[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100548524":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":26,"locations":26,"responsibleParty":30,"collaborators":26,"id":32,"slug":33,"hasResults":34,"nctId":35,"briefTitle":36,"officialTitle":37,"acronym":26,"eligibilityCriteria":38,"healthyVolunteers":34,"sex":39,"minAge":40,"maxAge":26,"enrollmentInfo":41,"targetDuration":26,"studyType":44,"phases":45,"briefSummary":47,"conditions":48,"keywords":26,"overallStatus":50,"whyStopped":26,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":26},{"fullName":5,"class":6},"Haisco Pharmaceutical Group Co., Ltd.","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"HSK16149 20mg-40mg bid","EXPERIMENTAL","Oral administration of 20mg twice daily for 12 weeks can be adjusted to 40mg twice daily based on the efficacy and tolerability of the subject",[13],"Drug: HSK16149 20mg-40mg BID",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Placebo,Oral,2 capsules, twice daily for 12 weeks",[19],"Drug: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","HSK16149 20mg-40mg BID","Oral, 20mg, BID, adjustable to 40mg, BID based on tolerability and efficacy;",[9],null,{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":26},"Placebo, oral, 2 capsules twice daily",[15],{"type":31,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100548524","phase-3-efficacy-and-safety-of-hsk16149-capsule-in-the-treatment-of-moderate-and-severe-central-neuropathic-pain-in-china-100548524",false,"NCT06422117","Efficacy and Safety of HSK16149 Capsule in the Treatment of Moderate and Severe Central Neuropathic Pain in China","A Multicenter, Randomized, Double-blind, Placebo-controlled Phase III Study to Evaluate the Efficacy and Safety of HSK16149 Capsule in the Treatment of Moderate to Severe Central Neuropathic Pain in China","Inclusion Criteria:\n\n1. Voluntarily sign an informed consent form;\n2. Able to read and complete survey questionnaires;\n3. Male or female patients aged ≥ 18 years old;\n4. The subject has a medical history and symptoms related to central neuropathic pain, including spinal cord related neuropathic pain (subject enrollment ≥ 50%), post-stroke central neuropathic pain, Parkinson's disease pain, and multiple sclerosis pain, and must meet the following criteria: a) pain duration ≥ 3 months; b) Characteristics that conform to neuropathic pain: DN4 scale score ≥ 4 points;\n5. During screening visits, patients were assessed to have an average pain visual analogue scale (VAS) score of ≥ 40 mm over the past 24 hours.\n\nExclusion Criteria:\n\n1. The presence of other painful diseases that may affect the evaluation of neuropathic pain;\n2. Patients with spinal cord injury or stroke whose condition is unstable and is expected to require surgical treatment;\n3. There is a chronic systemic disease that the investigator has assessed may affect the participant's participation in the study；\n4. Meet any of the following laboratory test results: a) Hematology: WBC\\\u003C3×109\u002FL, N\\\u003C 1.5 ×109\u002FL, PLT\\\u003C 75 ×109\u002FL, or HB\\\u003C 90 g\u002FL; b) Liver function: ALT or AST\\> 2.5 × ULN; Or TBIL\\> 1.5 × ULN; c) eGFR\\\u003C 60 mL\u002Fmin\u002F1.73 m2; d) Creatine kinase \\> 2.0 × ULN;\n5. Women who are pregnant, planning to become pregnant during the study period, or breastfeeding; Women who do not wish to use reliable contraceptive methods (including condoms, spermicides, or Iuds) for 28 days after signing up for the ICF from the beginning to the last trial drug administration, or who plan to use progesterone contraceptives during this period;\n6. Mechanical operators engaged in high-altitude work, motor vehicle driving and other dangerous activities during the study period;\n7. Participated in any other clinical study within 30 days prior to screening;\n8. The investigator determined that there were other conditions that were not suitable for study participation.","ALL","18 Years",{"count":42,"type":43},408,"ESTIMATED","INTERVENTIONAL",[46],"PHASE3","To evaluate the efficacy and safety of HSK16149 capsule in the treatment of moderate to severe central neuropathic pain compared with placebo.",[49],"Central Neuropathic Pain","NOT_YET_RECRUITING","2024-05-17",{"date":53,"type":54},"2024-05-20","ACTUAL",{"date":56,"type":43},"2024-05-30",{"date":58,"type":43},"2027-08-07",{"name":5,"class":6}]