[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100566138":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":40,"centralContacts":44,"locations":50,"responsibleParty":508,"collaborators":39,"id":510,"slug":511,"hasResults":512,"nctId":513,"briefTitle":514,"officialTitle":515,"acronym":39,"eligibilityCriteria":516,"healthyVolunteers":512,"sex":517,"minAge":39,"maxAge":39,"enrollmentInfo":518,"targetDuration":39,"studyType":521,"phases":522,"briefSummary":524,"conditions":525,"keywords":39,"overallStatus":53,"whyStopped":39,"lastUpdateSubmitDate":528,"lastUpdatePostDateStruct":529,"startDateStruct":532,"completionDateStruct":534,"leadSponsor":536,"locationsCount":537},{"fullName":5,"class":6},"Merck Sharp & Dohme LLC","INDUSTRY",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1: Low Dose Unblinded","EXPERIMENTAL","Participants receive a low dose subcutaneous (SC) tulisokibart regimen.",[13],"Drug: Tulisokibart",{"label":15,"type":10,"description":16,"interventionNames":17},"Group 2: High Dose Unblinded","Participants receive a high dose SC tulisokibart regimen.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Group 3: High Dose Blinded","Participants receive a blinded high dose SC tulisokibart regimen.",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Group 4: Low Dose Blinded","Participants receive a blinded low dose SC tulisokibart regimen.",[13,26],"Drug: Placebo to tulisokibart",[28,35],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"DRUG","Tulisokibart","Humanized monoclonal antibody that binds human tumor necrosis factor-like cytokine 1A (TL1A), administered subcutaneously",[9,15,19,23],[34],"MK-7240",{"type":29,"name":36,"description":37,"armGroupLabels":38,"otherNames":39},"Placebo to tulisokibart","Placebo matching SC tulisokibart",[23],null,[41],{"name":42,"affiliation":5,"role":43},"Medical Director","STUDY_DIRECTOR",[45],{"name":46,"role":47,"phone":48,"phoneExt":39,"email":49},"Toll Free Number","CONTACT","1-888-577-8839","Trialsites@msd.com",[51,69,82,95,107,120,132,141,153,165,177,190,203,217,229,244,257,270,283,297,312,324,339,352,365,378,385,391,404,413,426,435,444,457,470,483,495],{"facility":52,"status":53,"city":54,"state":55,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"Connecticut Clinical Research Institute ( Site 0297)","RECRUITING","Bristol","Connecticut","06010","United States","US",{"type":60,"coordinates":61},"Point",[62,63],-72.94927,41.67176,{"lat":63,"lon":62},[66],{"name":67,"role":47,"phone":68,"phoneExt":39,"email":39},"Study Coordinator","860-585-3000",{"facility":70,"status":53,"city":71,"state":72,"zip":73,"country":57,"countryCode":58,"cosmosGeoPoint":74,"geoPoint":78,"contacts":79},"St. Joseph Mercy Hospital - Huron Gastroenterology Associates ( Site 0287)","Ypsilanti","Michigan","48197",{"type":60,"coordinates":75},[76,77],-83.61299,42.24115,{"lat":77,"lon":76},[80],{"name":67,"role":47,"phone":81,"phoneExt":39,"email":39},"734-418-7736",{"facility":83,"status":53,"city":84,"state":85,"zip":86,"country":57,"countryCode":58,"cosmosGeoPoint":87,"geoPoint":91,"contacts":92},"BVL Research - Kansas ( Site 0292)","Liberty","Missouri","64068",{"type":60,"coordinates":88},[89,90],-94.41912,39.24611,{"lat":90,"lon":89},[93],{"name":67,"role":47,"phone":94,"phoneExt":39,"email":39},"785-217-6559",{"facility":96,"status":53,"city":97,"state":97,"zip":98,"country":57,"countryCode":58,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"New York Gastroenterology Associates ( Site 0253)","New York","10075",{"type":60,"coordinates":100},[101,102],-74.00597,40.71427,{"lat":102,"lon":101},[105],{"name":67,"role":47,"phone":106,"phoneExt":39,"email":39},"212-369-2490",{"facility":108,"status":53,"city":109,"state":110,"zip":111,"country":57,"countryCode":58,"cosmosGeoPoint":112,"geoPoint":116,"contacts":117},"GI Alliance - Digestive Health Associates of Texas - DHAT ( Site 0290)","Garland","Texas","75044",{"type":60,"coordinates":113},[114,115],-96.63888,32.91262,{"lat":115,"lon":114},[118],{"name":67,"role":47,"phone":119,"phoneExt":39,"email":39},"972-265-8201",{"facility":121,"status":53,"city":122,"state":110,"zip":123,"country":57,"countryCode":58,"cosmosGeoPoint":124,"geoPoint":128,"contacts":129},"GI Alliance - Lubbock ( Site 0288)","Lubbock","79410",{"type":60,"coordinates":125},[126,127],-101.85517,33.57786,{"lat":127,"lon":126},[130],{"name":67,"role":47,"phone":131,"phoneExt":39,"email":39},"806-793-3141",{"facility":133,"status":53,"city":122,"state":110,"zip":134,"country":57,"countryCode":58,"cosmosGeoPoint":135,"geoPoint":137,"contacts":138},"Caprock Gastro Research ( Site 0293)","79424",{"type":60,"coordinates":136},[126,127],{"lat":127,"lon":126},[139],{"name":67,"role":47,"phone":140,"phoneExt":39,"email":39},"808-239-1823",{"facility":142,"status":53,"city":143,"state":110,"zip":144,"country":57,"countryCode":58,"cosmosGeoPoint":145,"geoPoint":149,"contacts":150},"Southern Star Research Institute ( Site 0299)","San Antonio","78229",{"type":60,"coordinates":146},[147,148],-98.49363,29.42412,{"lat":148,"lon":147},[151],{"name":67,"role":47,"phone":152,"phoneExt":39,"email":39},"210-581-2812",{"facility":154,"status":53,"city":155,"state":110,"zip":156,"country":57,"countryCode":58,"cosmosGeoPoint":157,"geoPoint":161,"contacts":162},"GI Alliance - Southlake ( Site 0298)","Southlake","76092-9167",{"type":60,"coordinates":158},[159,160],-97.13418,32.94124,{"lat":160,"lon":159},[163],{"name":67,"role":47,"phone":164,"phoneExt":39,"email":39},"817-424-1525",{"facility":166,"status":53,"city":167,"state":110,"zip":168,"country":57,"countryCode":58,"cosmosGeoPoint":169,"geoPoint":173,"contacts":174},"Tyler Research Institute ( Site 0294)","Tyler","75701",{"type":60,"coordinates":170},[171,172],-95.30106,32.35126,{"lat":172,"lon":171},[175],{"name":67,"role":47,"phone":176,"phoneExt":39,"email":39},"903-630-6211",{"facility":178,"status":53,"city":179,"state":180,"zip":181,"country":57,"countryCode":58,"cosmosGeoPoint":182,"geoPoint":186,"contacts":187},"University of Virginia Health System ( Site 0291)","Charlottesville","Virginia","22908",{"type":60,"coordinates":183},[184,185],-78.47668,38.02931,{"lat":185,"lon":184},[188],{"name":67,"role":47,"phone":189,"phoneExt":39,"email":39},"434-243-3090",{"facility":191,"status":53,"city":192,"state":193,"zip":194,"country":57,"countryCode":58,"cosmosGeoPoint":195,"geoPoint":199,"contacts":200},"Washington Gastroenterology - Tacoma ( Site 0295)","Tacoma","Washington","98405",{"type":60,"coordinates":196},[197,198],-122.44429,47.25288,{"lat":198,"lon":197},[201],{"name":67,"role":47,"phone":202,"phoneExt":39,"email":39},"425-452-8547",{"facility":204,"status":53,"city":205,"state":206,"zip":207,"country":208,"countryCode":39,"cosmosGeoPoint":209,"geoPoint":213,"contacts":214},"Vojenská Nemocnice Brno-Internal department ( Site 0701)","Brno","Brno-mesto","615 00","Czechia",{"type":60,"coordinates":210},[211,212],16.60796,49.19522,{"lat":212,"lon":211},[215],{"name":67,"role":47,"phone":216,"phoneExt":39,"email":39},"+420 973 445 520",{"facility":218,"status":53,"city":219,"state":39,"zip":220,"country":208,"countryCode":39,"cosmosGeoPoint":221,"geoPoint":225,"contacts":226},"Hepato-Gastroenterologie HK ( Site 0700)","Hradec Králové","50012",{"type":60,"coordinates":222},[223,224],15.83277,50.20923,{"lat":224,"lon":223},[227],{"name":67,"role":47,"phone":228,"phoneExt":39,"email":39},"+420495218475",{"facility":230,"status":53,"city":231,"state":232,"zip":233,"country":234,"countryCode":235,"cosmosGeoPoint":236,"geoPoint":240,"contacts":241},"Centre Hospitalier Universitaire de Nice - Hôpital l'Archet ( Site 1002)","Nice","Alpes-Maritimes","06202","France","FR",{"type":60,"coordinates":237},[238,239],7.26608,43.70313,{"lat":239,"lon":238},[242],{"name":67,"role":47,"phone":243,"phoneExt":39,"email":39},"+33 (0)4 92 03 93 66",{"facility":245,"status":53,"city":246,"state":247,"zip":248,"country":234,"countryCode":235,"cosmosGeoPoint":249,"geoPoint":253,"contacts":254},"CMC Ambroise Paré Hartmann - Institut des MICI ( Site 1003)","Neuilly-sur-Seine","Hauts-de-Seine","92200",{"type":60,"coordinates":250},[251,252],2.26965,48.8846,{"lat":252,"lon":251},[255],{"name":67,"role":47,"phone":256,"phoneExt":39,"email":39},"+33141430573",{"facility":258,"status":53,"city":259,"state":260,"zip":261,"country":234,"countryCode":235,"cosmosGeoPoint":262,"geoPoint":266,"contacts":267},"CHRU De Nancy - Hopital de Brabois ( Site 1001)","Vandœuvre-lès-Nancy","Meurthe-et-Moselle","54500",{"type":60,"coordinates":263},[264,265],6.17114,48.66115,{"lat":265,"lon":264},[268],{"name":67,"role":47,"phone":269,"phoneExt":39,"email":39},"+33383157488",{"facility":271,"status":53,"city":272,"state":273,"zip":274,"country":234,"countryCode":235,"cosmosGeoPoint":275,"geoPoint":279,"contacts":280},"Hopital Claude Huriez CHRU LILLE ( Site 1004)","Lille","Nord","59037",{"type":60,"coordinates":276},[277,278],3.05512,50.63391,{"lat":278,"lon":277},[281],{"name":67,"role":47,"phone":282,"phoneExt":39,"email":39},"+33320445620",{"facility":284,"status":53,"city":285,"state":39,"zip":286,"country":287,"countryCode":288,"cosmosGeoPoint":289,"geoPoint":293,"contacts":294},"ARENSIA Exploratory Medicine Georgia ( Site 1104)","Tbilisi","0112","Georgia","GE",{"type":60,"coordinates":290},[291,292],44.83412,41.69143,{"lat":292,"lon":291},[295],{"name":67,"role":47,"phone":296,"phoneExt":39,"email":39},"+995 599 133 071",{"facility":298,"status":53,"city":299,"state":300,"zip":301,"country":302,"countryCode":303,"cosmosGeoPoint":304,"geoPoint":308,"contacts":309},"Békés Megyei Központi Kórház Dr. Réthy Pál Tagkórház-4. Belgyogyaszat Gasztroenterologia ( Site 1411)","Békéscsaba","Bekes County","5600","Hungary","HU",{"type":60,"coordinates":305},[306,307],21.1,46.68333,{"lat":307,"lon":306},[310],{"name":67,"role":47,"phone":311,"phoneExt":39,"email":39},"+36304366675",{"facility":313,"status":53,"city":314,"state":39,"zip":315,"country":302,"countryCode":303,"cosmosGeoPoint":316,"geoPoint":320,"contacts":321},"Semmelweis Egyetem ( Site 1400)","Budapest","1082",{"type":60,"coordinates":317},[318,319],19.04045,47.49835,{"lat":319,"lon":318},[322],{"name":67,"role":47,"phone":323,"phoneExt":39,"email":39},"3614591500\u002F52120",{"facility":325,"status":53,"city":326,"state":327,"zip":328,"country":329,"countryCode":330,"cosmosGeoPoint":331,"geoPoint":335,"contacts":336},"Rivermed Sp. z.o.o. ( Site 2206)","Poznan","Greater Poland Voivodeship","61-441","Poland","PL",{"type":60,"coordinates":332},[333,334],16.92993,52.40692,{"lat":334,"lon":333},[337],{"name":67,"role":47,"phone":338,"phoneExt":39,"email":39},"+ 48 692 132 092",{"facility":340,"status":53,"city":341,"state":342,"zip":343,"country":329,"countryCode":330,"cosmosGeoPoint":344,"geoPoint":348,"contacts":349},"Centrum Diagnostyczno - Lecznicze Barska sp. z o.o. ( Site 2208)","Włocławek","Kuyavian-Pomeranian Voivodeship","87-800",{"type":60,"coordinates":345},[346,347],19.0678,52.64817,{"lat":347,"lon":346},[350],{"name":67,"role":47,"phone":351,"phoneExt":39,"email":39},"+48542334000",{"facility":353,"status":53,"city":354,"state":355,"zip":356,"country":329,"countryCode":330,"cosmosGeoPoint":357,"geoPoint":361,"contacts":362},"Krakowskie Centrum Medyczne ( Site 2210)","Krakow","Lesser Poland Voivodeship","31-501",{"type":60,"coordinates":358},[359,360],19.93658,50.06143,{"lat":360,"lon":359},[363],{"name":67,"role":47,"phone":364,"phoneExt":39,"email":39},"+48124231722",{"facility":366,"status":53,"city":367,"state":368,"zip":369,"country":329,"countryCode":330,"cosmosGeoPoint":370,"geoPoint":374,"contacts":375},"Centrum Medyczne Oporow ( Site 2212)","Wroclaw","Lower Silesian Voivodeship","52-416",{"type":60,"coordinates":371},[372,373],17.03006,51.10286,{"lat":373,"lon":372},[376],{"name":67,"role":47,"phone":377,"phoneExt":39,"email":39},"+48717127077",{"facility":379,"status":380,"city":367,"state":368,"zip":381,"country":329,"countryCode":330,"cosmosGeoPoint":382,"geoPoint":384,"contacts":39},"Melita Medical Sp. z o.o. ( Site 2204)","ACTIVE_NOT_RECRUITING","53-611",{"type":60,"coordinates":383},[372,373],{"lat":373,"lon":372},{"facility":386,"status":380,"city":367,"state":368,"zip":387,"country":329,"countryCode":330,"cosmosGeoPoint":388,"geoPoint":390,"contacts":39},"Przychodnia Futuremeds Wroclaw ( Site 2211)","53-673",{"type":60,"coordinates":389},[372,373],{"lat":373,"lon":372},{"facility":392,"status":53,"city":393,"state":394,"zip":395,"country":329,"countryCode":330,"cosmosGeoPoint":396,"geoPoint":400,"contacts":401},"1 Wojskowy Szpital Kliniczny Z Poliklinika SPZOZ w Lublinie ( Site 2205)","Lublin","Lublin Voivodeship","20-059",{"type":60,"coordinates":397},[398,399],22.57009,51.25058,{"lat":399,"lon":398},[402],{"name":67,"role":47,"phone":403,"phoneExt":39,"email":39},"+48882935706",{"facility":405,"status":53,"city":393,"state":394,"zip":406,"country":329,"countryCode":330,"cosmosGeoPoint":407,"geoPoint":409,"contacts":410},"Medrise Sp. z o.o. ( Site 2200)","20-582",{"type":60,"coordinates":408},[398,399],{"lat":399,"lon":398},[411],{"name":67,"role":47,"phone":412,"phoneExt":39,"email":39},"+48572300747",{"facility":414,"status":53,"city":415,"state":416,"zip":417,"country":329,"countryCode":330,"cosmosGeoPoint":418,"geoPoint":422,"contacts":423},"EB Group Sp. Z o.o. Centrum Zdrowia MDM ( Site 2202)","Warsaw","Masovian Voivodeship","00-189",{"type":60,"coordinates":419},[420,421],21.01178,52.22977,{"lat":421,"lon":420},[424],{"name":67,"role":47,"phone":425,"phoneExt":39,"email":39},"+48663097750",{"facility":427,"status":53,"city":415,"state":416,"zip":428,"country":329,"countryCode":330,"cosmosGeoPoint":429,"geoPoint":431,"contacts":432},"Vivamed Sp. z o.o. ( Site 2201)","03-580",{"type":60,"coordinates":430},[420,421],{"lat":421,"lon":420},[433],{"name":67,"role":47,"phone":434,"phoneExt":39,"email":39},"+48226792883",{"facility":436,"status":53,"city":415,"state":416,"zip":437,"country":329,"countryCode":330,"cosmosGeoPoint":438,"geoPoint":440,"contacts":441},"WIP Warsaw IBD Point Professor Kierkus ( Site 2209)","04-501",{"type":60,"coordinates":439},[420,421],{"lat":421,"lon":420},[442],{"name":67,"role":47,"phone":443,"phoneExt":39,"email":39},"+48500111648",{"facility":445,"status":53,"city":446,"state":447,"zip":448,"country":329,"countryCode":330,"cosmosGeoPoint":449,"geoPoint":453,"contacts":454},"Vita Longa Sp. Zoo ( Site 2213)","Katowice","Silesian Voivodeship","40-748",{"type":60,"coordinates":450},[451,452],19.02173,50.2597,{"lat":452,"lon":451},[455],{"name":67,"role":47,"phone":456,"phoneExt":39,"email":39},"+48322029715",{"facility":458,"status":53,"city":459,"state":460,"zip":461,"country":329,"countryCode":330,"cosmosGeoPoint":462,"geoPoint":466,"contacts":467},"Sonomed Sp. z o. o. ( Site 2203)","Szczecin","West Pomeranian Voivodeship","71-685",{"type":60,"coordinates":463},[464,465],14.55302,53.42894,{"lat":465,"lon":464},[468],{"name":67,"role":47,"phone":469,"phoneExt":39,"email":39},"+91 820 11 10",{"facility":471,"status":53,"city":472,"state":473,"zip":474,"country":329,"countryCode":330,"cosmosGeoPoint":475,"geoPoint":479,"contacts":480},"Bonifraterskie Centrum Medyczne ( Site 2207)","Lodz","Łódź Voivodeship","93-357",{"type":60,"coordinates":476},[477,478],19.47395,51.77058,{"lat":478,"lon":477},[481],{"name":67,"role":47,"phone":482,"phoneExt":39,"email":39},"+48 42 685 51 39",{"facility":484,"status":380,"city":485,"state":486,"zip":487,"country":488,"countryCode":489,"cosmosGeoPoint":490,"geoPoint":494,"contacts":39},"Whipps Cross University Hospital ( Site 3400)","London","England","E11 1NR","United Kingdom","UK",{"type":60,"coordinates":491},[492,493],-0.12574,51.50853,{"lat":493,"lon":492},{"facility":496,"status":53,"city":497,"state":498,"zip":499,"country":488,"countryCode":489,"cosmosGeoPoint":500,"geoPoint":504,"contacts":505},"MAC Research - Merseyside ( Site 3401)","Prescot","Knowsley","L34 1BH",{"type":60,"coordinates":501},[502,503],-2.80031,53.42948,{"lat":503,"lon":502},[506],{"name":67,"role":47,"phone":507,"phoneExt":39,"email":39},"(0)151 482 4700",{"type":509,"investigatorFullName":39,"investigatorTitle":39,"investigatorAffiliation":39,"oldNameTitle":39,"oldOrganization":39},"SPONSOR","100566138","phase-3-extension-study-of-long-term-safety-and-efficacy-of-tulisokibart-in-participants-with-crohns-disease-or-ulcerative-colitis-mk-7240-011-100566138",false,"NCT06651281","Extension Study of Long-term Safety and Efficacy of Tulisokibart in Participants With Crohn's Disease or Ulcerative Colitis (MK-7240-011)","A Phase 3 Extension Study to Evaluate the Long-term Safety and Efficacy of Tulisokibart in Participants With Crohn's Disease or Ulcerative Colitis","Inclusion Criteria:\n\n* Has participated in a qualifying tulisokibart Phase 2 or Phase 3 parent study for CD or UC\n* The investigator determines that the participant derives clinical benefit from continued study intervention based upon clinical evaluations performed during their parent study\n* A participant assigned female sex at birth is not breastfeeding during the study intervention period and for at least 14 weeks after the last dose of study intervention\n* A participant of childbearing potential (POCBP) is not pregnant and has a negative highly sensitive pregnancy test (urine or serum) as required by local regulations within 24 hours (for a urine test) or 72 hours (for a serum test) before the first dose of study intervention\n* A POCBP uses an acceptable contraceptive method, or adheres to penile-vaginal intercourse abstinence as their preferred and usual lifestyle (abstinent on a long-term and persistent basis)\n\nExclusion Criteria:\n\n* Has prematurely discontinued study intervention in their parent study\n* Has received any protocol-specified prohibited medications during their parent study\n* Has known allergies, hypersensitivity, or intolerance to tulisokibart or its excipients","ALL",{"count":519,"type":520},1380,"ESTIMATED","INTERVENTIONAL",[523],"PHASE3","Researchers want to learn more about tulisokibart (also known as MK-7240) in an extension study. Tulisokibart is a medicine designed to treat active, moderate to severe Crohn's disease (CD) and ulcerative colitis (UC). An extension study is a type of study where people who received tulisokibart in certain other studies for CD or UC (called a parent study) may be able to join this study. The goals of this study are to learn about the safety of tulisokibart over time in people with CD or UC, and if people tolerate it.",[526,527],"Crohn Disease","Colitis, Ulcerative","2026-05-15",{"date":530,"type":531},"2026-05-19","ACTUAL",{"date":533,"type":531},"2024-11-25",{"date":535,"type":520},"2037-12-17",{"name":5,"class":6},37]