[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601917":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":40,"responsibleParty":230,"collaborators":26,"id":233,"slug":234,"hasResults":235,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":239,"eligibilityCriteria":240,"healthyVolunteers":235,"sex":241,"minAge":242,"maxAge":26,"enrollmentInfo":243,"targetDuration":26,"studyType":246,"phases":247,"briefSummary":249,"conditions":250,"keywords":253,"overallStatus":139,"whyStopped":26,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":258,"startDateStruct":261,"completionDateStruct":263,"leadSponsor":265,"locationsCount":266},{"fullName":5,"class":6},"Xijing Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Desflurane group","EXPERIMENTAL","After routine induction, anesthesia is maintained with inhaled desflurane, with the concentration adjusted as needed to maintain 0.5-2 MAC .Propofol is not used to maintain anesthesia during the whole anesthesia maintenance process, except during cardiopulmonary bypass.",[13],"Drug: Desflurane group",{"label":15,"type":16,"description":17,"interventionNames":18},"Propofol group","ACTIVE_COMPARATOR","3-8 mg\u002Fkg\u002Fh intravenous infusion of propofol to implement total intravenous anesthesia maintenance, without the use of any inhaled anesthetic drugs, can be maintained by intravenous targeted infusion or manual adjustment of intravenous infusion.",[19],"Drug: Propofol group",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Desflurane group","After routine induction, maintain anesthesia with inhaled desflurane , adjusting concentration as needed to sustain 0.5-2 MAC . To maximize the cardioprotective effects of inhaled anesthetics, adhere to this intraoperative strategy:\n\nMaintain ≥1 MAC continuous desflurane for ≥30 minutes ; For on-pump CABG , discontinue desflurane 15 minutes before initiating cardiopulmonary bypass (CPB) ;\n\nIf intraoperative desflurane cessation is required, implement a wash-in\u002Fwash-out strategy (recommended but non-mandatory):\n\nPerform 3 alternating cycles of:\n\nWash-in : ≥10 minutes of desflurane at ≥0.5 MAC, Wash-out : ≥10 minutes of complete cessation of inhaled anesthetics. Propofol is strictly prohibited for anesthesia maintenance throughout the procedure , except during CPB.",[9],null,{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":26},"Administer total intravenous anesthesia (TIVA) using propofol infusion at 3-8 mg\u002Fkg\u002Fh . No inhaled anesthetics are permitted for maintenance. This may be delivered via:target-controlled infusion (TCI) systems, or manual adjustment of intravenous infusion rates.",[15],[31],{"name":32,"affiliation":5,"role":33},"Chong Lei, M.D., phd","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":26,"email":39},"Chong Lei, M.D.& phd","CONTACT","18629011362","crystalleichong@126.com",[41,59,73,86,96,110,124,138,152,166,180,194,207,220],{"facility":42,"status":43,"city":44,"state":45,"zip":26,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Fuzhou University Affiliated Provincial Hospital","NOT_YET_RECRUITING","Fuzhou","Fujian","China","CN",{"type":49,"coordinates":50},"Point",[51,52],119.30611,26.06139,{"lat":52,"lon":51},[55],{"name":56,"role":37,"phone":57,"phoneExt":26,"email":58},"Lihua LEI, M.D.","86-13705045270","mzkleilihua@163.com",{"facility":60,"status":43,"city":61,"state":62,"zip":26,"country":46,"countryCode":47,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"Cangzhou People's Hospital","Cangzhou","Hebei",{"type":49,"coordinates":64},[65,66],116.85334,38.31124,{"lat":66,"lon":65},[69],{"name":70,"role":37,"phone":71,"phoneExt":26,"email":72},"Airong Zhang, M.D.","86-13582711769","Zhangairong66@sohu.com",{"facility":74,"status":43,"city":75,"state":62,"zip":26,"country":46,"countryCode":47,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"Hebei General Hospital","Shijiazhuang",{"type":49,"coordinates":77},[78,79],114.47861,38.04139,{"lat":79,"lon":78},[82],{"name":83,"role":37,"phone":84,"phoneExt":26,"email":85},"Jianli Li, M.D.","86-13785118676","hblijianli@163.com",{"facility":87,"status":43,"city":75,"state":62,"zip":26,"country":46,"countryCode":47,"cosmosGeoPoint":88,"geoPoint":90,"contacts":91},"The First Hospital of Hebei Medical University",{"type":49,"coordinates":89},[78,79],{"lat":79,"lon":78},[92],{"name":93,"role":37,"phone":94,"phoneExt":26,"email":95},"Li Wang, M.D.","86-13933170139","lw79812@163.com",{"facility":97,"status":43,"city":98,"state":99,"zip":26,"country":46,"countryCode":47,"cosmosGeoPoint":100,"geoPoint":104,"contacts":105},"The First Affiliated Hospital of Zhengzhou University","Zhengzhou","Henan",{"type":49,"coordinates":101},[102,103],113.64861,34.75778,{"lat":103,"lon":102},[106],{"name":107,"role":37,"phone":108,"phoneExt":26,"email":109},"Bin Li, M.D.","86-13676964593","li6121@163.com",{"facility":111,"status":43,"city":112,"state":113,"zip":26,"country":46,"countryCode":47,"cosmosGeoPoint":114,"geoPoint":118,"contacts":119},"Wuhan Asia Heart Hospital","Wuhan","Hubei",{"type":49,"coordinates":115},[116,117],114.26667,30.58333,{"lat":117,"lon":116},[120],{"name":121,"role":37,"phone":122,"phoneExt":26,"email":123},"Weiqin Huang, M.D.","86-13986115788","hwq2010@139.com",{"facility":125,"status":43,"city":126,"state":127,"zip":26,"country":46,"countryCode":47,"cosmosGeoPoint":128,"geoPoint":132,"contacts":133},"Jiangsu Province Hospital","Nanjin","Jiangsu",{"type":49,"coordinates":129},[130,131],121.74055,31.75772,{"lat":131,"lon":130},[134],{"name":135,"role":37,"phone":136,"phoneExt":26,"email":137},"Yu Chen, M.D.","86-1351033928","chenyu020219@163.com",{"facility":5,"status":139,"city":140,"state":141,"zip":142,"country":46,"countryCode":47,"cosmosGeoPoint":143,"geoPoint":147,"contacts":148},"RECRUITING","Xi'an","Shaanxi","710032",{"type":49,"coordinates":144},[145,146],108.92861,34.25833,{"lat":146,"lon":145},[149],{"name":150,"role":37,"phone":151,"phoneExt":26,"email":39},"Chong Lei, M.D. & phD","86-18629011362",{"facility":153,"status":43,"city":154,"state":155,"zip":26,"country":46,"countryCode":47,"cosmosGeoPoint":156,"geoPoint":160,"contacts":161},"Sichuan Provincial People's Hospital","Chengdu","Sichuan",{"type":49,"coordinates":157},[158,159],104.06667,30.66667,{"lat":159,"lon":158},[162],{"name":163,"role":37,"phone":164,"phoneExt":26,"email":165},"Qian LEI, M.D.","86-17744339891","leiqianggh@163.com",{"facility":167,"status":139,"city":168,"state":169,"zip":26,"country":46,"countryCode":47,"cosmosGeoPoint":170,"geoPoint":174,"contacts":175},"Tianjin Chest Hospital","Tianjin","Tianjin Municipality",{"type":49,"coordinates":171},[172,173],117.17667,39.14222,{"lat":173,"lon":172},[176],{"name":177,"role":37,"phone":178,"phoneExt":26,"email":179},"Jiange Han, M.D.","+86-13821001156","hanjiange@163.com",{"facility":181,"status":43,"city":182,"state":183,"zip":26,"country":46,"countryCode":47,"cosmosGeoPoint":184,"geoPoint":188,"contacts":189},"Ningbo No.2 Hospital","Ningbo","Zhejiang",{"type":49,"coordinates":185},[186,187],121.54945,29.87819,{"lat":187,"lon":186},[190],{"name":191,"role":37,"phone":192,"phoneExt":26,"email":193},"Junpin Chen, M.D.","86-13858222873","13858222873@163.com",{"facility":195,"status":43,"city":196,"state":26,"zip":26,"country":46,"countryCode":47,"cosmosGeoPoint":197,"geoPoint":201,"contacts":202},"Daping Hospital, Army Medical University","Chongqing",{"type":49,"coordinates":198},[199,200],106.55771,29.56026,{"lat":200,"lon":199},[203],{"name":204,"role":37,"phone":205,"phoneExt":26,"email":206},"Qingxiang MAO, M.D.","86-13594054231","qxmao@tmmu.edu.cn",{"facility":208,"status":139,"city":209,"state":26,"zip":26,"country":46,"countryCode":47,"cosmosGeoPoint":210,"geoPoint":214,"contacts":215},"Changhai Hospital","Shanghai",{"type":49,"coordinates":211},[212,213],121.45806,31.22222,{"lat":213,"lon":212},[216],{"name":217,"role":37,"phone":218,"phoneExt":26,"email":219},"Rui BAO, M.D.","86-13816947847","baorui_md@163.com",{"facility":221,"status":43,"city":209,"state":26,"zip":26,"country":46,"countryCode":47,"cosmosGeoPoint":222,"geoPoint":224,"contacts":225},"Zhongshan Hospital, Fudan University",{"type":49,"coordinates":223},[212,213],{"lat":213,"lon":212},[226],{"name":227,"role":37,"phone":228,"phoneExt":26,"email":229},"Kefang Guo, M.D.","86-13817706936","dr_guokefang@163.com",{"type":33,"investigatorFullName":231,"investigatorTitle":232,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Chong Lei, MD & phD","Principal investigator, Chief of Anesthesia Clinical Research Center, Xijing Hospitall","100601917","phase-3-desflurane-vs-propofol-for-cardiac-anesthesia-100601917",false,"NCT07116733","Desflurane vs. Propofol for Cardiac Anesthesia","Desflurane vs. Propofol for Cardiac Anesthesia: Impact on Developing Major Cardiac Events in Patients Undergoing CABG Procedure","DECIDE-CABG","Inclusion Criteria:\n\n1. Patients scheduled for elective coronary artery bypass grafting (CABG)\n2. Age ≥ 18 years old;\n3. Sign the informed consent form.\n\nExclusion Criteria:\n\n1. Emergency or urgent operation\n2. Concomitant valve or aortic surgery\n3. History of myocardial infarction in recent 30 days\n4. Current use of myocardial preconditioning-affecting medications, such as sulfonylurea (glibenclamide), allopurinol, theophylline, nicorandil(last dose \\\u003C 8 hrs), etc\n5. Participated in other randomized controlled clinical trials in recent 3 months\n6. General anesthesia in recent 30 days\n7. History of kidney and liver transplantation, or severe liver and kidney dysfunction (EGFR ≤ 20 mlgmin\u002F1.73 m2, conventional dialysis or patients who have started dialysis; Child Pugh grade C\u002Fcirrhosis)\n8. History of open heart surgery;\n9. Hemodynamic instability or severe heart failure (SBP\\\u003C90 mmHg or preoperative need of high-dose vasoactive drug support, placement of aortic balloon pump (IABP), ECMO or ventricular assist device, left ventricular ejection fraction\\\u003C30%)\n10. Adverse drug reactions to trial medications\n11. History of malignant hyperthermia\n12. Pregnancy or lactation","ALL","18 Years",{"count":244,"type":245},3560,"ESTIMATED","INTERVENTIONAL",[248],"PHASE3","To investigate whether the inhaled anesthetic desflurane, compared with propofol, exerts cardioprotective effects and reduces the incidence of severe postoperative major cardiac events in patients undergoing coronary artery bypass graft (CABG) surgery.",[251,252],"Cardiac Surgery","Coronary Artery Bypass Grafting",[254,255,251,256,252],"Desflurane","Propofol","Major Cardiac Event","2025-11-19",{"date":259,"type":260},"2025-11-25","ACTUAL",{"date":262,"type":260},"2025-10-20",{"date":264,"type":245},"2029-12-31",{"name":5,"class":6},14]