[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100338192":3},{"organization":4,"armGroups":7,"interventions":54,"overallOfficials":61,"centralContacts":65,"locations":73,"responsibleParty":1525,"collaborators":60,"id":1527,"slug":1528,"hasResults":1529,"nctId":1530,"briefTitle":1531,"officialTitle":1532,"acronym":1533,"eligibilityCriteria":1534,"healthyVolunteers":1529,"sex":1535,"minAge":1536,"maxAge":60,"enrollmentInfo":1537,"targetDuration":60,"studyType":1540,"phases":1541,"briefSummary":1543,"conditions":1544,"keywords":60,"overallStatus":809,"whyStopped":60,"lastUpdateSubmitDate":1546,"lastUpdatePostDateStruct":1547,"startDateStruct":1550,"completionDateStruct":1552,"leadSponsor":1554,"locationsCount":1555},{"fullName":5,"class":6},"Hoffmann-La Roche","INDUSTRY",[8,14,18,22,26,30,34,38,42,46,50],{"label":9,"type":10,"description":11,"interventionNames":12},"PDS Implant Cohort 1 (US only)","EXPERIMENTAL","Participants with PDS implant from Study GX28228 treated with refill-exchanges of 100 mg\u002FmL ranibizumab Q24W. Participants will switch to an every 12 weeks (Q12W) visit schedule from Week 168 to Week 240.\n\nEligible participants from Study GX28228 will be enrolled upon completion of their final visit.",[13],"Drug: PDS Implant with Ranibizumab 100 mg\u002FmL",{"label":15,"type":10,"description":16,"interventionNames":17},"PDS Implant Cohort 2 (US only)","Participants with PDS implant from Study GR40548 treated with refill-exchanges of 100 mg\u002FmL ranibizumab Q24W. Participants will switch to an every 12 weeks (Q12W) visit schedule from Week 144 to Week 240.\n\nEligible participants from Study GR40548 will be enrolled upon completion of their final visit.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"PDS Implant Cohort 3 (US only)","Participants in the intravitreal ranibizumab arm of Study GX28228 who will receive the PDS implant upon study entry and refill-exchanges of 100 mg\u002FmL ranibizumab Q24W. Participants will switch to an every 12 weeks (Q12W) visit schedule from Week 168 to Week 240.\n\nEligible participants from Study GX28228 will be enrolled upon completion of their final visit.",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"PDS Implant Cohort 4 (US only)","Participants in the intravitreal ranibizumab arm of Study GR40548 who will receive the PDS implant upon study entry and refill-exchanges of 100 mg\u002FmL ranibizumab Q24W. Participants will switch to an every 12 weeks (Q12W) visit schedule from Week 144 to Week 240.\n\nEligible participants from Study GR40548 will be enrolled upon completion of their final visit.",[13],{"label":27,"type":10,"description":28,"interventionNames":29},"PDS Implant Cohort 5 (ex-US only)","Participants from Study WR42221 who completed Week 24 but were not eligible to be randomized within WR42221 and who will be treated with refill-exchanges of ranibizumab 100 mg\u002FmL Q24W. Participants will be in the study for a minimum of 144 weeks and may continue after Week 144 until the PDS has received Health Authority approval (or non-approval) in their respective country and\u002For until the decision to close the study has been made by the sponsor.",[13],{"label":31,"type":10,"description":32,"interventionNames":33},"PDS Implant Cohort 6 (ex-US only)","Participants from Study WR42221 randomized to the Q24W arm, who will continue to be treated with refill-exchanges of ranibizumab 100 mg\u002FmL Q24W. Participants will be in the study for a minimum of 144 weeks and may continue after Week 144 until the PDS has received Health Authority approval (or non-approval) in their respective country and\u002For until the decision to close the study has been made by the sponsor.",[13],{"label":35,"type":10,"description":36,"interventionNames":37},"PDS Implant Cohort 7 (ex-US only)","Participants from Study WR42221 randomized to the Q36W arm, who will continue to be treated with refill-exchanges of ranibizumab 100 mg\u002FmL Q36W. Participants will be in the study for a minimum of 144 weeks and may continue after Week 144 until the PDS has received Health Authority approval (or non-approval) in their respective country and\u002For until the decision to close the study has been made by the sponsor.",[13],{"label":39,"type":10,"description":40,"interventionNames":41},"Sub-study 1: PDS Implant","Participants will receive PDS implant using TPC on Day 1 followed by refill-exchanges of ranibizumab 100 mg\u002FmL via the PDS Q24W.",[13],{"label":43,"type":10,"description":44,"interventionNames":45},"Sub-study 2: Cohort 1","Participants will undergo re-implantation with the updated PDS implant and receive 2 refill-exchanges of ranibizumab 100 mg\u002FmL Q24W.",[13],{"label":47,"type":10,"description":48,"interventionNames":49},"Sub-study 2: Cohort 2a","Participants who received an updated PDS implant, have \\\u003C 24 weeks post-re-implantation follow-up and no refill exchange visit in the main study, will undergo two refill-exchange procedures with ranibizumab 100 mg\u002FmL Q24W post main study re-implantation visit.",[13],{"label":51,"type":10,"description":52,"interventionNames":53},"Sub-study 2: Cohort 2b","Participants who received an updated PDS implant, have \\\u003C 48 weeks post-re-implantation follow-up and one refill exchange visit in the main study, will undergo one refill-exchange procedure with ranibizumab 100 mg\u002FmL Q24W post main study re-implantation visit.",[13],[55],{"type":56,"name":57,"description":58,"armGroupLabels":59,"otherNames":60},"DRUG","PDS Implant with Ranibizumab 100 mg\u002FmL","Will be administered as per the schedule described in individual arm",[9,15,19,23,27,31,35,39,43,47,51],null,[62],{"name":63,"affiliation":5,"role":64},"Clinical Trials","STUDY_DIRECTOR",[66,71],{"name":67,"role":68,"phone":69,"phoneExt":60,"email":70},"Reference Study ID Number: GR40549 https:\u002F\u002Fforpatients.roche.com\u002F","CONTACT","888-662-6728 (U.S. and Canada)","global-roche-genentech-trials@gene.com",{"name":72,"role":68,"phone":60,"phoneExt":60,"email":60},"Fastest response: use the inquiry form. No email attachments. https:\u002F\u002Fwww.gene.com\u002Fcontact-us\u002Fsubmit-medical-inquiry",[74,88,94,100,106,112,122,131,140,149,158,167,176,185,194,200,209,217,227,236,245,255,265,274,283,292,301,310,319,328,337,347,357,367,376,386,396,406,415,425,435,441,450,459,469,479,488,498,508,517,527,537,546,556,566,575,584,593,603,613,622,631,641,650,656,666,676,685,695,704,714,723,729,738,746,755,763,773,778,788,798,807,814,818,827,839,848,859,868,879,891,900,906,912,921,932,941,950,959,965,976,985,994,1003,1012,1021,1030,1039,1045,1054,1063,1072,1083,1092,1101,1110,1119,1128,1140,1150,1160,1170,1176,1186,1192,1198,1203,1212,1222,1227,1231,1243,1247,1257,1267,1277,1287,1295,1301,1307,1313,1322,1330,1341,1350,1359,1367,1376,1387,1395,1404,1413,1417,1427,1433,1439,1448,1457,1468,1477,1486,1492,1498,1507,1516],{"facility":75,"status":76,"city":77,"state":78,"zip":79,"country":80,"countryCode":81,"cosmosGeoPoint":82,"geoPoint":87,"contacts":60},"Retinal Research Institute, LLC","COMPLETED","Phoenix","Arizona","85014","United States","US",{"type":83,"coordinates":84},"Point",[85,86],-112.07404,33.44838,{"lat":86,"lon":85},{"facility":89,"status":76,"city":77,"state":78,"zip":90,"country":80,"countryCode":81,"cosmosGeoPoint":91,"geoPoint":93,"contacts":60},"Arizona Retina and Vitreous Consultants","85016",{"type":83,"coordinates":92},[85,86],{"lat":86,"lon":85},{"facility":95,"status":96,"city":77,"state":78,"zip":90,"country":80,"countryCode":81,"cosmosGeoPoint":97,"geoPoint":99,"contacts":60},"Barnet Dulaney Perkins Eye Center","ACTIVE_NOT_RECRUITING",{"type":83,"coordinates":98},[85,86],{"lat":86,"lon":85},{"facility":101,"status":76,"city":77,"state":78,"zip":102,"country":80,"countryCode":81,"cosmosGeoPoint":103,"geoPoint":105,"contacts":60},"Associated Retina Consultants","85020",{"type":83,"coordinates":104},[85,86],{"lat":86,"lon":85},{"facility":107,"status":76,"city":77,"state":78,"zip":108,"country":80,"countryCode":81,"cosmosGeoPoint":109,"geoPoint":111,"contacts":60},"Retinal Consultants of Arizona","85053",{"type":83,"coordinates":110},[85,86],{"lat":86,"lon":85},{"facility":113,"status":76,"city":114,"state":115,"zip":116,"country":80,"countryCode":81,"cosmosGeoPoint":117,"geoPoint":121,"contacts":60},"California Retina Consultants","Bakersfield","California","93309",{"type":83,"coordinates":118},[119,120],-119.01871,35.37329,{"lat":120,"lon":119},{"facility":123,"status":76,"city":124,"state":115,"zip":125,"country":80,"countryCode":81,"cosmosGeoPoint":126,"geoPoint":130,"contacts":60},"Retina-Vitreous Associates Medical Group","Beverly Hills","90211",{"type":83,"coordinates":127},[128,129],-118.40036,34.07362,{"lat":129,"lon":128},{"facility":132,"status":96,"city":133,"state":115,"zip":134,"country":80,"countryCode":81,"cosmosGeoPoint":135,"geoPoint":139,"contacts":60},"The Retina Partners","Encino","91436",{"type":83,"coordinates":136},[137,138],-118.50119,34.15917,{"lat":138,"lon":137},{"facility":141,"status":76,"city":142,"state":115,"zip":143,"country":80,"countryCode":81,"cosmosGeoPoint":144,"geoPoint":148,"contacts":60},"Jacobs Retina center at the Shiley eye Institute UCSD","La Jolla","92037",{"type":83,"coordinates":145},[146,147],-117.2742,32.84727,{"lat":147,"lon":146},{"facility":150,"status":76,"city":151,"state":115,"zip":152,"country":80,"countryCode":81,"cosmosGeoPoint":153,"geoPoint":157,"contacts":60},"Jules Stein Eye Institute\u002F UCLA","Los Angeles","90095-7000",{"type":83,"coordinates":154},[155,156],-118.24368,34.05223,{"lat":156,"lon":155},{"facility":159,"status":76,"city":160,"state":115,"zip":161,"country":80,"countryCode":81,"cosmosGeoPoint":162,"geoPoint":166,"contacts":60},"N CA Retina Vitreous Assoc","Mountain View","94040",{"type":83,"coordinates":163},[164,165],-122.08385,37.38605,{"lat":165,"lon":164},{"facility":168,"status":76,"city":169,"state":115,"zip":170,"country":80,"countryCode":81,"cosmosGeoPoint":171,"geoPoint":175,"contacts":60},"Retina Consultants, San Diego","Poway","92064",{"type":83,"coordinates":172},[173,174],-117.03586,32.96282,{"lat":174,"lon":173},{"facility":177,"status":76,"city":178,"state":115,"zip":179,"country":80,"countryCode":81,"cosmosGeoPoint":180,"geoPoint":184,"contacts":60},"Retinal Consultants Med Group","Sacramento","95841",{"type":83,"coordinates":181},[182,183],-121.4944,38.58157,{"lat":183,"lon":182},{"facility":186,"status":76,"city":187,"state":115,"zip":188,"country":80,"countryCode":81,"cosmosGeoPoint":189,"geoPoint":193,"contacts":60},"West Coast Retina Medical Group","San Francisco","94109",{"type":83,"coordinates":190},[191,192],-122.41942,37.77493,{"lat":192,"lon":191},{"facility":195,"status":76,"city":187,"state":115,"zip":196,"country":80,"countryCode":81,"cosmosGeoPoint":197,"geoPoint":199,"contacts":60},"UCSF","94158",{"type":83,"coordinates":198},[191,192],{"lat":192,"lon":191},{"facility":201,"status":76,"city":202,"state":115,"zip":203,"country":80,"countryCode":81,"cosmosGeoPoint":204,"geoPoint":208,"contacts":60},"Orange County Retina Med Group","Santa Ana","92705",{"type":83,"coordinates":205},[206,207],-117.86783,33.74557,{"lat":207,"lon":206},{"facility":113,"status":76,"city":210,"state":115,"zip":211,"country":80,"countryCode":81,"cosmosGeoPoint":212,"geoPoint":216,"contacts":60},"Santa Barbara","93103",{"type":83,"coordinates":213},[214,215],-119.69819,34.42083,{"lat":215,"lon":214},{"facility":218,"status":76,"city":219,"state":220,"zip":221,"country":80,"countryCode":81,"cosmosGeoPoint":222,"geoPoint":226,"contacts":60},"Southwest Retina Consultants","Durango","Colorado","81303",{"type":83,"coordinates":223},[224,225],-107.88007,37.27528,{"lat":225,"lon":224},{"facility":228,"status":76,"city":229,"state":220,"zip":230,"country":80,"countryCode":81,"cosmosGeoPoint":231,"geoPoint":235,"contacts":60},"Eye Center of Northern CO","Fort Collins","80528",{"type":83,"coordinates":232},[233,234],-105.08442,40.58526,{"lat":234,"lon":233},{"facility":237,"status":76,"city":238,"state":220,"zip":239,"country":80,"countryCode":81,"cosmosGeoPoint":240,"geoPoint":244,"contacts":60},"Colorado Retina Associates, PC","Lakewood","80228",{"type":83,"coordinates":241},[242,243],-105.08137,39.70471,{"lat":243,"lon":242},{"facility":246,"status":76,"city":247,"state":248,"zip":249,"country":80,"countryCode":81,"cosmosGeoPoint":250,"geoPoint":254,"contacts":60},"Retina Group of New England","Waterford","Connecticut","06385",{"type":83,"coordinates":251},[252,253],-72.13597,41.3417,{"lat":253,"lon":252},{"facility":256,"status":76,"city":257,"state":258,"zip":259,"country":80,"countryCode":81,"cosmosGeoPoint":260,"geoPoint":264,"contacts":60},"Florida Eye Microsurgical Inst","Boynton Beach","Florida","33426",{"type":83,"coordinates":261},[262,263],-80.06643,26.52535,{"lat":263,"lon":262},{"facility":266,"status":76,"city":267,"state":258,"zip":268,"country":80,"countryCode":81,"cosmosGeoPoint":269,"geoPoint":273,"contacts":60},"National Ophthalmic Research Institute","Fort Myers","33912",{"type":83,"coordinates":270},[271,272],-81.84059,26.62168,{"lat":272,"lon":271},{"facility":275,"status":76,"city":276,"state":258,"zip":277,"country":80,"countryCode":81,"cosmosGeoPoint":278,"geoPoint":282,"contacts":60},"Florida Eye Associates","Melbourne","32901",{"type":83,"coordinates":279},[280,281],-80.60811,28.08363,{"lat":281,"lon":280},{"facility":284,"status":76,"city":285,"state":258,"zip":286,"country":80,"countryCode":81,"cosmosGeoPoint":287,"geoPoint":291,"contacts":60},"Retina Care Specialists","Palm Beach Gardens","33410",{"type":83,"coordinates":288},[289,290],-80.13865,26.82339,{"lat":290,"lon":289},{"facility":293,"status":76,"city":294,"state":258,"zip":295,"country":80,"countryCode":81,"cosmosGeoPoint":296,"geoPoint":300,"contacts":60},"Retina Specialty Institute","Pensacola","32503",{"type":83,"coordinates":297},[298,299],-87.21691,30.42131,{"lat":299,"lon":298},{"facility":302,"status":76,"city":303,"state":258,"zip":304,"country":80,"countryCode":81,"cosmosGeoPoint":305,"geoPoint":309,"contacts":60},"Fort Lauderdale Eye Institute","Plantation","33324",{"type":83,"coordinates":306},[307,308],-80.23184,26.13421,{"lat":308,"lon":307},{"facility":311,"status":96,"city":312,"state":258,"zip":313,"country":80,"countryCode":81,"cosmosGeoPoint":314,"geoPoint":318,"contacts":60},"Retina Vitreous Assoc of FL","St. Petersburg","33711",{"type":83,"coordinates":315},[316,317],-82.67927,27.77086,{"lat":317,"lon":316},{"facility":320,"status":96,"city":321,"state":258,"zip":322,"country":80,"countryCode":81,"cosmosGeoPoint":323,"geoPoint":327,"contacts":60},"Southern Vitreoretinal Assoc","Tallahassee","32308",{"type":83,"coordinates":324},[325,326],-84.28073,30.43826,{"lat":326,"lon":325},{"facility":329,"status":76,"city":330,"state":258,"zip":331,"country":80,"countryCode":81,"cosmosGeoPoint":332,"geoPoint":336,"contacts":60},"Retina Associates of Florida, LLC","Tampa","33609",{"type":83,"coordinates":333},[334,335],-82.45843,27.94752,{"lat":335,"lon":334},{"facility":338,"status":76,"city":339,"state":340,"zip":341,"country":80,"countryCode":81,"cosmosGeoPoint":342,"geoPoint":346,"contacts":60},"Southeast Retina Center","Augusta","Georgia","30909",{"type":83,"coordinates":343},[344,345],-81.97484,33.47097,{"lat":345,"lon":344},{"facility":348,"status":349,"city":350,"state":340,"zip":351,"country":80,"countryCode":81,"cosmosGeoPoint":352,"geoPoint":356,"contacts":60},"Georgia Retina PC","WITHDRAWN","Marietta","30060",{"type":83,"coordinates":353},[354,355],-84.54993,33.9526,{"lat":355,"lon":354},{"facility":358,"status":76,"city":359,"state":360,"zip":361,"country":80,"countryCode":81,"cosmosGeoPoint":362,"geoPoint":366,"contacts":60},"Illinois Retina Associates","Joliet","Illinois","60435",{"type":83,"coordinates":363},[364,365],-88.0834,41.52519,{"lat":365,"lon":364},{"facility":368,"status":76,"city":369,"state":360,"zip":370,"country":80,"countryCode":81,"cosmosGeoPoint":371,"geoPoint":375,"contacts":60},"University Retina and Macula Associates, PC","Oak Forest","60452",{"type":83,"coordinates":372},[373,374],-87.74394,41.60281,{"lat":374,"lon":373},{"facility":377,"status":76,"city":378,"state":379,"zip":380,"country":80,"countryCode":81,"cosmosGeoPoint":381,"geoPoint":385,"contacts":60},"Wolfe Eye Clinic","West Des Moines","Iowa","50266",{"type":83,"coordinates":382},[383,384],-93.71133,41.57721,{"lat":384,"lon":383},{"facility":387,"status":76,"city":388,"state":389,"zip":390,"country":80,"countryCode":81,"cosmosGeoPoint":391,"geoPoint":395,"contacts":60},"Retina Associates","Lenexa","Kansas","66215",{"type":83,"coordinates":392},[393,394],-94.73357,38.95362,{"lat":394,"lon":393},{"facility":397,"status":76,"city":398,"state":399,"zip":400,"country":80,"countryCode":81,"cosmosGeoPoint":401,"geoPoint":405,"contacts":60},"Retina Associates of Kentucky","Lexington","Kentucky","40509",{"type":83,"coordinates":402},[403,404],-84.47772,37.98869,{"lat":404,"lon":403},{"facility":407,"status":349,"city":408,"state":399,"zip":409,"country":80,"countryCode":81,"cosmosGeoPoint":410,"geoPoint":414,"contacts":60},"Paducah Retinal Center","Paducah","42001",{"type":83,"coordinates":411},[412,413],-88.60005,37.08339,{"lat":413,"lon":412},{"facility":416,"status":76,"city":417,"state":418,"zip":419,"country":80,"countryCode":81,"cosmosGeoPoint":420,"geoPoint":424,"contacts":60},"Maine Eye Center","Portland","Maine","04101",{"type":83,"coordinates":421},[422,423],-70.2589,43.65737,{"lat":423,"lon":422},{"facility":426,"status":76,"city":427,"state":428,"zip":429,"country":80,"countryCode":81,"cosmosGeoPoint":430,"geoPoint":434,"contacts":60},"The Retina Care Center","Baltimore","Maryland","21209",{"type":83,"coordinates":431},[432,433],-76.61219,39.29038,{"lat":433,"lon":432},{"facility":436,"status":96,"city":427,"state":428,"zip":437,"country":80,"countryCode":81,"cosmosGeoPoint":438,"geoPoint":440,"contacts":60},"Johns Hopkins Med","21287",{"type":83,"coordinates":439},[432,433],{"lat":433,"lon":432},{"facility":442,"status":76,"city":443,"state":428,"zip":444,"country":80,"countryCode":81,"cosmosGeoPoint":445,"geoPoint":449,"contacts":60},"Retina Group of Washington","Chevy Chase","20815",{"type":83,"coordinates":446},[447,448],-77.07115,39.00287,{"lat":448,"lon":447},{"facility":451,"status":76,"city":452,"state":428,"zip":453,"country":80,"countryCode":81,"cosmosGeoPoint":454,"geoPoint":458,"contacts":60},"Retina Specialists","Towson","21204",{"type":83,"coordinates":455},[456,457],-76.60191,39.4015,{"lat":457,"lon":456},{"facility":460,"status":76,"city":461,"state":462,"zip":463,"country":80,"countryCode":81,"cosmosGeoPoint":464,"geoPoint":468,"contacts":60},"Ophthalmic Consultants of Boston","Boston","Massachusetts","02114",{"type":83,"coordinates":465},[466,467],-71.05977,42.35843,{"lat":467,"lon":466},{"facility":470,"status":76,"city":471,"state":472,"zip":473,"country":80,"countryCode":81,"cosmosGeoPoint":474,"geoPoint":478,"contacts":60},"Foundation for Vision Research","Grand Rapids","Michigan","49546",{"type":83,"coordinates":475},[476,477],-85.66809,42.96336,{"lat":477,"lon":476},{"facility":480,"status":76,"city":481,"state":472,"zip":482,"country":80,"countryCode":81,"cosmosGeoPoint":483,"geoPoint":487,"contacts":60},"Associated Retinal Consultants","Royal Oak","48073",{"type":83,"coordinates":484},[485,486],-83.14465,42.48948,{"lat":486,"lon":485},{"facility":489,"status":76,"city":490,"state":491,"zip":492,"country":80,"countryCode":81,"cosmosGeoPoint":493,"geoPoint":497,"contacts":60},"VitreoRetinal Surgery, PLLC.","Minneapolis","Minnesota","55435",{"type":83,"coordinates":494},[495,496],-93.26384,44.97997,{"lat":496,"lon":495},{"facility":499,"status":76,"city":500,"state":501,"zip":502,"country":80,"countryCode":81,"cosmosGeoPoint":503,"geoPoint":507,"contacts":60},"Midwest Vision Research Foundation","Chesterfield","Missouri","63017",{"type":83,"coordinates":504},[505,506],-90.57707,38.66311,{"lat":506,"lon":505},{"facility":509,"status":76,"city":510,"state":501,"zip":511,"country":80,"countryCode":81,"cosmosGeoPoint":512,"geoPoint":516,"contacts":60},"The Retina Institute - Chesterfield","St Louis","63128",{"type":83,"coordinates":513},[514,515],-90.19789,38.62727,{"lat":515,"lon":514},{"facility":518,"status":76,"city":519,"state":520,"zip":521,"country":80,"countryCode":81,"cosmosGeoPoint":522,"geoPoint":526,"contacts":60},"Sierra Eye Associates","Reno","Nevada","89502",{"type":83,"coordinates":523},[524,525],-119.8138,39.52963,{"lat":525,"lon":524},{"facility":528,"status":76,"city":529,"state":530,"zip":531,"country":80,"countryCode":81,"cosmosGeoPoint":532,"geoPoint":536,"contacts":60},"Envision Ocular, LLC","Bloomfield","New Jersey","07003",{"type":83,"coordinates":533},[534,535],-74.18542,40.80677,{"lat":535,"lon":534},{"facility":538,"status":76,"city":539,"state":530,"zip":540,"country":80,"countryCode":81,"cosmosGeoPoint":541,"geoPoint":545,"contacts":60},"Retina Associates of NJ","Teaneck","07666",{"type":83,"coordinates":542},[543,544],-74.01597,40.8976,{"lat":544,"lon":543},{"facility":547,"status":76,"city":548,"state":549,"zip":550,"country":80,"countryCode":81,"cosmosGeoPoint":551,"geoPoint":555,"contacts":60},"University of New Mexico","Albuquerque","New Mexico","87131",{"type":83,"coordinates":552},[553,554],-106.65114,35.08449,{"lat":554,"lon":553},{"facility":557,"status":76,"city":558,"state":559,"zip":560,"country":80,"countryCode":81,"cosmosGeoPoint":561,"geoPoint":565,"contacts":60},"Long Is. Vitreoretinal Consult","Great Neck","New York","11021",{"type":83,"coordinates":562},[563,564],-73.72846,40.80066,{"lat":564,"lon":563},{"facility":567,"status":76,"city":568,"state":559,"zip":569,"country":80,"countryCode":81,"cosmosGeoPoint":570,"geoPoint":574,"contacts":60},"Retina Assoc of Western NY","Rochester","14620",{"type":83,"coordinates":571},[572,573],-77.61556,43.15478,{"lat":573,"lon":572},{"facility":576,"status":76,"city":577,"state":559,"zip":578,"country":80,"countryCode":81,"cosmosGeoPoint":579,"geoPoint":583,"contacts":60},"Ophthalmic Consultants of Long Island","Rockville Centre","11570",{"type":83,"coordinates":580},[581,582],-73.64124,40.65871,{"lat":582,"lon":581},{"facility":585,"status":76,"city":586,"state":559,"zip":587,"country":80,"countryCode":81,"cosmosGeoPoint":588,"geoPoint":592,"contacts":60},"Retina Vit Surgeons\u002FCentral NY","Syracuse","13224",{"type":83,"coordinates":589},[590,591],-76.14742,43.04812,{"lat":591,"lon":590},{"facility":594,"status":76,"city":595,"state":596,"zip":597,"country":80,"countryCode":81,"cosmosGeoPoint":598,"geoPoint":602,"contacts":60},"Char Eye Ear &Throat Assoc","Charlotte","North Carolina","28210",{"type":83,"coordinates":599},[600,601],-80.84313,35.22709,{"lat":601,"lon":600},{"facility":604,"status":96,"city":605,"state":606,"zip":607,"country":80,"countryCode":81,"cosmosGeoPoint":608,"geoPoint":612,"contacts":60},"Cincinnati Eye Institute","Cincinnati","Ohio","45242",{"type":83,"coordinates":609},[610,611],-84.51439,39.12711,{"lat":611,"lon":610},{"facility":614,"status":76,"city":615,"state":606,"zip":616,"country":80,"countryCode":81,"cosmosGeoPoint":617,"geoPoint":621,"contacts":60},"The Cleveland Clinic Foundation","Cleveland","44195",{"type":83,"coordinates":618},[619,620],-81.69541,41.4995,{"lat":620,"lon":619},{"facility":623,"status":96,"city":624,"state":606,"zip":625,"country":80,"countryCode":81,"cosmosGeoPoint":626,"geoPoint":630,"contacts":60},"OSU Eye Physicians & Surgeons","Columbus","43212",{"type":83,"coordinates":627},[628,629],-82.99879,39.96118,{"lat":629,"lon":628},{"facility":632,"status":76,"city":633,"state":634,"zip":635,"country":80,"countryCode":81,"cosmosGeoPoint":636,"geoPoint":640,"contacts":60},"Retina Vitreous Center","Edmond","Oklahoma","73013",{"type":83,"coordinates":637},[638,639],-97.4781,35.65283,{"lat":639,"lon":638},{"facility":642,"status":76,"city":417,"state":643,"zip":644,"country":80,"countryCode":81,"cosmosGeoPoint":645,"geoPoint":649,"contacts":60},"Retina Northwest","Oregon","97221",{"type":83,"coordinates":646},[647,648],-122.67621,45.52345,{"lat":648,"lon":647},{"facility":651,"status":76,"city":417,"state":643,"zip":652,"country":80,"countryCode":81,"cosmosGeoPoint":653,"geoPoint":655,"contacts":60},"Oregon HSU","97239",{"type":83,"coordinates":654},[647,648],{"lat":648,"lon":647},{"facility":657,"status":76,"city":658,"state":659,"zip":660,"country":80,"countryCode":81,"cosmosGeoPoint":661,"geoPoint":665,"contacts":60},"Mid Atlantic Retina - Wills Eye Hospital","Philadelphia","Pennsylvania","19107",{"type":83,"coordinates":662},[663,664],-75.16362,39.95238,{"lat":664,"lon":663},{"facility":667,"status":76,"city":668,"state":669,"zip":670,"country":80,"countryCode":81,"cosmosGeoPoint":671,"geoPoint":675,"contacts":60},"Palmetto Retina Center","Florence","South Carolina","29501",{"type":83,"coordinates":672},[673,674],-79.76256,34.19543,{"lat":674,"lon":673},{"facility":677,"status":76,"city":678,"state":669,"zip":679,"country":80,"countryCode":81,"cosmosGeoPoint":680,"geoPoint":684,"contacts":60},"Palmetto Retina Center, LLC","West Columbia","29169",{"type":83,"coordinates":681},[682,683],-81.07398,33.99349,{"lat":683,"lon":682},{"facility":686,"status":76,"city":687,"state":688,"zip":689,"country":80,"countryCode":81,"cosmosGeoPoint":690,"geoPoint":694,"contacts":60},"Charles Retina Institute","Germantown","Tennessee","38138",{"type":83,"coordinates":691},[692,693],-89.81009,35.08676,{"lat":693,"lon":692},{"facility":696,"status":96,"city":697,"state":688,"zip":698,"country":80,"countryCode":81,"cosmosGeoPoint":699,"geoPoint":703,"contacts":60},"Tennessee Retina PC","Nashville","37203",{"type":83,"coordinates":700},[701,702],-86.78444,36.16589,{"lat":702,"lon":701},{"facility":705,"status":76,"city":706,"state":707,"zip":708,"country":80,"countryCode":81,"cosmosGeoPoint":709,"geoPoint":713,"contacts":60},"Texas Retina Associates","Arlington","Texas","76012",{"type":83,"coordinates":710},[711,712],-97.10807,32.73569,{"lat":712,"lon":711},{"facility":715,"status":76,"city":716,"state":707,"zip":717,"country":80,"countryCode":81,"cosmosGeoPoint":718,"geoPoint":722,"contacts":60},"Austin Retina Associates","Austin","78705",{"type":83,"coordinates":719},[720,721],-97.74306,30.26715,{"lat":721,"lon":720},{"facility":724,"status":96,"city":716,"state":707,"zip":725,"country":80,"countryCode":81,"cosmosGeoPoint":726,"geoPoint":728,"contacts":60},"Austin Clinical Research LLC","78750",{"type":83,"coordinates":727},[720,721],{"lat":721,"lon":720},{"facility":730,"status":76,"city":731,"state":707,"zip":732,"country":80,"countryCode":81,"cosmosGeoPoint":733,"geoPoint":737,"contacts":60},"Retina Consultants of Texas","Bellaire","77401",{"type":83,"coordinates":734},[735,736],-95.45883,29.70579,{"lat":736,"lon":735},{"facility":705,"status":76,"city":739,"state":707,"zip":740,"country":80,"countryCode":81,"cosmosGeoPoint":741,"geoPoint":745,"contacts":60},"Fort Worth","76104",{"type":83,"coordinates":742},[743,744],-97.32085,32.72541,{"lat":744,"lon":743},{"facility":747,"status":76,"city":748,"state":707,"zip":749,"country":80,"countryCode":81,"cosmosGeoPoint":750,"geoPoint":754,"contacts":60},"Med Center Ophthalmology Assoc","San Antonio","78240",{"type":83,"coordinates":751},[752,753],-98.49363,29.42412,{"lat":753,"lon":752},{"facility":730,"status":76,"city":756,"state":707,"zip":757,"country":80,"countryCode":81,"cosmosGeoPoint":758,"geoPoint":762,"contacts":60},"The Woodlands","77384",{"type":83,"coordinates":759},[760,761],-95.48938,30.15799,{"lat":761,"lon":760},{"facility":764,"status":76,"city":765,"state":766,"zip":767,"country":80,"countryCode":81,"cosmosGeoPoint":768,"geoPoint":772,"contacts":60},"Retina Associates of Utah, PLLC","Salt Lake City","Utah","84107",{"type":83,"coordinates":769},[770,771],-111.89105,40.76078,{"lat":771,"lon":770},{"facility":774,"status":76,"city":765,"state":766,"zip":767,"country":80,"countryCode":81,"cosmosGeoPoint":775,"geoPoint":777,"contacts":60},"Rocky Mountain Retina",{"type":83,"coordinates":776},[770,771],{"lat":771,"lon":770},{"facility":779,"status":76,"city":780,"state":781,"zip":782,"country":80,"countryCode":81,"cosmosGeoPoint":783,"geoPoint":787,"contacts":60},"Wagner Kapoor Institute","Virginia Beach","Virginia","23454",{"type":83,"coordinates":784},[785,786],-75.97799,36.85293,{"lat":786,"lon":785},{"facility":789,"status":76,"city":790,"state":791,"zip":792,"country":80,"countryCode":81,"cosmosGeoPoint":793,"geoPoint":797,"contacts":60},"Pacific Northwest Retina","Silverdale","Washington","98383",{"type":83,"coordinates":794},[795,796],-122.69487,47.64454,{"lat":796,"lon":795},{"facility":799,"status":76,"city":800,"state":791,"zip":801,"country":80,"countryCode":81,"cosmosGeoPoint":802,"geoPoint":806,"contacts":60},"Spokane Eye Clinical Research","Spokane","99204",{"type":83,"coordinates":803},[804,805],-117.42908,47.65966,{"lat":805,"lon":804},{"facility":808,"status":809,"city":810,"state":60,"zip":811,"country":812,"countryCode":813,"cosmosGeoPoint":60,"geoPoint":60,"contacts":60},"Oftalmos","RECRUITING","Capital Federal","C1120AAN","Argentina","AR",{"facility":815,"status":809,"city":816,"state":60,"zip":817,"country":812,"countryCode":813,"cosmosGeoPoint":60,"geoPoint":60,"contacts":60},"Centro Oftalmologico Dr. Charles S.A.","Ciudad Autonoma Buenos Aires","C1121ABB",{"facility":819,"status":809,"city":820,"state":60,"zip":821,"country":812,"countryCode":813,"cosmosGeoPoint":822,"geoPoint":826,"contacts":60},"Grupo Laser Vision","Rosario","S2000DLA",{"type":83,"coordinates":823},[824,825],-60.63932,-32.94682,{"lat":825,"lon":824},{"facility":828,"status":96,"city":829,"state":830,"zip":831,"country":832,"countryCode":833,"cosmosGeoPoint":834,"geoPoint":838,"contacts":60},"Eyeclinic Albury Wodonga","Albury","New South Wales","2640","Australia","AU",{"type":83,"coordinates":835},[836,837],146.92401,-36.07482,{"lat":837,"lon":836},{"facility":840,"status":809,"city":841,"state":830,"zip":842,"country":832,"countryCode":833,"cosmosGeoPoint":843,"geoPoint":847,"contacts":60},"Eye and Retina Consultants","Hurstville","2220",{"type":83,"coordinates":844},[845,846],151.10149,-33.9677,{"lat":846,"lon":845},{"facility":849,"status":809,"city":850,"state":60,"zip":851,"country":852,"countryCode":853,"cosmosGeoPoint":854,"geoPoint":858,"contacts":60},"LKH-Univ.Klinikum Graz","Graz","8036","Austria","AT",{"type":83,"coordinates":855},[856,857],15.44197,47.06733,{"lat":857,"lon":856},{"facility":860,"status":809,"city":861,"state":60,"zip":862,"country":852,"countryCode":853,"cosmosGeoPoint":863,"geoPoint":867,"contacts":60},"Medizinische Universitat Wien","Vienna","1090",{"type":83,"coordinates":864},[865,866],16.37208,48.20849,{"lat":866,"lon":865},{"facility":869,"status":349,"city":870,"state":60,"zip":871,"country":872,"countryCode":873,"cosmosGeoPoint":874,"geoPoint":878,"contacts":60},"UZ Leuven Gasthuisberg","Leuven","3000","Belgium","BE",{"type":83,"coordinates":875},[876,877],4.70093,50.87959,{"lat":877,"lon":876},{"facility":880,"status":809,"city":881,"state":882,"zip":883,"country":884,"countryCode":885,"cosmosGeoPoint":886,"geoPoint":890,"contacts":60},"Botelho Hospital da Visao","Blumenau","Santa Catarina","89052-504","Brazil","BR",{"type":83,"coordinates":887},[888,889],-49.06611,-26.91944,{"lat":889,"lon":888},{"facility":892,"status":809,"city":893,"state":893,"zip":894,"country":884,"countryCode":885,"cosmosGeoPoint":895,"geoPoint":899,"contacts":60},"Retina Clinic","São Paulo","01427-002",{"type":83,"coordinates":896},[897,898],-46.63611,-23.5475,{"lat":898,"lon":897},{"facility":901,"status":809,"city":893,"state":893,"zip":902,"country":884,"countryCode":885,"cosmosGeoPoint":903,"geoPoint":905,"contacts":60},"Universidade Federal de Sao Paulo - UNIFESPX","04023-062",{"type":83,"coordinates":904},[897,898],{"lat":898,"lon":897},{"facility":907,"status":809,"city":893,"state":893,"zip":908,"country":884,"countryCode":885,"cosmosGeoPoint":909,"geoPoint":911,"contacts":60},"Instituto da Visao IPEPO","04038-032",{"type":83,"coordinates":910},[897,898],{"lat":898,"lon":897},{"facility":913,"status":809,"city":914,"state":893,"zip":915,"country":884,"countryCode":885,"cosmosGeoPoint":916,"geoPoint":920,"contacts":60},"Hosp de Olhos de Sorocaba","Sorocaba","18031-060",{"type":83,"coordinates":917},[918,919],-47.45806,-23.50167,{"lat":919,"lon":918},{"facility":922,"status":809,"city":923,"state":60,"zip":924,"country":925,"countryCode":926,"cosmosGeoPoint":927,"geoPoint":931,"contacts":60},"Centre Retine Gallien","Bordeaux","33000","France","FR",{"type":83,"coordinates":928},[929,930],-0.58046,44.84124,{"lat":930,"lon":929},{"facility":933,"status":809,"city":934,"state":60,"zip":935,"country":925,"countryCode":926,"cosmosGeoPoint":936,"geoPoint":940,"contacts":60},"Hopital de la croix rousse","Lyon","69317",{"type":83,"coordinates":937},[938,939],4.84789,45.74906,{"lat":939,"lon":938},{"facility":942,"status":809,"city":943,"state":60,"zip":944,"country":925,"countryCode":926,"cosmosGeoPoint":945,"geoPoint":949,"contacts":60},"Centre Paradis Monticelli","Marseille","13008",{"type":83,"coordinates":946},[947,948],5.38107,43.29695,{"lat":948,"lon":947},{"facility":951,"status":809,"city":952,"state":60,"zip":953,"country":925,"countryCode":926,"cosmosGeoPoint":954,"geoPoint":958,"contacts":60},"Hopital Lariboisiere","Paris","75010",{"type":83,"coordinates":955},[956,957],2.3488,48.85341,{"lat":957,"lon":956},{"facility":960,"status":809,"city":952,"state":60,"zip":961,"country":925,"countryCode":926,"cosmosGeoPoint":962,"geoPoint":964,"contacts":60},"Fondation Rothschild","75940",{"type":83,"coordinates":963},[956,957],{"lat":957,"lon":956},{"facility":966,"status":809,"city":967,"state":60,"zip":968,"country":969,"countryCode":970,"cosmosGeoPoint":971,"geoPoint":975,"contacts":60},"Universitatsklinikum Bonn","Bonn","53127","Germany","DE",{"type":83,"coordinates":972},[973,974],7.09549,50.73438,{"lat":974,"lon":973},{"facility":977,"status":809,"city":978,"state":60,"zip":979,"country":969,"countryCode":970,"cosmosGeoPoint":980,"geoPoint":984,"contacts":60},"Universitatsklinikum Koln","Cologne","50937",{"type":83,"coordinates":981},[982,983],6.95,50.93333,{"lat":983,"lon":982},{"facility":986,"status":809,"city":987,"state":60,"zip":988,"country":969,"countryCode":970,"cosmosGeoPoint":989,"geoPoint":993,"contacts":60},"Medizinische Universitat Lausitz ? Carl Thiem","Cottbus","03048",{"type":83,"coordinates":990},[991,992],14.32888,51.75769,{"lat":992,"lon":991},{"facility":995,"status":809,"city":996,"state":60,"zip":997,"country":969,"countryCode":970,"cosmosGeoPoint":998,"geoPoint":1002,"contacts":60},"Universitätsklinikum Freiburg, Klinik für Augenheilkunde","Freiburg im Breisgau","79106",{"type":83,"coordinates":999},[1000,1001],7.85222,47.9959,{"lat":1001,"lon":1000},{"facility":1004,"status":809,"city":1005,"state":60,"zip":1006,"country":969,"countryCode":970,"cosmosGeoPoint":1007,"geoPoint":1011,"contacts":60},"Universitatsklinikum Hamburg-Eppendorf","Hamburg","20246",{"type":83,"coordinates":1008},[1009,1010],9.99302,53.55073,{"lat":1010,"lon":1009},{"facility":1013,"status":809,"city":1014,"state":60,"zip":1015,"country":969,"countryCode":970,"cosmosGeoPoint":1016,"geoPoint":1020,"contacts":60},"Klinikum der Stadt Ludwigshafen am Rhein gGmbH","Ludwigshafen","67063",{"type":83,"coordinates":1017},[1018,1019],9.06138,47.81663,{"lat":1019,"lon":1018},{"facility":1022,"status":809,"city":1023,"state":60,"zip":1024,"country":969,"countryCode":970,"cosmosGeoPoint":1025,"geoPoint":1029,"contacts":60},"LMU Klinikum der Universitat, Augenklinik","München","80336",{"type":83,"coordinates":1026},[1027,1028],13.31243,51.60698,{"lat":1028,"lon":1027},{"facility":1031,"status":809,"city":1032,"state":60,"zip":1033,"country":969,"countryCode":970,"cosmosGeoPoint":1034,"geoPoint":1038,"contacts":60},"Augenabteilung am St. Franziskus-Hospital","Münster","48145",{"type":83,"coordinates":1035},[1036,1037],7.62571,51.96236,{"lat":1037,"lon":1036},{"facility":1040,"status":809,"city":1032,"state":60,"zip":1041,"country":969,"countryCode":970,"cosmosGeoPoint":1042,"geoPoint":1044,"contacts":60},"Universitatsklinikum Munster","48149",{"type":83,"coordinates":1043},[1036,1037],{"lat":1037,"lon":1036},{"facility":1046,"status":809,"city":1047,"state":60,"zip":1048,"country":969,"countryCode":970,"cosmosGeoPoint":1049,"geoPoint":1053,"contacts":60},"Knappschaftsklinikum Saar GmbH","Sulzbach","66280",{"type":83,"coordinates":1050},[1051,1052],7.05696,49.29882,{"lat":1052,"lon":1051},{"facility":1055,"status":809,"city":1056,"state":60,"zip":1057,"country":969,"countryCode":970,"cosmosGeoPoint":1058,"geoPoint":1062,"contacts":60},"Universitatsklinikum Tubingen","Tübingen","72076",{"type":83,"coordinates":1059},[1060,1061],9.05222,48.52266,{"lat":1061,"lon":1060},{"facility":1064,"status":809,"city":1065,"state":60,"zip":1066,"country":969,"countryCode":970,"cosmosGeoPoint":1067,"geoPoint":1071,"contacts":60},"Universitatsklinikum Ulm, Augenklinik und Poliklinik","Ulm","89075",{"type":83,"coordinates":1068},[1069,1070],9.99155,48.39841,{"lat":1070,"lon":1069},{"facility":1073,"status":809,"city":1074,"state":60,"zip":1075,"country":1076,"countryCode":1077,"cosmosGeoPoint":1078,"geoPoint":1082,"contacts":60},"Rambam Medical Center","Haifa","3109601","Israel","IL",{"type":83,"coordinates":1079},[1080,1081],34.99928,32.81303,{"lat":1081,"lon":1080},{"facility":1084,"status":809,"city":1085,"state":60,"zip":1086,"country":1076,"countryCode":1077,"cosmosGeoPoint":1087,"geoPoint":1091,"contacts":60},"Hadassah MC","Jerusalem","9112001",{"type":83,"coordinates":1088},[1089,1090],35.21633,31.76904,{"lat":1090,"lon":1089},{"facility":1093,"status":809,"city":1094,"state":60,"zip":1095,"country":1076,"countryCode":1077,"cosmosGeoPoint":1096,"geoPoint":1100,"contacts":60},"Meir Medical Center","Kfar Saba","4428164",{"type":83,"coordinates":1097},[1098,1099],34.90694,32.175,{"lat":1099,"lon":1098},{"facility":1102,"status":809,"city":1103,"state":60,"zip":1104,"country":1076,"countryCode":1077,"cosmosGeoPoint":1105,"geoPoint":1109,"contacts":60},"Rabin MC","Petah Tikva","4941492",{"type":83,"coordinates":1106},[1107,1108],34.88747,32.08707,{"lat":1108,"lon":1107},{"facility":1111,"status":809,"city":1112,"state":60,"zip":1113,"country":1076,"countryCode":1077,"cosmosGeoPoint":1114,"geoPoint":1118,"contacts":60},"Kaplan Medical Center","Rehovot","7660101",{"type":83,"coordinates":1115},[1116,1117],34.81199,31.89421,{"lat":1117,"lon":1116},{"facility":1120,"status":809,"city":1121,"state":60,"zip":1122,"country":1076,"countryCode":1077,"cosmosGeoPoint":1123,"geoPoint":1127,"contacts":60},"Tel Aviv Sourasky MC","Tel Aviv","6423906",{"type":83,"coordinates":1124},[1125,1126],34.78057,32.08088,{"lat":1126,"lon":1125},{"facility":1129,"status":809,"city":1130,"state":1131,"zip":1132,"country":1133,"countryCode":1134,"cosmosGeoPoint":1135,"geoPoint":1139,"contacts":60},"Ospedale Clinicizzato SS Annunziata","Chieti","Abruzzo","66100","Italy","IT",{"type":83,"coordinates":1136},[1137,1138],14.16494,42.34827,{"lat":1138,"lon":1137},{"facility":1141,"status":809,"city":1142,"state":1143,"zip":1144,"country":1133,"countryCode":1134,"cosmosGeoPoint":1145,"geoPoint":1149,"contacts":60},"Policlinico di Bari","Bari","Apulia","70124",{"type":83,"coordinates":1146},[1147,1148],16.86982,41.12066,{"lat":1148,"lon":1147},{"facility":1151,"status":809,"city":1152,"state":1153,"zip":1154,"country":1133,"countryCode":1134,"cosmosGeoPoint":1155,"geoPoint":1159,"contacts":60},"Azienda Ospedaliero Universitaria \"Ospedali Riuniti\" Trieste-Ospedale Maggiore","Trieste","Friuli Venezia Giulia","34129",{"type":83,"coordinates":1156},[1157,1158],13.77678,45.64953,{"lat":1158,"lon":1157},{"facility":1161,"status":809,"city":1162,"state":1163,"zip":1164,"country":1133,"countryCode":1134,"cosmosGeoPoint":1165,"geoPoint":1169,"contacts":60},"Policlinico Universitario Agostino Gemelli","Rome","Lazio","00168",{"type":83,"coordinates":1166},[1167,1168],12.51133,41.89193,{"lat":1168,"lon":1167},{"facility":1171,"status":809,"city":1162,"state":1163,"zip":1172,"country":1133,"countryCode":1134,"cosmosGeoPoint":1173,"geoPoint":1175,"contacts":60},"Fondazione G.B. Bietti Per Lo Studio E La Ricerca in Oftalmologia-Presidio Ospedaliero Britannico","00198",{"type":83,"coordinates":1174},[1167,1168],{"lat":1168,"lon":1167},{"facility":1177,"status":809,"city":1178,"state":1179,"zip":1180,"country":1133,"countryCode":1134,"cosmosGeoPoint":1181,"geoPoint":1185,"contacts":60},"Fondazione Irccs Ca' Granda Ospedale Maggiore Policlinico-Clinica Regina Elena","Milan","Lombardy","20100",{"type":83,"coordinates":1182},[1183,1184],9.18951,45.46427,{"lat":1184,"lon":1183},{"facility":1187,"status":809,"city":1178,"state":1179,"zip":1188,"country":1133,"countryCode":1134,"cosmosGeoPoint":1189,"geoPoint":1191,"contacts":60},"Irccs Ospedale San Raffaele","20132",{"type":83,"coordinates":1190},[1183,1184],{"lat":1184,"lon":1183},{"facility":1193,"status":809,"city":1178,"state":1179,"zip":1194,"country":1133,"countryCode":1134,"cosmosGeoPoint":1195,"geoPoint":1197,"contacts":60},"Asst Fatebenefratelli Sacco","20157",{"type":83,"coordinates":1196},[1183,1184],{"lat":1184,"lon":1183},{"facility":1199,"status":809,"city":1200,"state":1201,"zip":1202,"country":1133,"countryCode":1134,"cosmosGeoPoint":60,"geoPoint":60,"contacts":60},"Azienda Ospedaliero Universitaria Ospedali Riuniti","Torrette - Ancona","The Marches","60126",{"facility":1204,"status":809,"city":668,"state":1205,"zip":1206,"country":1133,"countryCode":1134,"cosmosGeoPoint":1207,"geoPoint":1211,"contacts":60},"Azienda Ospedaliero-Universitaria Careggi","Tuscany","50134",{"type":83,"coordinates":1208},[1209,1210],11.24626,43.77925,{"lat":1210,"lon":1209},{"facility":1213,"status":809,"city":1214,"state":1215,"zip":1216,"country":1133,"countryCode":1134,"cosmosGeoPoint":1217,"geoPoint":1221,"contacts":60},"Azienda Ospedaliera di Perugia Ospedale S. Maria Della Misericordia","Perugia","Umbria","06129",{"type":83,"coordinates":1218},[1219,1220],12.38878,43.1122,{"lat":1220,"lon":1219},{"facility":1223,"status":809,"city":1224,"state":1225,"zip":1226,"country":1133,"countryCode":1134,"cosmosGeoPoint":60,"geoPoint":60,"contacts":60},"Ospedale Classificato Equiparato Sacro Cuore ? Don Calabria","Negrar - Verona","Veneto","37024",{"facility":1228,"status":809,"city":1229,"state":1225,"zip":1230,"country":1133,"countryCode":1134,"cosmosGeoPoint":60,"geoPoint":60,"contacts":60},"A.O. Universitaria S. Maria Della Misericordia Di Udine","Udine","33100",{"facility":1232,"status":809,"city":1233,"state":1234,"zip":1235,"country":1236,"countryCode":1237,"cosmosGeoPoint":1238,"geoPoint":1242,"contacts":60},"Hospital Universitario de Bellvitge","L'Hospitalet de Llobregat","Barcelona","08907","Spain","ES",{"type":83,"coordinates":1239},[1240,1241],2.10028,41.35967,{"lat":1241,"lon":1240},{"facility":1244,"status":809,"city":1245,"state":1234,"zip":1246,"country":1236,"countryCode":1237,"cosmosGeoPoint":60,"geoPoint":60,"contacts":60},"Hospital General de Catalunya","San Cugat Del Valles","08195",{"facility":1248,"status":809,"city":1249,"state":1250,"zip":1251,"country":1236,"countryCode":1237,"cosmosGeoPoint":1252,"geoPoint":1256,"contacts":60},"Hospital Universitario Puerta de Hierro","Majadahonda","Madrid","28222",{"type":83,"coordinates":1253},[1254,1255],-3.87182,40.47353,{"lat":1255,"lon":1254},{"facility":1258,"status":809,"city":1259,"state":1260,"zip":1261,"country":1236,"countryCode":1237,"cosmosGeoPoint":1262,"geoPoint":1266,"contacts":60},"Clinica Universitaria de Navarra","Pamplona","Navarre","31008",{"type":83,"coordinates":1263},[1264,1265],-1.64323,42.81687,{"lat":1265,"lon":1264},{"facility":1268,"status":809,"city":1269,"state":1270,"zip":1271,"country":1236,"countryCode":1237,"cosmosGeoPoint":1272,"geoPoint":1276,"contacts":60},"Instituto Oftalmologico Fernandez Vega","Oviedo","Principality of Asturias","33012",{"type":83,"coordinates":1273},[1274,1275],-5.84476,43.36029,{"lat":1275,"lon":1274},{"facility":1278,"status":809,"city":1279,"state":1280,"zip":1281,"country":1236,"countryCode":1237,"cosmosGeoPoint":1282,"geoPoint":1286,"contacts":60},"Oftalvist Valencia","Burjassot","Valencia","46100",{"type":83,"coordinates":1283},[1284,1285],-0.41327,39.50984,{"lat":1285,"lon":1284},{"facility":1288,"status":809,"city":1234,"state":60,"zip":1289,"country":1236,"countryCode":1237,"cosmosGeoPoint":1290,"geoPoint":1294,"contacts":60},"Centro de Oftalmologia Barraquer","08021",{"type":83,"coordinates":1291},[1292,1293],2.15899,41.38879,{"lat":1293,"lon":1292},{"facility":1296,"status":809,"city":1234,"state":60,"zip":1297,"country":1236,"countryCode":1237,"cosmosGeoPoint":1298,"geoPoint":1300,"contacts":60},"Institut de la Macula i la retina","08022",{"type":83,"coordinates":1299},[1292,1293],{"lat":1293,"lon":1292},{"facility":1302,"status":76,"city":1234,"state":60,"zip":1303,"country":1236,"countryCode":1237,"cosmosGeoPoint":1304,"geoPoint":1306,"contacts":60},"Hospital dos de maig","08025",{"type":83,"coordinates":1305},[1292,1293],{"lat":1293,"lon":1292},{"facility":1308,"status":809,"city":1234,"state":60,"zip":1309,"country":1236,"countryCode":1237,"cosmosGeoPoint":1310,"geoPoint":1312,"contacts":60},"Hospital Universitari Vall d'Hebron","08035",{"type":83,"coordinates":1311},[1292,1293],{"lat":1293,"lon":1292},{"facility":1314,"status":809,"city":1315,"state":60,"zip":1316,"country":1236,"countryCode":1237,"cosmosGeoPoint":1317,"geoPoint":1321,"contacts":60},"Hospital de la Arruzafa. Servicio de Oftalmologia","Córdoba","14012",{"type":83,"coordinates":1318},[1319,1320],-4.77275,37.89155,{"lat":1320,"lon":1319},{"facility":1323,"status":809,"city":1250,"state":60,"zip":1324,"country":1236,"countryCode":1237,"cosmosGeoPoint":1325,"geoPoint":1329,"contacts":60},"Clinica Baviera","28046",{"type":83,"coordinates":1326},[1327,1328],-3.70256,40.4165,{"lat":1328,"lon":1327},{"facility":1331,"status":809,"city":1332,"state":60,"zip":1333,"country":1334,"countryCode":1335,"cosmosGeoPoint":1336,"geoPoint":1340,"contacts":60},"Universitatsspital Basel Augenklinik Klinik","Basel","4056","Switzerland","CH",{"type":83,"coordinates":1337},[1338,1339],7.57327,47.55839,{"lat":1339,"lon":1338},{"facility":1342,"status":809,"city":1343,"state":60,"zip":1344,"country":1334,"countryCode":1335,"cosmosGeoPoint":1345,"geoPoint":1349,"contacts":60},"Inselspital Bern Ophthalmologische Klinik","Bern","3010",{"type":83,"coordinates":1346},[1347,1348],7.44744,46.94809,{"lat":1348,"lon":1347},{"facility":1351,"status":96,"city":1352,"state":60,"zip":1353,"country":1334,"countryCode":1335,"cosmosGeoPoint":1354,"geoPoint":1358,"contacts":60},"Vista Klinik Ophthalmologische Klinik","Binningen","4102",{"type":83,"coordinates":1355},[1356,1357],7.56932,47.54021,{"lat":1357,"lon":1356},{"facility":1360,"status":809,"city":1361,"state":60,"zip":60,"country":1334,"countryCode":1335,"cosmosGeoPoint":1362,"geoPoint":1366,"contacts":60},"Fondation Asile Des Aveugles ? Jules Gonin Eye Hospital","Lausanne",{"type":83,"coordinates":1363},[1364,1365],6.63282,46.516,{"lat":1365,"lon":1364},{"facility":1368,"status":96,"city":1369,"state":60,"zip":1370,"country":1334,"countryCode":1335,"cosmosGeoPoint":1371,"geoPoint":1375,"contacts":60},"Stadtspital Triemli Ophthalmologische Klinik","Zurich","8063",{"type":83,"coordinates":1372},[1373,1374],8.55,47.36667,{"lat":1374,"lon":1373},{"facility":1377,"status":809,"city":1378,"state":60,"zip":1379,"country":1380,"countryCode":1381,"cosmosGeoPoint":1382,"geoPoint":1386,"contacts":60},"Changhua Christian Hospital","Changhua","500","Taiwan","TW",{"type":83,"coordinates":1383},[1384,1385],120.5512,24.0692,{"lat":1385,"lon":1384},{"facility":1388,"status":809,"city":1389,"state":60,"zip":60,"country":1380,"countryCode":1381,"cosmosGeoPoint":1390,"geoPoint":1394,"contacts":60},"Kaohsiung Medical University Chung-Ho Memorial Hospital","Kaohsiung City",{"type":83,"coordinates":1391},[1392,1393],120.31333,22.61626,{"lat":1393,"lon":1392},{"facility":1396,"status":809,"city":1397,"state":60,"zip":1398,"country":1380,"countryCode":1381,"cosmosGeoPoint":1399,"geoPoint":1403,"contacts":60},"Taipei Veterans General Hospital","Taipei","11217",{"type":83,"coordinates":1400},[1401,1402],121.52639,25.05306,{"lat":1402,"lon":1401},{"facility":1405,"status":809,"city":1406,"state":60,"zip":1407,"country":1380,"countryCode":1381,"cosmosGeoPoint":1408,"geoPoint":1412,"contacts":60},"Chang Gung Medical Foundation - Linkou","Taoyuan","333",{"type":83,"coordinates":1409},[1410,1411],121.29696,24.99368,{"lat":1411,"lon":1410},{"facility":1414,"status":809,"city":1415,"state":60,"zip":1416,"country":1380,"countryCode":1381,"cosmosGeoPoint":60,"geoPoint":60,"contacts":60},"National Taiwan University Hospital","Zhongzheng Dist.","10002",{"facility":1418,"status":809,"city":1419,"state":60,"zip":1420,"country":1421,"countryCode":60,"cosmosGeoPoint":1422,"geoPoint":1426,"contacts":60},"Hacettepe University Medical Faculty","Ankara","06100","Turkey (Türkiye)",{"type":83,"coordinates":1423},[1424,1425],32.85427,39.91987,{"lat":1425,"lon":1424},{"facility":1428,"status":809,"city":1419,"state":60,"zip":1429,"country":1421,"countryCode":60,"cosmosGeoPoint":1430,"geoPoint":1432,"contacts":60},"Ankara Bilkent City Hospital","06490",{"type":83,"coordinates":1431},[1424,1425],{"lat":1425,"lon":1424},{"facility":1434,"status":809,"city":1419,"state":60,"zip":1435,"country":1421,"countryCode":60,"cosmosGeoPoint":1436,"geoPoint":1438,"contacts":60},"Ankara Etlik City Hospital","DUMMY_VALUE",{"type":83,"coordinates":1437},[1424,1425],{"lat":1425,"lon":1424},{"facility":1440,"status":809,"city":1441,"state":60,"zip":1442,"country":1421,"countryCode":60,"cosmosGeoPoint":1443,"geoPoint":1447,"contacts":60},"Beyoglu Goz Training and Research Hospital","Istanbul","34421",{"type":83,"coordinates":1444},[1445,1446],28.94966,41.01384,{"lat":1446,"lon":1445},{"facility":1449,"status":809,"city":1450,"state":60,"zip":1451,"country":1421,"countryCode":60,"cosmosGeoPoint":1452,"geoPoint":1456,"contacts":60},"Kocaeli University Medical Faculty","Kocaeli","41380",{"type":83,"coordinates":1453},[1454,1455],27.51145,39.62497,{"lat":1455,"lon":1454},{"facility":1458,"status":809,"city":1459,"state":60,"zip":1460,"country":1461,"countryCode":1462,"cosmosGeoPoint":1463,"geoPoint":1467,"contacts":60},"Bristol Eye Hospital","Bristol","BS1 2LX","United Kingdom","UK",{"type":83,"coordinates":1464},[1465,1466],-2.59665,51.45523,{"lat":1466,"lon":1465},{"facility":1469,"status":96,"city":1470,"state":60,"zip":1471,"country":1461,"countryCode":1462,"cosmosGeoPoint":1472,"geoPoint":1476,"contacts":60},"Royal Liverpool University Hospital","Liverpool","L7 8XP",{"type":83,"coordinates":1473},[1474,1475],-2.97794,53.41058,{"lat":1475,"lon":1474},{"facility":1478,"status":96,"city":1479,"state":60,"zip":1480,"country":1461,"countryCode":1462,"cosmosGeoPoint":1481,"geoPoint":1485,"contacts":60},"Moorfields Eye Hospital NHS Foundation Trust","London","EC1V 2PD",{"type":83,"coordinates":1482},[1483,1484],-0.12574,51.50853,{"lat":1484,"lon":1483},{"facility":1487,"status":809,"city":1479,"state":60,"zip":1488,"country":1461,"countryCode":1462,"cosmosGeoPoint":1489,"geoPoint":1491,"contacts":60},"Central Middlesex Hospital","NW10 7NS",{"type":83,"coordinates":1490},[1483,1484],{"lat":1484,"lon":1483},{"facility":1493,"status":96,"city":1479,"state":60,"zip":1494,"country":1461,"countryCode":1462,"cosmosGeoPoint":1495,"geoPoint":1497,"contacts":60},"Kings College Hospital NHS Foundation Trust","SE5 9RS",{"type":83,"coordinates":1496},[1483,1484],{"lat":1484,"lon":1483},{"facility":1499,"status":809,"city":1500,"state":60,"zip":1501,"country":1461,"countryCode":1462,"cosmosGeoPoint":1502,"geoPoint":1506,"contacts":60},"Royal Victoria Infirmary","Newcastle upon Tyne","NE1 4LP",{"type":83,"coordinates":1503},[1504,1505],-1.61396,54.97328,{"lat":1505,"lon":1504},{"facility":1508,"status":809,"city":1509,"state":60,"zip":1510,"country":1461,"countryCode":1462,"cosmosGeoPoint":1511,"geoPoint":1515,"contacts":60},"Sunderland Eye Infirmary","Sunderland","SR2 9HP",{"type":83,"coordinates":1512},[1513,1514],-1.38222,54.90465,{"lat":1514,"lon":1513},{"facility":1517,"status":809,"city":1518,"state":60,"zip":1519,"country":1461,"countryCode":1462,"cosmosGeoPoint":1520,"geoPoint":1524,"contacts":60},"Royal Wolverhampton hospital","Wolverhampton","WV10 0QP",{"type":83,"coordinates":1521},[1522,1523],-2.12296,52.58547,{"lat":1523,"lon":1522},{"type":1526,"investigatorFullName":60,"investigatorTitle":60,"investigatorAffiliation":60,"oldNameTitle":60,"oldOrganization":60},"SPONSOR","100338192","phase-3-extension-study-for-the-port-delivery-system-with-ranibizumab-portal-100338192",false,"NCT03683251","Extension Study for the Port Delivery System With Ranibizumab (Portal)","A Multicenter, Open-Label Extension Study to Evaluate the Long-Term Safety and Tolerability of the Port Delivery System With Ranibizumab in Patients With Neovascular Age-Related Macular Degeneration (Portal)","Portal","Inclusion Criteria:\n\n* Previous enrollment in and completion of Study GX28228 (Ladder) or Study GR40548 (Archway), without early treatment or study discontinuation in either study OR Previous enrollment in Study WR42221 (Velodrome) and either not eligible to be randomized in Study WR42221 at Week 24 or completed the study (from the Q24W or Q36W arm)\n* Ability and willingness to undertake all scheduled visits and assessments\n* For women of childbearing potential: agreement to remain abstinent or use contraceptive measures\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding, or intending to become pregnant during the treatment period and for at least 28 days after the last intravitreal injection of ranibizumab or 1 year after the last Implant refill-exchange of ranibizumab\n* History of other ocular diseases that give reasonable suspicion of a disease or condition that contraindicates the use of ranibizumab, that might affect interpretation of the results of the study or that renders the participant at high risk for treatment complications\n* History of other diseases, metabolic dysfunction, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of ranibizumab or placement of the Implant and that might affect interpretation of the results of the study or that renders the participant at high risk of treatment complications\n* Requirement for continuous use of any medications or treatments indicated in the \"Prohibited Therapy\"\n\nSub-study 1\n\nInclusion Criteria\n\n\\- For women of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive measures\n\nParticipants must meet the following ocular criteria for the study eye for substudy entry:\n\n* Diagnosis of exudative nAMD within 2 years prior to the enrollment visit\n* Previous treatment with at least two anti-VEGF ITV injections (e.g., ranibizumab, bevacizumab, or aflibercept) for nAMD per standard of care within 6 months prior to the enrollment visit\n* Demonstrated response to prior anti-VEGF ITV treatment since diagnosis, as evidenced at enrollment by the following:\n\nOverall decrease in nAMD disease activity detected on SD-OCT AND Stable or improved best-corrected visual acuity (BCVA)\n\n* All subtypes of nAMD lesions are permissible (i.e., type I, type II, type III, or mixed forms per optical coherence tomography (OCT) classification) nAMD lesions at the time of diagnosis must involve the macula (6 mm diameter centered at the fovea).\n* Sufficiently clear ocular media and adequate pupillary dilation to allow for analysis and grading by the central reading center of FP and SD-OCT images.\n\nExclusion Criteria Prior Ocular Treatments Study Eye\n\n* History of vitrectomy surgery, submacular surgery, or other surgical intervention for AMD\n* Prior treatment with Visudyne, external-beam radiation therapy, or transpupillary thermotherapy\n* Previous treatment with corticosteroid ITV injection\n* Previous intraocular device implantation\n* Previous laser (any type) used for AMD treatment\n\nEither Eye\n\n* Treatment with anti-VEGF agents other than ranibizumab within 1 month prior to the enrollment visit\n* Prior participation in a clinical trial involving anti-VEGF drugs within 6 months prior to the enrollment visit, other than ranibizumab\n\nCNV Lesion Charateristics Study Eye\n\n* Subretinal hemorrhage that involves the center of the fovea, if the hemorrhage is greater than 0.5 disc area (1.27 mm2 ) in size at screening\n* Subfoveal fibrosis or subfoveal atrophy\n\nEither Eye\n\n\\- CNV due to other causes, such as ocular histoplasmosis, trauma, or pathologic myopia\n\nConcurrent Ocular Conditions Study Eye\n\n* Retinal pigment epithelial tear\n* Any concurrent intraocular condition (e.g., cataract, glaucoma, diabetic retinopathy, or epiretinal membrane) that would either require surgical intervention during the study to prevent or treat visual loss that might result from that condition or affect interpretation of study results\n* Active intraocular inflammation (grade trace or above)\n* History of vitreous hemorrhage\n* History of rhegmatogenous retinal detachment\n* History of rhegmatogenous retinal tears or peripheral retinal breaks within 3 months prior to the enrollment visit\n* Aphakia or absence of the posterior capsule\n* Previous violation of the posterior capsule is also an exclusion criterion unless it occurred as a result of yttrium-aluminum garnet (YAG) laser posterior capsulotomy in association with prior, posterior chamber intraocular lens implantation.\n* Spherical equivalent of the refractive error demonstrating more than 8 diopters of myopia\n* Preoperative refractive error that exceeds 8 diopters of myopia, for participants who have undergone prior refractive or cataract surgery in the study eye\n* Intraocular surgery (including cataract surgery) within 3 months preceding the enrollment visit\n* Uncontrolled ocular hypertension or glaucoma and any such condition the investigator determines may require a glaucoma-filtering surgery during a patient's participation in the study\n* History of glaucoma-filtering surgery, tube shunts, or microinvasive glaucoma surgery\n* History of corneal transplant\n* History of prior vitrectomy surgery and absence of posterior capsule\n\nEither Eye\n\n* History of idiopathic or autoimmune-associated uveitis\n* Active infectious conjunctivitis, keratitis, scleritis, or endophthalmitis\n\nConcurrent Systemic Conditions\n\n* Inability to comply with study schedule or procedures as described in the study protocol\n* Uncontrolled blood pressure\n* History of stroke within the last 3 months prior to informed consent\n* Uncontrolled atrial fibrillation within 3 months of informed consent\n* History of myocardial infarction within the last 3 months prior to informed consent\n* History of other disease, metabolic dysfunction, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of ranibizumab or placement of the implant and that might affect interpretation of the results of the study or renders the patient at high risk of treatment complications in the opinion of the investigator\n* Current systemic treatment for a confirmed active systemic infection\n* Use of any systemic anti-VEGF agents\n* Chronic use of oral corticosteroids\n* Active cancer within 12 months of enrollment\n* Previous participation in any non-ocular (systemic) disease studies of investigational drugs within 1 month preceding the informed consent (excluding vitamins and minerals)\n* Use of antimitotic or antimetabolite therapy within 30 days or 5 elimination half-lives of the enrollment visit\n* History of albinism\n* Pregnant or breastfeeding, or intending to become pregnant during the treatment period and for at least 28 days after the last ITV injection of ranibizumab or 1 year after the last implant refill-exchange of ranibizumab\n\nSub-study 2\n\nInclusion Criteria:\n\n* Having experienced septum dislodgement in the original implant while in the main study or after exiting the main study Ocular Inclusion Criteria for Study Eye\n* Sufficiently clear ocular media and adequate pupillary dilation to allow for analysis and grading by central reading center\n\nExclusion Criteria (Cohort 1 only):\n\nConcurrent Ocular Conditions-Study Eye\n\n* Any ocular condition that may render the patient at high risk for surgical or treatment complications\n* Intraocular surgery (including cataract surgery) within 1 month preceding the enrollment visit\n* Any use of medicated intraocular implants (other than the PDS implant), at any time prior to enrollment\n* History of rhegmatogenous retinal tears or peripheral retinal breaks within 3 months prior to the enrollment visit\n* Any concurrent ocular condition that would require surgical intervention during the study to prevent or treat visual loss\n* Concurrent conjunctival, Tenon's capsule, and\u002For scleral condition in the supero-temporal quadrant of the eye (e.g., scarring, thinning, mass) that may affect the refill-exchange procedure of the PDS implant\n* Ongoing ocular complications that might affect participant safety\n\nConcurrent Ocular Conditions-Either Eye\n\n* Suspected or active ocular or periocular infection\n* Any history of uveitis\n* Active blepharitis\n\nConcurrent Systemic Conditions\n\n* Recent history (in the last 3 months prior to enrollment) of other disease, other non-diabetic metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a condition that contraindicates the use of ranibizumab or surgical placement of the PDS implant; that might affect interpretation of the results of the study; or that renders the participant at high risk for treatment complications\n* Active cancer within the last 12 months, except for appropriately treated carcinoma in situ of the cervix, non-melanoma skin carcinoma, or prostate cancer\n* Current systemic treatment for a confirmed active systemic infection - Participation in an investigational trial that involves treatment with any drug or device (with the exception of vitamins and minerals or enrollment in the main study GR40549) within 6 months prior to enrollment.\n* Use of antimitotic or antimetabolite therapy within 30 days or 5 elimination half-lives.","ALL","50 Years",{"count":1538,"type":1539},1000,"ESTIMATED","INTERVENTIONAL",[1542],"PHASE3","This study will evaluate the long-term safety and tolerability of the Port Delivery System with ranibizumab (PDS) (100 mg\u002FmL) in participants with neovascular age-related macular degeneration (nAMD) who have either completed Phase II Study GX28228 (Ladder), Phase III Study GR40548 (Archway), Phase IIIb Study WR42221 (Velodrome), or completed Week 24 visit in Study WR42221 but were not eligible to be randomized in WR42221.",[1545],"Neovascular Age-Related Macular Degeneration","2026-06-02",{"date":1548,"type":1549},"2026-06-04","ACTUAL",{"date":1551,"type":1549},"2018-09-20",{"date":1553,"type":1539},"2029-12-31",{"name":5,"class":6},165]