[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100591339":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":52,"centralContacts":57,"locations":68,"responsibleParty":84,"collaborators":48,"id":87,"slug":88,"hasResults":89,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":89,"sex":95,"minAge":96,"maxAge":97,"enrollmentInfo":98,"targetDuration":48,"studyType":101,"phases":102,"briefSummary":104,"conditions":105,"keywords":48,"overallStatus":71,"whyStopped":48,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"Al-Azhar University","OTHER",[8,14,19,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Dexmedetomidine group ( D group )","ACTIVE_COMPARATOR","Patients will receive 0.5 μg\u002Fkg dexmedetomidine in 10 ml normal saline 10 min before the end of surgery.",[13],"Drug: Dexmedetomidine",{"label":15,"type":10,"description":16,"interventionNames":17},"Magnesium sulfate group ( M group )","Patients will receive 30 mg\u002Fkg IV magnesium sulfate 50% in 10 ml normal saline 10 min before the end of surgery.",[18],"Drug: Magnesium sulfate",{"label":20,"type":10,"description":21,"interventionNames":22},"Lidocaine group ( L group )","Patients will receive lidocaine 1.5 mg\u002Fkg lidocaine in 10 ml normal saline 10 min before the end of surgery.",[23],"Drug: Lidocaine",{"label":25,"type":26,"description":27,"interventionNames":28},"Control group ( C group )","PLACEBO_COMPARATOR","Patients will receive 10 ml normal saline 10 min before the end of surgery.",[29],"Drug: normal saline",[31,38,44,49],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"DRUG","Dexmedetomidine","Patients will receive 0.5 μg\u002Fkg dexmedetomidine in 10ml normal saline 10 min before the end of surgery.",[9],[37],"dex",{"type":32,"name":39,"description":40,"armGroupLabels":41,"otherNames":42},"Magnesium sulfate","Patients will receive 30 mg\u002Fkg IV magnesium sulfate 50% 10 min before the end of surgery.",[15],[43],"MgSO4",{"type":32,"name":45,"description":46,"armGroupLabels":47,"otherNames":48},"Lidocaine","Patients will receive lidocaine 1.5 mg\u002Fkg lidocaine 10 min before the end of surgery.",[20],null,{"type":32,"name":50,"description":27,"armGroupLabels":51,"otherNames":48},"normal saline",[25],[53],{"name":54,"affiliation":55,"role":56},"Mahmoud T Abd Elhafeez, Specialist.Mcs","mahmoud.talaat750@gmail.com","PRINCIPAL_INVESTIGATOR",[58,64],{"name":59,"role":60,"phone":61,"phoneExt":62,"email":63},"Medhat H Allam, lecturer.MD","CONTACT","1003012989","+020","Medhathelaly@gmail.com",{"name":65,"role":60,"phone":66,"phoneExt":62,"email":67},"Osama H Ahmed, Professor.MD","1223460571","DOCTOR_OSAMA_HELAL@hotmail.com",[69],{"facility":70,"status":71,"city":72,"state":48,"zip":73,"country":74,"countryCode":75,"cosmosGeoPoint":76,"geoPoint":81,"contacts":82},"Faculty of Medicine, Al-Azhar university Assiut, Egypt.","RECRUITING","Asyut","2091110","Egypt","EG",{"type":77,"coordinates":78},"Point",[79,80],31.18368,27.18096,{"lat":80,"lon":79},[83],{"name":54,"role":60,"phone":48,"phoneExt":48,"email":55},{"type":56,"investigatorFullName":85,"investigatorTitle":86,"investigatorAffiliation":5,"oldNameTitle":48,"oldOrganization":48},"Mahmoud Talaat Abd Elhafeez Ahmed","Specialist. Mcs","100591339","phase-3-dexmedetomidine-magnesium-sulphate-and-lidocaine-for-cough-suppression-after-general-anesthesia-100591339",false,"NCT06979141","Dexmedetomidine, Magnesium Sulphate and Lidocaine for Cough Suppression After General Anesthesia","Comparative Study Between Efficacy of Dexmedetomidine, Magnesium Sulphate and Lidocaine for Cough Suppression During General Anesthetic Emergence","MgSO4\u002FDEX","Inclusion Criteria:\n\n* Aged 21-60 years.\n* Both genders.\n* Body mass index \\\u003C 30 kg\u002F m2\n* American Society of Anesthesiology (ASA) physical status I-II.\n* Mallampati score class I or II.\n* Patients undergoing surgery under general anesthesia.\n\nExclusion Criteria:\n\n* Known allergy to study drugs.\n* History of psychiatric illness.\n* Patients with major organ diseases.\n* Pre-existing neurological deficits.\n* Body mass index \\>30 kg\u002Fm2.\n* Active airway infection or history of tracheal and laryngeal surgery.\n* Lower esophageal sphincter incompetence (and reflux).\n* Increased intracranial and intraocular pressure.\n* Use of cough-inducing medications\n* Pregnant, and lactating women.","ALL","21 Years","60 Years",{"count":99,"type":100},300,"ESTIMATED","INTERVENTIONAL",[103],"PHASE3","The aim of this prospective randomized controlled double-blinded study is to compare the efficacy of dexmedetomidine, MgSO4 and lidocaine for cough suppression during general anesthetic emergence as regard number and severity.",[106],"Cough","2025-06-07",{"date":109,"type":110},"2025-06-11","ACTUAL",{"date":112,"type":110},"2025-06-02",{"date":114,"type":100},"2026-08-01",{"name":5,"class":6},1]