[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100355761":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":35,"centralContacts":35,"locations":44,"responsibleParty":67,"collaborators":70,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":35,"eligibilityCriteria":79,"healthyVolunteers":80,"sex":81,"minAge":82,"maxAge":35,"enrollmentInfo":83,"targetDuration":35,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":35,"overallStatus":47,"whyStopped":35,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"University of Alabama at Birmingham","OTHER",[8,15,21,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Early Withdrawal Exposure plus NAW Regulation Training","EXPERIMENTAL","The development, application, modification, and repeated practice of individualized withdrawal regulation strategies (e.g., behavioral and cognitive strategies for allaying withdrawal symptoms) across the first 4 hours of abstinence over 4 separate sessions.",[13,14],"Behavioral: cognitive-behavioral withdrawal regulation strategies","Behavioral: early withdrawal exposure",{"label":16,"type":17,"description":18,"interventionNames":19},"Early Withdrawal Exposure plus Relaxation Control Training","ACTIVE_COMPARATOR","The development, application, modification, and repeated practice of relaxation strategies across the first 4 hours of abstinence over 4 separate sessions.",[20,14],"Behavioral: relaxation strategies",{"label":22,"type":17,"description":23,"interventionNames":24},"NAW Regulation Training Only","The development, application, modification, and repeated practice of individualized withdrawal regulation strategies (e.g., behavioral and cognitive strategies for allaying withdrawal symptoms) over 4 separate sessions involving smoking as usual.",[13],{"label":26,"type":17,"description":27,"interventionNames":28},"Relaxation Control Training Only","The development, application, modification, and repeated practice of relaxation strategies over 4 separate sessions involving smoking as usual.",[20],[30,36,40],{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"BEHAVIORAL","cognitive-behavioral withdrawal regulation strategies","Participants will generate and refine individualized withdrawal regulation strategies with the aid of a therapist",[9,22],null,{"type":31,"name":37,"description":38,"armGroupLabels":39,"otherNames":35},"relaxation strategies","Participants will generate and refine relaxation techniques with the aid of a therapist",[16,26],{"type":31,"name":41,"description":42,"armGroupLabels":43,"otherNames":35},"early withdrawal exposure","Exposure to the first 4 hours of abstinence across 4 separate sessions",[9,16],[45],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Ryals Public Health Building","RECRUITING","Birmingham","Alabama","35294","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-86.80249,33.52066,{"lat":57,"lon":56},[60,65],{"name":61,"role":62,"phone":63,"phoneExt":35,"email":64},"Peter S Hendricks, PhD","CONTACT","205.202.1387","phendricks@uab.edu",{"name":61,"role":66,"phone":35,"phoneExt":35,"email":35},"PRINCIPAL_INVESTIGATOR",{"type":66,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":35,"oldOrganization":35},"Peter Hendricks","University Professor",[71],{"name":72,"class":73},"National Institute on Drug Abuse (NIDA)","NIH","100355761","phase-3-early-withdrawal-exposure-and-negative-affect-withdrawal-naw-regulation-training-for-smoking-cessation-100355761",false,"NCT03912194","Early Withdrawal Exposure and Negative Affect Withdrawal (NAW) Regulation Training for Smoking Cessation","Inclusion Criteria:\n\n* at least 18 years of age\n* smoke at least 5 cigarettes per day\n* Expired breath carbon monoxide (CO) reading of at least five parts per million\n* report the intention to quit\n* reside in the Birmingham area with no plan to relocate outside of the area in the next 6 months\n* access to a telephone\n\nExclusion Criteria:\n\n* inability to speak English\n* presence of a condition that contraindicates use of the nicotine patch\n* presence of conditions that might interfere with compliance with the protocol or greatly complicate treatment\n* any acutely life-threatening disease\n* concurrent participation in a formal treatment program for smoking cessation\n* current use of any pharmacotherapy for smoking cessation",true,"ALL","18 Years",{"count":84,"type":85},400,"ESTIMATED","INTERVENTIONAL",[88],"PHASE3","Smoking remains the single most preventable cause of morbidity and mortality in the United States, accounting for approximately half a million deaths every year. The current study will investigate the efficacy and mechanisms of change of a novel smoking cessation intervention. The current study will thus provide essential information regarding a treatment that has the potential to enhance the efficacy of existing smoking cessation interventions, thereby having a beneficial impact on the public health of the United States.",[91],"Tobacco Dependence","2026-03-09",{"date":94,"type":95},"2026-03-11","ACTUAL",{"date":97,"type":95},"2019-08-01",{"date":99,"type":85},"2026-07-01",{"name":5,"class":6},1]