[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100478622":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":46,"centralContacts":54,"locations":60,"responsibleParty":1011,"collaborators":1013,"id":1037,"slug":1038,"hasResults":1039,"nctId":1040,"briefTitle":1041,"officialTitle":1042,"acronym":1043,"eligibilityCriteria":1044,"healthyVolunteers":1039,"sex":1045,"minAge":1046,"maxAge":29,"enrollmentInfo":1047,"targetDuration":29,"studyType":1050,"phases":1051,"briefSummary":1053,"conditions":1054,"keywords":29,"overallStatus":63,"whyStopped":29,"lastUpdateSubmitDate":1059,"lastUpdatePostDateStruct":1060,"startDateStruct":1063,"completionDateStruct":1065,"leadSponsor":1067,"locationsCount":1068},{"fullName":5,"class":6},"European Organisation for Research and Treatment of Cancer - EORTC","NETWORK",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental arm","EXPERIMENTAL","elacestrant 400 mg\u002Fday orally once daily on a continuous dosing schedule",[13],"Drug: Elacestrant",{"label":15,"type":16,"description":17,"interventionNames":18},"Control arm","ACTIVE_COMPARATOR","standard endocrine treatment - the same they were receiving at the time of ctDNA detection",[19,20,21,22],"Drug: Tamoxifen","Drug: Letrozole 2.5mg","Drug: Anastrozole 1mg","Drug: Exemestane 25 MG",[24,30,34,38,42],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"DRUG","Elacestrant","400mg QD orally on a continuous dosing schedule",[9],null,{"type":25,"name":31,"description":32,"armGroupLabels":33,"otherNames":29},"Tamoxifen","20 mg QD orally on a continuous dosing schedule",[15],{"type":25,"name":35,"description":36,"armGroupLabels":37,"otherNames":29},"Letrozole 2.5mg","2.5 mg QD orally on a continuous dosing schedule",[15],{"type":25,"name":39,"description":40,"armGroupLabels":41,"otherNames":29},"Anastrozole 1mg","1 mg QD orally on a continuous dosing schedule",[15],{"type":25,"name":43,"description":44,"armGroupLabels":45,"otherNames":29},"Exemestane 25 MG","25 mg QD orally on a continuous dosing schedule",[15],[47,51],{"name":48,"affiliation":49,"role":50},"Michail Ignatiadis","Institut Jules Bordet, Belgium","STUDY_CHAIR",{"name":52,"affiliation":53,"role":50},"Emmanouil Saloustros","General University Hospital of Larissa, Greece",[55],{"name":56,"role":57,"phone":58,"phoneExt":29,"email":59},"EORTC HQ","CONTACT","+32 2 774 16 11","eortc@eortc.org",[61,74,83,88,97,106,115,124,133,142,151,162,171,182,191,200,209,218,227,236,245,250,259,267,276,280,289,298,309,318,327,336,345,354,363,372,381,390,399,408,416,425,434,442,451,460,468,476,485,496,505,513,524,530,536,541,549,560,569,578,587,596,605,614,623,631,639,648,657,666,675,684,692,701,710,719,730,739,748,757,766,775,784,794,802,813,822,831,840,849,855,864,873,882,888,893,902,911,920,929,938,943,949,958,964,975,983,992,1002],{"facility":62,"status":63,"city":64,"state":29,"zip":65,"country":66,"countryCode":67,"cosmosGeoPoint":68,"geoPoint":73,"contacts":29},"Institut Jules Bordet","RECRUITING","Anderlecht","1070","Belgium","BE",{"type":69,"coordinates":70},"Point",[71,72],4.31454,50.83619,{"lat":72,"lon":71},{"facility":75,"status":63,"city":76,"state":29,"zip":77,"country":66,"countryCode":67,"cosmosGeoPoint":78,"geoPoint":82,"contacts":29},"Cliniques Universitaires Saint-Luc","Brussels","1200",{"type":69,"coordinates":79},[80,81],4.34878,50.85045,{"lat":81,"lon":80},{"facility":84,"status":63,"city":76,"state":29,"zip":29,"country":66,"countryCode":67,"cosmosGeoPoint":85,"geoPoint":87,"contacts":29},"Hopital Universitaire Brugmann",{"type":69,"coordinates":86},[80,81],{"lat":81,"lon":80},{"facility":89,"status":63,"city":90,"state":29,"zip":91,"country":66,"countryCode":67,"cosmosGeoPoint":92,"geoPoint":96,"contacts":29},"Grand Hopital de Charleroi - Site Notre Dame","Charleroi","6000",{"type":69,"coordinates":93},[94,95],4.44448,50.41136,{"lat":95,"lon":94},{"facility":98,"status":63,"city":99,"state":29,"zip":100,"country":66,"countryCode":67,"cosmosGeoPoint":101,"geoPoint":105,"contacts":29},"CHU Helora Pole Hospitalier Jolimont - Hopital Jolimont","Haine-Saint-Paul","7100",{"type":69,"coordinates":102},[103,104],4.1885,50.45544,{"lat":104,"lon":103},{"facility":107,"status":63,"city":108,"state":29,"zip":109,"country":66,"countryCode":67,"cosmosGeoPoint":110,"geoPoint":114,"contacts":29},"AZ Groeninge Kortrijk - Campus Kennedylaan","Kortrijk","8500",{"type":69,"coordinates":111},[112,113],3.26487,50.82803,{"lat":113,"lon":112},{"facility":116,"status":63,"city":117,"state":29,"zip":118,"country":66,"countryCode":67,"cosmosGeoPoint":119,"geoPoint":123,"contacts":29},"U.Z. Leuven - Campus Gasthuisberg","Leuven","3000",{"type":69,"coordinates":120},[121,122],4.70093,50.87959,{"lat":122,"lon":121},{"facility":125,"status":63,"city":126,"state":29,"zip":127,"country":66,"countryCode":67,"cosmosGeoPoint":128,"geoPoint":132,"contacts":29},"CHU Site Sainte-Elisabeth-UCL Namur","Namur","5000",{"type":69,"coordinates":129},[130,131],4.86746,50.4669,{"lat":131,"lon":130},{"facility":134,"status":63,"city":135,"state":29,"zip":136,"country":66,"countryCode":67,"cosmosGeoPoint":137,"geoPoint":141,"contacts":29},"AZ Delta - Campus Rumbeke","Roeselare","8800",{"type":69,"coordinates":138},[139,140],3.12269,50.94653,{"lat":140,"lon":139},{"facility":143,"status":63,"city":144,"state":29,"zip":145,"country":66,"countryCode":67,"cosmosGeoPoint":146,"geoPoint":150,"contacts":29},"Centre Hospitalier Regional Verviers","Verviers","4800",{"type":69,"coordinates":147},[148,149],5.86241,50.58907,{"lat":149,"lon":148},{"facility":152,"status":63,"city":153,"state":29,"zip":154,"country":155,"countryCode":156,"cosmosGeoPoint":157,"geoPoint":161,"contacts":29},"German Oncology Center","Limassol","4108","Cyprus","CY",{"type":69,"coordinates":158},[159,160],33.03794,34.68406,{"lat":160,"lon":159},{"facility":163,"status":63,"city":164,"state":29,"zip":165,"country":155,"countryCode":156,"cosmosGeoPoint":166,"geoPoint":170,"contacts":29},"Bank Of Cyprus Oncology Centre","Stróvolos","2006",{"type":69,"coordinates":167},[168,169],33.33384,35.14867,{"lat":169,"lon":168},{"facility":172,"status":63,"city":173,"state":29,"zip":174,"country":175,"countryCode":176,"cosmosGeoPoint":177,"geoPoint":181,"contacts":29},"Clinique Belharra-Ramsay Sante","Bayonne","64100","France","FR",{"type":69,"coordinates":178},[179,180],-1.473,43.49316,{"lat":180,"lon":179},{"facility":183,"status":63,"city":184,"state":29,"zip":185,"country":175,"countryCode":176,"cosmosGeoPoint":186,"geoPoint":190,"contacts":29},"Centre de Radiotherapie Pierre Curie","Beuvry","62660",{"type":69,"coordinates":187},[188,189],2.68541,50.51674,{"lat":189,"lon":188},{"facility":192,"status":63,"city":193,"state":29,"zip":194,"country":175,"countryCode":176,"cosmosGeoPoint":195,"geoPoint":199,"contacts":29},"Centre Hospitalier - Boulogne Sur Mer","Boulogne-sur-Mer","62321",{"type":69,"coordinates":196},[197,198],1.61373,50.72485,{"lat":198,"lon":197},{"facility":201,"status":63,"city":202,"state":29,"zip":203,"country":175,"countryCode":176,"cosmosGeoPoint":204,"geoPoint":208,"contacts":29},"CHU de Lyon - Hopital Femme Mere Enfant","Bron","69677",{"type":69,"coordinates":205},[206,207],4.91303,45.73865,{"lat":207,"lon":206},{"facility":210,"status":63,"city":211,"state":29,"zip":212,"country":175,"countryCode":176,"cosmosGeoPoint":213,"geoPoint":217,"contacts":29},"Societe de Recherche Oncologique Clinique 37","Chambray-lès-Tours","31170",{"type":69,"coordinates":214},[215,216],0.70286,47.33537,{"lat":216,"lon":215},{"facility":219,"status":63,"city":220,"state":29,"zip":221,"country":175,"countryCode":176,"cosmosGeoPoint":222,"geoPoint":226,"contacts":29},"Hopital de Douai- Centre Leonard de Vinci","Dechy","59187",{"type":69,"coordinates":223},[224,225],3.11667,50.35,{"lat":225,"lon":224},{"facility":228,"status":63,"city":229,"state":29,"zip":230,"country":175,"countryCode":176,"cosmosGeoPoint":231,"geoPoint":235,"contacts":29},"CHU de Limoges - Hopital Dupuytren","Limoges","87042",{"type":69,"coordinates":232},[233,234],1.24759,45.83362,{"lat":234,"lon":233},{"facility":237,"status":63,"city":238,"state":29,"zip":239,"country":175,"countryCode":176,"cosmosGeoPoint":240,"geoPoint":244,"contacts":29},"CHU de Lyon - Hopital De La Croix Rousse","Lyon","69004",{"type":69,"coordinates":241},[242,243],4.84789,45.74906,{"lat":243,"lon":242},{"facility":246,"status":63,"city":238,"state":29,"zip":29,"country":175,"countryCode":176,"cosmosGeoPoint":247,"geoPoint":249,"contacts":29},"CHU de Lyon - Hopital de la Croix Rousse",{"type":69,"coordinates":248},[242,243],{"lat":243,"lon":242},{"facility":251,"status":63,"city":252,"state":29,"zip":253,"country":175,"countryCode":176,"cosmosGeoPoint":254,"geoPoint":258,"contacts":29},"Polyclinique De Gentilly - Centre d'Oncologie","Nancy","54100",{"type":69,"coordinates":255},[256,257],6.18496,48.68439,{"lat":257,"lon":256},{"facility":260,"status":63,"city":261,"state":29,"zip":29,"country":175,"countryCode":176,"cosmosGeoPoint":262,"geoPoint":266,"contacts":29},"Institut Curie - Hopital de Paris","Paris",{"type":69,"coordinates":263},[264,265],2.3488,48.85341,{"lat":265,"lon":264},{"facility":268,"status":63,"city":269,"state":29,"zip":270,"country":175,"countryCode":176,"cosmosGeoPoint":271,"geoPoint":275,"contacts":29},"CHU de Lyon - Hopital Lyon Sud","Pierre-Bénite","69495",{"type":69,"coordinates":272},[273,274],4.82424,45.70359,{"lat":274,"lon":273},{"facility":268,"status":63,"city":269,"state":29,"zip":29,"country":175,"countryCode":176,"cosmosGeoPoint":277,"geoPoint":279,"contacts":29},{"type":69,"coordinates":278},[273,274],{"lat":274,"lon":273},{"facility":281,"status":63,"city":282,"state":29,"zip":283,"country":175,"countryCode":176,"cosmosGeoPoint":284,"geoPoint":288,"contacts":29},"Institut Curie - l'Hopital de St Cloud","Saint-Cloud","92210",{"type":69,"coordinates":285},[286,287],2.20289,48.84598,{"lat":287,"lon":286},{"facility":290,"status":63,"city":291,"state":29,"zip":292,"country":175,"countryCode":176,"cosmosGeoPoint":293,"geoPoint":297,"contacts":29},"CHU de Toulouse - Institut Claudius Regaud - IUCT oncopole","Toulouse","31059",{"type":69,"coordinates":294},[295,296],1.44367,43.60426,{"lat":296,"lon":295},{"facility":299,"status":63,"city":300,"state":29,"zip":301,"country":302,"countryCode":303,"cosmosGeoPoint":304,"geoPoint":308,"contacts":29},"Universitaetsklinikum Aachen AOR - Medizinische Fakultaet der RWTH","Aachen","52074","Germany","DE",{"type":69,"coordinates":305},[306,307],6.08342,50.77664,{"lat":307,"lon":306},{"facility":310,"status":63,"city":311,"state":29,"zip":312,"country":302,"countryCode":303,"cosmosGeoPoint":313,"geoPoint":317,"contacts":29},"Gemeinschaftspraxis Augsburg","Augsburg","86150",{"type":69,"coordinates":314},[315,316],10.89851,48.37154,{"lat":316,"lon":315},{"facility":319,"status":63,"city":320,"state":29,"zip":321,"country":302,"countryCode":303,"cosmosGeoPoint":322,"geoPoint":326,"contacts":29},"Evangelisches Krankenhaus -Bergisch Gladbach","Bergisch Gladbach","51465",{"type":69,"coordinates":323},[324,325],7.13298,50.9856,{"lat":325,"lon":324},{"facility":328,"status":63,"city":329,"state":29,"zip":330,"country":302,"countryCode":303,"cosmosGeoPoint":331,"geoPoint":335,"contacts":29},"Marienhospital Bottrop gGmbH","Bottrop","46236",{"type":69,"coordinates":332},[333,334],6.9285,51.52392,{"lat":334,"lon":333},{"facility":337,"status":63,"city":338,"state":29,"zip":339,"country":302,"countryCode":303,"cosmosGeoPoint":340,"geoPoint":344,"contacts":29},"Hamatologische Onkologische Praxis Im Medicum","Bremen","28209",{"type":69,"coordinates":341},[342,343],8.80717,53.07582,{"lat":343,"lon":342},{"facility":346,"status":63,"city":347,"state":29,"zip":348,"country":302,"countryCode":303,"cosmosGeoPoint":349,"geoPoint":353,"contacts":29},"St Elisabeth-Krankenhaus","Cologne","50935",{"type":69,"coordinates":350},[351,352],6.95,50.93333,{"lat":352,"lon":351},{"facility":355,"status":63,"city":356,"state":29,"zip":357,"country":302,"countryCode":303,"cosmosGeoPoint":358,"geoPoint":362,"contacts":29},"Universitaetsklinikum Carl Gustav Carus (TUD)","Dresden","01307",{"type":69,"coordinates":359},[360,361],13.73832,51.05089,{"lat":361,"lon":360},{"facility":364,"status":63,"city":365,"state":29,"zip":366,"country":302,"countryCode":303,"cosmosGeoPoint":367,"geoPoint":371,"contacts":29},"Medizinische Hochschule Hannover","Hanover","30625",{"type":69,"coordinates":368},[369,370],9.73322,52.37052,{"lat":370,"lon":369},{"facility":373,"status":63,"city":374,"state":29,"zip":375,"country":302,"countryCode":303,"cosmosGeoPoint":376,"geoPoint":380,"contacts":29},"Gemeinschaftspraxis Dr. Pourfard \u002F Dr. Uleer","Hildesheim","31134",{"type":69,"coordinates":377},[378,379],9.95112,52.15077,{"lat":379,"lon":378},{"facility":382,"status":63,"city":383,"state":29,"zip":384,"country":302,"countryCode":303,"cosmosGeoPoint":385,"geoPoint":389,"contacts":29},"Klinikum Kassel Gmbh","Kassel","34125",{"type":69,"coordinates":386},[387,388],9.5,51.31667,{"lat":388,"lon":387},{"facility":391,"status":63,"city":392,"state":29,"zip":393,"country":302,"countryCode":303,"cosmosGeoPoint":394,"geoPoint":398,"contacts":29},"MVM MbH -Onkologie UnterEms, Leer-Papenburg-Emden","Leer","26789",{"type":69,"coordinates":395},[396,397],7.461,53.23157,{"lat":397,"lon":396},{"facility":400,"status":63,"city":401,"state":29,"zip":402,"country":302,"countryCode":303,"cosmosGeoPoint":403,"geoPoint":407,"contacts":29},"Busch MCZ GmbH","Mühlhausen","99974",{"type":69,"coordinates":404},[405,406],10.45275,51.20896,{"lat":406,"lon":405},{"facility":409,"status":63,"city":410,"state":29,"zip":29,"country":302,"countryCode":303,"cosmosGeoPoint":411,"geoPoint":415,"contacts":29},"Klinikum rechts der Isar München","München",{"type":69,"coordinates":412},[413,414],13.31243,51.60698,{"lat":414,"lon":413},{"facility":417,"status":63,"city":418,"state":29,"zip":419,"country":302,"countryCode":303,"cosmosGeoPoint":420,"geoPoint":424,"contacts":29},"Klinikum Nuernberg- Standort Nord","Nuremberg","90419",{"type":69,"coordinates":421},[422,423],11.07752,49.45421,{"lat":423,"lon":422},{"facility":426,"status":63,"city":427,"state":29,"zip":428,"country":302,"countryCode":303,"cosmosGeoPoint":429,"geoPoint":433,"contacts":29},"Klinikum Ernst von Bergmann gemeinnützige GmbH","Potsdam","14467",{"type":69,"coordinates":430},[431,432],13.06566,52.39886,{"lat":432,"lon":431},{"facility":435,"status":63,"city":436,"state":29,"zip":29,"country":302,"countryCode":303,"cosmosGeoPoint":437,"geoPoint":441,"contacts":29},"Mathias Spital Rheine","Rheine",{"type":69,"coordinates":438},[439,440],7.44055,52.28509,{"lat":440,"lon":439},{"facility":443,"status":63,"city":444,"state":29,"zip":445,"country":302,"countryCode":303,"cosmosGeoPoint":446,"geoPoint":450,"contacts":29},"Universitaetsklinikum Tuebingen-calwerstrasse","Tübingen","72076",{"type":69,"coordinates":447},[448,449],9.05222,48.52266,{"lat":449,"lon":448},{"facility":452,"status":63,"city":453,"state":29,"zip":454,"country":302,"countryCode":303,"cosmosGeoPoint":455,"geoPoint":459,"contacts":29},"Universitaetsklinikum Ulm-Michelsberg","Ulm","89075",{"type":69,"coordinates":456},[457,458],9.99155,48.39841,{"lat":458,"lon":457},{"facility":461,"status":63,"city":462,"state":29,"zip":29,"country":302,"countryCode":303,"cosmosGeoPoint":463,"geoPoint":467,"contacts":29},"GRN Klinik Weinheim","Weinheim",{"type":69,"coordinates":464},[465,466],8.66697,49.54887,{"lat":466,"lon":465},{"facility":469,"status":63,"city":470,"state":29,"zip":29,"country":302,"countryCode":303,"cosmosGeoPoint":471,"geoPoint":475,"contacts":29},"Rems-Murr-Kliniken gGmbH","Winnenden",{"type":69,"coordinates":472},[473,474],9.39819,48.87563,{"lat":474,"lon":473},{"facility":477,"status":63,"city":478,"state":29,"zip":479,"country":302,"countryCode":303,"cosmosGeoPoint":480,"geoPoint":484,"contacts":29},"HELIOS Kliniken - Helios Klinikum Wuppertal - Klin. Univ. Witten \u002F Herdecke","Wuppertal","42283",{"type":69,"coordinates":481},[482,483],7.14816,51.25627,{"lat":483,"lon":482},{"facility":486,"status":63,"city":487,"state":29,"zip":488,"country":489,"countryCode":490,"cosmosGeoPoint":491,"geoPoint":495,"contacts":29},"Diagnostic & Therapeutic Center of Athens Hygeia Hospital S.A.","Athens","15123","Greece","GR",{"type":69,"coordinates":492},[493,494],23.72784,37.98376,{"lat":494,"lon":493},{"facility":497,"status":63,"city":498,"state":29,"zip":499,"country":489,"countryCode":490,"cosmosGeoPoint":500,"geoPoint":504,"contacts":29},"General University Hospital of Larissa","Larissa","41110",{"type":69,"coordinates":501},[502,503],22.42112,39.62847,{"lat":503,"lon":502},{"facility":506,"status":63,"city":507,"state":29,"zip":29,"country":489,"countryCode":490,"cosmosGeoPoint":508,"geoPoint":512,"contacts":29},"Agios Loukas Clinic (St Lukes)","Thessaloniki",{"type":69,"coordinates":509},[510,511],22.93493,40.64072,{"lat":511,"lon":510},{"facility":514,"status":63,"city":515,"state":29,"zip":516,"country":517,"countryCode":518,"cosmosGeoPoint":519,"geoPoint":523,"contacts":29},"Mater Private Hospital","Dublin","D07 WKW8","Ireland","IE",{"type":69,"coordinates":520},[521,522],-6.24889,53.33306,{"lat":522,"lon":521},{"facility":525,"status":63,"city":515,"state":29,"zip":526,"country":517,"countryCode":518,"cosmosGeoPoint":527,"geoPoint":529,"contacts":29},"St. James'S Hospital","D08 NHY1",{"type":69,"coordinates":528},[521,522],{"lat":522,"lon":521},{"facility":531,"status":63,"city":515,"state":29,"zip":532,"country":517,"countryCode":518,"cosmosGeoPoint":533,"geoPoint":535,"contacts":29},"Beacon Hospital","D18 AK68",{"type":69,"coordinates":534},[521,522],{"lat":522,"lon":521},{"facility":537,"status":63,"city":515,"state":29,"zip":29,"country":517,"countryCode":518,"cosmosGeoPoint":538,"geoPoint":540,"contacts":29},"Mater Misericordia University Hospital",{"type":69,"coordinates":539},[521,522],{"lat":522,"lon":521},{"facility":542,"status":63,"city":543,"state":29,"zip":29,"country":517,"countryCode":518,"cosmosGeoPoint":544,"geoPoint":548,"contacts":29},"University Hospital Waterford","Waterford",{"type":69,"coordinates":545},[546,547],-7.11194,52.25833,{"lat":547,"lon":546},{"facility":550,"status":63,"city":551,"state":29,"zip":552,"country":553,"countryCode":554,"cosmosGeoPoint":555,"geoPoint":559,"contacts":29},"Centro Di Riferimento Oncologico","Aviano","33081","Italy","IT",{"type":69,"coordinates":556},[557,558],12.59472,46.07056,{"lat":558,"lon":557},{"facility":561,"status":63,"city":562,"state":29,"zip":563,"country":553,"countryCode":554,"cosmosGeoPoint":564,"geoPoint":568,"contacts":29},"Azienda Ospedaliera Papa Giovanni XXIII","Bergamo","24127",{"type":69,"coordinates":565},[566,567],9.66721,45.69601,{"lat":567,"lon":566},{"facility":570,"status":63,"city":571,"state":29,"zip":572,"country":553,"countryCode":554,"cosmosGeoPoint":573,"geoPoint":577,"contacts":29},"Univ. of Florence -Azienda Ospedaliero-Universitaria Careggi","Florence","50134",{"type":69,"coordinates":574},[575,576],11.24626,43.77925,{"lat":576,"lon":575},{"facility":579,"status":63,"city":580,"state":29,"zip":581,"country":553,"countryCode":554,"cosmosGeoPoint":582,"geoPoint":586,"contacts":29},"IRCCS Azienda Policlinico San Martino","Genova","16132",{"type":69,"coordinates":583},[584,585],11.87211,45.21604,{"lat":585,"lon":584},{"facility":588,"status":63,"city":589,"state":29,"zip":590,"country":553,"countryCode":554,"cosmosGeoPoint":591,"geoPoint":595,"contacts":29},"Azienda USL IRCCS Di Reggio Emilia Guastalla","Guastalla","42016",{"type":69,"coordinates":592},[593,594],10.66186,44.91172,{"lat":594,"lon":593},{"facility":597,"status":63,"city":598,"state":29,"zip":599,"country":553,"countryCode":554,"cosmosGeoPoint":600,"geoPoint":604,"contacts":29},"Ospedale Alessandro Manzoni","Lecco","23900",{"type":69,"coordinates":601},[602,603],9.39704,45.85589,{"lat":603,"lon":602},{"facility":606,"status":63,"city":607,"state":29,"zip":608,"country":553,"countryCode":554,"cosmosGeoPoint":609,"geoPoint":613,"contacts":29},"Azienda Unita Locale Socio-Sanitaria N. 9-Mater Salutis Hospital","Legnano","37045",{"type":69,"coordinates":610},[611,612],8.91506,45.59788,{"lat":612,"lon":611},{"facility":615,"status":63,"city":616,"state":29,"zip":617,"country":553,"countryCode":554,"cosmosGeoPoint":618,"geoPoint":622,"contacts":29},"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\"","Meldola","47014",{"type":69,"coordinates":619},[620,621],12.0626,44.12775,{"lat":621,"lon":620},{"facility":624,"status":63,"city":625,"state":29,"zip":29,"country":553,"countryCode":554,"cosmosGeoPoint":626,"geoPoint":630,"contacts":29},"Instituto Europeo di Oncologia","Milan",{"type":69,"coordinates":627},[628,629],12.59836,42.78235,{"lat":629,"lon":628},{"facility":632,"status":63,"city":633,"state":29,"zip":29,"country":553,"countryCode":554,"cosmosGeoPoint":634,"geoPoint":638,"contacts":29},"Azienda Ospedaliero - Universitaria Policlinico di Modena","Modena",{"type":69,"coordinates":635},[636,637],10.92539,44.64783,{"lat":637,"lon":636},{"facility":640,"status":63,"city":641,"state":29,"zip":642,"country":553,"countryCode":554,"cosmosGeoPoint":643,"geoPoint":647,"contacts":29},"University Hospital of Cagliari Duilio Casula Hospital Unit (Policlinico)","Monserrato","09042",{"type":69,"coordinates":644},[645,646],9.1444,39.25642,{"lat":646,"lon":645},{"facility":649,"status":63,"city":650,"state":29,"zip":651,"country":553,"countryCode":554,"cosmosGeoPoint":652,"geoPoint":656,"contacts":29},"Azienda Ospedaliera Universitaria \"Federico II\"","Naples","80131",{"type":69,"coordinates":653},[654,655],14.26811,40.85216,{"lat":655,"lon":654},{"facility":658,"status":63,"city":659,"state":29,"zip":660,"country":553,"countryCode":554,"cosmosGeoPoint":661,"geoPoint":665,"contacts":29},"Azienda Ospedaliero-Universitaria di Parma","Parma","43126",{"type":69,"coordinates":662},[663,664],10.32618,44.79935,{"lat":664,"lon":663},{"facility":667,"status":63,"city":668,"state":29,"zip":669,"country":553,"countryCode":554,"cosmosGeoPoint":670,"geoPoint":674,"contacts":29},"Istituti Clinici Scientifici Maugeri","Pavia","27100",{"type":69,"coordinates":671},[672,673],9.15917,45.19205,{"lat":673,"lon":672},{"facility":676,"status":63,"city":677,"state":29,"zip":678,"country":553,"countryCode":554,"cosmosGeoPoint":679,"geoPoint":683,"contacts":29},"San Maria della Misericordia Hospital","Perugia","06129",{"type":69,"coordinates":680},[681,682],12.38878,43.1122,{"lat":682,"lon":681},{"facility":685,"status":63,"city":686,"state":29,"zip":29,"country":553,"countryCode":554,"cosmosGeoPoint":687,"geoPoint":691,"contacts":29},"Ospedale P. Pederzoli Casa Di Cura Privata","Peschiera del Garda",{"type":69,"coordinates":688},[689,690],10.68614,45.43912,{"lat":690,"lon":689},{"facility":693,"status":63,"city":694,"state":29,"zip":695,"country":553,"countryCode":554,"cosmosGeoPoint":696,"geoPoint":700,"contacts":29},"Azienda Ospedaliera Universitaria Pisana","Pisa","56126",{"type":69,"coordinates":697},[698,699],10.4036,43.70853,{"lat":699,"lon":698},{"facility":702,"status":63,"city":703,"state":29,"zip":704,"country":553,"countryCode":554,"cosmosGeoPoint":705,"geoPoint":709,"contacts":29},"Azienda USL IRCCS Di Reggio Emilia - Maria Nuova","Reggio Emilia","42100",{"type":69,"coordinates":706},[707,708],10.63125,44.69825,{"lat":708,"lon":707},{"facility":711,"status":63,"city":712,"state":29,"zip":713,"country":553,"countryCode":554,"cosmosGeoPoint":714,"geoPoint":718,"contacts":29},"AUSL Romagna - AUSL Della Romagna - Infermi Hospital -Rimini","Rimini","47923",{"type":69,"coordinates":715},[716,717],12.56528,44.05755,{"lat":717,"lon":716},{"facility":720,"status":63,"city":721,"state":29,"zip":722,"country":723,"countryCode":724,"cosmosGeoPoint":725,"geoPoint":729,"contacts":29},"Flevoziekenhuis Stichting","Almere Stad","1315 RA","Netherlands","NL",{"type":69,"coordinates":726},[727,728],5.21413,52.37025,{"lat":728,"lon":727},{"facility":731,"status":63,"city":732,"state":29,"zip":733,"country":723,"countryCode":724,"cosmosGeoPoint":734,"geoPoint":738,"contacts":29},"Amsterdam UMC - locatie VUMC","Amsterdam","1081 HV",{"type":69,"coordinates":735},[736,737],4.88969,52.37403,{"lat":737,"lon":736},{"facility":740,"status":63,"city":741,"state":29,"zip":742,"country":723,"countryCode":724,"cosmosGeoPoint":743,"geoPoint":747,"contacts":29},"Rijnstate Hospital","Arnhem","6815",{"type":69,"coordinates":744},[745,746],5.91111,51.98,{"lat":746,"lon":745},{"facility":749,"status":63,"city":750,"state":29,"zip":751,"country":723,"countryCode":724,"cosmosGeoPoint":752,"geoPoint":756,"contacts":29},"Haaglanden Medisch Centrum","Leidschendam","2262 BA",{"type":69,"coordinates":753},[754,755],4.39281,52.08167,{"lat":755,"lon":754},{"facility":758,"status":63,"city":759,"state":29,"zip":760,"country":723,"countryCode":724,"cosmosGeoPoint":761,"geoPoint":765,"contacts":29},"Ikazia Ziekenhuis","Rotterdam","3083",{"type":69,"coordinates":762},[763,764],4.47917,51.9225,{"lat":764,"lon":763},{"facility":767,"status":63,"city":768,"state":29,"zip":769,"country":723,"countryCode":724,"cosmosGeoPoint":770,"geoPoint":774,"contacts":29},"Sint Antonius - St Antonius Ziekenhuis Utrecht","Utrecht","3543",{"type":69,"coordinates":771},[772,773],5.12222,52.09083,{"lat":773,"lon":772},{"facility":776,"status":63,"city":777,"state":29,"zip":778,"country":723,"countryCode":724,"cosmosGeoPoint":779,"geoPoint":783,"contacts":29},"VieCuri - Medisch Centrum voor Noord-Limburg - Locatie Venlo","Venlo","5912",{"type":69,"coordinates":780},[781,782],6.16806,51.37,{"lat":782,"lon":781},{"facility":785,"status":63,"city":786,"state":29,"zip":29,"country":787,"countryCode":788,"cosmosGeoPoint":789,"geoPoint":793,"contacts":29},"Hospital CUF Tejo","Lisbon","Portugal","PT",{"type":69,"coordinates":790},[791,792],-9.1498,38.72509,{"lat":792,"lon":791},{"facility":795,"status":63,"city":796,"state":29,"zip":29,"country":787,"countryCode":788,"cosmosGeoPoint":797,"geoPoint":801,"contacts":29},"Centro Hospitalar Vila Nova Gaia\u002FEspinho","Vila Nova de Gaia",{"type":69,"coordinates":798},[799,800],-8.61241,41.12401,{"lat":800,"lon":799},{"facility":803,"status":63,"city":804,"state":29,"zip":805,"country":806,"countryCode":807,"cosmosGeoPoint":808,"geoPoint":812,"contacts":29},"Hospital General Universitario Doctor Balmis","Alicante","03010","Spain","ES",{"type":69,"coordinates":809},[810,811],-0.48149,38.34517,{"lat":811,"lon":810},{"facility":814,"status":63,"city":815,"state":29,"zip":816,"country":806,"countryCode":807,"cosmosGeoPoint":817,"geoPoint":821,"contacts":29},"Hospital Universitario De Cruces","Barakaldo","48903",{"type":69,"coordinates":818},[819,820],-2.98813,43.29639,{"lat":820,"lon":819},{"facility":823,"status":63,"city":824,"state":29,"zip":825,"country":806,"countryCode":807,"cosmosGeoPoint":826,"geoPoint":830,"contacts":29},"Hospital Clinico Universitario - Virgen De La Arrixaca","El Palmar","30120",{"type":69,"coordinates":827},[828,829],-0.3174,39.31305,{"lat":829,"lon":828},{"facility":832,"status":63,"city":833,"state":29,"zip":834,"country":806,"countryCode":807,"cosmosGeoPoint":835,"geoPoint":839,"contacts":29},"ICO Girona - Hospital Doctor Josep Trueta","Girona","17007",{"type":69,"coordinates":836},[837,838],2.82493,41.98311,{"lat":838,"lon":837},{"facility":841,"status":63,"city":842,"state":29,"zip":843,"country":806,"countryCode":807,"cosmosGeoPoint":844,"geoPoint":848,"contacts":29},"Hospital Universitario Virgen De Las Nieves","Granada","18014",{"type":69,"coordinates":845},[846,847],-3.60667,37.18817,{"lat":847,"lon":846},{"facility":850,"status":63,"city":842,"state":29,"zip":851,"country":806,"countryCode":807,"cosmosGeoPoint":852,"geoPoint":854,"contacts":29},"Hospital Universitario Clinico San Cecilio","18016",{"type":69,"coordinates":853},[846,847],{"lat":847,"lon":846},{"facility":856,"status":63,"city":857,"state":29,"zip":858,"country":806,"countryCode":807,"cosmosGeoPoint":859,"geoPoint":863,"contacts":29},"ICO L'Hospitalet - Hospital Duran i Reynals","L'Hospitalet de Llobregat","08908",{"type":69,"coordinates":860},[861,862],2.10028,41.35967,{"lat":862,"lon":861},{"facility":865,"status":63,"city":866,"state":29,"zip":867,"country":806,"countryCode":807,"cosmosGeoPoint":868,"geoPoint":872,"contacts":29},"Hospital Universitari Arnau De Vilanova","Lleida","25196",{"type":69,"coordinates":869},[870,871],0.62218,41.61674,{"lat":871,"lon":870},{"facility":874,"status":63,"city":875,"state":29,"zip":876,"country":806,"countryCode":807,"cosmosGeoPoint":877,"geoPoint":881,"contacts":29},"Hospital Universitario 12 De Octubre","Madrid","28041",{"type":69,"coordinates":878},[879,880],-3.70256,40.4165,{"lat":880,"lon":879},{"facility":883,"status":63,"city":875,"state":29,"zip":884,"country":806,"countryCode":807,"cosmosGeoPoint":885,"geoPoint":887,"contacts":29},"Hospitales HM Sanchinarro-CIOCC","28050",{"type":69,"coordinates":886},[879,880],{"lat":880,"lon":879},{"facility":889,"status":63,"city":875,"state":29,"zip":29,"country":806,"countryCode":807,"cosmosGeoPoint":890,"geoPoint":892,"contacts":29},"Hospital Universitario Fundacion Jimenez Diaz",{"type":69,"coordinates":891},[879,880],{"lat":880,"lon":879},{"facility":894,"status":63,"city":895,"state":29,"zip":896,"country":806,"countryCode":807,"cosmosGeoPoint":897,"geoPoint":901,"contacts":29},"Althaia Xarxa Assistencial Universitaria De Manresa Fundacio Privada","Manresa","08242",{"type":69,"coordinates":898},[899,900],1.82399,41.72815,{"lat":900,"lon":899},{"facility":903,"status":63,"city":904,"state":29,"zip":905,"country":806,"countryCode":807,"cosmosGeoPoint":906,"geoPoint":910,"contacts":29},"Hospital Universitari Son Espases","Palma de Mallorca","07010",{"type":69,"coordinates":907},[908,909],2.65024,39.56939,{"lat":909,"lon":908},{"facility":912,"status":63,"city":913,"state":29,"zip":914,"country":806,"countryCode":807,"cosmosGeoPoint":915,"geoPoint":919,"contacts":29},"Hospital Universitario de Navarra","Pamplona","31008",{"type":69,"coordinates":916},[917,918],-1.64323,42.81687,{"lat":918,"lon":917},{"facility":921,"status":63,"city":922,"state":29,"zip":923,"country":806,"countryCode":807,"cosmosGeoPoint":924,"geoPoint":928,"contacts":29},"Hospital Sant Joan de Reus","Reus","43204",{"type":69,"coordinates":925},[926,927],1.10687,41.15612,{"lat":927,"lon":926},{"facility":930,"status":63,"city":931,"state":29,"zip":932,"country":806,"countryCode":807,"cosmosGeoPoint":933,"geoPoint":937,"contacts":29},"Hospital Quironsalud Sagrado Corazon","Seville","41013",{"type":69,"coordinates":934},[935,936],-5.97317,37.38283,{"lat":936,"lon":935},{"facility":939,"status":63,"city":931,"state":29,"zip":932,"country":806,"countryCode":807,"cosmosGeoPoint":940,"geoPoint":942,"contacts":29},"University Hospital Virgen del Rocio",{"type":69,"coordinates":941},[935,936],{"lat":936,"lon":935},{"facility":944,"status":63,"city":931,"state":29,"zip":945,"country":806,"countryCode":807,"cosmosGeoPoint":946,"geoPoint":948,"contacts":29},"Hospital Universitario Virgen De La Macarena","41071",{"type":69,"coordinates":947},[935,936],{"lat":936,"lon":935},{"facility":950,"status":63,"city":951,"state":29,"zip":952,"country":806,"countryCode":807,"cosmosGeoPoint":953,"geoPoint":957,"contacts":29},"Hospital Clinico Universitario De Valencia","Valencia","46010",{"type":69,"coordinates":954},[955,956],-0.37966,39.47391,{"lat":956,"lon":955},{"facility":959,"status":63,"city":951,"state":29,"zip":960,"country":806,"countryCode":807,"cosmosGeoPoint":961,"geoPoint":963,"contacts":29},"Hospital Universitario Y Politecnico La Fe","46026",{"type":69,"coordinates":962},[955,956],{"lat":956,"lon":955},{"facility":965,"status":63,"city":966,"state":29,"zip":967,"country":968,"countryCode":969,"cosmosGeoPoint":970,"geoPoint":974,"contacts":29},"Sodra Alvsborgs Sjukhus - Vastra Gotalandsregionen","Borås","50182","Sweden","SE",{"type":69,"coordinates":971},[972,973],12.9401,57.72101,{"lat":973,"lon":972},{"facility":976,"status":63,"city":977,"state":29,"zip":29,"country":968,"countryCode":969,"cosmosGeoPoint":978,"geoPoint":982,"contacts":29},"Skane University Hospital","Lund",{"type":69,"coordinates":979},[980,981],13.19321,55.70584,{"lat":981,"lon":980},{"facility":984,"status":63,"city":985,"state":29,"zip":986,"country":968,"countryCode":969,"cosmosGeoPoint":987,"geoPoint":991,"contacts":29},"Karolinska University Hospital, location Solna","Stockholm","17164",{"type":69,"coordinates":988},[989,990],18.06871,59.32938,{"lat":990,"lon":989},{"facility":993,"status":63,"city":994,"state":29,"zip":109,"country":995,"countryCode":996,"cosmosGeoPoint":997,"geoPoint":1001,"contacts":29},"Kantonsspital Frauenfeld- Breast Unit Thurgau","Frauenfeld","Switzerland","CH",{"type":69,"coordinates":998},[999,1000],8.89893,47.55776,{"lat":1000,"lon":999},{"facility":1003,"status":63,"city":1004,"state":29,"zip":1005,"country":995,"countryCode":996,"cosmosGeoPoint":1006,"geoPoint":1010,"contacts":29},"Buergerspital Solothurn -Brustzentrum","Solothurn","4500",{"type":69,"coordinates":1007},[1008,1009],7.53714,47.20791,{"lat":1009,"lon":1008},{"type":1012,"investigatorFullName":29,"investigatorTitle":29,"investigatorAffiliation":29,"oldNameTitle":29,"oldOrganization":29},"SPONSOR",[1014,1017,1019,1021,1023,1026,1028,1031,1033,1035],{"name":1015,"class":1016},"Menarini Group","INDUSTRY",{"name":1018,"class":1016},"Natera, Inc.",{"name":1020,"class":6},"Borstkanker Onderzoek Groep",{"name":1022,"class":6},"Cancer Trials Ireland",{"name":1024,"class":1025},"SOLTI Breast Cancer Research Group","OTHER",{"name":1027,"class":6},"ETOP IBCSG Partners Foundation",{"name":1029,"class":1030},"SUCCESS","UNKNOWN",{"name":1032,"class":1025},"Hellenic Cooperative Oncology Group",{"name":1034,"class":1025},"Hellenic Oncology Research Group",{"name":1036,"class":1025},"Swedish Breast Cancer Group","100478622","phase-3-elacestrant-for-treating-erher2--breast-cancer-patients-with-ctdna-relapse-treat-ctdna-100478622",false,"NCT05512364","Elacestrant for Treating ER+\u002FHER2- Breast Cancer Patients With ctDNA Relapse (TREAT ctDNA)","Elacestrant for Treating ER+\u002FHER2- Breast Cancer Patients With ctDNA Relapse","TREAT ctDNA","Inclusion Criteria:\n\n1. ctDNA screening phase:\n\n   Main inclusion criteria:\n\n   • Female (both pre- and postmenopausal) or male patients with histologically confirmed ER positive (regardless of PR),\n\n   HER2 negative breast cancer, according to local pathologist:\n   * ER-positive defined as ≥ 10% of cells staining positive for ER or Allred proportion score ≥3\n   * HER2-negative defined as a score of 0, 1+ by immunohistochemistry (IHC) or a negative in situ hybridization (ISH) based on single-probe average HER2 copy number, as per American Society of Clinical Oncology guidelines\n   * Intermediate to high risk of recurrence after definitive treatment for early breast cancer, defined as:\n\n   FOR PATIENTS TREATED WITH PRIMARY SURGERY:\n   * Any patient with ≥ 4 positive axillary lymph nodes (stage pN2-3).\n   * 1-3 positive axillary lymph nodes (stage pN1) and either:\n   * Tumour size ≥ 5 cm or\u002Fand\n   * Histologic grade 3 or\u002Fand\n   * Ki67≥20% or\u002Fand\n   * High genomic risk defined as Oncotype Dx Recurrence Score \\>=26, Mammaprint high risk, Prosigna score \\>40 or EPclin risk score \\>=4.0.\n   * Negative axillary lymph nodes (stage pN0) and tumour size ≥ 2 cm and either\n   * Histologic grade 3 a or\u002Fand\n   * Ki67≥20% and\u002For\n   * High genomic risk defined as Oncotype Dx Recurrence Score \\>=26, Mammaprint high risk, Prosigna score \\>60 or EPclin risk score \\>=4.0. FOR PATIENTS TREATED WITH NEOADJUVANT\n\n   SYSTEMIC TREATMENT FOLLOWED BY SURGERY:\n   * Patient may have received neoadjuvant endocrine therapy or neoadjuvant chemotherapy provided that:\n   * The initial tumour and\u002For the tumour after surgery meet the criteria above defined for patients treated with primary surgery or the initial tumour was staged as cT4anyN and\n   * There is no pathological complete response, defined as no invasive disease in the breast and axilla (ypT0\u002Fis ypN0).\n   * Age ≥18 years\n   * Patients must have received at least 1 year and up to 7.5 years of ET and planned to continue adjuvant ET during ctDNA screening phase\n   * Previous adjuvant CDK4\u002F6 inhibitor or PARP-inhibitor treatment is allowed provided it is completed\n   * Invasive multicentric \u002F multifocal disease is allowed provided that all the tested foci are ER+ HER2-. A sample from the highest-risk one, according to the investigator decision based on the size and grade, should be sent to Natera to build the patient ctDNA assay.\n   * Available tumour sample from resected or biopsied tissue, with a tumour content of ≥20% (30% preferred) either before or after macro dissection (if performed) and a cell viability of a minimum 100 cells.\n   * Core Needle Biopsies (CNB): recommended minimum of four (4) cores per block\n   * Fine Needle Aspirates (FNA) are not accepted\n   * The following sample types are acceptable:\n   * 6-10 unstained slides (charged and unbaked) of 10μm each (or 12-19 unstained slides at 5 μm each), PLUS one contiguous H\\&E slide. Minimum total tissue thickness must be 60μm OR\n   * FFPE tissue block with 25mm2 minimum surface area\n   * Written informed consent must be given according to ICH\u002FGCP, and national\u002Flocal regulations.\n\n   Main exclusion criteria:\n   * Suspected recurrent disease or known conflicts with the inclusion and exclusion criteria for the randomised trial\n   * Prior treatment with any SERD or investigational ER antagonist\n   * Previous history of invasive breast cancer\n   * Previous history of any other malignancy within the last 5 years, except for adequately treated basal cell or squamous cell skin cancer, or carcinoma in situ.\n   * Previous history of bone marrow and\u002For organ transplant\n   * Bilateral invasive breast cancer\n   * Participation in another clinical study, with the exception of the SURVIVE study and observational (non-interventional) and non-drug intervention clinical studies. Note: patients participating in interventional studies may participate once they enter the follow-up period of the study\n   * Blood transfusion within 3 months prior to registration or during the screening.\n2. Randomised trial:\n\nMain inclusion criteria:\n\n* ctDNA positive according to the Signatera ctDNA assay (main study ctDNA test) or other ctDNA assay approved for diagnostic purposes.\n* Patients must meet the eligibility criteria for the screening phase, with the exception of the tissue sample requirements.\n* Patients must receive adjuvant ET at the time of the ctDNA positive test\n* Absence of locoregional and\u002For metastatic disease and\u002For new malignancy, as investigated by:\n* Mammogram (unilateral in case of mastectomy; not required in patients having undergone bilateral mastectomy) NOTE: if local investigator plans to use MRIs instead of mammograms during the study, MRI will have to be performed at baseline.\n* CT thorax and abdomen\u002Fpelvis with IV contrast. In case of any contra-indications (medical or regulatory): CT thorax without contrast + MRI abdomen\u002Fpelvis.\n* Technetium-99m bone scintigraphy\n* Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-1\n* Adequate organ function\n* Women of childbearing potential (WOCBP) must have a negative highly sensitive serum or urine pregnancy test within 7 days prior to randomisation.\n\nMain exclusion criteria:\n\n* Any unresolved toxic effect of prior therapies or surgical procedures of Grade ≥ 2 according to Common Terminology Criteria of Adverse Events (CTCAE) v5.0, with the exception of alopecia, peripheral neuropathy and other toxicities not considered a safety risk for the participant at investigator's discretion\n* Unable or unwilling to avoid over-the-counter medications, dietary\u002Fherbal supplements, and\u002For foods that are moderate\u002Fstrong inhibitors or inducers of CYP3A4 activity\n* Known difficulty in tolerating oral medications or conditions which would impair absorption of oral medications\n* Any of the following cardiovascular disorders within 3 months before enrolment:\n* myocardial infarction\n* stroke\n* severe\u002Funstable angina\n* symptomatic cardiac arrhythmia\n* prolonged QTcF ≥ Grade 3 (i.e., \\> 500 msec)\n* heart failure ≥ Class III as defined by the New York Heart Association (NYHA) guidelines\n* CTCAE version 5.0 grade 3 or 4 dyslipidemia at the time of screening, defined as cholesterol\\>400 mg\u002FdL or \\>10.34 mmol\u002FL and\u002For triglycerides\\>500 mg\u002FdL or \\>5.7 mmol\u002FL.\n* Child-Pugh Score greater than Class A\n* Uncontrolled significant active infections (≥ grade 3 according to CTCAE version 5), including active hepatitis B virus (HBV), hepatitis C virus (HCV) or human immunodeficiency Virus (HIV)\n* Coagulopathy or any history of coagulopathy within the past 6 months, including history of deep vein thrombosis or pulmonary embolism","ALL","18 Years",{"count":1048,"type":1049},220,"ESTIMATED","INTERVENTIONAL",[1052],"PHASE3","This is an international, multi-center, randomised, open label, superiority phase III trial of elacestrant vs standard endocrine therapy in patients with ER+\u002FHER2- breast cancer and ctDNA relapse.\n\nDuring the ctDNA screening phase, patients will be tested at different timepoints to detect the presence of ctDNA in their blood.\n\nPatients who are found to be ctDNA-positive and have no evidence of distant metastasis, will be randomised 1:1 between standard endocrine treatment (the same they were receiving when tested ctDNA positive) versus elacestrant, provided they meet all eligibility criteria. After completion of the protocol treatment period, treatment will be left at the discretion of the treating physician.",[1055,1056,1057,1058],"ER-positive Breast Cancer","HER2-negative Breast Cancer","Stage IIB Breast Cancer","Stage III Breast Cancer","2026-05-13",{"date":1061,"type":1062},"2026-05-15","ACTUAL",{"date":1064,"type":1062},"2023-12-15",{"date":1066,"type":1049},"2035-11-01",{"name":5,"class":6},109]