[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623220":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":31,"centralContacts":39,"locations":46,"responsibleParty":60,"collaborators":31,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":31,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":31,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":87,"overallStatus":92,"whyStopped":31,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"University of Baghdad","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Resveratrol-Based Mouthwash","EXPERIMENTAL","Participants assigned to this arm will rinse with 10 mL of the resveratrol-based mouthwash for 30 seconds. Following rinsing, participants will be instructed to refrain from eating or drinking for at least 30 minutes.\n\nThe mouthwash will be used twice daily (at baseline and after 12 hours). During the 24-hour plaque re-growth period, participants will be instructed to avoid all forms of mechanical oral hygiene, including toothbrushing, flossing, and the use of any additional oral hygiene products.",[13],"Drug: Resveratrol-Based Mouthwash",{"label":15,"type":16,"description":17,"interventionNames":18},"Chlorhexidine Mouthwash (0.12%)","ACTIVE_COMPARATOR","Participants assigned to this arm will rinse with 10 mL of 0.12% chlorhexidine digluconate mouthwash for 30 seconds. After rinsing, participants will be instructed to refrain from eating or drinking for at least 30 minutes.\n\nThe mouthwash will be used twice daily (at baseline and after 12 hours). Throughout the 24-hour plaque re-growth period, participants will be instructed to avoid all mechanical oral hygiene measures, including toothbrushing, flossing, and the use of any additional plaque control products.",[19],"Drug: Chlorhexidine Gluconate 0.12 % Mouthwash",{"label":21,"type":22,"description":23,"interventionNames":24},"Placebo mouthwash","PLACEBO_COMPARATOR","Participants assigned to this arm will rinse with 10 mL of a placebo mouthwash for 30 seconds. After rinsing, participants will be instructed to refrain from eating or drinking for at least 30 minutes.\n\nThe mouthwash will be used twice daily (at baseline and after 12 hours). During the 24-hour plaque re-growth period, participants will be instructed to avoid all mechanical oral hygiene measures, including toothbrushing, flossing, and the use of any additional oral hygiene products.",[25],"Drug: Placebo mouthwash",[27,32,36],{"type":28,"name":9,"description":29,"armGroupLabels":30,"otherNames":31},"DRUG","This intervention represents the test group of the study and consists of a resveratrol-based mouthwash (Oroxil®), a patented formulation containing resveratrol and carvacrol. The mouthwash is evaluated as a chemical plaque control agent to assess its short-term anti-plaque efficacy using a 24-hour supragingival plaque re-growth model. The intervention is administered under controlled clinical conditions and compared with chlorhexidine and placebo mouthwashes within a randomized, double-blind, crossover study design.",[9],null,{"type":28,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"Chlorhexidine Gluconate 0.12 % Mouthwash","This intervention represents the positive control group of the study and involves the use of a 0.12% chlorhexidine digluconate mouthwash. The mouthwash is employed as a reference chemical plaque control agent to evaluate its short-term anti-plaque effect using a 24-hour supragingival plaque biofilm re-growth model. The intervention is administered under standardized and controlled clinical conditions and is compared with the resveratrol-based mouthwash and a placebo within a randomized, double-blind, three-period crossover study design.",[15],{"type":28,"name":21,"description":37,"armGroupLabels":38,"otherNames":31},"This intervention represents the negative control group of the study and involves the use of a placebo mouthwash with no active antimicrobial ingredients. The placebo is used to assess supragingival plaque biofilm re-growth under standardized conditions and to provide a baseline comparison for evaluating the short-term anti-plaque effects of the resveratrol-based and chlorhexidine mouthwashes. The intervention is administered under controlled clinical conditions within a randomized, double-blind, three-period crossover study design.",[21],[40],{"name":41,"role":42,"phone":43,"phoneExt":44,"email":45},"Ahmed Hashim alyasari, master degree","CONTACT","07731873348","+9640","ahmed.khudhair@uokerbala.edu.iq",[47],{"facility":48,"status":31,"city":49,"state":31,"zip":31,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Ahmed Hashim","Karbala","Iraq","IQ",{"type":53,"coordinates":54},"Point",[55,56],44.02488,32.61603,{"lat":56,"lon":55},[59],{"name":41,"role":42,"phone":43,"phoneExt":44,"email":45},{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","Ahmed Hashim Alyasari","Assistant professor of periodontology","100623220","phase-3-evaluation-of-the-anti-plaque-effect-of-a-resveratrol-based-mouthwash-using-a-24-hour-plaque-re-growth-100623220",false,"NCT07393802","Evaluation of the Anti-Plaque Effect of a Resveratrol-Based Mouthwash Using a 24-Hour Plaque Re-Growth","Evaluation of the Anti-Plaque Effect of a Resveratrol-Based Mouthwash Using a 24-Hour Plaque Biofilm Re-Growth Randomized Crossover Clinical Trial","Inclusion Criteria:\n\n* Age between 18 and 30 years\n* Systemically healthy individuals\n* Presence of at least 20 natural teeth\n* Clinically healthy gingiva with no signs of gingivitis or periodontitis\n* No probing depth \\>3 mm\n* No clinical attachment loss\n\nExclusion Criteria:\n\n* Presence of gingivitis or periodontitis\n* Active dental caries requiring treatment\n* History of periodontal therapy within the previous 6 months\n* Use of antibiotics, anti-inflammatory drugs, or antiseptic mouthwashes within the previous 3 months\n* Smoking or tobacco use\n* Pregnancy or lactation\n* Known allergy to any mouthwash components",true,"ALL","18 Years","25 Years",{"count":76,"type":77},20,"ESTIMATED","INTERVENTIONAL",[80],"PHASE3","Dental plaque is a biofilm that accumulates on tooth surfaces and is a primary factor in the development of gingival inflammation. While toothbrushing remains the main method for plaque control, the effectiveness of mechanical oral hygiene depends largely on individual compliance and technique. As a result, mouthwashes are commonly used as adjunctive chemical plaque control agents.\n\nChlorhexidine gluconate is an effective anti-plaque mouthwash, but its use is associated with undesirable effects that may limit patient acceptance. Resveratrol is a naturally derived compound with reported antimicrobial and anti-biofilm properties, suggesting its potential use as an alternative chemical plaque control agent.\n\nThis randomized, double-blind, placebo-controlled, three-period crossover clinical trial aims to evaluate the short-term anti-plaque effect of a resveratrol-based mouthwash by measuring supragingival plaque regrowth over a 24-hour period in periodontally healthy individuals. The effects of the resveratrol-based mouthwash will be compared with 0.12% chlorhexidine (CHX) and a placebo mouthwash under standardized conditions without mechanical oral hygiene",[83,84,85,86],"Mouthwash","Chlorhexidine","Biofilm Formation","Periodontal Health",[88,89,90,91],"Resveratrol","mouthwash","anti-plaque","crossover","NOT_YET_RECRUITING","2026-01-30",{"date":95,"type":96},"2026-02-06","ACTUAL",{"date":98,"type":77},"2026-03",{"date":100,"type":77},"2026-05",{"name":5,"class":6},1]