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limit of normal (ULN), serum transaminases ≤ 3 x ULN without presence of liver metastases or ≤ 5x ULN with presence of liver metastases.\n\nExclusion Criteria:\n\n* Patients who received prior palliative chemotherapy\n* Patients in whom local treatment of metastases is scheduled (i.e. liver surgery or stereotactic radiotherapy)\n* Candidates for triple chemotherapy\n* Patients who received prior adjuvant chemotherapy in the one year before inclusion in the study (chemotherapy before that time is allowed)\n* Patients with complete or incomplete dihydropyrimidine dehydrogenase (DPD) deficiency\n* Patients with Microsatellite instable (MSI)-high colorectal cancer\n* Patients with HIV or active hepatitis\n* Patients with severe kidney failure (defined as GFR ≤30ml\u002Fmin)\n* Patients with severe cognitive deficits making informed consent not possible","ALL","70 Years",{"count":363,"type":364},587,"ESTIMATED","INTERVENTIONAL",[367],"PHASE3","The goal of this phase III, open-label, 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