[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623381":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":11,"centralContacts":29,"locations":35,"responsibleParty":52,"collaborators":11,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":11,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":11,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":80,"whyStopped":11,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Badr University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Metformin Iontophoresis","ACTIVE_COMPARATOR",null,[13],"Drug: Metformin gel Iontophoresis",{"label":15,"type":10,"description":11,"interventionNames":16},"Iontophoresis Combined with Physical Therapy Rehabilitation",[17],"Device: Iontophoresis",[19,24],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":11},"DRUG","Metformin gel Iontophoresis","Metformin gel 2% Iontophoresis Combined with Physical Therapy Rehabilitation",[9],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"DEVICE","Iontophoresis","Iontophoresis with neutral gel Combined with Physical Therapy Rehabilitation",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},"‪Eman swan‬, Ph d","CONTACT","+201090111013","eman.said@buc.edu.eg",[36],{"facility":37,"status":11,"city":38,"state":11,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Badr University in Cairo","Cairo","11829","Egypt","EG",{"type":43,"coordinates":44},"Point",[45,46],31.24967,30.06263,{"lat":46,"lon":45},[49],{"name":50,"role":32,"phone":51,"phoneExt":11,"email":34},"‪Eman Sawan, PH D","01090111013",{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Eman Said Sawan","Lecturer","100623381","phase-3-effect-of-metformin-iontophoresis-on-knee-osteoarthritis-in-postmenopausal-women-100623381",false,"NCT07395895","Effect of Metformin Iontophoresis on Knee Osteoarthritis in Postmenopausal Women","Effect of Metformin Iontophoresis Combined With Physical Therapy Rehabilitation on Knee Osteoarthritis in Postmenopausal Women: A Randomized Double-Blind Placebo-Controlled Clinical Trial","Inclusion Criteria:\n\n* • Postmenopausal women aged 50-70 years.\n\n  * Clinical and radiographic diagnosis of knee osteoarthritis according to the American College of Rheumatology criteria.\n  * Radiographic severity classified as Kellgren-Lawrence grade II or III.\n  * Chronic knee pain for a duration of at least 3 months.\n  * Pain intensity ≥4 on the Visual Analog Scale.\n  * Ability to ambulate independently with or without assistive devices.\n  * Ability to understand and follow instructions.\n  * Willingness to participate and provide written informed consent.\n\nExclusion Criteria:\n\n* • Severe knee osteoarthritis (Kellgren-Lawrence grade IV).\n\n  * History of knee surgery or intra-articular injections within the previous 6 months.\n  * Presence of inflammatory rheumatic diseases such as rheumatoid arthritis or gout.\n  * Neurological disorders affecting lower limb function.\n  * Uncontrolled metabolic, cardiovascular, or systemic diseases.\n  * Current or recent use of metformin or other antidiabetic medications.\n  * Skin lesions, infections, or hypersensitivity at the iontophoresis site.\n  * Contraindications to electrotherapy such as pacemakers or implanted electronic devices.\n  * Body mass index ≥35 kg\u002Fm².\n  * Participation in another clinical trial within the last 3 months.","FEMALE","50 Years","70 Years",{"count":67,"type":68},68,"ESTIMATED","INTERVENTIONAL",[71],"PHASE3","This study is designed as a randomized, double-blind, placebo-controlled clinical trial with two parallel groups. All participants will receive a standardized physical therapy rehabilitation program. Participants will be randomly allocated into either a study group receiving metformin iontophoresis or a control group receiving placebo iontophoresis. Both participants and outcome assessors will be blinded to group allocation.",[74],"Osteoarthritis in Postmenopausal Women",[76,26,77,78,79],"Metformin gel","Physical Therapy Rehabilitation","Osteoarthritis","Postmenopausal Women","NOT_YET_RECRUITING","2026-02-01",{"date":83,"type":84},"2026-02-09","ACTUAL",{"date":86,"type":68},"2026-03-01",{"date":88,"type":68},"2026-05-01",{"name":5,"class":6},1]