[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100489919":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":37,"locations":47,"responsibleParty":836,"collaborators":838,"id":842,"slug":843,"hasResults":844,"nctId":845,"briefTitle":846,"officialTitle":847,"acronym":848,"eligibilityCriteria":849,"healthyVolunteers":844,"sex":850,"minAge":851,"maxAge":32,"enrollmentInfo":852,"targetDuration":32,"studyType":855,"phases":856,"briefSummary":858,"conditions":859,"keywords":866,"overallStatus":50,"whyStopped":32,"lastUpdateSubmitDate":867,"lastUpdatePostDateStruct":868,"startDateStruct":871,"completionDateStruct":873,"leadSponsor":875,"locationsCount":876},{"fullName":5,"class":6},"GOG Foundation","NETWORK",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"HIPEC","EXPERIMENTAL","Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Cisplatin 100 mg\u002Fm2 IP over 90 minutes at 42 degrees C",[13],"Drug: Cisplatin",{"label":15,"type":16,"description":17,"interventionNames":18},"No HIPEC","ACTIVE_COMPARATOR","No treatment",[19],"Other: No treatment",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Cisplatin","Cisplatin 100mg\u002Fm2 IP over 90 minutes at 42 degrees Celcius",[9],[27],"Platinol AQ",{"type":29,"name":17,"description":30,"armGroupLabels":31,"otherNames":32},"OTHER","No treatment with Cisplatin",[15],null,[34],{"name":35,"affiliation":5,"role":36},"Leslie Randall, MD","STUDY_CHAIR",[38,43],{"name":39,"role":40,"phone":41,"phoneExt":32,"email":42},"Sarin Chhab","CONTACT","215-854-0770","schhab@gog.org",{"name":44,"role":40,"phone":45,"phoneExt":32,"email":46},"Shanon Matkin","801-661-1584","smatkin@gog.org",[48,69,84,99,111,119,127,140,155,169,180,199,213,226,238,251,268,276,288,297,309,317,336,352,362,377,389,398,410,425,441,458,473,489,500,516,530,542,552,564,576,588,600,613,625,638,653,665,677,689,700,718,737,753,766,781,790,805,820],{"facility":49,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"City of Hope","RECRUITING","Duarte","California","91010","United States","US",{"type":57,"coordinates":58},"Point",[59,60],-117.97729,34.13945,{"lat":60,"lon":59},[63,66],{"name":64,"role":40,"phone":32,"phoneExt":32,"email":65},"Hesham Mahmoud","hmahmoud@coh.org",{"name":67,"role":68,"phone":32,"phoneExt":32,"email":32},"Thanh Dellinger, MD","PRINCIPAL_INVESTIGATOR",{"facility":70,"status":50,"city":71,"state":52,"zip":72,"country":54,"countryCode":55,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"University of California San Diego Moores Cancer Center","La Jolla","92037",{"type":57,"coordinates":74},[75,76],-117.2742,32.84727,{"lat":76,"lon":75},[79,82],{"name":80,"role":40,"phone":32,"phoneExt":32,"email":81},"Alexandrea Cronin","aocronin@health.ucsd.edu",{"name":83,"role":68,"phone":32,"phoneExt":32,"email":32},"Michael McHale, MD",{"facility":85,"status":50,"city":86,"state":52,"zip":87,"country":54,"countryCode":55,"cosmosGeoPoint":88,"geoPoint":92,"contacts":93},"Hoag Memorial Hospital Presbyterian","Newport Beach","92663",{"type":57,"coordinates":89},[90,91],-117.92895,33.61891,{"lat":91,"lon":90},[94,97],{"name":95,"role":40,"phone":32,"phoneExt":32,"email":96},"Atessa Kiani","atessa.kiani@hoag.org",{"name":98,"role":68,"phone":32,"phoneExt":32,"email":32},"Alberto Mendivil, MD",{"facility":100,"status":50,"city":101,"state":52,"zip":102,"country":54,"countryCode":55,"cosmosGeoPoint":103,"geoPoint":107,"contacts":108},"Stanford Ambulatory Surgery Center Lane Operating Room","Palo Alto","94034",{"type":57,"coordinates":104},[105,106],-122.14302,37.44188,{"lat":106,"lon":105},[109],{"name":110,"role":68,"phone":32,"phoneExt":32,"email":32},"Amer Karam, MD",{"facility":112,"status":50,"city":101,"state":52,"zip":113,"country":54,"countryCode":55,"cosmosGeoPoint":114,"geoPoint":116,"contacts":117},"Stanford Women's Cancer Center","94304",{"type":57,"coordinates":115},[105,106],{"lat":106,"lon":105},[118],{"name":110,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":120,"status":50,"city":101,"state":52,"zip":121,"country":54,"countryCode":55,"cosmosGeoPoint":122,"geoPoint":124,"contacts":125},"Stanford Hospital","94305",{"type":57,"coordinates":123},[105,106],{"lat":106,"lon":105},[126],{"name":110,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":128,"status":50,"city":129,"state":130,"zip":131,"country":54,"countryCode":55,"cosmosGeoPoint":132,"geoPoint":136,"contacts":137},"University of Colorado Hospital - Anshutz Cancer Pavilion","Aurora","Colorado","80045",{"type":57,"coordinates":133},[134,135],-104.83192,39.72943,{"lat":135,"lon":134},[138],{"name":139,"role":68,"phone":32,"phoneExt":32,"email":32},"Lindsay J Wheeler Brubaker, MD",{"facility":141,"status":50,"city":142,"state":143,"zip":144,"country":54,"countryCode":55,"cosmosGeoPoint":145,"geoPoint":149,"contacts":150},"Hartford Hospital","Hartford","Connecticut","06102",{"type":57,"coordinates":146},[147,148],-72.68509,41.76371,{"lat":148,"lon":147},[151,154],{"name":152,"role":40,"phone":32,"phoneExt":32,"email":153},"Amy Brown, MD","amy.brown@hhchealth.org",{"name":152,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":156,"status":50,"city":157,"state":143,"zip":158,"country":54,"countryCode":55,"cosmosGeoPoint":159,"geoPoint":163,"contacts":164},"Smilow Cancer Hospital at Yale- New Haven","New Haven","06511",{"type":57,"coordinates":160},[161,162],-72.92816,41.30815,{"lat":162,"lon":161},[165,167],{"name":166,"role":40,"phone":32,"phoneExt":32,"email":32},"Lisa Baker",{"name":168,"role":68,"phone":32,"phoneExt":32,"email":32},"Vaagn Andikyan, MD",{"facility":170,"status":50,"city":157,"state":143,"zip":171,"country":54,"countryCode":55,"cosmosGeoPoint":172,"geoPoint":174,"contacts":175},"Yale University School of Medicine","06520",{"type":57,"coordinates":173},[161,162],{"lat":162,"lon":161},[176,178],{"name":166,"role":40,"phone":32,"phoneExt":32,"email":177},"lisa.baker@yale.edu",{"name":179,"role":68,"phone":32,"phoneExt":32,"email":32},"Elena Ratner, MD",{"facility":181,"status":50,"city":182,"state":183,"zip":184,"country":54,"countryCode":55,"cosmosGeoPoint":185,"geoPoint":189,"contacts":190},"Sylvester Comprehensive Cancer Center - The Lennar Foundation Medical Center","Coral Gables","Florida","33146",{"type":57,"coordinates":186},[187,188],-80.26838,25.72149,{"lat":188,"lon":187},[191,194,197],{"name":192,"role":40,"phone":32,"phoneExt":32,"email":193},"Smita Bhukan","sxb9533@med.miami.edu",{"name":195,"role":40,"phone":32,"phoneExt":32,"email":196},"Patricia Rozas","px445@med.miami.edu",{"name":198,"role":68,"phone":32,"phoneExt":32,"email":32},"Abdulrahman K Sinno, MD",{"facility":200,"status":50,"city":201,"state":183,"zip":202,"country":54,"countryCode":55,"cosmosGeoPoint":203,"geoPoint":207,"contacts":208},"University of Miami Hospital and Clinics - Deerfield Beach","Deerfield Beach","33442",{"type":57,"coordinates":204},[205,206],-80.09977,26.31841,{"lat":206,"lon":205},[209,210,211],{"name":192,"role":40,"phone":32,"phoneExt":32,"email":193},{"name":195,"role":40,"phone":32,"phoneExt":32,"email":196},{"name":212,"role":68,"phone":32,"phoneExt":32,"email":32},"Abdulrahman Sinno, MD",{"facility":214,"status":50,"city":215,"state":183,"zip":216,"country":54,"countryCode":55,"cosmosGeoPoint":217,"geoPoint":221,"contacts":222},"University of Miami Hospital and Clinics","Miami","33136",{"type":57,"coordinates":218},[219,220],-80.19366,25.77427,{"lat":220,"lon":219},[223,224,225],{"name":192,"role":40,"phone":32,"phoneExt":32,"email":193},{"name":195,"role":40,"phone":32,"phoneExt":32,"email":196},{"name":212,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":227,"status":50,"city":215,"state":183,"zip":228,"country":54,"countryCode":55,"cosmosGeoPoint":229,"geoPoint":231,"contacts":232},"Miami Cancer Institute","33176",{"type":57,"coordinates":230},[219,220],{"lat":220,"lon":219},[233,236],{"name":234,"role":40,"phone":32,"phoneExt":32,"email":235},"Jacqueline Lebron","jacquelile@baptisthealth.net",{"name":237,"role":68,"phone":32,"phoneExt":32,"email":32},"John Diaz, MD",{"facility":239,"status":50,"city":240,"state":183,"zip":241,"country":54,"countryCode":55,"cosmosGeoPoint":242,"geoPoint":246,"contacts":247},"Sylvester Comprehensive Cancer Center - Plantation","Plantation","33324",{"type":57,"coordinates":243},[244,245],-80.23184,26.13421,{"lat":245,"lon":244},[248,249,250],{"name":192,"role":40,"phone":32,"phoneExt":32,"email":193},{"name":195,"role":40,"phone":32,"phoneExt":32,"email":196},{"name":212,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":252,"status":50,"city":253,"state":254,"zip":255,"country":54,"countryCode":55,"cosmosGeoPoint":256,"geoPoint":260,"contacts":261},"University of Kansas Hospital","Kansas City","Kansas","66160",{"type":57,"coordinates":257},[258,259],-94.62746,39.11417,{"lat":259,"lon":258},[262,266],{"name":263,"role":40,"phone":264,"phoneExt":32,"email":265},"KUCC Navigation","913-588-3671","kucc_navigation@kumc.edu",{"name":267,"role":68,"phone":32,"phoneExt":32,"email":32},"Andrea Jewell, MD",{"facility":269,"status":50,"city":253,"state":254,"zip":255,"country":54,"countryCode":55,"cosmosGeoPoint":270,"geoPoint":272,"contacts":273},"University of Kansas Medical Center MOB",{"type":57,"coordinates":271},[258,259],{"lat":259,"lon":258},[274,275],{"name":263,"role":40,"phone":264,"phoneExt":32,"email":265},{"name":267,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":277,"status":50,"city":278,"state":254,"zip":279,"country":54,"countryCode":55,"cosmosGeoPoint":280,"geoPoint":284,"contacts":285},"University of Kansas Cancer Center Overland Park","Overland Park","66210",{"type":57,"coordinates":281},[282,283],-94.67079,38.98223,{"lat":283,"lon":282},[286,287],{"name":263,"role":40,"phone":264,"phoneExt":32,"email":265},{"name":267,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":289,"status":50,"city":278,"state":254,"zip":290,"country":54,"countryCode":55,"cosmosGeoPoint":291,"geoPoint":293,"contacts":294},"University of Kansas Indian Creek Breast Surgery","66211",{"type":57,"coordinates":292},[282,283],{"lat":283,"lon":282},[295,296],{"name":263,"role":40,"phone":264,"phoneExt":32,"email":265},{"name":267,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":298,"status":50,"city":299,"state":254,"zip":300,"country":54,"countryCode":55,"cosmosGeoPoint":301,"geoPoint":305,"contacts":306},"University of Kansas Cancer Center Westwood","Westwood","66205",{"type":57,"coordinates":302},[303,304],-94.6169,39.04056,{"lat":304,"lon":303},[307,308],{"name":263,"role":40,"phone":264,"phoneExt":32,"email":265},{"name":267,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":310,"status":50,"city":299,"state":254,"zip":300,"country":54,"countryCode":55,"cosmosGeoPoint":311,"geoPoint":313,"contacts":314},"University of Kansas Clinical Research Center",{"type":57,"coordinates":312},[303,304],{"lat":304,"lon":303},[315,316],{"name":263,"role":40,"phone":264,"phoneExt":32,"email":265},{"name":267,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":318,"status":50,"city":319,"state":320,"zip":321,"country":54,"countryCode":55,"cosmosGeoPoint":322,"geoPoint":326,"contacts":327},"University of Kentucky Medical Center","Lexington","Kentucky","40536",{"type":57,"coordinates":323},[324,325],-84.47772,37.98869,{"lat":325,"lon":324},[328,331,334],{"name":329,"role":40,"phone":32,"phoneExt":32,"email":330},"Ashley Walton-Robbins","Ashley.Walton-Robbins@uky.edu",{"name":332,"role":40,"phone":32,"phoneExt":32,"email":333},"Aneesha Carter","aneesha.carter@uky.edu",{"name":335,"role":68,"phone":32,"phoneExt":32,"email":32},"Charles Dietrich, MD",{"facility":337,"status":50,"city":338,"state":339,"zip":340,"country":54,"countryCode":55,"cosmosGeoPoint":341,"geoPoint":345,"contacts":346},"LSU Health New Orleans","New Orleans","Louisiana","70112",{"type":57,"coordinates":342},[343,344],-90.07507,29.95465,{"lat":344,"lon":343},[347,350],{"name":348,"role":40,"phone":32,"phoneExt":32,"email":349},"Carla Laborde","cscion@lsuhsc.edu",{"name":351,"role":68,"phone":32,"phoneExt":32,"email":32},"Amelia Jernigan, MD",{"facility":353,"status":50,"city":338,"state":339,"zip":340,"country":54,"countryCode":55,"cosmosGeoPoint":354,"geoPoint":356,"contacts":357},"University Medical Center New Orleans",{"type":57,"coordinates":355},[343,344],{"lat":344,"lon":343},[358,361],{"name":359,"role":40,"phone":32,"phoneExt":32,"email":360},"Eileen Mederos","emede1@lsuhsc.edu",{"name":351,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":363,"status":50,"city":364,"state":365,"zip":366,"country":54,"countryCode":55,"cosmosGeoPoint":367,"geoPoint":371,"contacts":372},"Mayo Clinic","Rochester","Minnesota","55905",{"type":57,"coordinates":368},[369,370],-92.4699,44.02163,{"lat":370,"lon":369},[373,376],{"name":374,"role":40,"phone":32,"phoneExt":32,"email":375},"Carrie Langstraat, MD","langstraat.carrie@mayo.edu",{"name":374,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":378,"status":50,"city":253,"state":379,"zip":380,"country":54,"countryCode":55,"cosmosGeoPoint":381,"geoPoint":385,"contacts":386},"University of Kansas Cancer Center","Missouri","64116",{"type":57,"coordinates":382},[383,384],-94.57857,39.09973,{"lat":384,"lon":383},[387,388],{"name":263,"role":40,"phone":264,"phoneExt":32,"email":265},{"name":267,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":390,"status":50,"city":253,"state":379,"zip":391,"country":54,"countryCode":55,"cosmosGeoPoint":392,"geoPoint":394,"contacts":395},"University of Kansas Cancer Center North","64154",{"type":57,"coordinates":393},[383,384],{"lat":384,"lon":383},[396,397],{"name":263,"role":40,"phone":264,"phoneExt":32,"email":265},{"name":267,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":399,"status":50,"city":400,"state":379,"zip":401,"country":54,"countryCode":55,"cosmosGeoPoint":402,"geoPoint":406,"contacts":407},"University of Kansas Cancer Center Lee's Summit","Lee's Summit","64064",{"type":57,"coordinates":403},[404,405],-94.38217,38.91084,{"lat":405,"lon":404},[408,409],{"name":263,"role":40,"phone":264,"phoneExt":32,"email":265},{"name":267,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":411,"status":50,"city":412,"state":379,"zip":413,"country":54,"countryCode":55,"cosmosGeoPoint":414,"geoPoint":418,"contacts":419},"Washington University School of Medicine","St Louis","63110",{"type":57,"coordinates":415},[416,417],-90.19789,38.62727,{"lat":417,"lon":416},[420,423],{"name":421,"role":40,"phone":32,"phoneExt":32,"email":422},"Tiara Redrick","tredrick@wustl.edu",{"name":424,"role":68,"phone":32,"phoneExt":32,"email":32},"Premal Thaker, MD",{"facility":426,"status":50,"city":427,"state":428,"zip":429,"country":54,"countryCode":55,"cosmosGeoPoint":430,"geoPoint":434,"contacts":435},"Holy Name Medical Center","Teaneck","New Jersey","07666",{"type":57,"coordinates":431},[432,433],-74.01597,40.8976,{"lat":433,"lon":432},[436,439],{"name":437,"role":40,"phone":32,"phoneExt":32,"email":438},"Marissa Van Orden","mvanorden@holyname.org",{"name":440,"role":68,"phone":32,"phoneExt":32,"email":32},"Sharyn Lewin",{"facility":442,"status":50,"city":443,"state":444,"zip":445,"country":54,"countryCode":55,"cosmosGeoPoint":446,"geoPoint":450,"contacts":451},"University of New Mexico Comprehensive Cancer Center","Albuquerque","New Mexico","87102",{"type":57,"coordinates":447},[448,449],-106.65114,35.08449,{"lat":449,"lon":448},[452,456],{"name":453,"role":40,"phone":454,"phoneExt":32,"email":455},"Rebecca Baca","505-272-4946","ReBaca@salud.unm.edu",{"name":457,"role":68,"phone":32,"phoneExt":32,"email":32},"Carolyn Muller, MD",{"facility":459,"status":50,"city":460,"state":460,"zip":461,"country":54,"countryCode":55,"cosmosGeoPoint":462,"geoPoint":466,"contacts":467},"Memorial Sloan-Kettering Cancer Center","New York","10022",{"type":57,"coordinates":463},[464,465],-74.00597,40.71427,{"lat":465,"lon":464},[468,471],{"name":469,"role":40,"phone":32,"phoneExt":32,"email":470},"Bhavani Ramesh","rameshb@mskcc.org",{"name":472,"role":68,"phone":32,"phoneExt":32,"email":32},"Dennis Chi, MD",{"facility":474,"status":50,"city":475,"state":476,"zip":477,"country":54,"countryCode":55,"cosmosGeoPoint":478,"geoPoint":482,"contacts":483},"Duke Cancer Center","Durham","North Carolina","27710",{"type":57,"coordinates":479},[480,481],-78.89862,35.99403,{"lat":481,"lon":480},[484,487],{"name":485,"role":40,"phone":32,"phoneExt":32,"email":486},"Karen Grace","karen.grace@duke.edu",{"name":488,"role":68,"phone":32,"phoneExt":32,"email":32},"Jennifer L McNally, MD",{"facility":490,"status":50,"city":491,"state":476,"zip":492,"country":54,"countryCode":55,"cosmosGeoPoint":493,"geoPoint":497,"contacts":498},"Duke Women's Cancer Care Raleigh","Raleigh","27607",{"type":57,"coordinates":494},[495,496],-78.63861,35.7721,{"lat":496,"lon":495},[499],{"name":488,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":501,"status":50,"city":502,"state":503,"zip":504,"country":54,"countryCode":55,"cosmosGeoPoint":505,"geoPoint":509,"contacts":510},"UH Geauga Medical Center","Chardon","Ohio","44024",{"type":57,"coordinates":506},[507,508],-81.14899,41.61422,{"lat":508,"lon":507},[511,514],{"name":512,"role":40,"phone":32,"phoneExt":32,"email":513},"Lauren Patrick","lauren.patrick@UHHospitals.org",{"name":515,"role":68,"phone":32,"phoneExt":32,"email":32},"Sarah Lynam, MD",{"facility":517,"status":50,"city":518,"state":503,"zip":519,"country":54,"countryCode":55,"cosmosGeoPoint":520,"geoPoint":524,"contacts":525},"University of Cincinnati Medical Center","Cincinnati","45219",{"type":57,"coordinates":521},[522,523],-84.51439,39.12711,{"lat":523,"lon":522},[526,529],{"name":527,"role":40,"phone":32,"phoneExt":32,"email":528},"Caroline Billingsley, MD","billincn@ucmail.uc.edu",{"name":527,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":531,"status":50,"city":518,"state":503,"zip":532,"country":54,"countryCode":55,"cosmosGeoPoint":533,"geoPoint":535,"contacts":536},"TriHealth Cancer Institute - Good Samaritan Hospital","45220",{"type":57,"coordinates":534},[522,523],{"lat":523,"lon":522},[537,540],{"name":538,"role":40,"phone":32,"phoneExt":32,"email":539},"Patrick Newbury","patrick_newbury@trihealth.com",{"name":541,"role":68,"phone":32,"phoneExt":32,"email":32},"Robert Neff, MD",{"facility":543,"status":50,"city":518,"state":503,"zip":544,"country":54,"countryCode":55,"cosmosGeoPoint":545,"geoPoint":547,"contacts":548},"TriHealth Cancer Institute- Thomas Comprehensive Care Center","45242",{"type":57,"coordinates":546},[522,523],{"lat":523,"lon":522},[549,551],{"name":538,"role":40,"phone":32,"phoneExt":32,"email":550},"Patrick_Newbury@trihealth.com",{"name":541,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":553,"status":50,"city":554,"state":503,"zip":555,"country":54,"countryCode":55,"cosmosGeoPoint":556,"geoPoint":560,"contacts":561},"University Hospitals Cleveland Medical Center","Cleveland","44106",{"type":57,"coordinates":557},[558,559],-81.69541,41.4995,{"lat":559,"lon":558},[562,563],{"name":512,"role":40,"phone":32,"phoneExt":32,"email":513},{"name":515,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":565,"status":50,"city":554,"state":503,"zip":566,"country":54,"countryCode":55,"cosmosGeoPoint":567,"geoPoint":569,"contacts":570},"Cleveland Clinic","44195",{"type":57,"coordinates":568},[558,559],{"lat":559,"lon":558},[571,574],{"name":572,"role":40,"phone":32,"phoneExt":32,"email":573},"Jacqueline Ludwig","ludwigj@ccf.org",{"name":575,"role":68,"phone":32,"phoneExt":32,"email":32},"Robert Debernardo Jr., MD",{"facility":577,"status":50,"city":578,"state":503,"zip":579,"country":54,"countryCode":55,"cosmosGeoPoint":580,"geoPoint":584,"contacts":585},"SCC at Lake University","Mentor","44060",{"type":57,"coordinates":581},[582,583],-81.33955,41.66616,{"lat":583,"lon":582},[586,587],{"name":512,"role":40,"phone":32,"phoneExt":32,"email":513},{"name":515,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":589,"status":50,"city":590,"state":503,"zip":591,"country":54,"countryCode":55,"cosmosGeoPoint":592,"geoPoint":596,"contacts":597},"UH Minoff Health Center at Chagrin Highlands","Orange","44122",{"type":57,"coordinates":593},[594,595],-81.48067,41.44978,{"lat":595,"lon":594},[598,599],{"name":512,"role":40,"phone":32,"phoneExt":32,"email":513},{"name":515,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":601,"status":50,"city":602,"state":503,"zip":603,"country":54,"countryCode":55,"cosmosGeoPoint":604,"geoPoint":608,"contacts":609},"West Chester Hospital","West Chester","45069",{"type":57,"coordinates":605},[606,607],-84.40716,39.33172,{"lat":607,"lon":606},[610,612],{"name":611,"role":40,"phone":32,"phoneExt":32,"email":528},"Caroline Billingsley",{"name":527,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":614,"status":50,"city":615,"state":503,"zip":616,"country":54,"countryCode":55,"cosmosGeoPoint":617,"geoPoint":621,"contacts":622},"St. John Medical Center","Westlake","44145",{"type":57,"coordinates":618},[619,620],-81.91792,41.45532,{"lat":620,"lon":619},[623,624],{"name":512,"role":40,"phone":32,"phoneExt":32,"email":513},{"name":515,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":626,"status":50,"city":627,"state":628,"zip":629,"country":54,"countryCode":55,"cosmosGeoPoint":630,"geoPoint":634,"contacts":635},"Jefferson Abington Hospital","Abington","Pennsylvania","19001",{"type":57,"coordinates":631},[632,633],-75.11795,40.12067,{"lat":633,"lon":632},[636],{"name":637,"role":68,"phone":32,"phoneExt":32,"email":32},"Lea Moukarzel, MD",{"facility":639,"status":50,"city":640,"state":628,"zip":641,"country":54,"countryCode":55,"cosmosGeoPoint":642,"geoPoint":646,"contacts":647},"Jefferson Hospital","Jefferson Hills","15025",{"type":57,"coordinates":643},[644,645],-79.93199,40.29118,{"lat":645,"lon":644},[648,651],{"name":649,"role":40,"phone":32,"phoneExt":32,"email":650},"Siobhan Guyach","Siobhan.guyach@ahn.org",{"name":652,"role":68,"phone":32,"phoneExt":32,"email":32},"John Nakayama, MD",{"facility":654,"status":50,"city":655,"state":628,"zip":656,"country":54,"countryCode":55,"cosmosGeoPoint":657,"geoPoint":661,"contacts":662},"Forbes Hospital","Monroeville","15146",{"type":57,"coordinates":658},[659,660],-79.7881,40.42118,{"lat":660,"lon":659},[663,664],{"name":649,"role":40,"phone":32,"phoneExt":32,"email":650},{"name":652,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":666,"status":50,"city":667,"state":628,"zip":668,"country":54,"countryCode":55,"cosmosGeoPoint":669,"geoPoint":673,"contacts":674},"West Penn Hospital","Pittsburgh","15224",{"type":57,"coordinates":670},[671,672],-79.99589,40.44062,{"lat":672,"lon":671},[675,676],{"name":649,"role":40,"phone":32,"phoneExt":32,"email":650},{"name":652,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":678,"status":50,"city":679,"state":628,"zip":680,"country":54,"countryCode":55,"cosmosGeoPoint":681,"geoPoint":685,"contacts":686},"Wexford Hospital","Wexford","15090",{"type":57,"coordinates":682},[683,684],-80.05589,40.62646,{"lat":684,"lon":683},[687,688],{"name":649,"role":40,"phone":32,"phoneExt":32,"email":650},{"name":652,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":690,"status":50,"city":691,"state":628,"zip":692,"country":54,"countryCode":55,"cosmosGeoPoint":693,"geoPoint":697,"contacts":698},"Asplundh Cancer Pavilion","Willow Grove","19090",{"type":57,"coordinates":694},[695,696],-75.11573,40.144,{"lat":696,"lon":695},[699],{"name":637,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":701,"status":50,"city":702,"state":628,"zip":703,"country":54,"countryCode":55,"cosmosGeoPoint":704,"geoPoint":708,"contacts":709},"Lankenau Medical Center\u002FMainline Medical Center","Wynnewood","19096",{"type":57,"coordinates":705},[706,707],-75.27074,40.00289,{"lat":707,"lon":706},[710,713,716],{"name":711,"role":40,"phone":32,"phoneExt":32,"email":712},"Jessica Burrell","BurrellJe@mlhs.org",{"name":714,"role":40,"phone":32,"phoneExt":32,"email":715},"David Holtz","holtzD@mlhs.org",{"name":717,"role":68,"phone":32,"phoneExt":32,"email":32},"David Holtz, MD",{"facility":719,"status":50,"city":720,"state":721,"zip":722,"country":54,"countryCode":55,"cosmosGeoPoint":723,"geoPoint":727,"contacts":728},"Medical University of South Carolina (Hollings Cancer Center)","Charleston","South Carolina","29425",{"type":57,"coordinates":724},[725,726],-79.93275,32.77632,{"lat":726,"lon":725},[729,732,735],{"name":730,"role":40,"phone":32,"phoneExt":32,"email":731},"Carly Fecio","fecio@musc.edu",{"name":733,"role":40,"phone":32,"phoneExt":32,"email":734},"Brian Orr","orrb@musc.edu",{"name":736,"role":68,"phone":32,"phoneExt":32,"email":32},"Brian Orr, MD",{"facility":738,"status":50,"city":739,"state":740,"zip":741,"country":54,"countryCode":55,"cosmosGeoPoint":742,"geoPoint":746,"contacts":747},"Vanderbilt University Medical Center","Nashville","Tennessee","37232",{"type":57,"coordinates":743},[744,745],-86.78444,36.16589,{"lat":745,"lon":744},[748,751],{"name":749,"role":40,"phone":32,"phoneExt":32,"email":750},"Krista Garbacz","krista.garbacz@vumc.org",{"name":752,"role":68,"phone":32,"phoneExt":32,"email":32},"Marta Crispens, MD",{"facility":754,"status":50,"city":755,"state":756,"zip":757,"country":54,"countryCode":55,"cosmosGeoPoint":758,"geoPoint":762,"contacts":763},"Texas Oncology - Central South","Austin","Texas","78758",{"type":57,"coordinates":759},[760,761],-97.74306,30.26715,{"lat":761,"lon":760},[764],{"name":765,"role":68,"phone":32,"phoneExt":32,"email":32},"Helen Eshed, MD",{"facility":767,"status":50,"city":768,"state":756,"zip":769,"country":54,"countryCode":55,"cosmosGeoPoint":770,"geoPoint":774,"contacts":775},"Baylor College of Medicine Medical Center","Houston","77030",{"type":57,"coordinates":771},[772,773],-95.36327,29.76328,{"lat":773,"lon":772},[776,779],{"name":777,"role":40,"phone":32,"phoneExt":32,"email":778},"Carolyn Thibodeaux","carolynt@bcm.edu",{"name":780,"role":68,"phone":32,"phoneExt":32,"email":32},"Anthony Costales, MD",{"facility":782,"status":50,"city":768,"state":756,"zip":783,"country":54,"countryCode":55,"cosmosGeoPoint":784,"geoPoint":786,"contacts":787},"O'Quinn Medical Tower at McNair Campus","77054",{"type":57,"coordinates":785},[772,773],{"lat":773,"lon":772},[788,789],{"name":777,"role":40,"phone":32,"phoneExt":32,"email":778},{"name":780,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":791,"status":50,"city":792,"state":793,"zip":794,"country":54,"countryCode":55,"cosmosGeoPoint":795,"geoPoint":799,"contacts":800},"Inova Schar Cancer Institute","Fairfax","Virginia","22031",{"type":57,"coordinates":796},[797,798],-77.30637,38.84622,{"lat":798,"lon":797},[801,804],{"name":802,"role":40,"phone":32,"phoneExt":32,"email":803},"Adela Mahmutovic","adela.mahmutovic@inova.org",{"name":35,"role":68,"phone":32,"phoneExt":32,"email":32},{"facility":806,"status":50,"city":807,"state":793,"zip":808,"country":54,"countryCode":55,"cosmosGeoPoint":809,"geoPoint":813,"contacts":814},"Virginia Oncology Associates","Norfolk","23502",{"type":57,"coordinates":810},[811,812],-76.28522,36.84681,{"lat":812,"lon":811},[815,818],{"name":816,"role":40,"phone":32,"phoneExt":32,"email":817},"Jenny Marks","jenny.marks@usoncology.com",{"name":819,"role":68,"phone":32,"phoneExt":32,"email":32},"Danielle Chau, MD",{"facility":821,"status":50,"city":822,"state":823,"zip":824,"country":54,"countryCode":55,"cosmosGeoPoint":825,"geoPoint":829,"contacts":830},"Froedtert Memorial Lutheran Hospital & Medical College of Wisconsin","Milwaukee","Wisconsin","53226",{"type":57,"coordinates":826},[827,828],-87.90647,43.0389,{"lat":828,"lon":827},[831,834],{"name":832,"role":40,"phone":32,"phoneExt":32,"email":833},"Subarna Paul","supaul@mcw.edu",{"name":835,"role":68,"phone":32,"phoneExt":32,"email":32},"Denise Uyar, MD",{"type":837,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR",[839],{"name":840,"class":841},"GlaxoSmithKline","INDUSTRY","100489919","phase-3-heated-intraperitoneal-chemotherapy-followed-by-niraparib-for-ovarian-primary-peritoneal-and-fallopian-tube-cancer-100489919",false,"NCT05659381","Heated Intraperitoneal Chemotherapy Followed by Niraparib for Ovarian, Primary Peritoneal and Fallopian Tube Cancer","GOG-3068: A Phase III Randomized Trial of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) With Cisplatin Versus no HIPEC at the Time of Optimal Interval Cytoreductive Surgery Followed by Niraparib Maintenance in Patients With Homologous Recombinant Deficient (HRD +) Newly Diagnosed Stage III and IV Ovarian, Primary Peritoneal, and Fallopian Tube Cancer (Heated Ovarian Treatment Trial)","HOTT","Inclusion Criteria:\n\n1. Patients must have a pathologic diagnosis of high grade serous or endometroid epithelial ovarian, fallopian tube, or primary peritoneal carcinoma, FIGO stage III or IV documented on CT scan\u002FMRI, must be recommended and agree to undergo platinum-based neoadjuvant chemotherapy with or without physician choice bevacizumab (3-4 cycles allowed, with bevacizumab held for at least 28 days preoperatively) and are considered candidates for (and planned to have) interval cytoreductive surgery (iCRS) followed by chemotherapy and niraparib maintenance as determined by the enrolling investigator. Patients may continue bevacizumab after a minimum of 28 days post iCRS and during niraparib maintenance per local standard.\n2. Patients with stage IV disease must have complete response of extra-abdominal disease on preoperative imaging (e.g. pleural effusion, mediastinal, inguinal, supraclavicular lymphadenopathy, or other extra-abdominal metastases) or be deemed resectable with iCRS.\n3. Patients must have HRD\u002FLOH positive tumors. Patients with germline or somatic BRCA or other similar mutations (RAD51C, RAD51D, BRIP1, BARD) are not required to have HRD\u002FLOH testing. Patients without BRCA or germline mutations must have HRD\u002FLOH testing using Myriad myChoice®\u002FFoundation Medicine\u002FCaris Life Sciences platforms. HRD test results must be available prior to registration to meet entry criteria.\n4. Patients must have R0 (no gross\u002Fvisible residual disease) or R1 (gross\u002Fvisible residual disease ≤ 1.0 cm in the longest diameter) following iCRS and prior to randomization.\n5. Patient must have adequate bone marrow and organ function:\n\n   Bone marrow function:\n\n   Hemoglobin ≥ 8.5 g\u002FdL. Absolute neutrophil count (ANC) ≥ 1,500\u002Fmm3. Platelets ≥ 100,000\u002Fmm3.\n\n   Renal function:\n\n   Creatinine ≤ 1.3mg\u002Fdl OR Calculated creatinine clearance (≥ 30 mL\u002Fmin\u002F1.73 m2) per National Kidney Foundation guidelines and NHANES III\n\n   Hepatic function:\n\n   Bilirubin ≤ 1.5 times ULN. ALT ≤ 3 times the ULN. AST ≤ 3 times the ULN.\n\n   Neurologic function:\n\n   Peripheral neuropathy ≤ CTC AE grade 2.\n6. Patients must have an ECOG performance status of 0 or 1.\n7. Patient must be age \\> 18.\n8. Patients must have a life expectancy \\> 3 months.\n9. Patients of childbearing potential must have a negative serum pregnancy test within 28 days prior to iCRS and must be practicing an effective form of contraception (with failure rate \\\u003C1% per year) during the study period and for 6 months following the last dose of niraparib. Patients of childbearing potential must consent to pregnancy testing prior to receiving niraparib and monthly thereafter for the duration of the study.\n\n   Patients are considered postmenopausal and not of child-bearing potential if they are free from menses for \\>1 year or surgically sterilized.\n10. Patients must have normal blood pressure (BP) or adequately treated and controlled hypertension based on local standard of care (systolic BP ≤ 140 mmHg and diastolic ≤ 90 mmHg) prior to starting niraparib.\n11. Patients receiving corticosteroids may continue as long as their dose is stable for at least 4 weeks prior to randomization.\n12. Patients must agree to not donate blood during the study or for 90 days after the last dose of study treatment.\n13. Patients with known human immunodeficiency virus (HIV) are allowed if they meet all the following criteria:\n\n    1. Cluster of differentiation 4 ≥350\u002FµL and viral load \\\u003C400 copies\u002FmL\n    2. No history of acquired immunodeficiency syndrome-defining opportunistic infections within 12 months prior to enrollment\n    3. No history of HIV associated malignancy for the past 5 years\n    4. Concurrent antiretroviral therapy as per the most current National Institutes of Health (NIH) Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV started \\>4 weeks prior to study enrollment\n14. Patient or a legally authorized representative must have signed an approved informed consent and authorization permitting the release of personal health information.\n\nExclusion Criteria\n\n1. Patients with low-grade serous, clear cell, mucinous, non-epithelial ovarian cancers and borderline tumors.\n2. Patients who have received prior treatment for ovarian cancer other than the first 3-4 cycles of platinum based neoadjuvant chemotherapy. Prior neoadjuvant treatment with bevacizumab is allowed; bevacizumab must be held for 28 days prior to surgery.\n3. Patients whose tumors are HRD\u002FLOH negative.\n4. Patients not eligible for iCRS based on evidence of progression of disease during neoadjuvant chemotherapy (documented on CT scan\u002FMRI required within 35 days of iCRS).\n5. Patients not eligible for iCRS based on medical co-morbidities as per the enrolling investigator.\n6. Patients with stage IV disease without complete response of extra-abdominal disease on preoperative findings (e.g., pleural effusion, mediastinal, inguinal, supraclavicular lymphadenopathy, mesemchymal liver metastases or other extra-abdominal metastases) who are not deemed resectable with iCRS.\n7. Patients with a history of Myelodysplastic Syndrome or Acute Myeloid Leukemia.\n8. Patients who are pregnant or lactating.\n9. Patients with a severe infection requiring IV antibiotics within 2 weeks of planned randomization.\n10. Patients with other uncontrolled, intercurrent medical conditions.\n11. Patient with metastatic disease to the central nervous system.\n12. Patient with uncontrolled insulin dependent diabetes or pre-existing renal condition.\n13. Patients with pre-existing hearing loss related to prior platinum-based chemotherapy.\n14. Patients with Prior Reversible Encephalopathy Syndrome (PRES).\n15. Patients with current active liver or biliary disease (with the exception of Gilbert's syndrome or asymptomatic gallstones, liver metastases or otherwise stable chronic liver disease per investigator assessment). Severe hepatic impairment patients should be excluded.\n16. Patients with any clinically significant gastrointestinal (GI) abnormalities that may alter absorption such as malabsorption syndrome or major resection of the stomach and\u002For bowels that is not related to ovarian cancer.\n17. Patients with clinically significant cardiovascular disease (e.g., significant cardiac conduction abnormalities, uncontrolled hypertension, myocardial infarction, uncontrolled cardiac arrhythmia or unstable angina \\\u003C6 months to randomization, New York Heart Association Grade 2 or greater congestive heart failure, serious cardiac arrhythmia requiring medication, Grade 2 or greater peripheral vascular disease, and history of cerebrovascular accident within 6 months).\n18. Patients with an increased bleeding risk due to concurrent conditions (e.g., major injuries or major surgery within the past 28 days prior to study randomization and\u002For history of hemorrhagic stroke, transient ischemic attack, subarachnoid hemorrhage, or clinically significant hemorrhage within the past 3 months).\n19. Patients with known active hepatitis B (eg, hepatitis B surface antigen reactive) are excluded unless their HBV is stably controlled on nucleos(t)ide analogs (eg entecavir or tenofovir) which will be continued for the duration of the study.\n20. Patient has had investigational therapy administered within 4 weeks or within a time interval less than at least 5 half-lives of the investigational agent, whichever is longer, prior to study randomization.\n21. Patient has received a live vaccine within 30 days of study randomization. COVID-19 vaccines that do not contain live viruses are allowed at any time during the study.\n22. Patient has a diagnosis, detection, or treatment of another type of invasive cancer ≤ 2 years prior to initiating protocol therapy (except for basal or squamous cell carcinoma of the skin, cervical cancer in situ, and ductal cancer in situ (DCIS) that has been definitively treated).\n23. Patients must not have had radiotherapy encompassing \\> 20% of the bone marrow within 2 weeks of randomization; or any radiation therapy within 1 week prior to randomization.","FEMALE","18 Years",{"count":853,"type":854},220,"ESTIMATED","INTERVENTIONAL",[857],"PHASE3","Patients will be registered prior to, during or at the completion of neoadjuvant chemotherapy given per standard institutional guidelines +\u002F- bevacizumab on Day 1 every 21 days for 3-4 cycles. Registered patients who progress during neoadjuvant chemotherapy will not be eligible for iCRS and will be removed from the study.\n\nFollowing completion of neoadjuvant chemotherapy, interval cytoreductive surgery (iCRS) will be performed in the usual fashion in both arms. Patients will be randomized at the time of iCRS (iCRS must achieve no gross residual disease or no disease \\>1.0 cm in largest diameter) to receive HIPEC or no HIPEC. Patients randomized to HIPEC Arm will receive a single dose of cisplatin (100mg\u002Fm2 IP over 90 minutes at 42 C) as HIPEC. After postoperative recovery patients will receive standard post-operative platinum-based combination chemotherapy. Patients randomized to surgery only (No HIPEC Arm) will receive postoperative standard chemotherapy after recovery from surgery.\n\nBoth groups will receive an additional 2-3 cycles of platinum-based combination chemotherapy per standard institutional guidelines +\u002F- bevacizumab for a maximum total of 6 cycles of chemotherapy (neoadjuvant plus post-operative cycles) followed by niraparib individualized dosing +\u002F- bevacizumab until progression or 36 months (if no evidence of disease).",[860,861,862,863,864,865],"Stage III Ovarian Cancer","Stage IV Ovarian Cancer","Stage III Primary Peritoneal Cancer","Stage IV Primary Peritoneal Cancer","Stage III Fallopian Tube Cancer","Stage IV Fallopian Tube Cancer",[9],"2026-04-15",{"date":869,"type":870},"2026-04-16","ACTUAL",{"date":872,"type":870},"2024-03-08",{"date":874,"type":854},"2034-08-01",{"name":5,"class":6},59]