[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600087":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":45,"centralContacts":50,"locations":59,"responsibleParty":76,"collaborators":11,"id":80,"slug":81,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":11,"eligibilityCriteria":86,"healthyVolunteers":87,"sex":88,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":11,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":102,"overallStatus":61,"whyStopped":11,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":120},{"fullName":5,"class":6},"Poznan University of Physical Education","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"BA and SB supplementation (first group)","EXPERIMENTAL",null,[13],"Dietary Supplement: BA and SB supplementation",{"label":15,"type":10,"description":11,"interventionNames":16},"BA and PL2 supplementation (second group)",[17],"Dietary Supplement: BA and PL2 supplementation",{"label":19,"type":10,"description":11,"interventionNames":20},"PL1 and SB supplementation (third group)",[21],"Dietary Supplement: PL1 and SB supplementation",{"label":23,"type":24,"description":11,"interventionNames":25},"PL1 and PL2 supplementation (fourth group)","PLACEBO_COMPARATOR",[26],"Dietary Supplement: PL1 and PL2 supplementation",[28,33,37,41],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":11},"DIETARY_SUPPLEMENT","BA and SB supplementation","Assigned Interventions:\n\n* Beta-alanine (BA)\n* Sodium bicarbonate (SB)\n\nDescription:\n\n• Participants receive beta-alanine and sodium bicarbonate\n\nIntervention list \\& supplementation details:\n\n1. Beta-alanine (BA)\n\n   * Form: Gelatin capsules\n   * Substance: Pure beta-alanine\n   * Daily dose: 6.4 g\u002Fday\n   * Dosing schedule: Four equal servings taken with meals (breakfast, lunch, snack, dinner)\n   * Supplementation period: days 1 to 28\n2. Sodium bicarbonate (SB)\n\n   * Form: Gelatin capsules\n   * Substance: Pure sodium bicarbonate\n   * Daily dose: 0.3 g\u002Fkg body mass per day\n   * Dosing schedule: Three equal servings taken with meals (breakfast, lunch, dinner)\n   * Supplementation period: days 21 to 28 of BA or PL1 supplementation\n\nRationale:\n\n• This group tests the combined effects of BA and SB",[9],{"type":29,"name":34,"description":35,"armGroupLabels":36,"otherNames":11},"BA and PL2 supplementation","Participants in this intervention group will undergo chronic supplementation with beta-alanine (BA) and an inert placebo (PL2) matched to the sodium bicarbonate (SB) protocol.\n\n* Beta-alanine (pure, in gelatin capsules) will be administered at a total daily dose of 6.4 g, divided into four servings taken with meals, over a period of 28 consecutive days.\n* PL2 (placebo matched to SB, in gelatin capsules) will be administered from Day 21 to Day 28 of beta-alanine supplementation, at a daily dose of 0.3 g per kg of body mass, divided into three equal servings taken with meals.\n\nThis group allows for evaluation of the isolated effects of BA supplementation when combined with a placebo comparator to SB",[15],{"type":29,"name":38,"description":39,"armGroupLabels":40,"otherNames":11},"PL1 and SB supplementation","Assigned Interventions:\n\n* Placebo matched to BA (PL1)\n* Sodium bicarbonate (SB)\n\nDescription:\n\n• Participants receive only sodium bicarbonate as the active compound and placebo capsules matching the BA protocol.\n\nIntervention list \\& supplementation details:\n\n1. Placebo matched to BA (PL1)\n\n   * Form: Gelatin capsules\n   * Substance: Inert substance matched in appearance and dosing schedule to BA\n   * Daily dose: 6.4 g\u002Fday\n   * Dosing schedule: Four equal servings taken with meals (breakfast, lunch, snack, dinner)\n   * Supplementation period: days 1 to 28\n2. Sodium bicarbonate (SB)\n\n   * Form: Gelatin capsules\n   * Substance: Pure sodium bicarbonate\n   * Daily dose: 0.3 g\u002Fkg body mass per day\n   * Dosing schedule: Three equal servings taken with meals (breakfast, lunch, dinner)\n   * Supplementation period: days 21 to 28 of BA or PL1 supplementation\n\nRationale:\n\n• This group tests the isolated effects of SB",[19],{"type":29,"name":42,"description":43,"armGroupLabels":44,"otherNames":11},"PL1 and PL2 supplementation","Assigned Interventions:\n\n* Placebo matched to BA (PL1)\n* Placebo matched to SB (PL2)\n\nDescription:\n\n• Participants receive two matched placebos.\n\nIntervention list \\& supplementation details:\n\n1. Placebo matched to BA (PL1)\n\n   * Form: Gelatin capsules\n   * Substance: Inert substance matched in appearance and dosing schedule to BA\n   * Daily dose: 6.4 g\u002Fday\n   * Dosing schedule: Four equal servings taken with meals (breakfast, lunch, snack, dinner)\n   * Supplementation period: days 1 to 28\n2. Placebo matched to SB (PL2)\n\n   * Form: Gelatin capsules\n   * Substance: Inert substance matched in appearance and timing to SB\n   * Daily dose: 0.3 g\u002Fkg body mass per day\n   * Dosing schedule: Three equal servings taken with meals (breakfast, lunch, dinner)\n   * Supplementation period: days 21 to 28 of BA or PL1 supplementation\n\nRationale:\n\n• This serves as the control group for comparison with all active intervention arms.",[23],[46],{"name":47,"affiliation":48,"role":49},"Krzysztof Durkalec-Michalski, PhD","Department of Sports Dietetics, Poznan University of Physical Education Poznań","STUDY_CHAIR",[51,56],{"name":52,"role":53,"phone":54,"phoneExt":11,"email":55},"Jakub Adamczewski, MSc","CONTACT","+48 66 317 56 06","adamczewski@awf.poznan.pl",{"name":47,"role":53,"phone":57,"phoneExt":11,"email":58},"+48 61 835 51 65","durkalec-michalski@awf.poznan.pl",[60],{"facility":48,"status":61,"city":62,"state":63,"zip":64,"country":65,"countryCode":66,"cosmosGeoPoint":67,"geoPoint":72,"contacts":73},"RECRUITING","Poznan","Wielkopolska","61-871","Poland","PL",{"type":68,"coordinates":69},"Point",[70,71],16.92993,52.40692,{"lat":71,"lon":70},[74,75],{"name":52,"role":53,"phone":54,"phoneExt":11,"email":55},{"name":47,"role":53,"phone":57,"phoneExt":11,"email":58},{"type":77,"investigatorFullName":78,"investigatorTitle":79,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Krzysztof Durkalec-Michalski","Prof.","100600087","phase-3-effects-of--alanine-and-sodium-bicarbonate-supplementation-on-physical-capacity-and-biochemical-markers-concentrations-100600087",false,"NCT07092930","Effects of β-alanine and Sodium Bicarbonate Supplementation on Physical Capacity and Biochemical Markers Concentrations","Evaluation of the Synergistic Effect of β-alanine and Sodium Bicarbonate Supplementation on Physical Capacity and Blood Biochemical Markers Concentrations in Trained Female Basketball Players","Inclusion Criteria:\n\n* written consent to participate,\n* general good health condition,\n* a current medical clearance to practice sports,\n* training experience: at least 4 years,\n* minimum of 4 workout sessions (in the discipline covered by the study) a week.\n\nExclusion Criteria:\n\n* current injury,\n* any health-related contraindication,\n* declared general feeling of being unwell,\n* taking supplements, especially ergogenic supplements that modulate extra- and intracellular capacity 3 months prior to research (except taking protein and\u002For carbohydrate powders, isotonic drinks),\n* unwilling to follow the study protocol.",true,"FEMALE","16 Years","40 Years",{"count":92,"type":93},100,"ESTIMATED","INTERVENTIONAL",[96],"PHASE3","This randomized, double-blind, placebo-controlled, parallel-group study aims to evaluate the potential synergistic effect of beta-alanine (BA) and sodium bicarbonate (SB) supplementation, compared to their separate administration or placebo (PL), on physical performance and selected blood biochemical markers in highly trained female basketball players.",[99,100,101],"Supplementation","Sports","Female Athletes",[103,104,105,106,107,108,109,110],"Beta-alanine","Sodium bicarbonate","Ergogenic aids","Sports nutrition","Team sports","Physical capacity","Body composition","Blood and urine biochemical markers","2025-07-28",{"date":113,"type":114},"2025-07-30","ACTUAL",{"date":116,"type":114},"2023-10-01",{"date":118,"type":93},"2025-12",{"name":5,"class":6},1]