[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615141":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":39,"responsibleParty":57,"collaborators":60,"id":94,"slug":95,"hasResults":96,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":100,"eligibilityCriteria":101,"healthyVolunteers":96,"sex":102,"minAge":103,"maxAge":104,"enrollmentInfo":105,"targetDuration":25,"studyType":108,"phases":109,"briefSummary":111,"conditions":112,"keywords":115,"overallStatus":119,"whyStopped":25,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":129},{"fullName":5,"class":6},"Tongji Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Glimepiride group","EXPERIMENTAL","Standardized treatment for chronic heart failure + standardized treatment for type 2 diabetes + oral glimepiride (initial oral dose is 2 mg once daily. After 4 weeks, adjust the oral dose based on glycemic control and tolerability: If glycemic control is adequate, maintain the initial oral dose. If glycemic control is inadequate, modify the oral dose to 4 mg once daily.)",[13],"Drug: Glimepiride (oral)",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo group","PLACEBO_COMPARATOR","Standardized treatment for chronic heart failure + standardized treatment for type 2 diabetes + oral placebo (equivalent placebo administered according to the same regimen)",[19],"Drug: Placebo",[21,26],{"type":22,"name":23,"description":11,"armGroupLabels":24,"otherNames":25},"DRUG","Glimepiride (oral)",[9],null,{"type":22,"name":27,"description":17,"armGroupLabels":28,"otherNames":25},"Placebo",[15],[30,35],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"Dao Wen Wang","CONTACT","+86-027-6937-8422","dwwang@tjh.tjmu.edu.cn",{"name":36,"role":32,"phone":37,"phoneExt":25,"email":38},"Li Ni","+86-027-8366-2479","nili@tjh.tjmu.edu.cn",[40],{"facility":41,"status":25,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Tongji Hostipal","Wuhan","Hubei","430030","China","CN",{"type":48,"coordinates":49},"Point",[50,51],114.26667,30.58333,{"lat":51,"lon":50},[54,55],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},{"name":36,"role":32,"phone":56,"phoneExt":25,"email":38},"+8613407192299",{"type":58,"investigatorFullName":31,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Prof.",[61,63,65,67,69,71,73,75,77,79,81,83,86,88,90,92],{"name":62,"class":6},"Shanghai Zhongshan Hospital",{"name":64,"class":6},"Nanjing Medical University",{"name":66,"class":6},"Second Xiangya Hospital of Central South University",{"name":68,"class":6},"Huaxi Hospital",{"name":70,"class":6},"Zhongnan Hospital",{"name":72,"class":6},"Xiangya Hospital",{"name":74,"class":6},"Beijing Anzhen Hospital",{"name":76,"class":6},"The First Affiliated Hospital of Air Force Medicial University",{"name":78,"class":6},"Chinese Academy of Medical Sciences, Fuwai Hospital",{"name":80,"class":6},"The First Affiliated Hospital of Zhengzhou University",{"name":82,"class":6},"First Affiliated Hospital of Xinjiang Medical University",{"name":84,"class":85},"Anhui Provincial Hospital","OTHER_GOV",{"name":87,"class":6},"Southwest Medical University",{"name":89,"class":6},"First Hospital of China Medical University",{"name":91,"class":6},"Wuhan Central Hospital",{"name":93,"class":6},"Tianjin Medical University","100615141","phase-3-efficacy-evaluation-of-glimepiride-in-patients-with-type-2-diabetes-mellitus-and-chronic-heart-failure-with-reduced-ejection-fraction-100615141",false,"NCT07288749","Efficacy Evaluation of Glimepiride in Patients With Type 2 Diabetes Mellitus and Chronic Heart Failure With Reduced Ejection Fraction.","Efficacy Evaluation of Glimepiride in Patients With Type 2 Diabetes Mellitus and Chronic Heart Failure With Reduced Ejection Fraction: A Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Trial.","GLID-HF","Inclusion Criteria:\n\n1. Age between 18 and 80 years old at the time of enrollment; gender is not restricted.\n2. Patients diagnosed with type 2 diabetes according to the \"Chinese Diabetes Prevention and Management Guidelines (2024 Edition)\" issued by the Chinese Medical Association Diabetes Branch, with a confirmed diagnosis at least three months prior.\n3. According to the \"Chinese Guidelines for the Diagnosis and Treatment of Heart Failure (2024 Edition)\" issued by the Chinese Society of Cardiology, the diagnosis is heart failure with reduced ejection fraction (HFrEF) or heart failure with mildly reduced ejection fraction (HFmrEF), confirmed at least three months prior.\n4. NYHA heart failure classification stage II-IV;\n5. Within 12 months prior to enrollment, left ventricular ejection fraction (LVEF) was \\\u003C 50%, as determined by echocardiography, nuclear ventriculography, angiography, or cardiac magnetic resonance imaging.\n6. NT-proBNP levels ≥ 600 pg\u002FmL in patients with no recent hospitalization for heart failure; NT-proBNP levels ≥ 400 pg\u002FmL within the past 12 months due to heart failure hospitalization; NT-proBNP levels ≥ 900 pg\u002FmL in patients with heart failure complicated by atrial fibrillation\u002Fflutter.\n7. Patients must have experienced stable heart failure symptoms for at least three months prior to enrollment and must have received standardized chronic heart failure therapy and guideline-directed diabetes management for no less than two weeks before enrollment, with no dose adjustments during this period.\n8. Participation is voluntary and requires signing an informed consent form; follow-up can extend beyond three years.\n\nExclusion Criteria:\n\n1. Heart failure caused by valvular disease, congenital heart conditions, pericardial diseases, arrhythmias, or non-cardiogenic illnesses; as well as heart failure resulting from failure of vital organs such as renal or hepatic failure; and right-sided heart failure due to pulmonary origin or other definitive causes.\n2. Currently experiencing acute decompensated heart failure (ADHF) or hospitalized for ADHF within the previous four weeks before enrollment.\n3. Patients scheduled to undergo coronary artery revascularization (percutaneous coronary intervention \\[PCI\\] or coronary artery bypass grafting \\[CABG\\]) or cardiac resynchronization therapy following randomization, or who have received cardiac resynchronization therapy within 12 weeks prior to enrollment.\n4. Any conditions other than cardiovascular diseases, including but not limited to malignancies with an expected survival of less than three years, severe mental disorders, hematologic diseases, neuroendocrine disorders, elevated liver transaminases and alkaline phosphatase levels exceeding three times the upper limit of normal (ULN), renal impairment indicated by serum creatinine greater than 2 mg\u002FdL (176.82 µmol\u002FL), and hyperkalemia with serum potassium levels exceeding 5.5 mmol\u002FL.\n5. Chronic kidney disease stage 3b or more advanced renal impairment (i.e., estimated glomerular filtration rate \\[eGFR\\]\u002Fcreatinine clearance \\[CrCl\\] \\\u003C45 ml\u002Fmin);\n6. Left ventricular outflow tract obstruction, acute or fulminant myocarditis, aortic aneurysm, aortic dissection, or significant hemodynamic changes caused by unrepaired valves;\n7. Cardiac shock, uncontrollable malignant arrhythmias, second-degree or higher sinus or atrioventricular block without pacemaker therapy, progressive unstable angina pectoris, or acute myocardial infarction;\n8. Uncontrolled hypertension with systolic blood pressure (SBP) ≥180 mmHg and\u002For diastolic blood pressure (DBP) ≥110 mmHg; or SBP \\\u003C90 mmHg and\u002For DBP \\\u003C60 mmHg;\n9. Female patients who are pregnant, planning to become pregnant, or breastfeeding;\n10. Patients who have participated in any other investigational medicinal product clinical trial within the past 4 weeks;\n11. Patients with a history of allergies or hypersensitivity to glimepiride or its derivatives;\n12. Received glimepiride treatment within 8 weeks prior to enrollment or previously demonstrated intolerance to glimepiride;\n13. Patients refusing to comply with study requirements to complete the research;\n14. Conditions where the investigator deems the patient unable to understand and\u002For comply with study medications, procedures, or any other circumstances that may prevent completion of the study;\n15. Any other reason deemed inappropriate for inclusion by the study physician.","ALL","18 Years","80 Years",{"count":106,"type":107},1484,"ESTIMATED","INTERVENTIONAL",[110],"PHASE3","Evaluating the safety and efficacy of glimepiride in patients with type 2 diabetes and chronic heart failure with reduced ejection fraction--a multicenter randomized controlled study.",[113,114],"Type 2 Diabetes Mellitus (T2DM)","Chronic Heart Failure (CHF)",[113,116,117,118],"Chronic heart failure (CHF)","Glimepiride","Randomized clinical trial","NOT_YET_RECRUITING","2025-12-05",{"date":122,"type":123},"2025-12-17","ACTUAL",{"date":125,"type":107},"2026-01-01",{"date":127,"type":107},"2031-12-31",{"name":5,"class":6},1]