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Fe","Valencia","46026",{"type":56,"coordinates":1262},[1263,1264],-0.37966,39.47391,{"lat":1264,"lon":1263},{"facility":1267,"status":63,"city":1268,"state":30,"zip":1269,"country":1270,"countryCode":1271,"cosmosGeoPoint":1272,"geoPoint":1276,"contacts":30},"Queen Elizabeth University Campus","Glasgow","G11 6NT","United Kingdom","UK",{"type":56,"coordinates":1273},[1274,1275],-4.25763,55.86515,{"lat":1275,"lon":1274},{"facility":1278,"status":49,"city":1279,"state":30,"zip":1280,"country":1270,"countryCode":1271,"cosmosGeoPoint":1281,"geoPoint":1285,"contacts":30},"Royal Surrey County Hospital","Guildford","GU2 7XX",{"type":56,"coordinates":1282},[1283,1284],-0.57427,51.23536,{"lat":1284,"lon":1283},{"facility":1287,"status":63,"city":1288,"state":30,"zip":1289,"country":1270,"countryCode":1271,"cosmosGeoPoint":1290,"geoPoint":1294,"contacts":30},"St Thomas' Hospital","London","SE1 7EH",{"type":56,"coordinates":1291},[1292,1293],-0.12574,51.50853,{"lat":1293,"lon":1292},{"facility":1296,"status":63,"city":1288,"state":30,"zip":1297,"country":1270,"countryCode":1271,"cosmosGeoPoint":1298,"geoPoint":1300,"contacts":30},"King's College Hospital","SE5 9RS",{"type":56,"coordinates":1299},[1292,1293],{"lat":1293,"lon":1292},{"facility":1302,"status":63,"city":1303,"state":30,"zip":1304,"country":1270,"countryCode":1271,"cosmosGeoPoint":1305,"geoPoint":1309,"contacts":30},"Derriford Hospital","Plymouth","PL6 8DH",{"type":56,"coordinates":1306},[1307,1308],-4.14305,50.37153,{"lat":1308,"lon":1307},{"type":1311,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100494804","phase-3-efficacy-and-safety-of-trimodulin-bt588-in-subjects-with-severe-community-acquired-pneumonia-scap-100494804",false,"NCT05722938","Efficacy and Safety of Trimodulin (BT588) in Subjects With Severe Community-acquired Pneumonia (sCAP)","A Randomized, Placebo-controlled, Double-blind, Multi-center, Phase III Trial to Assess the Efficacy and Safety of Trimodulin (BT588) in Adult Hospitalized Subjects With Severe Community-acquired Pneumonia (sCAP)","ESsCAPE","Main Inclusion Criteria:\n\n1. Written informed consent.\n2. Hospitalized, adult (≥ 18 years of age) subject.\n3. Signs of inflammation based on C-reactive protein threshold level.\n4. Diagnosis of active community-acquired pneumonia (CAP) before hospital-admission or within 48 hours after admission.\n5. Radiological (or other imaging technology) evidence consistent with active pneumonia.\n6. Acute respiratory failure requiring IMV.\n\nMain Exclusion Criteria:\n\n1. For an incapacitated subject: any indication that the subject's presumed will would be against inclusion in the trial.\n2. Pregnant or lactating women.\n3. Subjects of childbearing potential not willing to use reliable contraceptive measures during the trial and for 15 weeks after the last IMP treatment.\n4. Subjects on ECMO at start of IMP treatment.\n5. Suspected hospital-acquired pneumonia (HAP) including ventilator-associated pneumonia (VAP).\n6. Subjects discharged from hospital within the previous 14 days.\n7. Defined neutrophil counts up to one calendar day prior to start of IMP treatment.\n8. Defined platelet counts up to one calendar day prior to start of IMP treatment.\n9. Defined hemoglobin within up to one calendar day prior to start of IMP treatment.\n10. Pre-existing hemolytic disease.\n11. Thromboembolic events (TEEs) caused by other reasons than the current sCAP within 3 months before start of IMP treatment unless the risk for further TEEs can be adequately managed with standard prophylaxis or treatment.\n12. Severe renal impairment prior to start of IMP treatment.\n13. End-stage renal disease (ESRD) or known primary focal segmental glomerulosclerosis (FSGS).\n14. Pre-existing severe lung diseases concomitant to current sCAP (e.g. active tuberculosis, active lung cancer).\n15. Pre-existing decompensated heart failure.\n16. Pre-existing severe hepatic cirrhosis (Child Pugh score ≥ 10 points), or severe hepatic impairment (Child Pugh score ≥ 10 points), or hepatocellular carcinoma.\n17. Known intolerance to proteins of human origin or known allergic reactions to components of trimodulin \u002F placebo.\n18. Selective immunoglobulin A (IgA) deficiency with known antibodies to IgA.\n19. Life expectancy of less than 90 days, according to the investigator's clinical judgment, because of medical conditions related neither to sCAP nor to sCAP-associated septic conditions.\n20. Morbid obesity with high body mass index (BMI) ≥ 40 kg\u002Fm2, or malnutrition with low BMI \\\u003C 16 kg\u002Fm2.\n21. Treatment with polyvalent immunoglobulin preparations during the last 21 days before start of IMP treatment.\n22. Known treatment with predefined medications, during the last 2 days before start of IMP treatment.\n23. Hematopoietic stem cell transplantation or previous lung transplantation.\n24. Treatment with investigational medications\u002Fprocedures not according to SoC of the trial site, due to participation in another interventional clinical trial within 30 days before start of IMP treatment, or previous treatment with IMP in this clinical trial.","ALL","18 Years",{"count":1323,"type":1324},590,"ESTIMATED","INTERVENTIONAL",[1327],"PHASE3","The main objective of the trial is to assess the efficacy and safety of trimodulin as adjunctive treatment to standard of care (SoC) compared to placebo plus SoC in adult hospitalized subjects with sCAP on invasive mechanical ventilation (IMV).\n\nOther objectives are to determine detailed pharmacokinetic (PK) properties of trimodulin in a PK substudy and to determine its pharmacodynamic (PD) properties.",[1330],"Community-acquired Pneumonia",[1332],"Severe Community-acquired Pneumonia","2026-03-30",{"date":1335,"type":1336},"2026-04-03","ACTUAL",{"date":1338,"type":1336},"2023-09-09",{"date":1340,"type":1324},"2028-07-31",{"name":5,"class":6},147]