[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629026":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":39,"responsibleParty":514,"collaborators":25,"id":518,"slug":519,"hasResults":520,"nctId":521,"briefTitle":522,"officialTitle":523,"acronym":25,"eligibilityCriteria":524,"healthyVolunteers":520,"sex":525,"minAge":526,"maxAge":527,"enrollmentInfo":528,"targetDuration":25,"studyType":531,"phases":532,"briefSummary":534,"conditions":535,"keywords":25,"overallStatus":537,"whyStopped":25,"lastUpdateSubmitDate":538,"lastUpdatePostDateStruct":539,"startDateStruct":542,"completionDateStruct":544,"leadSponsor":546,"locationsCount":547},{"fullName":5,"class":6},"Southwest Hospital, China","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"TNK intra-arterial thrombolysis group","EXPERIMENTAL","Intra-arterial thrombolysis",[13],"Procedure: Intra-arterial thrombolysis",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard medical therapy group","ACTIVE_COMPARATOR","Only standard medical therapy",[19],"Other: Standard medical treatment",[21,26],{"type":22,"name":11,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","A standardized microcatheter-based technique was used to administer recombinant TNK-tPA directly into the thrombus. The total dose (0.0625 mg\u002Fkg, max 6.25 mg) was delivered in three equal parts: distally, within the mid-clot, and proximally. Angiographic reassessment at 5 minutes determined if a second identical dose was required (max cumulative dose: 0.125 mg\u002Fkg). The procedure was continuously monitored and could be terminated immediately for safety concerns.",[9],null,{"type":6,"name":27,"description":27,"armGroupLabels":28,"otherNames":25},"Standard medical treatment",[15],[30,35],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"Xianhua Hou","CONTACT","86-13594020663","houxianhua@tmmu.edu.cn",{"name":36,"role":32,"phone":37,"phoneExt":25,"email":38},"Lin Chen","86-18602300737","406019975@qq.com",[40,52,64,72,85,98,110,122,133,145,154,166,171,180,189,198,207,219,231,242,254,266,274,286,295,304,316,325,337,349,361,373,384,389,401,413,421,430,442,454,466,478,490,498,506],{"facility":41,"status":25,"city":42,"state":43,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":25},"Affiliated Hospital of Youjiang Medical University for Nationalities","Baise City","Guangxi","China","CN",{"type":47,"coordinates":48},"Point",[49,50],106.62684,23.89013,{"lat":50,"lon":49},{"facility":53,"status":25,"city":54,"state":43,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":55,"geoPoint":59,"contacts":60},"Guilin People'S Hospital","Guilin",{"type":47,"coordinates":56},[57,58],110.29639,25.28022,{"lat":58,"lon":57},[61],{"name":62,"role":32,"phone":63,"phoneExt":25,"email":25},"Pan Honghua","+86 18978337949",{"facility":65,"status":25,"city":66,"state":67,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":25,"geoPoint":25,"contacts":68},"The People's Hospital Of QianNan","Qiannan","Guizhou",[69],{"name":70,"role":32,"phone":71,"phoneExt":25,"email":25},"Jiang Maojun","+86 15185516184",{"facility":73,"status":25,"city":74,"state":75,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"Chongzhou People's Hospital","Chengdu","Sichuan",{"type":47,"coordinates":77},[78,79],104.06667,30.66667,{"lat":79,"lon":78},[82],{"name":83,"role":32,"phone":84,"phoneExt":25,"email":25},"Wu Youlin","+86 18628172896",{"facility":86,"status":25,"city":87,"state":88,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":89,"geoPoint":93,"contacts":94},"Dali Nationality Autonomous Prefecture Hospital","Dali","Yunnan",{"type":47,"coordinates":90},[91,92],100.21229,25.58474,{"lat":92,"lon":91},[95],{"name":96,"role":32,"phone":97,"phoneExt":25,"email":25},"Han Shibo","+86 18908722303",{"facility":99,"status":25,"city":100,"state":88,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":101,"geoPoint":105,"contacts":106},"Qujing Central Hospital of Yunnan Province","Qujing",{"type":47,"coordinates":102},[103,104],103.78333,25.48333,{"lat":104,"lon":103},[107],{"name":108,"role":32,"phone":109,"phoneExt":25,"email":25},"Chen Boyu","+86 18064858755",{"facility":111,"status":25,"city":112,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":113,"geoPoint":117,"contacts":118},"Ankang Central Hospital","Ankang",{"type":47,"coordinates":114},[115,116],109.01722,32.68,{"lat":116,"lon":115},[119],{"name":120,"role":32,"phone":121,"phoneExt":25,"email":25},"Chu Xingjv","+86 15319843133",{"facility":123,"status":25,"city":124,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":125,"geoPoint":129,"contacts":130},"The People'S Hospital of Anyang City","Anyang",{"type":47,"coordinates":126},[127,128],114.38278,36.096,{"lat":128,"lon":127},[131],{"name":132,"role":32,"phone":25,"phoneExt":25,"email":25},"Zhang Jiangang",{"facility":134,"status":25,"city":135,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":136,"geoPoint":140,"contacts":141},"Changchun Central Hospital","Changchun",{"type":47,"coordinates":137},[138,139],125.32278,43.88,{"lat":139,"lon":138},[142],{"name":143,"role":32,"phone":144,"phoneExt":25,"email":25},"Wang Lesheng","+86 13596227220",{"facility":146,"status":25,"city":74,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":147,"geoPoint":149,"contacts":150},"Chengdu Second People's Hospital",{"type":47,"coordinates":148},[78,79],{"lat":79,"lon":78},[151],{"name":152,"role":32,"phone":153,"phoneExt":25,"email":25},"Wu Changchuan","+86 15388151282",{"facility":155,"status":25,"city":156,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":157,"geoPoint":161,"contacts":162},"Chonggang General Hospital","Chongqing",{"type":47,"coordinates":158},[159,160],106.55771,29.56026,{"lat":160,"lon":159},[163],{"name":164,"role":32,"phone":165,"phoneExt":25,"email":25},"Ding Chawen","+86 17764830950",{"facility":167,"status":25,"city":156,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":168,"geoPoint":170,"contacts":25},"Chongqing University Fuling Hospital",{"type":47,"coordinates":169},[159,160],{"lat":160,"lon":159},{"facility":172,"status":25,"city":156,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":173,"geoPoint":175,"contacts":176},"Jiangjin Central Hospital",{"type":47,"coordinates":174},[159,160],{"lat":160,"lon":159},[177],{"name":178,"role":32,"phone":179,"phoneExt":25,"email":25},"Zhang Zuowen","+86 15823472901",{"facility":181,"status":25,"city":156,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":182,"geoPoint":184,"contacts":185},"The Ninth People'S Hospital of Chongqing",{"type":47,"coordinates":183},[159,160],{"lat":160,"lon":159},[186],{"name":187,"role":32,"phone":188,"phoneExt":25,"email":25},"Huang Shuchun","+86 18708533468",{"facility":190,"status":25,"city":156,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":191,"geoPoint":193,"contacts":194},"The Thrid Affiliated Hospital of CQMU",{"type":47,"coordinates":192},[159,160],{"lat":160,"lon":159},[195],{"name":196,"role":32,"phone":197,"phoneExt":25,"email":25},"Cheng Saiyu","+86 13527598096",{"facility":199,"status":25,"city":156,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":200,"geoPoint":202,"contacts":203},"Yunyang County People'S Hospital",{"type":47,"coordinates":201},[159,160],{"lat":160,"lon":159},[204],{"name":205,"role":32,"phone":206,"phoneExt":25,"email":25},"Cai Tieying","+86 13896311415",{"facility":208,"status":25,"city":209,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":210,"geoPoint":214,"contacts":215},"The First Affiliated Hospital of Fujian Medicaluniversity","Fuzhou",{"type":47,"coordinates":211},[212,213],119.30611,26.06139,{"lat":213,"lon":212},[216],{"name":217,"role":32,"phone":218,"phoneExt":25,"email":25},"Zhao Wenlong","+86 18060893376",{"facility":220,"status":25,"city":221,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":222,"geoPoint":226,"contacts":227},"Guangyuan Central Hospital","Guangyuan",{"type":47,"coordinates":223},[224,225],105.823,32.44201,{"lat":225,"lon":224},[228],{"name":229,"role":32,"phone":230,"phoneExt":25,"email":25},"Pu Tianqiang","+86 18227306608",{"facility":232,"status":25,"city":67,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":233,"geoPoint":237,"contacts":238},"Qiandongnan Prefecture People's Hospital",{"type":47,"coordinates":234},[235,236],110.58333,31.01667,{"lat":236,"lon":235},[239],{"name":240,"role":32,"phone":241,"phoneExt":25,"email":25},"Shen Jian","+86 15985527337",{"facility":243,"status":25,"city":244,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":245,"geoPoint":249,"contacts":250},"Huaibei Miners General Hospital","Huaibei",{"type":47,"coordinates":246},[247,248],116.79167,33.97444,{"lat":248,"lon":247},[251],{"name":252,"role":32,"phone":253,"phoneExt":25,"email":25},"Ma Xinan","+86 15805619166",{"facility":255,"status":25,"city":256,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":257,"geoPoint":261,"contacts":262},"The People's Hospital of Jianyang City","Jianyang",{"type":47,"coordinates":258},[259,260],120.76206,32.70681,{"lat":260,"lon":259},[263],{"name":264,"role":32,"phone":265,"phoneExt":25,"email":25},"Tang Jie","+86 15123825598",{"facility":267,"status":25,"city":268,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":269,"geoPoint":273,"contacts":25},"The 960th Hospital of the PLA Joint Logistics Support Force","Jinan",{"type":47,"coordinates":270},[271,272],116.99722,36.66833,{"lat":272,"lon":271},{"facility":275,"status":25,"city":276,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":277,"geoPoint":281,"contacts":282},"Luoyang Mengjin People's Hospital","Luoyang",{"type":47,"coordinates":278},[279,280],112.43684,34.67345,{"lat":280,"lon":279},[283],{"name":284,"role":32,"phone":285,"phoneExt":25,"email":25},"Zhao Haojin","+86 18937982836",{"facility":287,"status":25,"city":276,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":288,"geoPoint":290,"contacts":291},"The First Affiliated Hospital of Henan University of Science and Technology",{"type":47,"coordinates":289},[279,280],{"lat":280,"lon":279},[292],{"name":293,"role":32,"phone":294,"phoneExt":25,"email":25},"Shen Ruile","+86 15703790088",{"facility":296,"status":25,"city":276,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":297,"geoPoint":299,"contacts":300},"Yiyang County People'S Hospital",{"type":47,"coordinates":298},[279,280],{"lat":280,"lon":279},[301],{"name":302,"role":32,"phone":303,"phoneExt":25,"email":25},"Zhao Jingjing","+86 18103797861",{"facility":305,"status":25,"city":306,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":307,"geoPoint":311,"contacts":312},"The Affiliated Hospital of Southwest Medical University","Luzhou",{"type":47,"coordinates":308},[309,310],105.42575,28.8903,{"lat":310,"lon":309},[313],{"name":314,"role":32,"phone":315,"phoneExt":25,"email":25},"Yuan Zhengzhou","+86 18111209050",{"facility":317,"status":25,"city":306,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":318,"geoPoint":320,"contacts":321},"The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University",{"type":47,"coordinates":319},[309,310],{"lat":310,"lon":309},[322],{"name":323,"role":32,"phone":324,"phoneExt":25,"email":25},"Guo Zhaoyun","+86 13440011005",{"facility":326,"status":25,"city":327,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":328,"geoPoint":332,"contacts":333},"Mianyang 404 Hospital","Mianyang",{"type":47,"coordinates":329},[330,331],104.68168,31.46784,{"lat":331,"lon":330},[334],{"name":335,"role":32,"phone":336,"phoneExt":25,"email":25},"Luo Jun","+86 13518319060",{"facility":338,"status":25,"city":339,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":340,"geoPoint":344,"contacts":345},"Mudanjiang First People's Hospital","Mudanjiang",{"type":47,"coordinates":341},[342,343],129.62594,44.54804,{"lat":343,"lon":342},[346],{"name":347,"role":32,"phone":348,"phoneExt":25,"email":25},"Yu Pengfei","+86 13604609208",{"facility":350,"status":25,"city":351,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":352,"geoPoint":356,"contacts":357},"The First People's Hospital of Qingzhen","Qingzhen",{"type":47,"coordinates":353},[354,355],106.46667,26.55,{"lat":355,"lon":354},[358],{"name":359,"role":32,"phone":360,"phoneExt":25,"email":25},"Fu Hang","+86 15338501820",{"facility":362,"status":25,"city":363,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":364,"geoPoint":368,"contacts":369},"Yellow River Sanmenxia Hospital","Sanmenxia",{"type":47,"coordinates":365},[366,367],111.19287,34.78081,{"lat":367,"lon":366},[370],{"name":371,"role":32,"phone":372,"phoneExt":25,"email":25},"Wu Xiaofeng","+86 13639893979",{"facility":374,"status":25,"city":375,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":376,"geoPoint":380,"contacts":381},"Ninglin People's Hospital","Shangqiu",{"type":47,"coordinates":377},[378,379],115.65613,34.4143,{"lat":379,"lon":378},[382],{"name":383,"role":32,"phone":25,"phoneExt":25,"email":25},"Ju Zhixiang",{"facility":385,"status":25,"city":375,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":386,"geoPoint":388,"contacts":25},"The First People'S Hospital of Shangqiu",{"type":47,"coordinates":387},[378,379],{"lat":379,"lon":378},{"facility":390,"status":25,"city":391,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":392,"geoPoint":396,"contacts":397},"The People's Hospital Of An Jv","Suining",{"type":47,"coordinates":393},[394,395],105.57332,30.50802,{"lat":395,"lon":394},[398],{"name":399,"role":32,"phone":400,"phoneExt":25,"email":25},"Liao Jiasheng","+86 18398444888",{"facility":402,"status":25,"city":403,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":404,"geoPoint":408,"contacts":409},"Yutian Hospital","Tangshan",{"type":47,"coordinates":405},[406,407],118.18319,39.64381,{"lat":407,"lon":406},[410],{"name":411,"role":32,"phone":412,"phoneExt":25,"email":25},"Li Haijun","+86 13111464171",{"facility":414,"status":25,"city":415,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":416,"geoPoint":420,"contacts":25},"Wuhan Puren Hospital","Wuhan",{"type":47,"coordinates":417},[418,419],114.26667,30.58333,{"lat":419,"lon":418},{"facility":422,"status":25,"city":415,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":423,"geoPoint":425,"contacts":426},"Zhongnan Hospital of Wuhan University",{"type":47,"coordinates":424},[418,419],{"lat":419,"lon":418},[427],{"name":428,"role":32,"phone":429,"phoneExt":25,"email":25},"Mei Bin","+86 13037196699",{"facility":431,"status":25,"city":432,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":433,"geoPoint":437,"contacts":438},"Xiangyang No.1 People's Hospital","Xiangyang",{"type":47,"coordinates":434},[435,436],112.14479,32.0422,{"lat":436,"lon":435},[439],{"name":440,"role":32,"phone":441,"phoneExt":25,"email":25},"Zhou Peiyang","+86 13597491119",{"facility":443,"status":25,"city":444,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":445,"geoPoint":449,"contacts":450},"Yaan People's Hospital","Ya'an",{"type":47,"coordinates":446},[447,448],102.999,29.98521,{"lat":448,"lon":447},[451],{"name":452,"role":32,"phone":453,"phoneExt":25,"email":25},"Wang Jian","+86 13550064528",{"facility":455,"status":25,"city":456,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":457,"geoPoint":461,"contacts":462},"Yichang Central People's Hospital","Yichang",{"type":47,"coordinates":458},[459,460],111.28472,30.71444,{"lat":460,"lon":459},[463],{"name":464,"role":32,"phone":465,"phoneExt":25,"email":25},"Zhou Jinghua","+86 15971663190",{"facility":467,"status":25,"city":468,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":469,"geoPoint":473,"contacts":474},"Zhengzhou Central Hospital","Zhengzhou",{"type":47,"coordinates":470},[471,472],113.64861,34.75778,{"lat":472,"lon":471},[475],{"name":476,"role":32,"phone":477,"phoneExt":25,"email":25},"Zhou You","+86 15713891958",{"facility":479,"status":25,"city":480,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":481,"geoPoint":485,"contacts":486},"Zhoukou Central Hospital","Zhoukou",{"type":47,"coordinates":482},[483,484],114.63333,33.63333,{"lat":484,"lon":483},[487],{"name":488,"role":32,"phone":489,"phoneExt":25,"email":25},"Li Shuai","+86 18595389709",{"facility":491,"status":25,"city":492,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":493,"geoPoint":497,"contacts":25},"Zhumadian Central Hospital","Zhumadian",{"type":47,"coordinates":494},[495,496],114.02944,32.97944,{"lat":496,"lon":495},{"facility":499,"status":25,"city":500,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":501,"geoPoint":505,"contacts":25},"Zhuzhou Central Hospital","Zhuzhou",{"type":47,"coordinates":502},[503,504],113.15,27.83333,{"lat":504,"lon":503},{"facility":507,"status":25,"city":508,"state":25,"zip":25,"country":44,"countryCode":45,"cosmosGeoPoint":509,"geoPoint":513,"contacts":25},"Zigong Third People's Hospital","Zigong",{"type":47,"coordinates":510},[511,512],104.77689,29.34162,{"lat":512,"lon":511},{"type":515,"investigatorFullName":516,"investigatorTitle":517,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Zhenhua Zhou","Professor","100629026","phase-3-efficacy-and-safety-of-intra-arterial-tenecteplase-in-acute-ischemic-stroke-patients-with-medium-vessel-occlusion-stroke-date-mevo-100629026",false,"NCT07469293","Efficacy and Safety of Intra-arterial Tenecteplase in Acute Ischemic Stroke Patients With Medium Vessel Occlusion Stroke (DATE-MeVO)","Efficacy and Safety of Intra-arterial Tenecteplase in Acute Ischemic Stroke Patients With Medium Vessel Occlusion Stroke (DATE-MeVO): A Multicenter, Prospective, Randomized Controlled, Open-label, Blinded-Endpoint Clinical Trial","Inclusion Criteria:\n\n1. Age ≥18 years old\n2. Acute isolated intracranial medium vessel occlusion (Distal middle cerebral artery M2; M3 and M4 segments of the middle cerebral artery; A1-A4 segments of the anterior cerebral artery; P1-P3 segments of the posterior cerebral artery), confirmed by imaging, with symptom onset to randomization within 24 hours;\n3. NlHSS score ≥ 5\n4. CT scan performed within 24 hours confirming that the ischemic lesion does not involve more than one-third of the territory supplied by the responsible vessel (no evidence of early large infarction)\n5. Patients with premorbid mRS 0 or 1\n6. Written informed consent obtained from the participant or a legally authorized representative\n\nExclusion Criteria:\n\n1. Intracranial hemorrhage confirmed by cranial CT or MRI;\n2. Already received intravenous thrombolysis;\n3. Planned mechanical thrombectomy;\n4. Intraoperative DSA showing vessel rupture, dissection, or contrast agent extravasation;\n5. Pregnant or breastfeeding women;\n6. Allergy to contrast agents or tenecteplase;\n7. Systolic blood pressure \\> 185 mmHg or diastolic blood pressure \\> 110 mmHg, and failure to control with oral antihypertensive medications;\n8. Genetic or acquired bleeding disorders, coagulation factor deficiencies; coagulation dysfunction, INR \\> 1.7, or use of novel oral anticoagulants within 48 hours;\n9. Blood glucose \\\u003C 2.8 mmol\u002FL (50 mg\u002FdL) or \\> 22.2 mmol\u002FL (400 mg\u002FdL), platelet count \\\u003C 100 × 10\\^9\u002FL;\n10. History of bleeding within the past month (gastrointestinal or urinary tract bleeding);\n11. Chronic hemodialysis or severe renal insufficiency (glomerular filtration rate \\\u003C 30 mL\u002Fmin or serum creatinine \\> 220 μmol\u002FL (2.5 mg\u002FdL));\n12. Severe mental disorders or inability to provide informed consent and comply with follow-up due to dementia;\n13. Concurrent malignant tumors or severe systemic diseases with an expected survival time of less than 90 days;\n14. Intracranial aneurysms or arteriovenous malformations;\n15. Participation in another clinical interventional trial within 30 days prior to randomization or currently participating in another clinical interventional trial;\n16. Occlusions in multiple vascular territories confirmed by CTA\u002FMRA;\n17. Other reasons that the investigator deems inappropriate for participation in the trial","ALL","18 Years","100 Years",{"count":529,"type":530},488,"ESTIMATED","INTERVENTIONAL",[533],"PHASE3","DATE-MeVO is an investigator-initiated, multicenter, prospective, randomized controlled, open-label, blinded endpoint (PROBE) clinical trial aiming at evaluating the efficacy and safety of tenecteplase combined with standard medications in acute ischemic stroke patients with medium vessel occlusion stroke within 24 hours of onset.",[536],"Acute Ischemic Stroke","NOT_YET_RECRUITING","2026-03-18",{"date":540,"type":541},"2026-03-20","ACTUAL",{"date":543,"type":530},"2026-03-25",{"date":545,"type":530},"2028-12-31",{"name":5,"class":6},45]