally once a day for 12 months",[9],null,{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":26},"Participants will receive a matching placebo taken once daily by mouth for 12 months.",[15],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":26,"email":35},"Poppy Dr. Ian Paterson","CONTACT","1-613-696-7000","dpaterson@ottawaheart.ca",{"name":37,"role":33,"phone":38,"phoneExt":39,"email":40},"Poppy MacPhee","6136967000","14646","pmacphee@ottawaheart.ca",[42],{"facility":43,"status":26,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"University of Ottawa Heart Institute","Ottawa","Ontario","K1Y 4W7","Canada","CA",{"type":50,"coordinates":51},"Point",[52,53],-75.69812,45.41117,{"lat":53,"lon":52},[56,57],{"name":37,"role":33,"phone":38,"phoneExt":39,"email":40},{"name":58,"role":59,"phone":26,"phoneExt":26,"email":26},"Ian Paterson","PRINCIPAL_INVESTIGATOR",{"type":61,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100585813","phase-3-dapagliflozin-for-long-covid-syndrome-100585813",false,"NCT06907251","Dapagliflozin for Long COVID Syndrome","DALCO","Inclusion Criteria:\n\n* 18 years of age or older and willing and able to provide informed consent\n* Patients with a history of positive COVID-19 test (polymerase chain reaction or rapid test) or have been diagnosed with COVID-19 by a health care provider.\n* New or persistent symptoms at least 12 weeks from infection and present for at least 8 weeks that is not explained by an alternative diagnosis (64).\n* Women of childbearing potential (WOCBP) who, if sexually active, are willing to use to use at least one highly effective methods of contraception throughout the study.\n\nExclusion Criteria:\n\n* History of diabetes\n* Prior heart failure\n* Weight loss treatment with glucagon-like peptide-1 receptor agonists (e.g. liraglutide, semaglutide)\n* Pregnancy or planned pregnancy in the next 12 months. We will ask WOCBP about the possibility of pregnancy at the time of screening and if so, then pregnancy testing will be offered. If testing is declined in this instance, then they will be excluded from the study.\n* Women who are breastfeeding\n* Severe renal impairment (eGFR\\\u003C30mL\u002Fmin1.73m2)\n* Known history of allergy or hypersensitivity to dapagliflozin\n\nExclusion for optional MRI portion of the protocol:\n\n\\- Any contraindication to MRI","ALL","18 Years",{"count":72,"type":73},192,"ESTIMATED","INTERVENTIONAL",[76],"PHASE3","This is a randomized, placebo-controlled study. Patients with long COVID will be randomized to receive dapagliflozin or placebo for 12 months.",[79,80,81],"COVID - 19","Long COVID Syndrome","SARS CoV-2",[83,84,85],"Covid-19","Long Covid syndrome","sars cov-2","NOT_YET_RECRUITING","2026-06-30",{"date":89,"type":90},"2026-07-01","ACTUAL",{"date":92,"type":73},"2026-09-01",{"date":94,"type":73},"2029-06-30",{"name":5,"class":6},1]